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Quick Hits: The Women's Hormone Masterclass: A Deep Dive Into Testosterone, Dutasteride, SHBG, & Menopause Weight Gain with Dr. Kyle Gillett

The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health

Release Date: 03/10/2026

The Real Reason Your Menopause Belly Shows Up Even When You’re Doing Everything Right with Siobhan Mitchell

The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health

Join our FREE upcoming masterclass: Why Midlife Weight Gain Won’t Budge A smarter way to use GLP-1s in midlife without wrecking muscle or metabolism When: April 30th 11 am PST Register here: There comes a point for so many women in their late 30s and 40s when they look in the mirror, or down at their belly, and think, what is happening to my body? You’re still eating well. You’re still exercising. You’re still trying to do all the “right” things. And yet your body suddenly feels like it is playing by a completely different set of rules. In this episode, I sit down with Dr....

Part 2: What Midlife Women Need to Know About Testosterone & Steroids with Victoria Felkar

The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health

In this second of two parts, I sit down with Victoria Felkar again to unpack the complicated, often glamorized world of androgens, testosterone therapy, and anabolic steroids for women. Are these hormones empowering tools—or ticking time bombs? How do you know the difference? We dive into what’s really happening beneath the surface when women start layering in testosterone or other androgens, especially without a solid hormonal foundation in place. Have you ever wondered why some women feel amazing on testosterone, while others spiral into acne, hair loss, mood swings, or worse? What role...

Quick Hits: Cracking the Genetic Code: Unlocking the Link Between Genetics, Hormones, Detox, Diets, Mood, and More

The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health

Welcome to Quick Hits — where we bring you the most impactful moments from past episodes in under 15 minutes. Today’s clip comes from one of our most replayed conversations. If you want the full episode, check the link in the description below. Have you ever wondered what your DNA says about your diet and hormones? Well in today's episode we are going to explore the connection between genetics and popular diets like keto, vegan, and low carb. Additionally, we'll explore how DNA reports can help us better understand our hormones and their impact on our health. Kashif Khan the Chief...

Part 1: Women Have Been Lied To About Testosterone with Victoria Felkar

The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health

In this episode, I’m joined by the brilliant Victoria Felkar, and we go where most conversations in women’s health simply don’t: anabolic steroids. Why has this topic been so misunderstood—and even feared—by women, especially in midlife? Are we lumping very different hormones into one “scary” category without truly understanding them? Victoria shares her own jaw-dropping health story—one that led to sky-high androgens, medical confusion, and even accusations of steroid use. How did a teenage experience with birth control, stress, and recovery from an eating disorder spiral...

Quick Hits: The Hidden Role of Melatonin in Hormones, Aging, and Sleep with Deanna Minich

The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health

Welcome to Quick Hits — where we bring you the most impactful moments from past episodes in under 15 minutes. Today’s clip comes from one of our most replayed conversations. If you want the full episode, check the link in the description below. Listen to the full peptide here: Dr. Deanna Minich, is a Certified Functional Medicine Practitioner, with a Masters of Science degree in Human Nutrition , and a Doctorate in Medical Sciences. She is an international lecturer, educator, and author, with over twenty years of experience in academia and in the food and dietary...

The Menopause Metabolic Storm: Why Estrogen Loss Makes Weight Gain So Hard to Escape

The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health

Are you ready for a true masterclass? In this solo episode, I’m diving deep into estrogen and metabolic health—and trust me, this one challenged even me. Is estrogen really making you gain weight, or is the real problem what happens when it drops? If you’ve hit your 40s or 50s and suddenly nothing works anymore, you need to hear this. Why does belly fat seem to appear overnight in perimenopause? Why does your energy tank, your cravings skyrocket, and your mood feel completely hijacked? I unpack the science behind estradiol and how it impacts insulin, cortisol, thyroid, muscle,...

Quick Hits: From Breast Cancer to Bone Health: The Uncharted Territory of HRT & Chronic Diseases in Menopause with Dr. Elizabeth Yurth

The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health

Listen to the full peptide here: Download on Apple and on your favorite podcast platform. Welcome to Quick Hits — where we bring you the most impactful moments from past episodes in under 15 minutes. Today’s clip comes from one of our most replayed conversations. Today we're talking about the crucial world of women's hormonal health with Dr. Elizabeth Yurth from the Boulder Longevity Institute. We discuss how hormonal imbalances impact everything from chronic disease to daily vitality. We also demystify hormone replacement therapy, emphasizing its importance beyond just reproductive...

The Mental Health Crisis No One Is Linking to Hormones with Dr. Louise Newson

The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health

Why are so many of us blindsided by anxiety, depression, rage, or even suicidal thoughts in midlife? And why are hormones so often left out of the conversation? I’m joined by the incredible Dr. Louise Newson, a UK-based GP and menopause specialist, to talk about something far too many women experience in silence—mental health struggles during perimenopause and menopause. We dive deep into what’s really happening in the brain when estrogen, progesterone, and testosterone start to fluctuate or decline. Could your low mood, brain fog, loss of confidence, or even a new ADHD diagnosis be...

Copper Peptides & Exosomes: The Skin Regeneration Breakthrough for Women Over 40

The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health

Have you looked in the mirror lately and wondered, when did my skin change like this? In this episode, I’m joined by Debbi Barber (founder of Vitali Regenerative Skincare) and Dr. Jordan Plews (a stem cell scientist and co-founder of Xytogen Biotech) to unpack what’s really happening to our skin in midlife—and what we can actually do about it. Is it just aging… or is there something deeper going on at the cellular level? We dive into copper peptides (GHK-Cu) and exosomes—what they are, where they come from, and why they might be the future of regenerative skincare. Can you really...

The Hormone–Histamine Connection Doctors Aren’t Talking About

The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health

In this Hormone Hotline episode, I’m answering a powerful question about estrogen HRT, histamine intolerance, and mast cell activation during perimenopause and long COVID. Why do histamine flares explode when hormones start shifting? Is estrogen really the villain—or is something deeper driving the chaos? I share my own long battle with histamine hives, food reactions, and hormone swings—and what finally moved the needle. Why do so many women get worse on a low histamine diet over time? Could unstable estrogen levels be more triggering than estrogen itself? And what role does...

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In this quick hits I sit down with Dr. Gillett, to exam the complex world of women's hormones today. We'll be focusing on androgens like testosterone, DHEA, and dihydrotestosterone, and their profound impact on female health. Dr. Gillett provides insights on the role of binding globulins, hormone replacement therapy, and the interplay between insulin and androgens. We also discuss the challenges of menopausal weight gain, the benefits of GLP-1 medications for weight loss, and practical strategies anyone can use for maintaining lean body mass.

In this episode we discuss:

How androgens such as testosterone, DHEA, and dihydrotestosterone affect women's well-being.
Why sex hormone binding globulin (SHBG) is critical for hormone dynamics and stability.
Understanding the impact of thyroid binding globulin and cortisol binding globulin on hormone balance.
How hormone replacement therapy (HRT) influences women's bodies, especially regarding androgens.
Managing testosterone replacement therapy to avoid virilization symptoms like facial hair and voice changes.
The role of DHT blockers in managing androgen-related conditions.
How SHBG can be harnessed for overall hormone stability and health benefits.
Challenges of menopausal weight gain and how hormonal changes affect body composition.
Why integrating proper lifestyle habits is essential alongside GLP-1 medications for effective weight loss.
How to maintain lean body mass through hormone therapy and lifestyle changes.
How oral contraceptives and other synthetic hormones impact SHBG levels and overall hormone balance.
The significance of SHBG levels for individuals on hormone replacement therapy or contraceptives.
Exploring different forms of testosterone administration, including subcutaneous and intramuscular injections.
How estrogen and progesterone influence testosterone levels through negative feedback inhibition.
How poor sleep quality and hormonal changes contribute to menopausal weight gain.
The paradoxical effects of hormone replacement therapy on body composition and fat gain.
Why high SHBG must be paired with adequate hormone levels to avoid feeling unwell.
Discussing the challenges faced when SHBG levels are artificially high due to medication.

Kyle Gillett https://gilletthealth.com/

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