Immune Booster 27: Interferons, JAKs, and STATs with George Stark
Immune
George Stark from the Cleveland Clinic reflects on his early training in biochemistry and how several sabbatical leaves sparked pivotal changes in his research trajectory, eventually drawing him to interferon signaling where he helped establish the core principles of the JAK–STAT pathway and uncovered interesting roles for interferon signaling in cancer. Host: Guest: Subscribe (free): , , Become a of Immune! Links for this episode Development of the technique (PNAS, 1977) Development of for proteins (PNAS, 1979) Discovery...
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Immune 103: Cytokines 101
Immune
The Immune team talks all about cytokines, from what they are to immunotherapies against them to treat diseases. Hosts: , , and Subscribe (free): , , Become a of Immune! Links for this episode and complement (mBio 2026) against viruses (Virology blog, 2009) Biologics (Int J Cell Bio, 2016) Biologics (JACI, 2022) Time stamps by . Thanks! Music by Tatami. Immune logo image by Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as...
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Immune Booster 26: Immune defense against parasitic worms with Irah King
Immune
Irah King from McGill University talks about his passion to understand how our immune system detects and responds to helminthic worm infections, how the worms can reprogram those responses, and how these pathways might be exploited to develop new treatments for inflammatory diseases. Host: Guest: Subscribe (free): , , Become a of Immune! Links for this episode against intestinal infection (Cell, 2025) in Early Life (Cell, Host, & Microbe, 2024) and parasitic infection (Mucoslal Immunol, 2023) the intestinal epithelium...
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Immune102: Living longer without B cells
Immune
The Immune team discusses a paper describing the negative effects of old B cells on T cells and longevity and a snippet on an interesting vaccine approach to promote competition between gut commensals. Hosts: , , and Subscribe (free): , , Become a of Immune! Links for this episode of gut bacteria (Science 2025) B cells drive (Sci Immunol 2026) Time stamps by . Thanks! Music by Tatami. Immune logo image by Send your immunology questions and comments to immune@microbe.tv Information on this podcast...
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Immune Booster 25: Out of the anti-vax woods with Ellen Woods
Immune
A former anti-vax mom talks about going down the rabbit hole, her mindset shift, the importance of doctors who are willing to talk with patients about vaccines, and why she is now a vaccine advocate. Host: Guest Subscribe (free): , , Become a of Immune! Links for this episode foundation information and advocacy us about vaccine hesitancy with vaccine hesitant people Time stamps by . Thanks! Music by . Logo image by Send your immunology questions and comments to immune@microbe.tv Information on this...
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Immune Booster 24: Tolerating pregnancy with Gabrielle Rizzuto
Immune
Gabrielle Rizzuto from Memorial Sloan Kettering Cancer Center discusses her work on the curious immunology of pregnancy and how a woman tolerates a genetically different baby but quickly rejects a mismatched organ donation. Host: Guest Subscribe (free): , , Become a of Immune! Links for this episode at MSKCC -maternal interface (Nature, 2022) The tolerance (J Exp Med, 2022) of fetal-maternal interface (Nature, 2023) Time stamps by . Thanks! Music by . Logo image by Send your immunology questions and comments...
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Immune 101: Ink and immunity
Immune
Immune discusses how tattoo ink accumulates in lymph nodes, promotes inflammation and influences response to two different vaccines. Hosts: , , and Subscribe (free): , , Become a of Immune! Links for this episode IL-9, CD8 cells and vaccines Time stamps by . Thanks! Music by Tatami. Immune logo image by Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.
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Immune Booster 23: Critical windows during immune system development with Anna Beaudin
Immune
Anna Beaudin from University of Utah talks about the key thread of her career, development, and how that influences her research on the events happening during critical prenatal windows shapes everything from the developing immune system to hearing loss. Host: Guest Subscribe (free): , , Become a of Immune! Links for this episode at University of Utah PhD work on Postdoc work on and hematopoietic stem cell development on postnatal immunity Early life inflammation and Time stamps by . Thanks! Music by . Logo image...
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Immune Booster #22 T cell signaling and selection with Leslie Berg
Immune
Leslie Berg talks about her career studying T cell receptor signaling, T cell development, and the importance of mentors in her career. Host: Guest: Subscribe (free): , , Become a of Immune! Links for this episode at University of Colorado Anschutz TCR thresholds and ITK (PNAS) Review on TCR signaling (Nat Immunol) Generation of (Mol Cell Bio) in TCR transgenic mice (Nature) Thymic n TCR transgenic mice (Cell) Berg information Time stamps by . Thanks! Music by . Logo image by Send...
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Immune 100: Immune turns 100!
Immune
The whole Immune gang gathers with special guests Gretchen Diehl and Shruti Naik at The Incubator with an audience to celebrate the 100th episode. Hosts: , , and Guests: and Subscribe (free): , , Become a of Immune! Links for this episode Diehl: Gut development (Nature 2021) Diehl: Bacteria-i (Gut Microbes 2022) Diehl: Microbiota, and colitis (Gut Microbes 2022) Diehl: E. coli-activated inflammation (Cell Rep 2025) Naik: skin inflammation (Science 2012) Naik: IL-17...
info_outlineThe Immune team discusses the groundbreaking discoveries of regulatory T cells, which was the topic of the 2025 Nobel Prize in Physiology or Medicine.
Hosts: Vincent Racaniello, Cindy Leifer, and Brianne Barker
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Links for this episode
- MicrobeTV Discord Server
- Sakaguchi lab paper on FoxP3 and regulatory T cells (Science 2003)
- Brunkow and Ramsdell description of scurfy mouse mutation (Nature 2001)
- Nobel Prize writeup on Treg discoveries
- Time stamps by Jolene Ramsey. Thanks!
Music by Tatami.
Immune logo image by Blausen Medical
Send your immunology questions and comments to immune@microbe.tv
Information on this podcast should not be construed as medical advice.