CM#5 Nootropics & Neurotrophic Peptides - Ultimate Guide
Release Date: 12/03/2024
#24: Beyond the Burn: The Science of Blood Flow Restriction with Dr. Mike DeBord
Architect of Resilience
Today we’re diving into revolutionary fitness and rehabilitation techniques with Dr. Mike Debord, a pioneer behind B3 Sciences. Dr. Mike is a leading expert in blood flow restriction (BFR) training, a method that's changing the game for athletes, rehab patients, and fitness enthusiasts alike. From understanding the origins of BFR and its scientific underpinnings to real-world applications and personalized training protocols, we cover it all. This episode is packed with insights on how BFR can amplify muscle growth, expedite recovery, and even improve cardiovascular health. Tune in to learn...
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CM#6 Cancer, Metformin, and the mTOR Pathway: Separating Fact from Fiction in Insulin Mimetic Therapy
Architect of Resilience
Chris Duffin sits down with expert guest Anthony Castor to delve deep into the fascinating world of insulin mimetics, glucose metabolism, and their implications for overall health and aging. The conversation kicks off with an examination of metformin's widespread use in diabetes management and its controversial potential benefits in cancer prevention, as highlighted in a recent study that casts doubt on its anti-cancer efficacy. Anthony and Chris explore the intricacies of balancing key cellular pathways—AMPK and mTOR—and their roles in muscle metabolism and aging. They discuss how the...
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Atlas Power Shrugged - Old Time Lifts for Gains
Architect of Resilience
Our guest, Atlas Power Shrugged, is not only a strength coach but also the author of the upcoming book "Old Time Lifts for Modern Lifters." Together, we'll explore the importance of having a solid plan and gradually progressing in your training, discuss the critique of misleading training boot camps, and delve into the significance of mental toughness in the business world. We're also going to unpack the art and science behind unique and historical weightlifting maneuvers like the one-arm snatch and Arthur Saxon's bent press. We'll hear about Atlas's extraordinary personal achievements,...
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NGT#3 LiftLab App - Harnesing Technology for Training
Architect of Resilience
Chris Duffin is joined by Alex Miller, a dedicated innovator transforming the fitness tech landscape. They'll dive into the groundbreaking features of the Lift Lab app—a cutting-edge training tool designed to bring personalized coaching right to your phone. From sophisticated AI that analyzes your movement to a uniquely adaptable coaching system, the Lift Lab app is changing the game by focusing on simplicity and effectiveness. Alex Miller will share insights into the advanced pose estimation models, the importance of personalized stress management, and how the app leverages years of data to...
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#31: Graham Tuttle - The Bearfoot Sprinter flips the script & interviews Duffin
Architect of Resilience
In this episode, titled "Bearfoot Sprinter," our host Chris Duffin, a heavyweight in the world of strength training and athletic innovation, delves into an incredible conversation with the barefoot sprinter himself, Graham Tuttle. Explore their insightful discussion on managing health through integrative approaches to medicine, combining Western technology with traditional insights. Graham and Chris highlight the profound connection between physical and emotional well-being, discussing techniques such as dynamic neuromuscular stabilization and the critical role of proper breathing. Here are 3...
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CM#5 Nootropics & Neurotrophic Peptides - Ultimate Guide
Architect of Resilience
In today's episode, host Chris Duffin dives deep into the fascinating world of cognitive enhancement with special guest Anthony Castor. We'll explore a range of nootropic peptides and supplements designed to boost brain function, resilience, and overall well-being. Chris and Anthony discuss such potent peptides as C Max and Celnac, revealing their roles in cognitive enhancement, neuroprotection, and stress resistance. We'll learn about Synapsin's ginsenoside RG3, and its anti-aging properties, and the intriguing nootropic properties of NewPEPT. Listen as Anthony shares personal anecdotes about...
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#020: Sean Rockett - Tell me where it hurts
Architect of Resilience
In today's episode, your hosts Sean Rockett and Chris Duffin dive deep into the world of physical and mental fortitude, focusing on the intersection of sports medicine, technology, and personal resilience. Sean Rockett, a renowned orthopedic surgeon and CrossFit enthusiast, shares his insights on the importance of short, efficient workouts and mental health benefits from activities like using a sauna to de-stress. We explore the future of orthopedics, including advancements in technology and regenerative medicine that may revolutionize how we treat conditions like arthritis and tendon...
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NGT#2 Dynamic Corespondance: Mastering Force Vectors and Exercise Selection
Architect of Resilience
We'll discuss a recent client case study, offering insights into long-term strategic planning and the importance of balancing stress with adaptability. Alex and Chris will break down the nuances of athlete assessment, exercise classification, and the often-overlooked force vectors crucial for effective training. They'll also touch on innovative tool development for coaches, highlighting their commitment to continuous education and the integration of kinematic and kinetic analyses into exercise selection. Prepare for a deep dive into the principles of dynamic correspondence, the hierarchy of...
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#019: Alec Blenis - Hybrid Hustle: Balancing Endurance, Strength, and Science for Peak Performance
Architect of Resilience
Chris Duffin sits down with elite hybrid athlete and coach, Alec Blenis. Together, they dive deep into the complexities and philosophies of effective training, resilience, and athletic performance. This episode explores a variety of compelling topics such as understanding life as a form of periodization, the debate between training hard versus perfecting technique, and the benefits of tackling both eccentric and concentric exercises. They emphasize the importance of minimizing complexity and fear in training, advocating for a balanced, progressive approach. Chris and Alec also delve into...
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CM#4 Exercise in a Pill? Exploring the Metabolic Magic of SLU-PP-332
Architect of Resilience
We’re thrilled to have Anthony Castor on the show. We'll be discussing a groundbreaking compound, SLU-PP 332, which uniquely targets estrogen-related receptors to enhance energy metabolism, aid fat loss, and improve mitochondrial health. Anthony will explain the fascinating concept of mitochondrial biogenesis and how SLU-PP 332 mimics the benefits of exercise by activating nuclear receptors and promoting metabolic efficiency. Hear about his personal experience with this potent compound, the protocols he followed, and the impressive outcomes he observed in energy, mental clarity, and health...
info_outlineIn today's episode, host Chris Duffin dives deep into the fascinating world of cognitive enhancement with special guest Anthony Castor. We'll explore a range of nootropic peptides and supplements designed to boost brain function, resilience, and overall well-being.
Chris and Anthony discuss such potent peptides as C Max and Celnac, revealing their roles in cognitive enhancement, neuroprotection, and stress resistance. We'll learn about Synapsin's ginsenoside RG3, and its anti-aging properties, and the intriguing nootropic properties of NewPEPT. Listen as Anthony shares personal anecdotes about using compounds like Dihexa for synapse formation and modafinil for enhancing wakefulness and cognitive performance.
Throughout the conversation, we’ll also delve into the science behind these compounds, examining their neurotransmitter modulation, neuroprotection, and practical applications for high-stress jobs, shift work, and productivity boosts. Additionally, we'll cover lifestyle practices that complement these cognitive enhancers, emphasizing the importance of sleep, hydration, and a balanced diet.
This episode of the ARCHITECT of RESILIENCE podcast is available on Apple, Spotify & YouTube, and is sponsored by
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Anthony Castor is a dedicated researcher in the field of neuropharmacology, specializing in the study and application of various compounds like peptides, small molecules, and ginsenosides, each offering unique benefits for brain health. He explores how these compounds act as neurotransmitter modulators, neuroprotective agents, and enhancers of synaptogenesis and neuroplasticity. Castor’s work focuses on mitigating brain cell damage through the reduction of oxidative stress, inflammation, and excitotoxicity, while also promoting growth factors like brain-derived neurotropic factor (BDNF) and hepatocyte growth factor (HGF). His insights contribute significantly to the development of therapeutic strategies for brain health and cognitive function.
Contents:
00:00 Neurotrophics and nootropics enhance brain function.
10:00 Pigs share biological similarities; cerebralysin aids brain repair.
11:30 Cerebralysin protects neurons, boosts brain resilience.
20:45 Old treatment impresses physicians due to proven safety.
28:01 Free radicals cause oxidative stress, cell damage.
29:02 Modafinil reduces oxidative stress, protects neurons.
36:22 FGL peptide aids neuron interaction, brain development.
43:02 Reduces stress, boosts brain function, potential treatment.
48:09 Supports immune balance, reduces anxiety, enhances cognition.
52:09 Low acetylcholine affects memory and performance.
58:26 NeuroPept: versatile nootropic for memory and protection.
01:07:53 Enhances learning, memory via receptor sensitivity.
01:13:21 Galectin 3: hopeful Alzheimer's treatment target discovered.
01:18:31 Modafinil enhances wakefulness and cognitive performance.
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