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Oxford Sparks Big Questions

Release Date: 04/16/2025

What happened to the birds in 'The Twelve Days of Christmas'? show art What happened to the birds in 'The Twelve Days of Christmas'?

Oxford Sparks Big Questions

We all know it. We've all sung it. Perhaps we've even answered a quiz question about it*. The Twelve Days of Christmas has become as quintessentially festive as a figgy pudding, or the bad joke in your Christmas cracker. But why exactly is your 'true love' gifting all these birds? And importantly, how are they faring nowadays? Prof Andy Gosler (from the Edward Grey Institute in the Department of Biology, and Institute of Human Sciences in the School of Anthropology) is the only professor of 'ethno-ornithology' in the world, specialising in the study of the relationships between birds and...

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What is quantum computing? show art What is quantum computing?

Oxford Sparks Big Questions

Want to make something feel immediately complicated, inaccessible or downright mysterious? Stick the word 'quantum' in front of it. Or, at least, that's how many of us feel. But don't worry! Experimental physicist William Cutler from Oxford's Department of Physics is here to break things down, explaining exactly what a quantum computer is, and sharing the remarkable potential that quantum computing holds for advancing fields ranging from drug-discovery to internet security.

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Could vaccinations stop people from getting cancer? show art Could vaccinations stop people from getting cancer?

Oxford Sparks Big Questions

Finding a cure for cancer is unarguably one of the biggest medical challenges that we face. But what if we could find a way to prevent cancer before it even starts? In this special extended edition of the Big Questions Podcast, we chat to Professor Sarah Blagden, an experimental oncologist at the University of Oxford, and Anna Fry, who has the cancer predisposing condition Lynch Syndrome - putting her at increased risk of developing colorectal and other cancers. Sarah explains how clinical trials of vaccines targeting 'pre-cancer' could revolutionise the fight against cancer, beginning with...

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Why do I bite my nails? show art Why do I bite my nails?

Oxford Sparks Big Questions

Many of us will be familiar with Body-Focused Repetitive Behaviours (BFRBs), perhaps without even realising it. Such behaviours - which include hair-pulling, nail biting and skin picking - can not only cause physical harm, but also often bring feelings of shame. Because of this, open discussion around BFRBs has been limited. In this episode of The Big Questions Podcast, we chat to Prof Clare Mackay from Oxford's Department of Psychiatry, who both studies and lives with BFRBs. 

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How do you find a theoretical particle? show art How do you find a theoretical particle?

Oxford Sparks Big Questions

How do you detect a particle that emits no light - in other words, something invisible? This is the intriguing challenge faced by scientists hunting for 'dark matter'. In our series finale, we talk to Elizabeth Bloomfield from Oxford's Department of Physics about dark matter, how we know it exists, and why her research is taking her deep beneath a mountain in Italy in the quest to find it.

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Is there a better way to screen blood? show art Is there a better way to screen blood?

Oxford Sparks Big Questions

What's the best gift you can give? To the millions of people whose lives have been saved by complete strangers, the answer would be simple: blood. But what exactly happens when blood has been donated, and how do we know it is safe? We chat to Dr Richard Mayne from Oxford's Experimental Medicine Division about genomics, Next-Generation Sequencing, blood screening (...and Star Trek).  Could you be a blood-donating hero? Blood stocks are currently critically low, with the NHS Blood and Transplant (NHSBT) group in urgent need of new donors. Click here, and you'll be on your way to saving...

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How does Ozempic actually work? show art How does Ozempic actually work?

Oxford Sparks Big Questions

Whether you've been served an advert for it, or just heard about it in the media, it's likely that 'Ozempic' isn't a totally unfamiliar word. Now often associated with weight-loss, Ozempic is actually the brand name for a drug used to treat diabetes. So what exactly is it, how does it work, and is it safe? We chat to diabetes and endocrinology (hormone) expert Dr Annie de Bray to find out.  

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Why does a stranger's phone noise annoy me? show art Why does a stranger's phone noise annoy me?

Oxford Sparks Big Questions

We've all been there...you're on the train, maybe tired after a long day, and all you can hear is one side of a fellow passenger's not-too-interesting phone conversation. Or worse, their choice of music, made tinny and monotonous by the awkward angle of their phone speaker. It's irritating, sure, but for some people it goes beyond mild annoyance, into the realms of anger and panic. For these people - who suffer from a condition called 'misophonia' - phone noise, or sounds such as chewing or breathing, are a real problem. We chat to Dr Jane Gregory, a researcher at Oxford's Department of...

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What's the origin of water on Earth? show art What's the origin of water on Earth?

Oxford Sparks Big Questions

With more than 70% of its surface covered in water, Earth is rightly known as the "blue planet". But where did this water - so essential to life - originate? While some theories suggest that hydrogen was delivered to Earth from space via asteroids, new research indicates that the building blocks for water may have been present on our planet all along. We chat to Tom Barrett from Oxford's Department of Earth Sciences to find out more.    

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How can robots investigate underwater volcanoes? show art How can robots investigate underwater volcanoes?

Oxford Sparks Big Questions

What do you do when the subject of your research lies deep beneath the waves? Send down an underwater robot, of course! We chat to volcanologist Sofia Della Sala about her recent fieldwork expedition to Santorini, where she used a Remotely Operated Vehicle, or ROV, to search for hydrothermal vents in the Aegean Sea. These vents - which are like hot springs on the sea floor - could provide vital insight into the volcanic and tectonic activity in the region.

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More Episodes

"I still don't believe it happened..."

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What's the best tactic for tackling the numbers round? How did he prepare? Did he really only have 30 seconds to find a solution? Tom gives us a glimpse behind-the-scenes of this British institution.