CM#5 Nootropics & Neurotrophic Peptides - Ultimate Guide
Release Date: 12/03/2024
EPS. 28: Stephan Kesting - Frozen Ground, Unbroken Spirit: The Fight Against the Odds
Architect of Resilience
Today, we take an unforgettable journey into the frozen grounds of resilience with our guest, Stephen Kesting. Stephen is not only a Brazilian jiu-jitsu black belt and renowned martial arts educator but also an intrepid adventurer whose life story combines the thrill of wilderness survival with profound insights into personal strength and perseverance. In this episode, Stephen recounts his gripping survival journey through the subarctic wilderness, a story captured in his book "Perseverance: Life and Death in the Subarctic." We explore themes of mental toughness, the dichotomy between...
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CM#8: Biohacking Mitochondria for Peak Performance w/ SLU-PP-332 & BAM15
Architect of Resilience
In today’s episode, we are diving deep into the fascinating world of biohacking mitochondrial health for peak performance. Chris Duffin is joined by guest Anthony Castor as they explore groundbreaking compounds that can enhance cellular energy and optimize your body's energy systems for better performance, longevity, and overall well-being. From understanding the vital roles of mitochondrial fission and fusion to discovering cutting-edge compounds like SLU, PP332, and BAM15, this conversation is packed with insights that can revolutionize how you view your mitochondrial health. Learn...
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#27: Ali Gilbert - Leveling Up Men’s Health: on Wellness, Hormones, and Overcoming Bias
Architect of Resilience
We explore the nuances of men's health with renowned fitness professional Ali Gilbert. Specializing in hormonal optimization and strength training, Ali shares insights from over two decades of experience in transforming men's lives. As she discusses her journey into the niche of men's health, Ali highlights the critical role of testosterone therapy and its often overlooked benefits beyond muscles and sexual health. The podcast delves into the challenges and misconceptions surrounding testosterone therapy, coupled with insights on how hormonal health significantly impacts mental clarity,...
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CM#7: Head Strong: The Science and Strategy Behind Concussion Recovery
Architect of Resilience
Today, we're diving deep into an important topic in the world of sports and beyond – concussions. Our host, Chris Duffin, welcomes guest Anthony Castor to explore the complexities of traumatic brain injuries, often caused by sudden jolts or blows to the head. The episode uncovers the neurological changes that these injuries entail, discussing both their short-term symptoms, like headaches and confusion, and long-term effects, including cognitive impairment and mood disorders. Moreover, Chris and Anthony delve into a variety of healing protocols, emphasizing the pivotal role of peptides in...
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#26: Ketones Unlocked: The Science, Benefits, and Future of Nature’s Superfuel with Frank Llosa
Architect of Resilience
"Ketones Unlocked." In this episode, join host Chris Duffin as he delves into the fascinating world of ketones and their impact on metabolic health and performance optimization. Joined by guest experts Frank Llosa, founder and CEO of Ketone Aid, and Dr. Mike Debord, along with co-host Anthony Castor, they explore the biochemical magic of exogenous ketones in redefining energy, endurance, and mental clarity. Whether you're aiming for peak athletic performance, battling everyday brain fog, or seeking clarity in a chaotic world, this episode offers actionable insights into integrating these super...
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BFR Discussion Highlights! What is it all about?
Architect of Resilience
This is a 24 minute snippit from my incredible conversation with Dr. Mike on BFR training. Check out the full episode here, Dr. Mike is a leading expert in blood flow restriction (BFR) training, a method that's changing the game for athletes, rehab patients, and fitness enthusiasts alike. From understanding the origins of BFR and its scientific underpinnings to real-world applications and personalized training protocols. This episode of the ARCHITECT of RESILIENCE podcast is available on Apple, Spotify & YouTube, and is sponsored by @marekhealth : Performance. Longevity....
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#25: Revolutionizing Recovery: Dr. Rahul Desai on the Power of Light and Regeneration
Architect of Resilience
Chris Duffin welcomes Rahul Desai, a renowned expert in regenerative orthopedic medicine and founder of Restore PDX and Redvive. Join us as we explore Rahul's journey from radiology to regenerative medicine, where his innovative techniques in tissue regeneration have set new standards in the field. Delving into the world of red light therapy, or photobiomodulation, Rahul shares fascinating insights into its impact on enhancing tissue recovery, reducing inflammation, and accelerating healing. Discover how precision diagnosis and cutting-edge therapeutic approaches are helping people overcome...
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#24: Beyond the Burn: The Science of Blood Flow Restriction with Dr. Mike DeBord
Architect of Resilience
Today we’re diving into revolutionary fitness and rehabilitation techniques with Dr. Mike Debord, a pioneer behind B3 Sciences. Dr. Mike is a leading expert in blood flow restriction (BFR) training, a method that's changing the game for athletes, rehab patients, and fitness enthusiasts alike. From understanding the origins of BFR and its scientific underpinnings to real-world applications and personalized training protocols, we cover it all. This episode is packed with insights on how BFR can amplify muscle growth, expedite recovery, and even improve cardiovascular health. Tune in to learn...
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CM#6: Cancer, Metformin, and the mTOR Pathway: Separating Fact from Fiction in Insulin Mimetic Therapy
Architect of Resilience
Chris Duffin sits down with expert guest Anthony Castor to delve deep into the fascinating world of insulin mimetics, glucose metabolism, and their implications for overall health and aging. The conversation kicks off with an examination of metformin's widespread use in diabetes management and its controversial potential benefits in cancer prevention, as highlighted in a recent study that casts doubt on its anti-cancer efficacy. Anthony and Chris explore the intricacies of balancing key cellular pathways—AMPK and mTOR—and their roles in muscle metabolism and aging. They discuss how the...
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Atlas Power Shrugged - Old Time Lifts for Gains
Architect of Resilience
Our guest, Atlas Power Shrugged, is not only a strength coach but also the author of the upcoming book "Old Time Lifts for Modern Lifters." Together, we'll explore the importance of having a solid plan and gradually progressing in your training, discuss the critique of misleading training boot camps, and delve into the significance of mental toughness in the business world. We're also going to unpack the art and science behind unique and historical weightlifting maneuvers like the one-arm snatch and Arthur Saxon's bent press. We'll hear about Atlas's extraordinary personal achievements,...
info_outlineIn today's episode, host Chris Duffin dives deep into the fascinating world of cognitive enhancement with special guest Anthony Castor. We'll explore a range of nootropic peptides and supplements designed to boost brain function, resilience, and overall well-being.
Chris and Anthony discuss such potent peptides as C Max and Celnac, revealing their roles in cognitive enhancement, neuroprotection, and stress resistance. We'll learn about Synapsin's ginsenoside RG3, and its anti-aging properties, and the intriguing nootropic properties of NewPEPT. Listen as Anthony shares personal anecdotes about using compounds like Dihexa for synapse formation and modafinil for enhancing wakefulness and cognitive performance.
Throughout the conversation, we’ll also delve into the science behind these compounds, examining their neurotransmitter modulation, neuroprotection, and practical applications for high-stress jobs, shift work, and productivity boosts. Additionally, we'll cover lifestyle practices that complement these cognitive enhancers, emphasizing the importance of sleep, hydration, and a balanced diet.
This episode of the ARCHITECT of RESILIENCE podcast is available on Apple, Spotify & YouTube, and is sponsored by
@marekhealth : Performance. Longevity. Optimization. 🔬 Use code RESILIENCE for 10% off your first bloodwork at https://marekhealth.com/chrisduffin
@buildfastformula : Build Smart. Build Strong. Build Fast. 💪🏼🧬 Use code RESILIENCE for 10% off your order at https://buildfastformula.com
Anthony Castor is a dedicated researcher in the field of neuropharmacology, specializing in the study and application of various compounds like peptides, small molecules, and ginsenosides, each offering unique benefits for brain health. He explores how these compounds act as neurotransmitter modulators, neuroprotective agents, and enhancers of synaptogenesis and neuroplasticity. Castor’s work focuses on mitigating brain cell damage through the reduction of oxidative stress, inflammation, and excitotoxicity, while also promoting growth factors like brain-derived neurotropic factor (BDNF) and hepatocyte growth factor (HGF). His insights contribute significantly to the development of therapeutic strategies for brain health and cognitive function.
Contents:
00:00 Neurotrophics and nootropics enhance brain function.
10:00 Pigs share biological similarities; cerebralysin aids brain repair.
11:30 Cerebralysin protects neurons, boosts brain resilience.
20:45 Old treatment impresses physicians due to proven safety.
28:01 Free radicals cause oxidative stress, cell damage.
29:02 Modafinil reduces oxidative stress, protects neurons.
36:22 FGL peptide aids neuron interaction, brain development.
43:02 Reduces stress, boosts brain function, potential treatment.
48:09 Supports immune balance, reduces anxiety, enhances cognition.
52:09 Low acetylcholine affects memory and performance.
58:26 NeuroPept: versatile nootropic for memory and protection.
01:07:53 Enhances learning, memory via receptor sensitivity.
01:13:21 Galectin 3: hopeful Alzheimer's treatment target discovered.
01:18:31 Modafinil enhances wakefulness and cognitive performance.
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