Using Precision Medicine to Reverse Alzheimer's Disease with Dr. Heather Sandison: Rational Wellness podcast 464
Release Date: 06/04/2026
The Microglia are a Key to Brain Health with Dr. David Perlmutter | Rational Wellness Podcast 475
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Dr. David Perlmutter on Microglia, Metabolism, and a New Paradigm for Neurodegenerative Disease Dr. Ben Weitz introduces the Rational Wellness Podcast and interviews neurologist and author Dr. David Perlmutter about his upcoming book, Brain Defenders, describing a neuroscience shift from neuron-centered thinking to the brain’s immune cells (glia/microglia) as key drivers of neurodegeneration. Perlmutter argues microglial polarization (supportive M2 vs destructive M1) is upstream of protein accumulations like beta-amyloid, alpha-synuclein, and phosphorylated tau, and is strongly...
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Rational Wellness Podcast Episode 020: Bioidentical Hormones for Women with Dr. Jill Stocker
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Breast Implant Illness with Dr. Robert Whitfield | Rational Wellness Podcast 474
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Mold Remediation with Michael Rubino | Rational Wellness Podcast 473
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Dr. Philip Goglia explains to Dr. Ben Weitz how to improve athletic performance through nutrition. [If you enjoy this podcast, please give us a positive review on Itunes, so more people will find The Rational Wellness Podcast] Podcast Details Dr. Goglia explained that using the correct macronutrient food pattern that fits each person's metabolism is crucial. This can be determined via a questionnaire and by looking at a lipid profile. If you are efficient at burning fats and carbohydrates and you consume a vegan diet, it will not work very well. Some people are efficient at...
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The Science of Breathwork with Dr. Sachin Patel: Rational Wellness Podcast 471
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The Science of Peptides with Dr. Chris Shade: Rational Wellness Podcast 470
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New Ways of Understanding and Treating SIBO with Dr. Allison Siebecker | Rational Wellness Podcast 469
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New Research and Clinical Updates on SIBO: Methane, Hydrogen Sulfide, Elemental Diet, Herbs, Probiotics, and Testing with Dr. Allison Siebecker Dr. Ben Weitz interviews Dr. Allison Siebecker on major updates in understanding and treating SIBO/IMO, drawing from new DDW conference findings. Highlights include a methane-targeting enzyme inhibitor drug (CS06) that rapidly lowers methane without acting as an antibiotic; a delayed-release NAC plus rifaximin formulation that improves outcomes and may allow lower rifaximin dosing; and a new elemental diet formulation (MBiota) reported to reach up...
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Polyendocrine Metabolic Ovarian Syndrome with Dr Felice Gersh | Rational Wellness Podcast 468
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Using Precision Medicine to Reverse Alzheimer's Disease with Dr. Heather Sandison | Rational Wellness Podcast 464
Dr. Ben Weitz interviews Dr. Heather Sandison about a precision, multimodal approach to Alzheimer’s and cognitive decline that challenges the amyloid-only model. Sandison cites a 2026 Cochrane review finding anti-amyloid antibody therapies remove plaque but don’t meaningfully improve cognition and carry risks like brain bleeding and swelling, arguing cognitive decline is driven by multiple modifiable factors. She reviews lifestyle-intervention research (Bredesen/Toups 2022, her 2023 study, Ornish 2024, and the Alzheimer’s Association POINTER trial) showing cognitive improvements, discusses key drivers such as toxins (mycotoxins, metals, chemicals), infections, metabolic flexibility/ketosis, sleep, stress, and social connection, and outlines evaluation tools including MoCA, CNS Vital Signs, MRI volumetrics with arterial spin labeling, and blood biomarkers like p-tau217, Aβ 42/40, and NfL, plus interpreting nutrients via homocysteine.
00:00 Show Intro
00:59 Alzheimers Rethink
01:34 Guest Background
02:48 Trial Clarification
03:39 Limits Of Amyloid Drugs
05:29 Houseplant Brain Analogy
07:10 Lifestyle Trials Evidence
09:41 Research Funding Reality
11:08 Preventable Dementia Risks
12:44 Synapses And Social Ties
15:13 Drivers Beyond Amyloid
17:27 Toxins As Key Factor
18:52 Why Toxins Get Ignored
20:42 Metabolic Flexibility Diet
23:33 Ketosis For Cognition
24:57 Exogenous Ketones Guide
26:57 MCT And Coconut Oil
27:10 Coconut Oil Ketones
28:10 Apollo Wearable Ad
29:42 Cognitive Testing Tools
31:17 Advanced Brain Imaging
33:56 Blood Biomarkers Explained
37:39 Nutrients And Homocysteine
40:29 Vitamin D And Calcium
41:53 Treatment Priorities
43:47 Sleep Apnea First
45:53 Hormones And Peptides
48:48 Wrap Up And Resources
49:53 Podcast Outro
Dr. Heather Sandison is the founder of Solcere Health Clinic in San Diego, California and Marama, a pioneering residential care facility focused on personalized, root-cause approaches to dementia. She is also the primary investigator and author of a peer-reviewed study published in the Journal of Alzheimer’s Disease demonstrating improvements in cognition using a personalized lifestyle intervention, and the author of the New York Times best selling book Reversing Alzheimer’s. Her website is DrHeatherSandison.com.