Focus on Resistance Pathways to Target Blood Cancers and Graft-Versus-Host Disease with Peter Ordentlich Syndax Pharmaceuticals
Release Date: 06/10/2025
Using AI to Address Medical Record Dirty Data with Dr. Jay Anders Medicomp TRANSCRIPT
Empowered Patient Podcast
Dr. Jay Anders, Chief Medical Officer at Medicomp Systems, discusses the issue of dirty data — inaccurate and inconsistent medical data — and its origins, as well as how technology can be used to maintain correct health records. These kinds of errors can lead to incorrect diagnoses, inappropriate treatment, and negative consequences for patients, providers, and payers. AI and other technologies are being leveraged to help identify and flag inconsistencies, providing stakeholders with the tools to prioritize accuracy over efficiency. Jay explains, "What we do at Medicomp is a...
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Using AI to Address Medical Record Dirty Data with Dr. Jay Anders Medicomp
Empowered Patient Podcast
Dr. Jay Anders, Chief Medical Officer at Medicomp Systems, discusses the issue of dirty data — inaccurate and inconsistent medical data — and its origins, as well as how technology can be used to maintain correct health records. These kinds of errors can lead to incorrect diagnoses, inappropriate treatment, and negative consequences for patients, providers, and payers. AI and other technologies are being leveraged to help identify and flag inconsistencies, providing stakeholders with the tools to prioritize accuracy over efficiency. Jay explains, "What we do at Medicomp is a...
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Ultra-Fast Cardiac CT Imaging Transforming Cardiovascular Diagnostics with Doug Ryan Arineta TRANSCRIPT
Empowered Patient Podcast
Doug Ryan, CEO of Arineta, describes the advancements in cardiac CT imaging technology and how their ultra-fast scanning is revealing more accurate and higher-quality imaging of the heart. Using wide-area coverage and deep learning image reconstruction, the Arineta platform can detect arterial occlusions and coronary plaque buildup, which is a significant risk factor for sudden cardiac events and is often missed when relying solely on calcium scoring. The development of a mobile cardiac CT scanning unit is improving access to this technology, particularly in rural and underserved areas. Doug...
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Ultra-Fast Cardiac CT Imaging Transforming Cardiovascular Diagnostics with Doug Ryan Arineta
Empowered Patient Podcast
Doug Ryan, CEO of Arineta, describes the advancements in cardiac CT imaging technology and how their ultra-fast scanning is revealing more accurate and higher-quality imaging of the heart. Using wide-area coverage and deep learning image reconstruction, the Arineta platform can detect arterial occlusions and coronary plaque buildup, which is a significant risk factor for sudden cardiac events and is often missed when relying solely on calcium scoring. The development of a mobile cardiac CT scanning unit is improving access to this technology, particularly in rural and underserved areas. Doug...
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Cybersecurity and Hidden Dangers of Healthcare Interoperability with Kory Daniels Trustwave TRANSCRIPT
Empowered Patient Podcast
Kory Daniels, Chief Information Security Officer at Trustwave, highlights the unique cybersecurity challenges facing the healthcare industry, particularly in this environment of funding constraints and the increasing sophistication of cyberattacks. Healthcare data is highly valuable to cybercriminals, who can use it for ransomware attacks, identity and insurance fraud, and other nefarious purposes. AI can be part of both the attack and the solution, helping to build in more cyber resilience and awareness about vulnerabilities. Kory explains, "Healthcare is a prime target for...
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Cybersecurity and Hidden Dangers of Healthcare Interoperability with Kory Daniels Trustwave
Empowered Patient Podcast
Kory Daniels, Chief Information Security Officer at Trustwave, highlights the unique cybersecurity challenges facing the healthcare industry, particularly in this environment of funding constraints and the increasing sophistication of cyberattacks. Healthcare data is highly valuable to cybercriminals, who can use it for ransomware attacks, identity and insurance fraud, and other nefarious purposes. AI can be part of both the attack and the solution, helping to build in more cyber resilience and awareness about vulnerabilities. Kory explains, "Healthcare is a prime target for...
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How AI and Telehealth are Transforming Patient Access with Matt Brown CHG Healthcare TRANSCRIPT
Empowered Patient Podcast
Matt Brown, VP of Telehealth at Advisory Services at CHG Healthcare, discusses the current state and future of telehealth, including the rapid adoption during the COVID-19 pandemic, the role of technology and AI in enhancing telehealth experiences, and how telehealth can help address physician and nurse burnout. Improved internet access, mobile device usage, and consumer preferences for convenience have driven the increasing telehealth usage for initial visits, follow-up appointments, and chronic care management. Matt explains, "We are the nation's largest staffing agency. So, we're...
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How AI and Telehealth are Transforming Patient Access with Matt Brown CHG Healthcare
Empowered Patient Podcast
Matt Brown, VP of Telehealth at Advisory Services at CHG Healthcare, discusses the current state and future of telehealth, including the rapid adoption during the COVID-19 pandemic, the role of technology and AI in enhancing telehealth experiences, and how telehealth can help address physician and nurse burnout. Improved internet access, mobile device usage, and consumer preferences for convenience have driven the increasing telehealth usage for initial visits, follow-up appointments, and chronic care management. Matt explains, "We are the nation's largest staffing agency. So, we're...
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Localized Immunotherapy to Treat Metastatic Prostate Cancer with Dr. Chuck Link Syncromune TRANSCRIPT
Empowered Patient Podcast
Dr. Chuck Link is the Executive Chairman of Syncromune, a company developing a novel immunotherapy approach for solid tumors by delivering the therapy into the tumor and surrounding lymph nodes to stimulate a systemic immune response. Their complex drug has four different components with varying levels of activity that activate the immune system and counteract immune suppression. This in situ immunotherapy technology, SYNC-T, was tested in a phase 1 trial for metastatic castration-resistant prostate cancer, which showed high response rates and a favorable safety profile with low rates of...
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Localized Immunotherapy to Treat Metastatic Prostate Cancer with Dr. Chuck Link Syncromune
Empowered Patient Podcast
Dr. Chuck Link is the Executive Chairman of Syncromune, a company developing a novel immunotherapy approach for solid tumors by delivering the therapy into the tumor and surrounding lymph nodes to stimulate a systemic immune response. Their complex drug has four different components with varying levels of activity that activate the immune system and counteract immune suppression. This in situ immunotherapy technology, SYNC-T, was tested in a phase 1 trial for metastatic castration-resistant prostate cancer, which showed high response rates and a favorable safety profile with low rates of...
info_outlinePeter Ordentlich, Chief Scientific Officer and Founder at Syndax Pharmaceuticals, a clinical oncology company, is focused on developing precision medicine approaches to treat cancer and chronic graft-versus-host disease. The menin protein plays a critical role in driving certain types of blood cancers, and the Synex therapy is a menin inhibitor that can disrupt this cancer-driving pathway. The platform is also developing an antibody addressing the unmet needs in cGVHD to reduce the disease-driving macrophages.
Peter explains, "Syndax is a clinical oncology company, which means we're focused primarily on cancer, and we're primarily doing clinical development. We started the company really looking at resistance pathways to developing cancer, and we've been focused on two main areas. One in the indication space of leukemia, which are certain types of blood cancers, and that's with a program we have around the small molecule drug called revumenib. We are also focused in another area of diseases called chronic graft-versus-host disease. These are diseases that happen post-stem cell transplant, and there we're developing an antibody called axatilimab. And so those two programs are really what we've been focusing on for the last five or six years and have led to each of those drugs."
"So menin is a very interesting protein, and basically what this is, it's called a scaffold protein. And you can imagine a scaffold, just something you build things upon. And so menin interacts with DNA through a variety of other factors, and you build on top of this a complex of other proteins that can turn genes on and off. And in the case of certain types of leukemias, the mutation that creates certain other cancer-causing proteins binds to menin. That's what drives certain genes that drive leukemia to always be turned on. And so what we've tried to do and others have tried to do is disrupt that interaction and essentially cause the scaffold to fall apart. And when that falls apart, you can no longer keep those genes on that drive leukemia, and instead, you have genes that essentially cause the cell to stop growing."
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