Next Generation Monoclonal Antibodies for Inflammatory Respiratory Diseases with Barry Quart Connect Biopharma TRANSCRIPT
Release Date: 06/06/2025
Empowered Patient Podcast
Barry Quart, CEO of Connect Biopharma, is developing the next generation of monoclonal antibodies targeting inflammatory respiratory diseases such as COPD and asthma. Administered subcutaneously, their lead program targets IL-4 and has demonstrated the ability to rapidly improve airway function and reduce the incidence of acute exacerbations in these patients. Current treatments rely on steroids and bronchodilators, which do not address the underlying inflammatory causes, an area that has largely been under-addressed by other biologic developers. Barry explains, "Connect has been dedicated...
info_outlineEmpowered Patient Podcast
Barry Quart, CEO of Connect Biopharma, is developing the next generation of monoclonal antibodies targeting inflammatory respiratory diseases such as COPD and asthma. Administered subcutaneously, their lead program targets IL-4 and has demonstrated the ability to rapidly improve airway function and reduce the incidence of acute exacerbations in these patients. Current treatments rely on steroids and bronchodilators, which do not address the underlying inflammatory causes, an area that has largely been under-addressed by other biologic developers. Barry explains, "Connect has been dedicated...
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Dr. Kilian Kelly, Chief Executive Officer and Managing Director of Cynata Therapeutics, has taken on the challenge of manufacturing stem cell therapies consistently and at scale in order to drive the advancements necessary for the next generation of regenerative medicine. Cynata is employing a novel approach that utilizes a single source of pluripotent stem cells (iPSCs) and mesenchymal cell ancestors (MCAs) to generate mesenchymal stem cells (MSCs). Lead programs are targeting graft-versus-host disease, osteoarthritis, and diabetic wounds, where clinical trials have shown great promise to...
info_outlineEmpowered Patient Podcast
Dr. Kilian Kelly, Chief Executive Officer and Managing Director of Cynata Therapeutics, has taken on the challenge of manufacturing stem cell therapies consistently and at scale in order to drive the advancements necessary for the next generation of regenerative medicine. Cynata is employing a novel approach that utilizes a single source of pluripotent stem cells (iPSCs) and mesenchymal cell ancestors (MCAs) to generate mesenchymal stem cells (MSCs). Lead programs are targeting graft-versus-host disease, osteoarthritis, and diabetic wounds, where clinical trials have shown great promise to...
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info_outlineEmpowered Patient Podcast
Shauna Sweeney, Founder of tendercare, aims to assist caregivers with digital tools and expert support to simplify the process of caring for an aging family member. Recognizing the essential role of caregivers in the quality of life of the patient, tendercare provides a user-friendly interface that incorporates data from wearables and remote sensors to identify early warning signs of risks, help coordinate care, and encourage proactive preparation. The Magic Magnet feature allows caregivers and emergency responders to quickly update and share critical health information. Shauna...
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Karen Sussman Horgan is the Co-Founder and CEO of VAL Health, a behavioral economics consulting firm that helps healthcare organizations drive engagement and nudge patients to improve their health and lifestyle choices. Behavioral economics is the science of understanding how patients make irrational choices based on biases, fear, and faulty analysis of outcomes and risk. Nudges can be carrots or sticks, but in healthcare, the focus is on making the right path easier to follow, reducing friction, and introducing positive reinforcements rather than penalties. Karen explains, "We work across...
info_outlineEmpowered Patient Podcast
Karen Sussman Horgan is the Co-Founder and CEO of VAL Health, a behavioral economics consulting firm that helps healthcare organizations drive engagement and nudge patients to improve their health and lifestyle choices. Behavioral economics is the science of understanding how patients make irrational choices based on biases, fear, and faulty analysis of outcomes and risk. Nudges can be carrots or sticks, but in healthcare, the focus is on making the right path easier to follow, reducing friction, and introducing positive reinforcements rather than penalties. Karen explains, "We work across...
info_outlineEmpowered Patient Podcast
Christine Lee, Head of Health Strategy and Partnerships at AnalyticsIQ, focuses on helping healthcare brands and pharmaceutical companies better understand and engage with healthcare providers by taking into account data beyond their professional lives. This data-driven Provider as a Person approach analyzes the healthcare professional's personal characteristics, outside interests, decision-making style, and preferred method of communication. The goal is to foster more meaningful relationships with providers, address provider burnout, and improve patient outcomes. Christine explains,...
info_outlineEmpowered Patient Podcast
Christine Lee, Head of Health Strategy and Partnerships at AnalyticsIQ, focuses on helping healthcare brands and pharmaceutical companies better understand and engage with healthcare providers by taking into account data beyond their professional lives. This data-driven Provider as a Person approach analyzes the healthcare professional's personal characteristics, outside interests, decision-making style, and preferred method of communication. The goal is to foster more meaningful relationships with providers, address provider burnout, and improve patient outcomes. Christine explains,...
info_outlineBarry Quart, CEO of Connect Biopharma, is developing the next generation of monoclonal antibodies targeting inflammatory respiratory diseases such as COPD and asthma. Administered subcutaneously, their lead program targets IL-4 and has demonstrated the ability to rapidly improve airway function and reduce the incidence of acute exacerbations in these patients. Current treatments rely on steroids and bronchodilators, which do not address the underlying inflammatory causes, an area that has largely been under-addressed by other biologic developers.
Barry explains, "Connect has been dedicated for quite a few years to designing next-generation monoclonal antibodies targeting inflammatory diseases. I joined the company last year and really kind of turned the ship towards a sole focus on our lead program, which is rademikibart, a second-generation Dupixent, a monoclonal antibody targeting IL-4, a really important target for certain inflammatory diseases."
"IL-4 can be used as a monoclonal antibody targeting IL-4 for diseases such as atopic dermatitis, asthma, and COPD, as well as several other conditions. We're focused on asthma and COPD. So, inflammatory respiratory disease, because our product has some unique characteristics that are going to allow us to focus on an area that's really been completely ignored by other developers of biologics in the respiratory space, and specifically on patients having acute exacerbations."
#ConnectBiopharma #MonoclonalAntibody #IL4 #COPD #Asthma #AtopicDermatitis #InflammatoryDiseases #RespiratoryDiseases