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Kevin Tracey returns to the podcast to give an update about his work at the Feinstein Institutes, the field of bioelectronic medicine and exciting vagus nerve clinical trials underway

Neural Implant podcast - the people behind Brain-Machine Interface revolutions

Release Date: 03/13/2023

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Neural Implant podcast - the people behind Brain-Machine Interface revolutions

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Neural Implant podcast - the people behind Brain-Machine Interface revolutions

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 "Welcome to today's episode! Our guest, , co-founder and CEO of , brings innovation to neural implants. With roots in France and a Harvard PhD, he's leading groundbreaking work. Welcome, Paul!"  Top 3 Takeaways: "It's a good time to ask the question: What if we could develop solutions tailored for this problem instead of borrowing from the semiconductor industry? That's what Axsoft is about. We emphasize developing soft materials that offer better long-term biocompatibility. Additionally, these materials are suitable for micro and nano fabrication and remain stable inside the...

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Neural Implant podcast - the people behind Brain-Machine Interface revolutions

Welcome to the Neural Implant Podcast! In this episode, the podcast team presents a live panel recording from the Bio L Conference at the International Winter School on Bioelectronics in Austria in March 2024. Hosted by Ladan, the panel discusses various types of neural implants with esteemed guests: Drs . (LCP neural implants), (PEDOT electrode coatings), (parylene neural implants), and (PDMS neural implants). Tune in as they explore the fascinating world of soft implantable electrodes and brain-nervous system interfaces.   Top 3 Takeaways: “In the next five or 10 years, I...

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In today's episode, we're joined by , a seasoned pain physician with a unique approach to his work. With extensive experience in regional anesthesia and pain management, Carles shares insights gained from his years of practical experience as he pursues his PhD in Spain.  Top 3 Takeaways: "We believe we have the opportunity to target the site of action more effectively. That's why we've founded Spinally, the startup we're currently leading. Our goal is to pioneer intrathecal spinal cord stimulation." "The Dura Mater is highly elastic, closing approximately 80-90% within the first 30...

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is now the Chief Technology Officer at which is developing a minimally invasive neural implant for the treatment of depression and mental health issues. Steve was at Medtronic for 26 years before moving over to the startup landscape. Top 3 Takeaways:  "Starting a big program that you don't know how to finish is a very expensive endeavor, and so you want to really shake out all the science risk, all the technology risk,  be pretty sure you can execute a thing before you turn on that big engine because it's expensive once you go" "We know stimulation of the dorsal lateral...

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is a research group leader at the Central European Institute of Technology () located in Brno, Czech Republic. There he studies neural implant fabrication and materials specializing in silicon, parylene, and polyimide devices. He has also started to designs and fabricate devices on a contract basis for other research groups and companies. And, his institute is the one that has been recently sponsoring the podcast! This podcast is sponsored by CEITEC Nano, check out their Neurotech Device Manufacturing Capabilities  Top 3 Takeaways: "You can just buy stuff on the internet very simple red...

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Neural Implant podcast - the people behind Brain-Machine Interface revolutions

is an Associate Professor in the Department of Otolaryngology Head and Neck Surgery and also has appointments with the Department of Biomedical Engineering and the Department of Electrical and Computer Engineering. His research is in the areas of bioinstrumentation and neural engineering. In this episode we talk about his freeform nerual stimulator which allows for DC and any other waveforms without any electrolytic effects on the electrodes. This opens up many possibilities for neural stimulation. We also talk about his startup Aidar which is like a 'tricorder' all-in-one medical diagnostic...

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Kevin Tracey returns to the podcast to give an update about his work at the Feinstein Institutes and the work at SetPoint Medical.

Top 3 Takeaways:

  • "Two years we discovered that a drug called Famotidine, which is sold as a generic drug Pepcid AC is actually a pharmacological or a drug-based vagus nerve stimulator. And we proved first in mice that famotidine placed directly in very small amounts placed directly in the brains of mice activates the vagus nerve. And this in turn turned off cytokine storm, which of course is a big problem in Covid 19"
  • "A company that I've co-founded, Setpoint Medical, is currently deep into clinical trials in the United States called ResetRA, which is on clinical trials.gov or on the SetPoint website for rheumatoid arthritis patients. And that trial is enrolling many patients up to, I think 250 patients will be studied according to the websites and we're hoping that goes very well. And we're hoping, I'm hoping that leads to FDA approval for vagus nerve stimulation in the US in the coming days or coming in the coming months"
  • "I think we're very close now to vagus nerve stimulation becoming a reality for millions of patients. And I, I hope, and I see a time when patients have the. Of  choosing vagus nerve stimulation as a simple, safe therapy instead of dangerous, expensive drugs with black box warnings that are minimally effective."

0;30 "Do you wanna introduce yourself and talk about some of your work, especially as neuromodulation pertains to the immune system?"

2:45 "So the last time when we talked it was 2020. So pandemic, everything was upside down. But then you were telling me before we started recording that it was also especially busy for you at that time. So what were you up to around then?"

6:00 What were the quantitative takeaways of the Famotidine Covid trials?

8:15 "Why didn't it become standard practice?"

11:00 "You're saying the famotidine has this effect on the vagus nerve. Does this mean we no longer need vagus nerve stimulators? Can we just take Pepcid, AC?"

15:00 Do you want to talk about the Bioelectronic Medicine Summit?

17:30 What were some of the highlights of the Summit?

 19:30 "You mentioned some interesting results. Is that something you can share now or is that something that we should be on the lookout for?"

21:30 "You were also featured recently in the Wall Street Journal and New York Times, what was that like and what were the articles about?"

23:15 "So what's exciting you now for 2023 and what's on the horizon for you for the next few years?"

27:15 "Is there anything that we didn't talk about that you wanted to mention?"