CM#3 Nicotine Unfiltered: Exploring the Surprising Science
Release Date: 10/22/2024
#36: Nathalie Niddam - Foundations First: Peptide Wisdom & Resilience
Architect of Resilience
Today, we’re excited to dive deep into the science and strategy of healing, aging, and true resilience with Natalie Nidham—a renowned peptide and bioregulator expert, host of the Longevity with Natalie Nidham podcast, and founder of one of the world’s largest peptide communities. In this conversation, Chris Duffin sits down with Natalie to explore her journey from holistic nutrition to becoming a trusted leader in the world of cellular optimization and biohacking. With her uniquely grounded, systems-based approach, Natalie shares why building real resilience starts from the inside...
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#35: Read Your Blood, Save Your Life: Dr. Eric Serrano’s No-BS Health Blueprint
Architect of Resilience
We’re bringing you a powerhouse episode this week! In Episode 35 of the Architect of Resilience Podcast, co-hosts Chris Duffin and Anthony Castor sit down with the legendary Eric Serrano for a deep-dive conversation that bridges cellular health, hydration, hormones, and the foundations of well-being. We dive deep into the foundations of resilient health—including hormone optimization, cellular hydration, nutrition, and the art of overcoming life’s challenges. Eric Serrano shares hard-won wisdom from decades serving athletes, bodybuilders, and practitioners worldwide. He opens up about...
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#34: The Antioxidant Revolution: How C60 Rewires Cellular Health w/Jessica MacNaughton
Architect of Resilience
Chris sits down with Jessica MacNaughton, CEO and co-founder of C60 Power, and a pioneering voice in health innovation and mitochondrial resilience. After a personal health crisis shifted her path from commercial real estate to holistic wellness, Jessica became a passionate advocate for Carbon 60—a Nobel Prize-winning molecule shown to support energy, cellular health, and longevity. Chris and Jessica dive deep into the science behind C60, exploring its powerful antioxidant properties, impact on inflammation, hormone regulation, and even cognitive function. From elite athletes recovering...
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#33: Testosterone, Truth & Transformation: Dylan Gemelli’s Path to Purpose
Architect of Resilience
Chris Duffin sits down with Dylan Gemelli—a trailblazing voice in biohacking, health optimization, and performance enhancement. Dylan’s story is one of raw resilience: from his early days as a multi-sport athlete and personal trainer, through adversity and personal transformation after serving time in prison, to becoming a respected digital health influencer and top-ranked podcaster. Together, Chris and Dylan dive deep into what true strength and resilience mean, exploring how adversity and personal accountability shape lasting success. Dylan shares how his time in prison was a powerful...
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Cell Med #11: The Dark Side of the Blue Pill: When Methylene Blue Misses the Mark
Architect of Resilience
Chris Duffin sits down with Anthony Castore to dig into the buzz surrounding methylene blue—dubbed by some as a miracle for boosting mitochondrial efficiency and ATP production. But is it really the game-changer it’s hyped up to be? Together, Chris and Anthony break down what methylene blue is, why people are jumping on the bandwagon, and crucially, why they aren’t recommending it for everyday use. From mitochondrial function and the importance of nitric oxide in everything from heart health to brain power (and yes, even erections), to alternative ways of optimizing your body’s...
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#32: Recalibrating the Driven: Kris Gethin on Supplements, Peptides, Strategy & Self-Awareness
Architect of Resilience
Chris Duffin sits down with world-renowned hybrid athlete, elite performance coach, and bestselling author, Kris Gethin. Known for redefining boundaries in fitness—from professional bodybuilding to Ironman triathlons and ultra-marathons—Kris has become a leading voice in the world of health optimization, biohacking, and longevity. Chris and Kris dive deep into topics ranging from overcoming self-doubt and societal expectations, building resilience through discipline, navigating the world of peptides and biohacking, and the evolving landscape of fitness—from chasing aesthetics to...
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#31: Clark Bartram - The Truth About TRT, Mindset, and Male Vitality
Architect of Resilience
In this episode, host Chris Duffin sits down with the legendary Clark Bartram—Marine veteran, National Fitness Hall of Fame inductee, and founder of the Maximized Man Elite program. Known as America’s most trusted fitness professional, Clark has dedicated his life to inspiring men to reclaim their vitality, strength, and purpose—naturally and sustainably. Clark Bartram’s journey in men’s health and fitness is nothing short of remarkable. Once a U.S. Marine, Clark transformed his discipline and passion into a decades-spanning career—earning recognition as “America’s most trusted...
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#30: James Maynard - Mindset, Muscle, and Miracles: Jared Maynard’s Road from ICU to Powerlifting
Architect of Resilience
In this episode, we dive deep with James (Jared) Maynard—a physiotherapist, strength coach, and competitive powerlifter—who not long ago faced a life-threatening health crisis. What began as a simple head cold spiraled quickly into organ failure, a rare autoimmune condition called HLH, and five weeks on life support. James takes us through the harrowing journey of fighting for his life, grappling with the loss of his physical strength, and rebuilding himself from the ground up—both physically and mentally. Through candid conversations, he and Chris explore the daunting challenges of...
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CM#10: Beyond Peptides: Chris Duffin’s Four Keys to Recovery and Superhuman Healing
Architect of Resilience
In this episode, host Chris Duffin sits down with guest Anthony Castor for a deep dive into the world of recovery, healing, and performance optimization—specifically through the lens of peptides and beyond. Building on their recent conversation, Chris reveals his unique framework for developing cutting-edge recovery protocols, which combines four essential pillars: cellular, neurological, biomechanical, and hydrodynamic approaches. Together, they unpack how these modalities—ranging from peptide therapies and blood flow restriction to innovative equipment design and red light therapy—can...
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CM#9: Peptides Part 1 - Beyond More is Better: Precision Approaches to Peptides and Cellular Health
Architect of Resilience
Chris Duffin is joined by Anthony Castor for an in-depth exploration of peptides and their role in optimizing health, training, and recovery. Together, they break down the complexities of building peptide protocols—discussing how to identify bottlenecks in your own training or wellness, the art and science of combining interventions effectively (without overcomplicating or wasting resources), and why understanding cellular pathways and mechanisms of action matters. Whether you’re curious about cellular medicine, looking to fine-tune your supplement stack, or just want sharper tools...
info_outlineChris Duffin sits down with expert Anthony Castor to dive into the controversial world of nicotine and its effects on our brain and body. We'll explore how nicotine impacts neurotransmitters like dopamine, acetylcholine, norepinephrine, serotonin, and glutamate—shedding light on its roles in mood regulation, cognitive enhancement, fat loss, and even immune support.
Together, Chris and Anthony will discuss the benefits and risks of nicotine use, comparing different delivery methods like gum, patches, and inhalers, and emphasizing the importance of moderation. They'll also delve into the historical context of nicotine, its pharmacokinetics, and its potential for aiding conditions like Alzheimer's, Parkinson's, and autoimmune diseases.
Additionally, we'll hear about cutting-edge treatments in neural therapy and the synergy between nicotine and other cognitive enhancers. So, whether you're curious about the scientific intricacies or practical applications of nicotine, stay tuned for an engaging and informative discussion on harnessing the power of this complex compound for resilience and peak performance.
Anthony Castor is a distinguished chemist and researcher, renowned for his work on the effects of alkaloids on the human nervous system. Inspired by the early 19th-century discoveries of Wilhelm Heinrich Posselt and Carl Ludwig Reinman, who first isolated nicotine, Anthony has dedicated his career to examining its profound impact on body chemistry. With a keen focus on how nicotine binds to nicotinic acetylcholine receptors, Anthony's research has advanced our understanding of this powerful alkaloid, positioning him as a leading figure in the field of neurochemistry. His work continues to shed light on the complexities of naturally occurring compounds like nicotine, caffeine, and morphine, all of which share the commonality of containing nitrogen.
This episode of the ARCHITECT of RESILIENCE podcast is available on Apple, Spotify & YouTube, and is sponsored by
@naboso_technology : The Foundation of Movement. 🦶🏼Use Code RESILIENCE for 20% off your first order at https://www.naboso.com
@marekhealth : Performance. Longevity. Optimization. 🔬 Use code RESILIENCE for 10% off your first bloodwork at https://marekhealth.com/chrisduffin
Contents:
00:00 Discussing nicotine benefits and responsible usage.
06:21 Nicotine mimics acetylcholine, enhancing attention and activity.
12:54 Limited stimulant use enhances mood and focus.
20:38 Popularity for cognitive enhancement in healthy populations.
25:20 Heightened blood pressure risks heart disease, awareness crucial.
27:41 High glutamate levels lead to neurotoxicity concerns.
37:33 Prefer patches and gum for safer alternatives.
38:25 Nicotine gum offers faster onset, sustained concentration.
48:25 Caffeine blocks adenosine, affecting sleep cycles.
53:29 Fans use PPAR gamma agonists for health.
57:44 Brain compounds support synapses, memory, and neurogenesis.
59:40 Top telemed platform for health optimization available.
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