Episode 411: An Encouraging Clinical Trial for Progressive MS with Jason Tardio
Release Date: 07/14/2025
Special Episode: Dr. Aaron Boster Explains MS Clinical Trials
RealTalk MS
You're living with MS, and maybe you're thinking about participating in an MS clinical trial. But how do they work? Are they safe? What's the difference between Phase 1, 2, and 3 trials? What are the real patient risks and benefits of participating in a clinical trial? In this special episode of RealTalk MS, we're getting answers to those questions and so much more from my guest, Dr. Aaron Boster. Dr. Boster is the founder of the Boster Center for Multiple Sclerosis in Columbus, Ohio, where he brings over 20 years of experience as an MS clinician. Dr. Boster has also participated...
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Episode 420: A DIY Kit for Improving Your MS Journey with Julie Polisena
RealTalk MS
Disease-modifying therapies are the cornerstone of MS treatment, but they're not the only piece of the puzzle. Beyond prescription medications, self-care that includes making healthy lifestyle choices can significantly improve your quality of life with MS. Julie Polisena knows this firsthand. Julie lives with MS, and in a recent blog post, she shared a comprehensive list of the lifestyle changes that have improved her quality of life with MS. Julie joins us today to discuss some of the most impactful changes you can make to start your own journey toward better health and wellness. ...
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Episode 419: A Whole-Person Health Approach to MS Care with Dr. Lynne Shinto
RealTalk MS
Some people living with MS adhere to a treatment plan based exclusively on what we might consider traditional medicine. Others opt for alternative treatments. And, still, others take a whole-person health approach, blending integrative medicine with traditional treatments designed to support an individual's mind and body. Dr. Lynne Shinto joins me to discuss how a whole-person health approach can transform living with MS. Dr. Shinto is a Professor of Neurology and an MS Specialist at the Center for Women's Health at Oregon Health and Science University. We're also sharing some...
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Episode 418: The Importance of Developing a Growth Mindset When You're Living With MS with Dr. Mirian Franco
RealTalk MS
Living with MS means living with uncertainty, possible physical disability or cognitive dysfunction, bouts of crushing fatigue, mood changes, and let's not forget the very real irritation of well-meaning people telling you how healthy you look. Just processing the world around you can feel challenging. In this episode, psychologist Dr. Miriam Franco joins me to discuss how developing a growth mindset can make all the difference in how you experience your MS journey. We're also sharing a real-world example of how the drastic cuts in federal funding are already impacting MS care. We'll...
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Episode 417: Music and the Body with Emmy Award-Winning Composer Jeff Beal
RealTalk MS
If you've watched the critically acclaimed series, House of Cards, on Netflix, or the OCD detective series, Monk, on the USA Network, you've already listened to some of five-time Emmy award-winning composer Jeff Beal's work. This week, Jeff joins me to discuss his journey as an artist and as someone living with MS. We're also sharing all the details about the free event taking place at the Broad Stage in Santa Monica, California, on September 1, when Jeff joins conductor Leonard Slatkin and the Los Angeles Chamber Orchestra for a free concert featuring three of Jeff's works, including a...
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Episode 416: The Updated McDonald Diagnostic Criteria for MS with Dr. Andrew Solomon
RealTalk MS
Since 2001, clinicians have relied on the McDonald Diagnostic Criteria as the gold standard for diagnosing someone with multiple sclerosis. As science continues to add to our understanding of MS, the McDonald Criteria have been updated in 2005, 2010, 2017, and most recently in 2024. This latest iteration of the McDonald criteria will be published in September, and today, Dr. Andrew Solomon is giving us a preview of what these changes are, what they mean, and how they're going to improve the process of diagnosing someone with MS. We'll also share results of a study that show...
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Episode 415: Your Money -- Ways to Earn and Hold Onto More of It When You're Living with MS with Beth Scott and Paula Cole
RealTalk MS
Living with MS is expensive. Very expensive. It's estimated that the average cost of living with MS is over $88,000 per year. How, in the midst of financial stress and uncertainty, can you formulate a financial plan that takes MS into account? Paula Cole lives with MS, and she also lives with a lot of financial planning savvy. Paula joins the podcast to share tips and strategies for establishing a personal financial plan for you and your family -- even while you're coping with MS. And Beth Scott, the director of case management at the Patient Advocate Foundation, joins us to...
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Episode 414: Finding Peace in the Midst of Uncertainty with Andrea Arzt, LCSW, MSCS
RealTalk MS
Living with MS has always meant living with uncertainty. Left unchecked, that uncertainty can lead to anxiety, which can make your MS symptoms feel worse. This week, Licensed Clinical Social Worker, Andrea Arzt, joins me to share tips and strategies for finding peace in the midst of uncertainty. You'll also meet the CEO of the MS International Federation, Dr. Lydia Makaroff. And you'll hear how artist Gordon Keith is combining his art with philanthropy in support of MS Canada. We have a lot to talk about! Are you ready for RealTalk MS??! This Week: Finding peace during...
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Episode 413: How AI Will Impact MS Patient Care with Dr. Brad Willingham
RealTalk MS
We're witnessing the early stages of a paradigm shift, as artificial intelligence is beginning to impact virtually every aspect of healthcare, from research to patient care. And there's much, much more to come. This week, Dr. Brad Willingham, the Director of MS Research at Shepherd Center in Atlanta, joins me to discuss how AI will impact MS patient care. We'll also share the encouraging results from a Phase 2 open-label extension study for Fenebrutinib, an investigational disease-modifying therapy. We'll tell you about study results that show exercise interventions that...
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Episode 412: Understanding Late-Onset MS with Dr. Jacqueline Nicholas
RealTalk MS
More people over the age of 50 are being diagnosed with MS than ever before. When you consider the other health conditions that often develop as we age, and you add the fact that our immune system changes with age, there's a lot to think about when it comes to diagnosing and treating late-onset MS. This week, Dr. Jacqueline Nicholas, the System Chief of Neuroimmunology and Multiple Sclerosis at the OhioHealth Multiple Sclerosis Center, joins me to help us better understand late-onset MS. We'll also tell you about research results that could lead to a simple blood test that can...
info_outlineBack in Episode #401, we reported promising results from a Phase 2 clinical trial for vidofludimus calcium and its impact on progressive MS. This therapy is being developed by Immunic Therapeutics, and this week, Jason Tardio, Immunic's President and Chief Operating Officer, joins me to share some of the specifics of that clinical trial.
We're also sharing the encouraging results from a study that focused on the efficacy of neural stem cell transplantation as a remyelination therapy.
We'll tell you about a study in the U.K. that measured disability progression among people with MS five years after undergoing autologous hematopoietic stem cell transplantation (aHSCT).
You'll learn about an AI tool that can predict whether someone living with MS is likely to experience progression independent of relapse activity (PIRA) with a high degree of accuracy.
We'll tell you where you can catch the International Progressive MS Alliance webcast featuring a panel of experts discussing the future role of digital tools in MS research.
We'll explain how one of the less publicized aspects of the One Big Beautiful Bill Act will impact future MS care.
And Crush MS is less than two weeks away! We're sharing all the details!
We have a lot to talk about! Are you ready for RealTalk MS??!
This Week: Encouraging results from a clinical trial for progressive MS. :22
How a less-publicized aspect of the One Big Beautiful Bill Act will impact future MS patient care 1:18
A study looked at the efficacy of neural stem cell transplantation as a remyelination therapy 4:31
A study in the U.K. analyzed disability progression among people with MS five years after receiving autologous hematopoietic stem cell therapy (aHSCT) 7:42
Can AI accurately predict who will experience progression independent of relapse activity (PIRA)? 10:45
Don't miss the International Progressive MS Alliance webcast featuring experts discussing the future role of digital tools in MS research 12:40
Are you ready to support MS research while spending the afternoon in a Napa Valley vineyard? Get all the details to attend Crush MS 13:45
Jason Tardio, President and Chief Operating Officer of Immunic Therapeutics, discusses the recent Phase 2 clinical trial for vidofludimus calcium as a therapy for progressive MS 15:03
Share this episode 30:03
Have you downloaded the free RealTalk MS app? 30:23
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LINKS
If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com
Become an MS Activist
https://nationalmssociety.org/advocacy
STUDY: Remyelination of Chronic Demyelinated Lesions With Directly Induced Neural Stem Cells
https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awaf208/8185601
STUDY: Autologous Haemotopoietic Stem Cell Transplantation in the U.K.: A 20-Year Retrospective Analysis of Activity Haematological Outcomes from the British Society of Blood And Marrow Transplantation and Cellular Therapy
https://onlinelibrary.wiley.com/doi/epdf/10.1111/bjh.20199
STUDY: Deep Learning to Predict Progression Independent of Relapse Activity at a First Demyelinating Event
https://academic.oup.com/braincomms/article/7/4/fcaf243/8185588
WEBCAST: A Discussion From the International Progressive MS Alliance's Digital Tools Workshop
https://msif.org/news/2025/07/08/webcast-digital-tools
EVENT: Crush MS
https://crushms.org
Join the RealTalk MS Facebook Group
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RealTalk MS Episode 411
Guest: Jason Tardio