Transforming Cough Analysis and Respiratory Healthcare Through AI and Digital Therapeutics with Tamsin Chislett Hyfe
Release Date: 05/14/2025
Empowered Patient Podcast
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info_outlineEmpowered Patient Podcast
Barry Quart, CEO of Connect Biopharma, is developing the next generation of monoclonal antibodies targeting inflammatory respiratory diseases such as COPD and asthma. Administered subcutaneously, their lead program targets IL-4 and has demonstrated the ability to rapidly improve airway function and reduce the incidence of acute exacerbations in these patients. Current treatments rely on steroids and bronchodilators, which do not address the underlying inflammatory causes, an area that has largely been under-addressed by other biologic developers. Barry explains, "Connect has been dedicated...
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Dr. Kilian Kelly, Chief Executive Officer and Managing Director of Cynata Therapeutics, has taken on the challenge of manufacturing stem cell therapies consistently and at scale in order to drive the advancements necessary for the next generation of regenerative medicine. Cynata is employing a novel approach that utilizes a single source of pluripotent stem cells (iPSCs) and mesenchymal cell ancestors (MCAs) to generate mesenchymal stem cells (MSCs). Lead programs are targeting graft-versus-host disease, osteoarthritis, and diabetic wounds, where clinical trials have shown great promise to...
info_outlineEmpowered Patient Podcast
Dr. Kilian Kelly, Chief Executive Officer and Managing Director of Cynata Therapeutics, has taken on the challenge of manufacturing stem cell therapies consistently and at scale in order to drive the advancements necessary for the next generation of regenerative medicine. Cynata is employing a novel approach that utilizes a single source of pluripotent stem cells (iPSCs) and mesenchymal cell ancestors (MCAs) to generate mesenchymal stem cells (MSCs). Lead programs are targeting graft-versus-host disease, osteoarthritis, and diabetic wounds, where clinical trials have shown great promise to...
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info_outlineEmpowered Patient Podcast
Shauna Sweeney, Founder of tendercare, aims to assist caregivers with digital tools and expert support to simplify the process of caring for an aging family member. Recognizing the essential role of caregivers in the quality of life of the patient, tendercare provides a user-friendly interface that incorporates data from wearables and remote sensors to identify early warning signs of risks, help coordinate care, and encourage proactive preparation. The Magic Magnet feature allows caregivers and emergency responders to quickly update and share critical health information. Shauna...
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Karen Sussman Horgan is the Co-Founder and CEO of VAL Health, a behavioral economics consulting firm that helps healthcare organizations drive engagement and nudge patients to improve their health and lifestyle choices. Behavioral economics is the science of understanding how patients make irrational choices based on biases, fear, and faulty analysis of outcomes and risk. Nudges can be carrots or sticks, but in healthcare, the focus is on making the right path easier to follow, reducing friction, and introducing positive reinforcements rather than penalties. Karen explains, "We work across...
info_outlineEmpowered Patient Podcast
Karen Sussman Horgan is the Co-Founder and CEO of VAL Health, a behavioral economics consulting firm that helps healthcare organizations drive engagement and nudge patients to improve their health and lifestyle choices. Behavioral economics is the science of understanding how patients make irrational choices based on biases, fear, and faulty analysis of outcomes and risk. Nudges can be carrots or sticks, but in healthcare, the focus is on making the right path easier to follow, reducing friction, and introducing positive reinforcements rather than penalties. Karen explains, "We work across...
info_outlineEmpowered Patient Podcast
Christine Lee, Head of Health Strategy and Partnerships at AnalyticsIQ, focuses on helping healthcare brands and pharmaceutical companies better understand and engage with healthcare providers by taking into account data beyond their professional lives. This data-driven Provider as a Person approach analyzes the healthcare professional's personal characteristics, outside interests, decision-making style, and preferred method of communication. The goal is to foster more meaningful relationships with providers, address provider burnout, and improve patient outcomes. Christine explains,...
info_outlineEmpowered Patient Podcast
Christine Lee, Head of Health Strategy and Partnerships at AnalyticsIQ, focuses on helping healthcare brands and pharmaceutical companies better understand and engage with healthcare providers by taking into account data beyond their professional lives. This data-driven Provider as a Person approach analyzes the healthcare professional's personal characteristics, outside interests, decision-making style, and preferred method of communication. The goal is to foster more meaningful relationships with providers, address provider burnout, and improve patient outcomes. Christine explains,...
info_outlineTamsin Chislett, CEO of Hyfe, highlights the importance of understanding coughs for healthcare providers, the lack of information about coughs, and Hyfe's advancements in building a database and developing biomarkers based on different kinds of coughs. Hyfe's AI technology, which can integrate with other devices and platforms for remote patient monitoring, enables passive, continuous tracking of cough patterns that can be used in research and clinical trials. Opportunities for digital therapeutics include chronic cough, COPD, lung cancer, respiratory infections, and cardiovascular diseases.
Tamsin elaborates, "Hyfe is the global leader in AI power. The problem we're trying to solve is that you have this really common symptom cough, which has been experienced by every human alive and is experienced daily by many people, yet to discuss it, measure it, monitor it, or even manage it, we're entirely reliant on subjective data. Everyone's had the experience of going into a primary care doctor, and saying I've got a really bad cough. The doctor says How bad is it, and is it getting worse? We don't even have the proper language to describe it."
"We want to get to the point where, in those situations, the doctor can start to get objective data about the patient's cough patterns and use that instead. The way we see it is that there was a time when to measure fever, we put a hand on a patient's forehead. We hope that within a few years, thanks to Hyfe's technology, we should not be in the same position with cough. So we're always looking to have objective data."
"I think the interesting thing about cough is that because it's never been measurable, it hasn't been studied anywhere near as much as it probably should have. And even in the first five years of Hyfe's life, we've seen an explosion in cough-related science now that it's possible to monitor coughs with a smartphone, a smart watch, or anything with a microphone running Hyfe's technology. We've seen exciting science across a whole range, many of which are intuitive when you start thinking about cough, acute cough is a big one and respiratory infections, but there's also chronic cough."
"There's also COPD, there's IPF, there's lung cancer, there are so many respiratory and even cardiology diseases where cough is a cardinal symptom, a really clear sign of exacerbation of disease or worsening. However, to date, it has not been able to be measured, and cough monitoring with Hyfe allows you to monitor cough over time, see patterns, and use those patterns to optimize patient care in the future."
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