Using Neuroimaging and Deep Brain Stimulation to Provide Durable Relief for Severe Treatment-Resistant Depression with Dr. Mark George TRANSCEND Study TRANSCRIPT
Release Date: 08/25/2026
Cows Producing Human Antibodies for a New Type 1 Diabetes Treatment with Samuel Reich SAB Bio TRANSCRIPT
Empowered Patient Podcast
Samuel Reich, Chief Executive Officer at SAB Bio, is developing a fully human antibody therapy designed to transform type 1 diabetes treatment by preserving patients' beta cells and their ability to produce insulin, rather than just managing symptoms with insulin and glucose monitoring. The drug is produced using the company's bovine platform which uses genetically modified cows to generate human immunoglobulins offering a safer more scalable alternative to rabbit-derived therapies. If successful, this approach could represent a functional cure, potentially transforming type 1 diabetes from a...
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Cows Producing Human Antibodies for a New Type 1 Diabetes Treatment with Samuel Reich SAB Bio
Empowered Patient Podcast
Samuel Reich, Chief Executive Officer at SAB Bio, is developing a fully human antibody therapy designed to transform type 1 diabetes treatment by preserving patients' beta cells and their ability to produce insulin, rather than just managing symptoms with insulin and glucose monitoring. The drug is produced using the company's bovine platform which uses genetically modified cows to generate human immunoglobulins offering a safer more scalable alternative to rabbit-derived therapies. If successful, this approach could represent a functional cure, potentially transforming type 1 diabetes from a...
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Role of Cloud Fax in Fast and Secure Healthcare Messaging with Marcus Ionker Retarus TRANSCRIPT
Empowered Patient Podcast
Marcus Ionker, Product Line Manager and Messaging Evangelist at Retarus, which is a cloud-based transactional electronic messaging service provider offering fax, SMS, email, and logistics services to regulated industries like healthcare. By moving fax to the cloud, Retarus helps providers and payers reduce administrative costs, improve patient services, and comply with privacy regulations. The company is addressing the critical challenge of providing reliable, secure, and fast messaging to replace outdated physical fax machines and to eliminate paper-based processes in favor of digital...
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Role of Cloud Fax in Fast and Secure Healthcare Messaging with Marcus Ionker Retarus
Empowered Patient Podcast
Marcus Ionker, Product Line Manager and Messaging Evangelist at Retarus, which is a cloud-based transactional electronic messaging service provider offering fax, SMS, email, and logistics services to regulated industries like healthcare. By moving fax to the cloud, Retarus helps providers and payers reduce administrative costs, improve patient services, and comply with privacy regulations. The company is addressing the critical challenge of providing reliable, secure, and fast messaging to replace outdated physical fax machines and to eliminate paper-based processes in favor of digital...
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Disease-Modifying Allogeneic Treatment for Chronic Sciatica with Andrew Hall Consano Bio TRANSCRIPT
Empowered Patient Podcast
Andrew Hall, CEO of Consano Bio, is developing an allogeneic approach to treat chronic sciatica by activating healing in damaged spinal nerves, emulating the natural healing properties of human platelets. This condition currently has no approved treatments and is managed through symptomatic approaches like opioids, muscle relaxers, or surgery. Consano Bio's lead candidate represents the first potential disease-modifying therapy for pain management and can be manufactured at scale to treat the estimated 10 million Americans affected by this condition. Andrew explains, "We are developing...
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Disease-Modifying Allogeneic Treatment for Chronic Sciatica with Andrew Hall Consano Bio
Empowered Patient Podcast
Andrew Hall, CEO of Consano Bio, is developing an allogeneic approach to treat chronic sciatica by activating healing in damaged spinal nerves, emulating the natural healing properties of human platelets. This condition currently has no approved treatments and is managed through symptomatic approaches like opioids, muscle relaxers, or surgery. Consano Bio's lead candidate represents the first potential disease-modifying therapy for pain management and can be manufactured at scale to treat the estimated 10 million Americans affected by this condition. Andrew explains, "We are developing...
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How Real-Time Location Data and AI Improve Utilization of Clinic Exam Rooms with Isobel Handler Kontakt io TRANSCRIPT
Empowered Patient Podcast
Isobel Handler, Senior Director of Product Management at Kontakt.io addresses critical inefficiencies in clinical exam room utilization. By capturing data about staff-patient interactions and facility usage, the Kontakt.io platform incorporates real-time location data to optimize patient access, reduce waiting time, and improve staff safety. The solution helps healthcare organizations understand their current capacity utilization before investing in new facilities and supports integration of digital tools to include virtual visits and asychronous communication to better serve patients...
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How Real-Time Location Data and AI Improve Utilization of Clinic Exam Rooms with Isobel Handler Kontakt io
Empowered Patient Podcast
Isobel Handler, Senior Director of Product Management at Kontakt.io addresses critical inefficiencies in clinical exam room utilization. By capturing data about staff-patient interactions and facility usage, the Kontakt.io platform incorporates real-time location data to optimize patient access, reduce waiting time, and improve staff safety. The solution helps healthcare organizations understand their current capacity utilization before investing in new facilities and supports integration of digital tools to include virtual visits and asychronous communication to better serve patients...
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Treating Dysfunction of Resistance Arteries to Restore Blood Flow with Dr. Steffen-Sebastian Bolz QanatPharma TRANSCRIPT
Empowered Patient Podcast
Dr. Steffen-Sebastian Bolz, Founder of QanatPharma, emphasizes the critical role of resistance arteries, microscopic blood vessels that regulate blood flow and pressure throughout the body, in maintaining organ function. Due to their size, these resistance arteries have been overlooked but with new lab techniques, QP is discovering how their dysfunction contributes to heart failure, cognitive impairment and strokes. The company's lead candidate is a repurposed drug already approved for cystic fibrosis that shows promise in restoring brain blood flow and cognitive function in heart failure...
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Treating Dysfunction of Resistance Arteries to Restore Blood Flow with Dr. Steffen-Sebastian Bolz QanatPharma
Empowered Patient Podcast
Dr. Steffen-Sebastian Bolz, Founder of QanatPharma, emphasizes the critical role of resistance arteries, microscopic blood vessels that regulate blood flow and pressure throughout the body, in maintaining organ function. Due to their size, these resistance arteries have been overlooked but with new lab techniques, QP is discovering how their dysfunction contributes to heart failure, cognitive impairment and strokes. The company's lead candidate is a repurposed drug already approved for cystic fibrosis that shows promise in restoring brain blood flow and cognitive function in heart failure...
info_outlineDr. Mark George is the principal psychiatric investigator of Abbott's TRANSCEND study and also a professor of psychiatry at MUSC Health Institute of Psychiatry. The TRANSCEND study represents a paradigm shift in depression treatment by investigating deep brain stimulation as a potential solution for treatment-resistant depression. This research involves surgically implanting a device that delivers targeted electrical stimulation to specific brain circuits. By reframing depression as a brain disorder rather than a chemical imbalance, this study emphasizes the biological nature of depression, offering an alternative to a condition with limited options.
Mark explains, "There are a lot of people, unfortunately, maybe a quarter of the people with depression who lead lives of misery where the medications and talking just don't get them back on their game. And so that's what we call treatment-resistant depression. And that's where I've spent my career trying to come up with new treatments."
"Well, so if the medications aren't working, you can try even more medicines, but the odds go way down. So there's a whole class of things where we actually stimulate the brain to try to, non-invasively and not using a pill, get in and change circuits in the brain. And those have started to really transform the care of treatment-resistant depression. There are several of them that are both non-invasive, and then others that are invasive."
"But the real holy grail would be for us to find the circuit or the spot in the brain and be able to put something there and then fix it. And then there you go, you live your life, and it would not be a pill that you have to take every day. And it would not have systemic side effects like medications. It wouldn't cause weight gain, sexual side effects, those kinds of things. So the real interest in the deep brain stimulation study that Abbott TRANSCEND is: “Could we stick a wire in the area of the brain that's not working right and pass very, very small amounts of electricity and really wake somebody up and get them out of their depression?”
#Abbott #DBS #TRANSCENDstudy #TRD #TreatmentReistantDepression
