Saloni Dattani - The Hidden Bottleneck Holding Back the Future of Medicine (Ep. 312)
Infinite Loops
Saloni Dattani, author of the Scientific Discovery Substack and founding editor of magazine, joins Infinite Loops to discuss why medical innovation is often much slower than it needs to be. We explore why so much research still begins in animal models, how poor data distorts our understanding of disease, why clinical trials are one of the biggest bottlenecks in medicine, and how better systems could help promising treatments reach patients faster. Important Links: Read more from Saloni here: And here: And listen to Saloni's podcast "Hard Drugs" here:
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Brian Potter - How to Fix America’s Building Problem
Infinite Loops
Why has America become so bad at building housing, infrastructure, and major projects? Brian Potter, author of The Origins of Efficiency and writer of Construction Physics, explains why prefab housing keeps failing and why there are no easy fixes to America’s building problem. We discuss Katerra, California’s anti-growth turn, and the deeper logic behind local opposition to growth: concentrated harms and diffuse benefits. Important Links: Read Brian's newsletter Construction Physics here: Read Brian's book The Origins of Efficiency here: Learn more about Brian here:
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Alex Petkas - What Ancient Greece Can Teach Us About AI and the Future (Ep. 310)
Infinite Loops
What can Aristotle, Plato, Prometheus, and the Greek city-states teach us about AI, innovation, and the future of human flourishing? Alex Petkas joins the show to explore how old myths still matter in a world shaped by technology. We talk about Prometheus as the foundational myth of tech, Plato’s fear that writing would become a tool for forgetting, the real lesson of Icarus, why decentralization creates cultural power, and what it means to remain fully human in the age of AI. Important Links: Learn More about The Cost of Glory: Check out Alex's Youtube Channel: Alex's Twitter: The...
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Sam Arbesman - Why Future Belongs to Curious People (Ep. 309)
Infinite Loops
Scientist and writer Sam Arbesman joins us for a wide-ranging conversation on AI, optimism, science, education, archives, science fiction, and why the history of computing still has so much to teach us. We talk about why pessimism is often mistaken for sophistication, why AI may reward open-mindedness more than intelligence, why science works even though scientists are imperfect, and why the future may depend on revisiting forgotten ideas from the past. Important Links: Learn more about Sam here: Read Sam's latest book: Sam's Substack: Neal Stephenson's Innovation Starvation: ...
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Johnathan Bi - Why the Best Founders Might Need a Little Delusion (Ep. 308)
Infinite Loops
Johnathan Bi returns to Infinite Loops for a conversation about founders, delusion, America, religion, mysticism, and the strange tension between truth and action. We explore why some of the most effective builders may be the least introspective, why societies often run on useful fictions, how America encourages megalomania, what happens when materialism starts to feel incomplete, and why the “seeker” may matter even more in the age of AI. The episode moves from Plato and Caesar to founders, mystics, near-death experiences, and the future of human creativity. Important Links: Johnathan's...
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Polina Pompliano - What Truly Drives Successful People (Ep. 307)
Infinite Loops
Polina Pompliano studies some of the most successful people in the world—and what she’s found challenges how we think about success, creativity, and human behavior. In this episode of Infinite Loops, we explore the mental models behind high performers, why we misunderstand people (including ourselves), and what it really takes to see the world differently. From creativity and rationality to identity, media bias, and the hidden motivations driving success, this conversation is a deep dive into how great thinkers actually operate. Important Links: Check out Polina's new book: More...
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Adam Mastroianni - Why Creativity Feels Like It's Dying (Ep. 306)
Infinite Loops
In this episode of Infinite Loops, we speak with Adam Mastroianni—experimental psychologist and sharp critic of modern culture and science. We ask, why does creativity feel like it’s fading? From endless remakes to cultural sameness, Adam argues that as society becomes more stable and risk-averse, we may be unintentionally reducing the “deviance” that drives originality and breakthrough thinking. We also discuss why science should get weirder, how to fight credentialism, and the dangers of professionalization. Important Links: To learn more about Adam Mastroianni: Adam's Piece on...
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Arkady Kulik - The Psychology of Self-Deception (Ep. 305)
Infinite Loops
In this episode of Infinite Loops, we sit down with venture capitalist and physicist Arkady Kulikov to explore the psychology behind founders, responsibility, and self-deception. Kulik discusses why the hardest problems in business are almost always human problems, how great founders deal with stress, and why the biggest lie entrepreneurs tell is often to themselves. He also explains how investors evaluate founder psychology, why difficult conversations are essential in business, and why resilience is more about adaptability than stubbornness. Important Links: Listen to our last...
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Angus Fletcher - The Biggest Mistake We Made About Intelligence (Ep. 304)
Infinite Loops
In this episode of Infinite Loops, Jim O’Shaughnessy sits down with Angus Fletcher, Professor of Story Science at Ohio State University's Project Narrative and author of multiple books at the intersection of narrative theory, psychology, and brain science. Angus’ research challenges one of the most widely accepted ideas in modern culture: that the human brain works like a computer. Drawing on his work with U.S. Army Special Operations, he argues that humans think not in equations, but in actions and stories — and that modern education systems are failing to cultivate the...
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Jonathan Tepper - Growing Up in the Heroin Capital of Europe (Ep. 303)
Infinite Loops
In this episode of Infinite Loops, we sit down with author Jonathan Tepper to discuss his extraordinary childhood. In 1985, when Jonathan was seven, his missionary parents moved the family to San Blas — then the heroin capital of Europe — to start a drug rehabilitation center. Jonathan and his brothers grew up alongside former bank robbers, prison survivors, and people living through the AIDS epidemic. These recovering addicts became like older siblings to them. What began with one man in a small apartment grew into a global movement operating in 20 countries. Jonathan's memoir, Shooting...
info_outlineHello everyone, Jim here. We're taking a brief break from new episodes to spotlight a golden oldie from the Infinite Loops archive. This conversation from December 2023 remains one of my favorites. Fresh episodes return next week, but first, enjoy this conversation with the inimitable George Mack.
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Writer, marketer, entrepreneur, and master of mental models, George Mack returns to discuss the top 0.1% of ideas he’s ever come across, from treating life as a video game to spotting high-agency individuals.
Important Links:
- George’s Twitter
- The Lindy Library
- Roy: A Life Well Lived (Rick and Morty)
- How to Spot High Agency People
- The Mack Meditation
- What is ignored by the media — but will be studied by historians?
- The Early-Late Razor
Show Notes:
- Treating Life as a Video Game
- Finding the Important Metrics
- Embrace Momentum; Embrace Constraints
- How to Spot High Agency People
- How to Increase Your Agency
- The Mack Meditation & Silence as Alpha
- Why Pessimism vs Optimism is the Wrong Debate
- The Future of Media
- What is Ignored by the Media but will be Studied by Historians?
- The Reddit to Facebook Continuum
- George’s Most Midwit Opinion
- Randomness & Feeding the Algorithm
- How to Retain Curiosity
- George as Emperor of the World
Books Mentioned:
- The Hypomanic Edge: The Link Between (a Little) Craziness and (a Lot Of) Success in America; by John Gartner
- Happy: Why More or Less Everything is Absolutely Fine; by Derren Brown
- What Works on Wall Street; by Jim O’Shaughnessy
- The Secret; by Rhonda Byrne
- Gödel, Escher, Bach: an Eternal Golden Braid; by Douglas Hofstadter
- The Beginning of Infinity: Explanations that Transform the World; by David Deutsch