CM#3 Nicotine Unfiltered: Exploring the Surprising Science
Release Date: 10/22/2024
#31: Clark Bartram - The Truth About TRT, Mindset, and Male Vitality
Architect of Resilience
In this episode, host Chris Duffin sits down with the legendary Clark Bartram—Marine veteran, National Fitness Hall of Fame inductee, and founder of the Maximized Man Elite program. Known as America’s most trusted fitness professional, Clark has dedicated his life to inspiring men to reclaim their vitality, strength, and purpose—naturally and sustainably. Clark Bartram’s journey in men’s health and fitness is nothing short of remarkable. Once a U.S. Marine, Clark transformed his discipline and passion into a decades-spanning career—earning recognition as “America’s most trusted...
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#30: James Maynard - Mindset, Muscle, and Miracles: Jared Maynard’s Road from ICU to Powerlifting
Architect of Resilience
In this episode, we dive deep with James (Jared) Maynard—a physiotherapist, strength coach, and competitive powerlifter—who not long ago faced a life-threatening health crisis. What began as a simple head cold spiraled quickly into organ failure, a rare autoimmune condition called HLH, and five weeks on life support. James takes us through the harrowing journey of fighting for his life, grappling with the loss of his physical strength, and rebuilding himself from the ground up—both physically and mentally. Through candid conversations, he and Chris explore the daunting challenges of...
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CM#10: Beyond Peptides: Chris Duffin’s Four Keys to Recovery and Superhuman Healing
Architect of Resilience
In this episode, host Chris Duffin sits down with guest Anthony Castor for a deep dive into the world of recovery, healing, and performance optimization—specifically through the lens of peptides and beyond. Building on their recent conversation, Chris reveals his unique framework for developing cutting-edge recovery protocols, which combines four essential pillars: cellular, neurological, biomechanical, and hydrodynamic approaches. Together, they unpack how these modalities—ranging from peptide therapies and blood flow restriction to innovative equipment design and red light therapy—can...
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CM#9: Peptides Part 1 - Beyond More is Better: Precision Approaches to Peptides and Cellular Health
Architect of Resilience
Chris Duffin is joined by Anthony Castor for an in-depth exploration of peptides and their role in optimizing health, training, and recovery. Together, they break down the complexities of building peptide protocols—discussing how to identify bottlenecks in your own training or wellness, the art and science of combining interventions effectively (without overcomplicating or wasting resources), and why understanding cellular pathways and mechanisms of action matters. Whether you’re curious about cellular medicine, looking to fine-tune your supplement stack, or just want sharper tools...
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Dr. Rahul Desai - Unlocking Red Light Therapy for Recovery and Performance
Architect of Resilience
On this special episode of the Architect of Resilience Podcast, host Chris Duffin welcomes back Dr. Rahul Desai, a regenerative musculoskeletal radiologist and expert in innovative therapies for joint and spine health. Originally recorded during a private member community session, this conversation dives deep into the cutting-edge world of red and near-infrared light therapy—otherwise known as photobiomodulation. Dr. Desai shares his extensive experience using platelet-rich plasma (PRP), bone marrow, and fat-derived treatments to help patients heal without surgery, and he unpacks the science...
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EPS. 28: Stephan Kesting - Frozen Ground, Unbroken Spirit: The Fight Against the Odds
Architect of Resilience
Today, we take an unforgettable journey into the frozen grounds of resilience with our guest, Stephen Kesting. Stephen is not only a Brazilian jiu-jitsu black belt and renowned martial arts educator but also an intrepid adventurer whose life story combines the thrill of wilderness survival with profound insights into personal strength and perseverance. In this episode, Stephen recounts his gripping survival journey through the subarctic wilderness, a story captured in his book "Perseverance: Life and Death in the Subarctic." We explore themes of mental toughness, the dichotomy between...
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CM#8: Biohacking Mitochondria for Peak Performance w/ SLU-PP-332 & BAM15
Architect of Resilience
In today’s episode, we are diving deep into the fascinating world of biohacking mitochondrial health for peak performance. Chris Duffin is joined by guest Anthony Castor as they explore groundbreaking compounds that can enhance cellular energy and optimize your body's energy systems for better performance, longevity, and overall well-being. From understanding the vital roles of mitochondrial fission and fusion to discovering cutting-edge compounds like SLU, PP332, and BAM15, this conversation is packed with insights that can revolutionize how you view your mitochondrial health. Learn...
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#27: Ali Gilbert - Leveling Up Men’s Health: on Wellness, Hormones, and Overcoming Bias
Architect of Resilience
We explore the nuances of men's health with renowned fitness professional Ali Gilbert. Specializing in hormonal optimization and strength training, Ali shares insights from over two decades of experience in transforming men's lives. As she discusses her journey into the niche of men's health, Ali highlights the critical role of testosterone therapy and its often overlooked benefits beyond muscles and sexual health. The podcast delves into the challenges and misconceptions surrounding testosterone therapy, coupled with insights on how hormonal health significantly impacts mental clarity,...
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CM#7: Head Strong: The Science and Strategy Behind Concussion Recovery
Architect of Resilience
Today, we're diving deep into an important topic in the world of sports and beyond – concussions. Our host, Chris Duffin, welcomes guest Anthony Castor to explore the complexities of traumatic brain injuries, often caused by sudden jolts or blows to the head. The episode uncovers the neurological changes that these injuries entail, discussing both their short-term symptoms, like headaches and confusion, and long-term effects, including cognitive impairment and mood disorders. Moreover, Chris and Anthony delve into a variety of healing protocols, emphasizing the pivotal role of peptides in...
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#26: Ketones Unlocked: The Science, Benefits, and Future of Nature’s Superfuel with Frank Llosa
Architect of Resilience
"Ketones Unlocked." In this episode, join host Chris Duffin as he delves into the fascinating world of ketones and their impact on metabolic health and performance optimization. Joined by guest experts Frank Llosa, founder and CEO of Ketone Aid, and Dr. Mike Debord, along with co-host Anthony Castor, they explore the biochemical magic of exogenous ketones in redefining energy, endurance, and mental clarity. Whether you're aiming for peak athletic performance, battling everyday brain fog, or seeking clarity in a chaotic world, this episode offers actionable insights into integrating these super...
info_outlineChris Duffin sits down with expert Anthony Castor to dive into the controversial world of nicotine and its effects on our brain and body. We'll explore how nicotine impacts neurotransmitters like dopamine, acetylcholine, norepinephrine, serotonin, and glutamate—shedding light on its roles in mood regulation, cognitive enhancement, fat loss, and even immune support.
Together, Chris and Anthony will discuss the benefits and risks of nicotine use, comparing different delivery methods like gum, patches, and inhalers, and emphasizing the importance of moderation. They'll also delve into the historical context of nicotine, its pharmacokinetics, and its potential for aiding conditions like Alzheimer's, Parkinson's, and autoimmune diseases.
Additionally, we'll hear about cutting-edge treatments in neural therapy and the synergy between nicotine and other cognitive enhancers. So, whether you're curious about the scientific intricacies or practical applications of nicotine, stay tuned for an engaging and informative discussion on harnessing the power of this complex compound for resilience and peak performance.
Anthony Castor is a distinguished chemist and researcher, renowned for his work on the effects of alkaloids on the human nervous system. Inspired by the early 19th-century discoveries of Wilhelm Heinrich Posselt and Carl Ludwig Reinman, who first isolated nicotine, Anthony has dedicated his career to examining its profound impact on body chemistry. With a keen focus on how nicotine binds to nicotinic acetylcholine receptors, Anthony's research has advanced our understanding of this powerful alkaloid, positioning him as a leading figure in the field of neurochemistry. His work continues to shed light on the complexities of naturally occurring compounds like nicotine, caffeine, and morphine, all of which share the commonality of containing nitrogen.
This episode of the ARCHITECT of RESILIENCE podcast is available on Apple, Spotify & YouTube, and is sponsored by
@naboso_technology : The Foundation of Movement. 🦶🏼Use Code RESILIENCE for 20% off your first order at https://www.naboso.com
@marekhealth : Performance. Longevity. Optimization. 🔬 Use code RESILIENCE for 10% off your first bloodwork at https://marekhealth.com/chrisduffin
Contents:
00:00 Discussing nicotine benefits and responsible usage.
06:21 Nicotine mimics acetylcholine, enhancing attention and activity.
12:54 Limited stimulant use enhances mood and focus.
20:38 Popularity for cognitive enhancement in healthy populations.
25:20 Heightened blood pressure risks heart disease, awareness crucial.
27:41 High glutamate levels lead to neurotoxicity concerns.
37:33 Prefer patches and gum for safer alternatives.
38:25 Nicotine gum offers faster onset, sustained concentration.
48:25 Caffeine blocks adenosine, affecting sleep cycles.
53:29 Fans use PPAR gamma agonists for health.
57:44 Brain compounds support synapses, memory, and neurogenesis.
59:40 Top telemed platform for health optimization available.
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