Addressing Extracellular Matrix Breakdown That Leads to Age-Related Diseases with Dr. Sherif Idriss Elastin Biosciences TRANSCRIPT
Release Date: 09/24/2024
Using Deep Brain Stimulation for Treatment-Resistant Depression with Dr. Josh Eloge Connected Neuroscience TRANSCRIPT
Empowered Patient Podcast
Dr. Josh Eloge, Associate Director for the Woman's Board Treatment Research Center, Assistant Professor of Psychiatry and Behavioral Sciences at the Rush University Medical Center, and Founder of Connected Neuroscience has a focus on treatment-resistant depression which is defined as depression that is not relieved by at least two first-line medications. Research has identified that TRD is associated with hyperactivity in a specific brain region, shifting attention from a chemical view of depression to a neurobiological one. Research on deep-brain stimulation and implantable technology...
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Using Deep Brain Stimulation for Treatment-Resistant Depression with Dr. Josh Eloge Connected Neuroscience
Empowered Patient Podcast
Dr. Josh Eloge, Associate Director for the Woman's Board Treatment Research Center, Assistant Professor of Psychiatry and Behavioral Sciences at the Rush University Medical Center, and Founder of Connected Neuroscience has a focus on treatment-resistant depression which is defined as depression that is not relieved by at least two first-line medications. Research has identified that TRD is associated with hyperactivity in a specific brain region, shifting attention from a chemical view of depression to a neurobiological one. Research on deep-brain stimulation and implantable technology...
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Addressing Health Disparities Through Workforce Diversity and Improved Access to Clinical Trials with Dr. Eugene Manley STEMM & Cancer Health Equity Foundation TRANSCRIPT
Empowered Patient Podcast
Dr. Eugene Manley, biomedical scientist turned social impact leader and Founder and CEO of the STEMM & Cancer Health Equity Foundation, is focused on increasing STEMM workforce diversity and improving outcomes for underserved cancer patients. He highlights the lack of diversity in foundational lung cancer research and the need to expand the number of cell lines being included to develop more effective therapies. Eugene also raises concerns about barriers to clinical trial participation and the need to engage local community partners and AI to raise awareness and improve...
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Addressing Health Disparities Through Workforce Diversity and Improved Access to Clinical Trials with Dr. Eugene Manley STEMM & Cancer Health Equity Foundation
Empowered Patient Podcast
Dr. Eugene Manley, biomedical scientist turned social impact leader and Founder and CEO of the STEMM & Cancer Health Equity Foundation, is focused on increasing STEMM workforce diversity and improving outcomes for underserved cancer patients. He highlights the lack of diversity in foundational lung cancer research and the need to expand the number of cell lines being included to develop more effective therapies. Eugene also raises concerns about barriers to clinical trial participation and the need to engage local community partners and AI to raise awareness and improve...
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How Community-Based Clinical Trials Can Transform Patient Access and Participation with Ro Wickramasinghe Pi Health TRANSCRIPT
Empowered Patient Podcast
Ro Wickramasinghe, Vice President and Head of Global Business at Pi Health, identifies fundamental problems plaguing clinical trials, including operational inefficiencies and limited access to trials. Pi Health is addressing these challenges by developing an integrated software platform for clinical trial sponsors, sites, and patients and partnering with community-based cancer treatment centers worldwide. The company has built a hospital in India to serve as a living laboratory to test and refine its model to democratize access and increase the ethnic diversity of trial...
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How Community-Based Clinical Trials Can Transform Patient Access and Participation with Ro Wickramasinghe Pi Health
Empowered Patient Podcast
Ro Wickramasinghe, Vice President and Head of Global Business at Pi Health, identifies fundamental problems plaguing clinical trials, including operational inefficiencies and limited access to trials. Pi Health is addressing these challenges by developing an integrated software platform for clinical trial sponsors, sites, and patients and partnering with community-based cancer treatment centers worldwide. The company has built a hospital in India to serve as a living laboratory to test and refine its model to democratize access and increase the ethnic diversity of trial...
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Implantable Blood Glucose Monitors Provide Years of Accurate Monitoring with Paul Goode Glucotrack TRANSCRIPT
Empowered Patient Podcast
Paul Goode, President and CEO of Glucotrack, discusses the evolution and future of continuous glucose and continuous blood glucose monitoring for people with diabetes, as well as opportunities for implantable CMG monitors. In addition to convenience and comfort, the Glucotrack implantable CGM monitor is designed to be more accurate and measure blood glucose. This approach eliminates the lag time associated with wearable CGMs that measure interstitial fluid, enabling faster, more effective treatment decisions. Paul explains, "When you look at the market penetration of CGM in the US,...
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Implantable Blood Glucose Monitors Provide Years of Accurate Monitoring with Paul Goode Glucotrack
Empowered Patient Podcast
Paul Goode, President and CEO of Glucotrack, discusses the evolution and future of continuous glucose and continuous blood glucose monitoring for people with diabetes, as well as opportunities for implantable CMG monitors. In addition to convenience and comfort, the Glucotrack implantable CGM monitor is designed to be more accurate and measure blood glucose. This approach eliminates the lag time associated with wearable CGMs that measure interstitial fluid, enabling faster, more effective treatment decisions. Paul explains, "When you look at the market penetration of CGM in the US,...
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VR-Based Vision Therapy for Lazy Eye and Binocular Vision Disorders with Ben Backus and James Blaha Vivid Vision TRANSCRIPT
Empowered Patient Podcast
Ben Backus, Chief Science Officer, and James Blaha, CEO and Founder of Vivid Vision, discuss their work addressing binocular dysfunctions and improving visual field testing. Their innovative visual test uses a consumer-grade VR headset to deliver a gamified, less stressful, more engaging experience for patients, encouraging longer, more frequent testing. This approach also improves dataset precision and overcomes barriers in clinical trials for new therapeutics for diseases such as glaucoma and macular degeneration, potentially accelerating the development of vision-saving treatments. Ben...
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VR-Based Vision Therapy for Lazy Eye and Binocular Vision Disorders with Ben Backus and James Blaha Vivid Vision
Empowered Patient Podcast
Ben Backus, Chief Science Officer, and James Blaha, CEO and Founder of Vivid Vision, discuss their work addressing binocular dysfunctions and improving visual field testing. Their innovative visual test uses a consumer-grade VR headset to deliver a gamified, less stressful, more engaging experience for patients, encouraging longer, more frequent testing. This approach also improves dataset precision and overcomes barriers in clinical trials for new therapeutics for diseases such as glaucoma and macular degeneration, potentially accelerating the development of vision-saving treatments. Ben...
info_outlineDr. Sherif Idriss is the CEO of Elastin Biosciences, a company focused on targeting aging-related diseases by restoring elastin, a key protein in the extracellular matrix that provides elasticity and resilience to organs and tissues. They are developing small molecule therapies for diseases linked to elastin deficiency, including Williams syndrome and abdominal aortic aneurysm. As elastin degrades over time due to aging, it leads to loss of tissue structural integrity and function, contributing to numerous age-related diseases.
Sherif explains, "One of the hallmarks of aging is the loss of the extracellular matrix, which is composed of several proteins. Collagen is quite famous, but also elastin is the other major protein that is responsible for the elasticity of the different organs. For example, in our skin, the loss of elastin is associated with us looking older and having all the aging signs and wrinkles on the skin. If you imagine that there are other organs inside that we don’t visually see, then you have also the blood vessels, the lungs, a lot of the connective tissue. The extracellular matrix proteins and elastin itself are also aging in the same way and have their own form of damage one way or another. All of this contributes to aging and aging-related diseases as well."
"Another kind of disease is the category of rare diseases. In this case, we aim to target Williams syndrome, a rare disease characterized by a genetic partial deletion of around 26 genes. One of these genes is elastin itself, so some genetic material is still there, but there is not enough. We would like to try to push the elastin production up in Williams syndrome, and this would help rectify a lot of the disease issues, particularly when it comes to the cardiovascular system because Williams syndrome patients have quite a lot of issues with the cardiovascular system from birth and all through life."
#ElastinBiosciences #Aging #AgingRelatedDiseases #Elastin #WilliamsSyndrome
