CM#3 Nicotine Unfiltered: Exploring the Surprising Science
Release Date: 10/22/2024
EPS. 28: Stephan Kesting - Frozen Ground, Unbroken Spirit: The Fight Against the Odds
Architect of Resilience
Today, we take an unforgettable journey into the frozen grounds of resilience with our guest, Stephen Kesting. Stephen is not only a Brazilian jiu-jitsu black belt and renowned martial arts educator but also an intrepid adventurer whose life story combines the thrill of wilderness survival with profound insights into personal strength and perseverance. In this episode, Stephen recounts his gripping survival journey through the subarctic wilderness, a story captured in his book "Perseverance: Life and Death in the Subarctic." We explore themes of mental toughness, the dichotomy between...
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CM#8: Biohacking Mitochondria for Peak Performance w/ SLU-PP-332 & BAM15
Architect of Resilience
In today’s episode, we are diving deep into the fascinating world of biohacking mitochondrial health for peak performance. Chris Duffin is joined by guest Anthony Castor as they explore groundbreaking compounds that can enhance cellular energy and optimize your body's energy systems for better performance, longevity, and overall well-being. From understanding the vital roles of mitochondrial fission and fusion to discovering cutting-edge compounds like SLU, PP332, and BAM15, this conversation is packed with insights that can revolutionize how you view your mitochondrial health. Learn...
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#27: Ali Gilbert - Leveling Up Men’s Health: on Wellness, Hormones, and Overcoming Bias
Architect of Resilience
We explore the nuances of men's health with renowned fitness professional Ali Gilbert. Specializing in hormonal optimization and strength training, Ali shares insights from over two decades of experience in transforming men's lives. As she discusses her journey into the niche of men's health, Ali highlights the critical role of testosterone therapy and its often overlooked benefits beyond muscles and sexual health. The podcast delves into the challenges and misconceptions surrounding testosterone therapy, coupled with insights on how hormonal health significantly impacts mental clarity,...
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CM#7: Head Strong: The Science and Strategy Behind Concussion Recovery
Architect of Resilience
Today, we're diving deep into an important topic in the world of sports and beyond – concussions. Our host, Chris Duffin, welcomes guest Anthony Castor to explore the complexities of traumatic brain injuries, often caused by sudden jolts or blows to the head. The episode uncovers the neurological changes that these injuries entail, discussing both their short-term symptoms, like headaches and confusion, and long-term effects, including cognitive impairment and mood disorders. Moreover, Chris and Anthony delve into a variety of healing protocols, emphasizing the pivotal role of peptides in...
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#26: Ketones Unlocked: The Science, Benefits, and Future of Nature’s Superfuel with Frank Llosa
Architect of Resilience
"Ketones Unlocked." In this episode, join host Chris Duffin as he delves into the fascinating world of ketones and their impact on metabolic health and performance optimization. Joined by guest experts Frank Llosa, founder and CEO of Ketone Aid, and Dr. Mike Debord, along with co-host Anthony Castor, they explore the biochemical magic of exogenous ketones in redefining energy, endurance, and mental clarity. Whether you're aiming for peak athletic performance, battling everyday brain fog, or seeking clarity in a chaotic world, this episode offers actionable insights into integrating these super...
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BFR Discussion Highlights! What is it all about?
Architect of Resilience
This is a 24 minute snippit from my incredible conversation with Dr. Mike on BFR training. Check out the full episode here, Dr. Mike is a leading expert in blood flow restriction (BFR) training, a method that's changing the game for athletes, rehab patients, and fitness enthusiasts alike. From understanding the origins of BFR and its scientific underpinnings to real-world applications and personalized training protocols. This episode of the ARCHITECT of RESILIENCE podcast is available on Apple, Spotify & YouTube, and is sponsored by @marekhealth : Performance. Longevity....
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#25: Revolutionizing Recovery: Dr. Rahul Desai on the Power of Light and Regeneration
Architect of Resilience
Chris Duffin welcomes Rahul Desai, a renowned expert in regenerative orthopedic medicine and founder of Restore PDX and Redvive. Join us as we explore Rahul's journey from radiology to regenerative medicine, where his innovative techniques in tissue regeneration have set new standards in the field. Delving into the world of red light therapy, or photobiomodulation, Rahul shares fascinating insights into its impact on enhancing tissue recovery, reducing inflammation, and accelerating healing. Discover how precision diagnosis and cutting-edge therapeutic approaches are helping people overcome...
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#24: Beyond the Burn: The Science of Blood Flow Restriction with Dr. Mike DeBord
Architect of Resilience
Today we’re diving into revolutionary fitness and rehabilitation techniques with Dr. Mike Debord, a pioneer behind B3 Sciences. Dr. Mike is a leading expert in blood flow restriction (BFR) training, a method that's changing the game for athletes, rehab patients, and fitness enthusiasts alike. From understanding the origins of BFR and its scientific underpinnings to real-world applications and personalized training protocols, we cover it all. This episode is packed with insights on how BFR can amplify muscle growth, expedite recovery, and even improve cardiovascular health. Tune in to learn...
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CM#6: Cancer, Metformin, and the mTOR Pathway: Separating Fact from Fiction in Insulin Mimetic Therapy
Architect of Resilience
Chris Duffin sits down with expert guest Anthony Castor to delve deep into the fascinating world of insulin mimetics, glucose metabolism, and their implications for overall health and aging. The conversation kicks off with an examination of metformin's widespread use in diabetes management and its controversial potential benefits in cancer prevention, as highlighted in a recent study that casts doubt on its anti-cancer efficacy. Anthony and Chris explore the intricacies of balancing key cellular pathways—AMPK and mTOR—and their roles in muscle metabolism and aging. They discuss how the...
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Atlas Power Shrugged - Old Time Lifts for Gains
Architect of Resilience
Our guest, Atlas Power Shrugged, is not only a strength coach but also the author of the upcoming book "Old Time Lifts for Modern Lifters." Together, we'll explore the importance of having a solid plan and gradually progressing in your training, discuss the critique of misleading training boot camps, and delve into the significance of mental toughness in the business world. We're also going to unpack the art and science behind unique and historical weightlifting maneuvers like the one-arm snatch and Arthur Saxon's bent press. We'll hear about Atlas's extraordinary personal achievements,...
info_outlineChris Duffin sits down with expert Anthony Castor to dive into the controversial world of nicotine and its effects on our brain and body. We'll explore how nicotine impacts neurotransmitters like dopamine, acetylcholine, norepinephrine, serotonin, and glutamate—shedding light on its roles in mood regulation, cognitive enhancement, fat loss, and even immune support.
Together, Chris and Anthony will discuss the benefits and risks of nicotine use, comparing different delivery methods like gum, patches, and inhalers, and emphasizing the importance of moderation. They'll also delve into the historical context of nicotine, its pharmacokinetics, and its potential for aiding conditions like Alzheimer's, Parkinson's, and autoimmune diseases.
Additionally, we'll hear about cutting-edge treatments in neural therapy and the synergy between nicotine and other cognitive enhancers. So, whether you're curious about the scientific intricacies or practical applications of nicotine, stay tuned for an engaging and informative discussion on harnessing the power of this complex compound for resilience and peak performance.
Anthony Castor is a distinguished chemist and researcher, renowned for his work on the effects of alkaloids on the human nervous system. Inspired by the early 19th-century discoveries of Wilhelm Heinrich Posselt and Carl Ludwig Reinman, who first isolated nicotine, Anthony has dedicated his career to examining its profound impact on body chemistry. With a keen focus on how nicotine binds to nicotinic acetylcholine receptors, Anthony's research has advanced our understanding of this powerful alkaloid, positioning him as a leading figure in the field of neurochemistry. His work continues to shed light on the complexities of naturally occurring compounds like nicotine, caffeine, and morphine, all of which share the commonality of containing nitrogen.
This episode of the ARCHITECT of RESILIENCE podcast is available on Apple, Spotify & YouTube, and is sponsored by
@naboso_technology : The Foundation of Movement. 🦶🏼Use Code RESILIENCE for 20% off your first order at https://www.naboso.com
@marekhealth : Performance. Longevity. Optimization. 🔬 Use code RESILIENCE for 10% off your first bloodwork at https://marekhealth.com/chrisduffin
Contents:
00:00 Discussing nicotine benefits and responsible usage.
06:21 Nicotine mimics acetylcholine, enhancing attention and activity.
12:54 Limited stimulant use enhances mood and focus.
20:38 Popularity for cognitive enhancement in healthy populations.
25:20 Heightened blood pressure risks heart disease, awareness crucial.
27:41 High glutamate levels lead to neurotoxicity concerns.
37:33 Prefer patches and gum for safer alternatives.
38:25 Nicotine gum offers faster onset, sustained concentration.
48:25 Caffeine blocks adenosine, affecting sleep cycles.
53:29 Fans use PPAR gamma agonists for health.
57:44 Brain compounds support synapses, memory, and neurogenesis.
59:40 Top telemed platform for health optimization available.
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