Episode #552 - ScaleUp Club Special: Scaling Deep Tech - with Mark Kotter
Release Date: 12/15/2025
Episode #574 - Neurodiversity, Franchising & Relentless Focus – with Rachael Jackson
ScaleUp Radio
In this episode of ScaleUp Radio, Kevin Brent sits down with Rachael Jackson, a dynamic entrepreneur who has turned personal challenges into entrepreneurial strengths. From launching her business through a franchise model to reframing dyslexia as a leadership asset, Rachael’s story is all about strategic thinking and relentless focus. Key Highlights Franchise as a Strategic Launchpad: Rachael chose a WIBN franchise to de-risk her startup journey, gaining crucial business experience and a peer network before launching her dream venture. Relentless Focus = Results: She became...
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Episode #573 - ScaleUp Radio Shorts: The Pivot Point: Moving from Busy to Impactful
ScaleUp Radio
This week on ScaleUp Radio Shorts, Kevin and Louise unpack two fascinating recent conversations, one with Samantha Thurlow of In Collaboration, and one with Graeme Tennick of Tennick Accountants. Different sectors. Same pivotal moment. Both guests hit a point where “business as usual” stopped working, and had to rethink structure, mindset, and action to move forward. 🔎 What We Cover 1️⃣ The Associate Trap Samantha built her agency on a flexible associate model. It worked, until it didn’t. Growth meant more work… but not more profit. Flexibility became a ceiling. Her...
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Episode #572 - From Virtual Assistant to Strategic Agency: Evolving for Growth - with Samantha Thurlow
ScaleUp Radio
In this episode of ScaleUp Radio, Kevin Brent is joined by Samantha Thurlow, founder of In Collaboration, a business support agency that’s grown from offering virtual assistant services to delivering full-service strategy, admin, and marketing. As her business evolves into a two-brand model, with the launch of Creative Bean Studios, Sam shares how she’s adapting to market shifts, overcoming growing pains, and preparing for the next stage of her scaleup journey. Key Takeaways Pivoting the Business Model: Sam transitioned In Collaboration from a flexible associate model to a hybrid employed...
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Episode #571 - ScaleUp Club - Dr. Serge Santos on Letting Go, Building Legacy, and Leading with Purpose
ScaleUp Radio
This episode of ScaleUp Radio is part of our Scale-Up Club spotlight series – a special format where we welcome back a previous guest to go deeper in a live Q&A session with our Scale-Up Club members. This time, we shine the spotlight on Dr. Serge Santos, also known as The Business Physicist – and for good reason. Serge brings a rare blend of financial acumen, physics-trained problem solving, and a deep passion for business legacy. From being made redundant in 2013 to raising £700 million and running three growing businesses under his Bedrock Enterprises group, Serge speaks with...
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Episode #570 - ScaleUp Radio Shorts – The Veteran vs The Challenger: Value, Grit & the Art of Scaling
ScaleUp Radio
In this punchy episode of ScaleUp Radio Shorts, hosts Kevin Brent and Louise Blunt unpack the sharpest lessons from two remarkably different guests – and the surprising connections between them. On one side: 🧠 Andrew Bloch; seasoned PR expert, co-founder of Frank PR, and now high-level "fixer" and M&A advisor. On the other: 🚀 Claudiu Cogalniceanu; scrappy startup founder of Sentrya, fighting phishing with tech while driving Uber to fund his dream. Despite being at opposite ends of the business spectrum, their journeys share deep truths about scaling, resilience, and self-awareness....
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Episode #569 - Turning Procrastination Into Progress – How Graeme Tennick Is Reimagining Accountancy Through Impact, Habits and Accountability
ScaleUp Radio
In this episode of ScaleUp Radio, Kevin Brent is joined by Graeme Tennick, the founder of Tennick Accountants – a firm that’s challenging the traditional view of accountants as compliance providers by driving real strategic impact for clients and the wider community. Graeme shares how his firm has rooted itself in a compelling mission: to make lives better – for their team, their clients, and even the world. And this isn’t just a tagline. From the way they set goals with clients to how they measure internal performance and reward behaviour, it’s clear that purpose drives everything...
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Episode #568 - ScaleUp Club - How to Build a High-Performing Team Culture - with Alina Stancu
ScaleUp Radio
In this special ScaleUp Club VIP session, we’re joined by Alina Stancu, co-founder of The Orange Notebook, for a focused and interactive discussion on what it really takes to build a high-performing team culture, even with a remote team or contractors. Through practical frameworks, lived experience, and powerful case studies, Alina guides us through how culture is either fuelling or silently stalling your business, and what you can do about it. You’ll hear: 🔸 Why most cultural breakdowns stem from missing safety and purpose – and why these two ingredients are non-negotiable. 🔸 How...
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Episode #567 - Rocket Science vs Business Rates - Scaling Lessons from Both Worlds
ScaleUp Radio
In this special edition of ScaleUp Radio Shorts, Kevin Brent and Granger Forson dive into two recent interviews that couldn’t be more different on the surface; but reveal some remarkably similar lessons underneath. On one side, we have Aqeel Shamsul, founder of cutting-edge space biotech startup Frontier Space, turning microgravity into a drug development advantage. On the other, Tom Perry and Ella Chapman from Holloway Bond, redefining the approach to business rates recovery through data-led outreach and customer-first practices. From rocket science to rateable values, this episode is a...
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Episode #566 - Why Doing Things Differently with approaching Business Rates Helped This Young Business Scale Without Losing Control - with Tom Perry & Ella Chapman
ScaleUp Radio
Granger Forson here from and on LinkedIn, and in this episode of ScaleUp Radio I’m joined by Tom Perry and Ella Chapman, founders of Holloway Bond. In just three years, Tom and Ella have quietly built a specialist business that champions companies who are unknowingly overpaying business rates. Rather than chasing every prospect, Holloway Bond flips the model on its head by using data to proactively identify who they can truly help, before ever picking up the phone. What stands out immediately is their integrity. Operating on a no-win-no-fee basis, they only take on...
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Episode #565 - Unlocking Drug Discovery in Space - with Aqeel Shamsul of Frontier Space
ScaleUp Radio
What if the future of drug discovery isn’t on Earth? In this episode of ScaleUp Radio, Kevin Brent is joined by Aqeel Shamsul, the visionary CEO and co-founder of Frontier Space, a UK-based space biotech company developing shoebox-sized biolabs to unlock the power of microgravity for pharmaceutical R&D. Spun out of Aqeel’s PhD at Cranfield University, Frontier Space is on a mission to make in-space research and biomanufacturing accessible, affordable, and impactful, and they’ve already achieved what few startups can: bootstrapping two space missions and securing over £1.3M in...
info_outlineIn this exclusive ScaleUp Club session, Kevin Brent sits down with Dr Mark Kotter, the visionary neurosurgeon and founder of Bit Bio, a revolutionary deep tech company transforming how we produce human cells at scale.
Bit Bio has raised over £250 million, and what started as academic frustration with the limits of regenerative medicine has become a game-changing platform for industrial-scale cell production. But it hasn’t been an easy ride.
From a near-collapse caused by co-founder misalignment to pioneering an intensive, values-driven hiring process, Mark shares a raw and honest look at what it takes to scale a company at the edge of biotech innovation.
🔑 Key Takeaways:
- Explicit Alignment Is Crucial: Co-founder misalignment nearly destroyed the company. Mark remortgaged his house to buy them out — and rebuilt with clear purpose and cultural values at the core.
- Fundraising Is a Full-Time Role: To scale such a novel tech, Mark handed off the science to a CSO and focused entirely on securing capital — over £250M to date.
- Hire People Smarter Than You: By sourcing key hires from VC due diligence teams and investing in deep expertise, Bit Bio gained the credibility and capability needed to scale.
- De-Risk Through Automation: Building biology, manufacturing, and QC processes from scratch is risky — automation and miniaturisation helped deliver £250M/year capacity from just 300m².
💡 The One Key Thing:
If your team’s alignment isn’t crystal clear — it’s a ticking time bomb.
Quick heads-up — we’re looking for a handful of founders to test our new AI-powered Smart90 Lite app. It’s built to help you stay accountable and actually deliver on your goals — in just a few minutes a day. It’s free while we’re in testing, and your feedback will directly shape the final version. You can get access by emailing kevin@biz-smart.co.uk.
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For now, continue listening for the full discussion with Mark.
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Kevin's Latest Book Is Available!
Drawing on BizSmart’s own research and experiences of working with hundreds of owner-managers, Kevin Brent explores the key reasons why most organisations do not scale and how the challenges change as they reach different milestones on the ScaleUp Journey. He then details a practical step by step guide to successfully navigate between the milestones in the form of ESUS - a proven system for entrepreneurs to scale up.
More on the Book HERE - https://www.esusgroup.co.uk/
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