Improving the Mitochondrial-Microbiome Connection for Optimal Health with Jason Prall
Dr. Jockers Functional Nutrition
Release Date: 12/23/2025
Dr. Jockers Functional Nutrition
In this episode, Dr. Jockers shares the top seven foods to help clear arterial plaque, lower blood pressure, and reduce heart disease risk. He explains how nutrients like omega-3s, magnesium, and antioxidants play a crucial role in maintaining a healthy cardiovascular system. You’ll learn about the powerful benefits of wild-caught salmon, extra virgin olive oil, and pomegranates for supporting heart health and reducing plaque buildup. Dr. Jockers emphasizes the importance of nutrient-dense, low-toxin foods for optimal artery function. Dr. Jockers also discusses how vitamins K2,...
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In this episode, Dr. David Jockers explains the latest research on saturated fat and its role in heart disease. He breaks down why many studies don’t link saturated fat to higher heart disease risk and what factors actually matter when assessing fat consumption. You’ll discover why oxidative stability, not the smoke point, is the real key when choosing fats for cooking. Dr. Jockers shares which fats are most stable and why they’re better for your health in the long term. We also dive into the role saturated fat plays for those with specific genetic markers, like APOE4...
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In this episode, Dr. Jockers sits down with Dr. Jack Wolfson, board-certified cardiologist and founder of Natural Heart Doctor, to challenge everything you think you know about heart disease. You’ll discover why the “100-year heart” isn’t a myth but a design principle. They unpack how true health is built through eat well, live well, think well — and why testing, not guessing, changes everything. You’ll learn why lowering cholesterol or blood pressure with medication isn’t the same as addressing root causes. Dr. Wolfson explains the real role of inflammation, oxidative...
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In this episode, Dr. Jockers explains how certain vegetables can lead to bloating and discomfort, particularly for those with small intestinal bacterial overgrowth (SIBO). He highlights the connection between oral bacteria, low stomach acid, and digestive distress caused by fermentable fibers in vegetables. You'll learn about the role of FODMAPs—fermentable oligosaccharides, disaccharides, monosaccharides, and polyols—and why they can trigger digestive issues like gas and bloating. Dr. Jockers shares which vegetables, like broccoli and cauliflower, are more likely to cause these symptoms....
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In this episode, Dr. David Jockers explores the hidden dangers of cholesterol medications, revealing how statins can cause more harm than good. You'll learn how these common drugs may increase your risk of type 2 diabetes, muscle loss, and even dementia. Dr. Jockers discusses the vital role cholesterol plays in your body, particularly for brain health and hormone production. He explains why lowering cholesterol may not be the solution, and how focusing on inflammation can be far more beneficial for your heart health. The episode also covers practical alternatives to statins, like a blood...
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In this episode, Dr. Jockers is joined by Dr. Audrey Schnell to explore the underlying causes of self-sabotage and how to break the cycle. Discover how outdated internal models, hidden blind spots, and a fear of change prevent us from following through on our goals. Dr. Schnell shares valuable insights on rewiring the brain to overcome these patterns. You’ll learn how small, consistent habits can create a momentum cycle, making it easier to stick to positive changes. Dr. Schnell emphasizes the importance of sleep in maintaining motivation and focus, and how a well-rested brain can...
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In this episode, Dr. Jockers dives into the top two deficiencies linked to cancer and autoimmune diseases. He discusses how sunlight and infrared wavelengths play a crucial role in reducing inflammation and supporting immune function. Dr. Jockers explains the vital connection between vitamin D and cancer prevention. We also explore the power of red light therapy and its ability to increase cellular energy production. Dr. Jockers highlights how these simple interventions can have a profound effect on overall health and disease prevention. Dr. Jockers shares practical tips on...
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In this episode, Dr. David Jockers reveals the dangers of processed seed oils and how they poison your mitochondria, preventing your body from burning fat efficiently. You'll learn how these oils contribute to chronic inflammation and oxidative stress, making fat burning nearly impossible. Dr. Jockers also explains the harmful effects of processed sugars and starches, which spike insulin levels and keep your body in sugar-burning mode. By reducing these ingredients, you can kickstart fat burning and improve overall metabolic health. The episode dives into the harmful chemicals found in many...
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In this episode, Dr. David Jockers dives into the benefits of the Protein Sparing Modified Fast, a powerful tool for burning fat, especially visceral fat. He explains how this strategy promotes fat loss while preserving lean muscle mass, even with a calorie-restricted diet. Dr. Jockers shares how fasting triggers autophagy and the role it plays in cellular rejuvenation, helping the body break down old, damaged mitochondria and replace them with healthier ones. He also discusses how protein-sparing fasting impacts insulin sensitivity, brain function, and overall resilience, while...
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In this episode, Dr. Jockers answers one of the most common questions he gets: are popcorn and chips cooked in beef tallow healthy? He breaks down the impact of cooking oils and shares how the oil you use makes all the difference in your snacks' healthiness. You’ll learn why corn, often used for popcorn, isn't the best food choice due to its GMO status, high glycemic impact, and potential mycotoxins. Dr. Jockers also discusses the pro-inflammatory effects of acrylamide, which forms when starches are cooked at high heat. Dr. Jockers reveals how Masa chips cooked in beef tallow,...
info_outlineIn this episode, Dr. Jockers explores with Jason Prall how mitochondrial health and the gut microbiome are deeply connected, shaping energy, inflammation, and long-term resilience. You’ll learn why mitochondria are far more than energy producers and how their communication drives whole-body health.
In this episode, you’ll discover how the microbiome helps translate food into signals that influence mitochondrial function, metabolism, and cellular repair. Jason breaks down why diversity in the gut matters and how everyday choices quietly shape this internal dialogue.
In this episode, you’ll hear practical insights on how sleep, light exposure, movement, fasting, and stress act as signals that either strengthen or weaken this mitochondrial–microbiome connection. The conversation leaves space to rethink how small lifestyle shifts can create powerful biological change.
In This Episode:
00:00 Introduction to Human and Mitochondrial DNA
04:06 Deep Dive into Mitochondria and Aging
14:01 Understanding the Gut Microbiome
25:38 Environmental Factors Affecting Health
29:19 Mindfulness and Detoxification
29:55 Impact of Thoughts on Health
31:06 Personalized Health Approaches
31:39 Universal Health Strategies
33:43 Importance of Sleep
37:19 Exercise and Movement
41:07 Fasting and Meal Timing
45:48 Stress and Recovery Balance
48:42 Final Thoughts and Resources
If you want practical, natural strategies to balance your hormones, heal your gut, boost your energy, and slow aging, don’t miss The Dr. Josh Axe Show. Dr. Axe blends ancient wisdom with cutting-edge science and brings on world-class experts for unfiltered conversations you won’t hear anywhere else. Transform your health from the inside out and subscribe to The Dr. Josh Axe Show, with new episodes every Monday and Thursday.
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“Every disease involves mitochondria—when mitochondrial function fails, the body breaks down.”
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Paleovalley Bone Broth Protein: Save 15% on grass-fed bone broth protein at paleovalley.com/jockers.
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Book: https://amzn.to/3YC78Wt
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Website – https://drjockers.com/
If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/