Mpox Treatment Strategies, Clinical Presentation, and Diagnostic Approaches
JAMA Clinical Reviews
Mpox is an evolving global health threat, and clinicians should be aware of characteristic signs and symptoms to ensure timely diagnosis and appropriate management. Author Jason Zucker, MD, MS, of Columbia University Irving Medical Center...
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Calcific Aortic Stenosis: Symptoms, Diagnosis, and Treatment
JAMA Clinical Reviews
Calcific aortic stenosis affects approximately 12% of people >75 years in the US and worldwide leads to more than 100 000 deaths each year. Catherine M. Otto, MD, PhD, of the University of Washington School of Medicine, Seattle,...
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CAR T Cells and T-Cell Therapies for Cancer
JAMA Clinical Reviews
CAR T cells are genetically engineered to express a receptor that recognizes and kills tumor cells. CAR T-cell products are now FDA approved for 6 hematologic malignancies. Author Jennifer N. Brudno, MD, National Cancer Institute, joins...
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Diagnosis and Treatment of Peptic Ulcer Disease
JAMA Clinical Reviews
Peptic ulcer disease affects approximately 1% of the population in the US, and H pylori is a common cause of peptic ulcer disease. Author Nimish Vakil, MD, a gastroenterologist from the University of Wisconsin, Madison, discusses current...
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Strategies for Helping Patients Navigate High Prescription Drug Costs
JAMA Clinical Reviews
High prescription costs are a major barrier to the optimal treatment of many health conditions. Prescribers need tools to help patients find the lowest drug costs. Author Hussain S. Lalani, MD, MPH, MSc, of Brigham and Women's Hospital and...
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Preexposure Prophylaxis (PrEP) Options for HIV
JAMA Clinical Reviews
Even though highly effective medications are currently available to prevent HIV, there are about 1.3 million new infections worldwide each year. Monica Gandhi, MD, MPH, of the University of California San Francisco joins JAMA Senior Editor...
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Update on Over-the-Counter (OTC) Contraception
JAMA Clinical Reviews
In July 2023, the US Food and Drug Administration (FDA) approved Opill, a daily progestin-only oral contraceptive for over-the-counter sale to people of all ages. Daniel Grossman, MD, discusses this and more with JAMA Associate Editor...
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Dialysis for Chronic Kidney Failure
JAMA Clinical Reviews
Selection of hemodialysis or peritoneal dialysis and timing of dialysis initiation are influenced by patient symptoms, laboratory trajectories, patient preferences, and therapy cost and availability; shared decision-making is key. Jennifer...
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Diagnosis and Treatment of Chronic Spontaneous Urticaria
JAMA Clinical Reviews
Chronic spontaneous urticaria affects approximately 1% of the general population worldwide, impairs patients’ quality of life, and is associated with multiple comorbidities. Pavel Kolkhir, MD, discusses the current evidence on the...
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Diagnosis and Treatment of Community-Acquired Pneumonia (CAP)
JAMA Clinical Reviews
Community-acquired pneumonia is associated with approximately 740 000 hospitalizations and 41 000 deaths in the US annually. JAMA Review authors Scott A. Flanders, MD, and Valerie M. Vaughn, MD, MSc, discuss diagnosis and treatment of community-acquired pneumonia with JAMA Deputy Editor Mary McGrae McDermott, MD. Related Content:
info_outlineApproximately 9% of US adults experience major depression each year, with lifetime prevalence nearly 17% for men and 30% for women. Effective first-line depression treatments include forms of psychotherapy and medication. Close monitoring significantly improves likelihood of treatment success. Gregory E. Simon, MD, MPH, discusses depression treatment with JAMA Senior Editor Karen E. Lasser, MD, MPH.
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