Addressing Extracellular Matrix Breakdown That Leads to Age-Related Diseases with Dr. Sherif Idriss Elastin Biosciences TRANSCRIPT
Release Date: 09/24/2024
Innovations in Cell Therapy for Relapsed and Refractory Multiple Myeloma with Dr. Chris Heery Arcellx TRANSCRIPT
Empowered Patient Podcast
Dr. Chris Heery is Chief Medical Officer at Arcellx, a company focusing on developing anito-cel, a significant advancement in CAR-T cell therapy, to treat relapsed and refractory multiple myeloma (rrMM). Multiple myeloma is a rare type of blood cancer that affects plasma cells in the bone marrow and has few treatment options. Arcellx is showing promising data from clinical trials with patients with rrMM who have failed prior therapies and have received Fast Track, Orphan Drug, and Regenerative Medicine Advanced Therapy Designations from the FDA for anito-cel. Chris explains, "The company was...
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Innovations in Cell Therapy for Relapsed and Refractory Multiple Myeloma with Dr. Chris Heery Arcellx
Empowered Patient Podcast
Dr. Chris Heery is Chief Medical Officer at Arcellx, a company focusing on developing anito-cel, a significant advancement in CAR-T cell therapy, to treat relapsed and refractory multiple myeloma (rrMM). Multiple myeloma is a rare type of blood cancer that affects plasma cells in the bone marrow and has few treatment options. Arcellx is showing promising data from clinical trials with patients with rrMM who have failed prior therapies and have received Fast Track, Orphan Drug, and Regenerative Medicine Advanced Therapy Designations from the FDA for anito-cel. Chris explains, "The company was...
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Hyperbaric Oxygen Therapy for Treating PTSD and Cognitive Decline with Dr. Mohammed Elamir Aviv Clinics TRANSCRIPT
Empowered Patient Podcast
Dr. Mohammed Elamir, lead physician at Aviv Clinics, offers diagnostics and treatments for brain injuries such as PTSD, stroke, and traumatic brain injury and to address cognitive decline. After comprehensive physical and mental assessment, including brain scans, patients receive hyperbaric oxygen therapy and other therapies like psychotherapy and neurocognitive training. Individualized plans are designed to get to the root causes of neurological and cognitive issues and stimulate the growth of new cells and blood flow, even for patients with long-standing conditions. Dr. Mo explains,...
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Hyperbaric Oxygen Therapy for Treating PTSD and Cognitive Decline with Dr. Mohammed Elamir Aviv Clinics
Empowered Patient Podcast
Dr. Mohammed Elamir, lead physician at Aviv Clinics, offers diagnostics and treatments for brain injuries such as PTSD, stroke, and traumatic brain injury and to address cognitive decline. After comprehensive physical and mental assessment, including brain scans, patients receive hyperbaric oxygen therapy and other therapies like psychotherapy and neurocognitive training. Individualized plans are designed to get to the root causes of neurological and cognitive issues and stimulate the growth of new cells and blood flow, even for patients with long-standing conditions. Dr. Mo explains,...
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Power of Gait Analysis to Predict and Monitor Health Conditions with Tomer Shussman OneStep TRANSCRIPT
Empowered Patient Podcast
Tomer Shussman, the Co-Founder and CEO of OneStep, is at the forefront of motion intelligence and gait analysis. OneStep provides a smartphone app that monitors movement and provides real-time data about gait patterns and changes over time. The system can predict and prevent conditions like falls, provide information about overall health, and reveal early warning signs for Parkinson's, Alzheimer's, and other aging-related diseases. Integrating OneStep's gait analysis data with Epic electronic health records allows healthcare providers to streamline documentation and leverage gait data to...
info_outline
Power of Gait Analysis to Predict and Monitor Health Conditions with Tomer Shussman OneStep
Empowered Patient Podcast
Tomer Shussman, the Co-Founder and CEO of OneStep, is at the forefront of motion intelligence and gait analysis. OneStep provides a smartphone app that monitors movement and provides real-time data about gait patterns and changes over time. The system can predict and prevent conditions like falls, provide information about overall health, and reveal early warning signs for Parkinson's, Alzheimer's, and other aging-related diseases. Integrating OneStep's gait analysis data with Epic electronic health records allows healthcare providers to streamline documentation and leverage gait data to...
info_outline
Addressing Extracellular Matrix Breakdown That Leads to Age-Related Diseases with Dr. Sherif Idriss Elastin Biosciences TRANSCRIPT
Empowered Patient Podcast
Dr. Sherif Idriss is the CEO of Elastin Biosciences, a company focused on targeting aging-related diseases by restoring elastin, a key protein in the extracellular matrix that provides elasticity and resilience to organs and tissues. They are developing small molecule therapies for diseases linked to elastin deficiency, including Williams syndrome and abdominal aortic aneurysm. As elastin degrades over time due to aging, it leads to loss of tissue structural integrity and function, contributing to numerous age-related diseases. Sherif explains, "One of the hallmarks of aging is...
info_outline
Addressing Extracellular Matrix Breakdown That Leads to Age-Related Diseases with Dr. Sherif Idriss Elastin Biosciences
Empowered Patient Podcast
Dr. Sherif Idriss is the CEO of Elastin Biosciences, a company focused on targeting aging-related diseases by restoring elastin, a key protein in the extracellular matrix that provides elasticity and resilience to organs and tissues. They are developing small molecule therapies for diseases linked to elastin deficiency, including Williams syndrome and abdominal aortic aneurysm. As elastin degrades over time due to aging, it leads to loss of tissue structural integrity and function, contributing to numerous age-related diseases. Sherif explains, "One of the hallmarks of aging is...
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Treating Septic Shock with Nanoparticle Formulation that Redistributes Nitric Oxide with Dr. Harven DeShield Vivacelle Bio TRANSCRIPT
Empowered Patient Podcast
Dr. Harven DeShield is the CEO and Co-Founder of Vivacelle Bio, which is developing a nanoparticle-based treatment called VBI-S to address the underlying causes of septic shock. The treatment works by efficiently redistributing nitric oxide to help regulate blood pressure and improve organ function, reducing the need for traditional vasopressor treatments. Vivacelle is also developing a product to help address hemorrhagic shock and minimize reperfusion injury. Harven explains, "There are seven aspects to septic shock - actually eight. So, first, you have an infection. You have to have an...
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Treating Septic Shock with Nanoparticle Formulation that Redistributes Nitric Oxide with Dr. Harven DeShield Vivacelle Bio
Empowered Patient Podcast
Dr. Harven DeShield is the CEO and Co-Founder of Vivacelle Bio, which is developing a nanoparticle-based treatment called VBI-S to address the underlying causes of septic shock. The treatment works by efficiently redistributing nitric oxide to help regulate blood pressure and improve organ function, reducing the need for traditional vasopressor treatments. Vivacelle is also developing a product to help address hemorrhagic shock and minimize reperfusion injury. Harven explains, "There are seven aspects to septic shock - actually eight. So, first, you have an infection. You have to have an...
info_outlineDr. Sherif Idriss is the CEO of Elastin Biosciences, a company focused on targeting aging-related diseases by restoring elastin, a key protein in the extracellular matrix that provides elasticity and resilience to organs and tissues. They are developing small molecule therapies for diseases linked to elastin deficiency, including Williams syndrome and abdominal aortic aneurysm. As elastin degrades over time due to aging, it leads to loss of tissue structural integrity and function, contributing to numerous age-related diseases.
Sherif explains, "One of the hallmarks of aging is the loss of the extracellular matrix, which is composed of several proteins. Collagen is quite famous, but also elastin is the other major protein that is responsible for the elasticity of the different organs. For example, in our skin, the loss of elastin is associated with us looking older and having all the aging signs and wrinkles on the skin. If you imagine that there are other organs inside that we don’t visually see, then you have also the blood vessels, the lungs, a lot of the connective tissue. The extracellular matrix proteins and elastin itself are also aging in the same way and have their own form of damage one way or another. All of this contributes to aging and aging-related diseases as well."
"Another kind of disease is the category of rare diseases. In this case, we aim to target Williams syndrome, a rare disease characterized by a genetic partial deletion of around 26 genes. One of these genes is elastin itself, so some genetic material is still there, but there is not enough. We would like to try to push the elastin production up in Williams syndrome, and this would help rectify a lot of the disease issues, particularly when it comes to the cardiovascular system because Williams syndrome patients have quite a lot of issues with the cardiovascular system from birth and all through life."
#ElastinBiosciences #Aging #AgingRelatedDiseases #Elastin #WilliamsSyndrome
