Episode #574 - Neurodiversity, Franchising & Relentless Focus – with Rachael Jackson
ScaleUp Radio
In this episode of ScaleUp Radio, Kevin Brent sits down with Rachael Jackson, a dynamic entrepreneur who has turned personal challenges into entrepreneurial strengths. From launching her business through a franchise model to reframing dyslexia as a leadership asset, Rachael’s story is all about strategic thinking and relentless focus. Key Highlights Franchise as a Strategic Launchpad: Rachael chose a WIBN franchise to de-risk her startup journey, gaining crucial business experience and a peer network before launching her dream venture. Relentless Focus = Results: She became...
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Episode #573 - ScaleUp Radio Shorts: The Pivot Point: Moving from Busy to Impactful
ScaleUp Radio
This week on ScaleUp Radio Shorts, Kevin and Louise unpack two fascinating recent conversations, one with Samantha Thurlow of In Collaboration, and one with Graeme Tennick of Tennick Accountants. Different sectors. Same pivotal moment. Both guests hit a point where “business as usual” stopped working, and had to rethink structure, mindset, and action to move forward. 🔎 What We Cover 1️⃣ The Associate Trap Samantha built her agency on a flexible associate model. It worked, until it didn’t. Growth meant more work… but not more profit. Flexibility became a ceiling. Her...
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Episode #572 - From Virtual Assistant to Strategic Agency: Evolving for Growth - with Samantha Thurlow
ScaleUp Radio
In this episode of ScaleUp Radio, Kevin Brent is joined by Samantha Thurlow, founder of In Collaboration, a business support agency that’s grown from offering virtual assistant services to delivering full-service strategy, admin, and marketing. As her business evolves into a two-brand model, with the launch of Creative Bean Studios, Sam shares how she’s adapting to market shifts, overcoming growing pains, and preparing for the next stage of her scaleup journey. Key Takeaways Pivoting the Business Model: Sam transitioned In Collaboration from a flexible associate model to a hybrid employed...
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Episode #571 - ScaleUp Club - Dr. Serge Santos on Letting Go, Building Legacy, and Leading with Purpose
ScaleUp Radio
This episode of ScaleUp Radio is part of our Scale-Up Club spotlight series – a special format where we welcome back a previous guest to go deeper in a live Q&A session with our Scale-Up Club members. This time, we shine the spotlight on Dr. Serge Santos, also known as The Business Physicist – and for good reason. Serge brings a rare blend of financial acumen, physics-trained problem solving, and a deep passion for business legacy. From being made redundant in 2013 to raising £700 million and running three growing businesses under his Bedrock Enterprises group, Serge speaks with...
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Episode #570 - ScaleUp Radio Shorts – The Veteran vs The Challenger: Value, Grit & the Art of Scaling
ScaleUp Radio
In this punchy episode of ScaleUp Radio Shorts, hosts Kevin Brent and Louise Blunt unpack the sharpest lessons from two remarkably different guests – and the surprising connections between them. On one side: 🧠 Andrew Bloch; seasoned PR expert, co-founder of Frank PR, and now high-level "fixer" and M&A advisor. On the other: 🚀 Claudiu Cogalniceanu; scrappy startup founder of Sentrya, fighting phishing with tech while driving Uber to fund his dream. Despite being at opposite ends of the business spectrum, their journeys share deep truths about scaling, resilience, and self-awareness....
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Episode #569 - Turning Procrastination Into Progress – How Graeme Tennick Is Reimagining Accountancy Through Impact, Habits and Accountability
ScaleUp Radio
In this episode of ScaleUp Radio, Kevin Brent is joined by Graeme Tennick, the founder of Tennick Accountants – a firm that’s challenging the traditional view of accountants as compliance providers by driving real strategic impact for clients and the wider community. Graeme shares how his firm has rooted itself in a compelling mission: to make lives better – for their team, their clients, and even the world. And this isn’t just a tagline. From the way they set goals with clients to how they measure internal performance and reward behaviour, it’s clear that purpose drives everything...
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Episode #568 - ScaleUp Club - How to Build a High-Performing Team Culture - with Alina Stancu
ScaleUp Radio
In this special ScaleUp Club VIP session, we’re joined by Alina Stancu, co-founder of The Orange Notebook, for a focused and interactive discussion on what it really takes to build a high-performing team culture, even with a remote team or contractors. Through practical frameworks, lived experience, and powerful case studies, Alina guides us through how culture is either fuelling or silently stalling your business, and what you can do about it. You’ll hear: 🔸 Why most cultural breakdowns stem from missing safety and purpose – and why these two ingredients are non-negotiable. 🔸 How...
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Episode #567 - Rocket Science vs Business Rates - Scaling Lessons from Both Worlds
ScaleUp Radio
In this special edition of ScaleUp Radio Shorts, Kevin Brent and Granger Forson dive into two recent interviews that couldn’t be more different on the surface; but reveal some remarkably similar lessons underneath. On one side, we have Aqeel Shamsul, founder of cutting-edge space biotech startup Frontier Space, turning microgravity into a drug development advantage. On the other, Tom Perry and Ella Chapman from Holloway Bond, redefining the approach to business rates recovery through data-led outreach and customer-first practices. From rocket science to rateable values, this episode is a...
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Episode #566 - Why Doing Things Differently with approaching Business Rates Helped This Young Business Scale Without Losing Control - with Tom Perry & Ella Chapman
ScaleUp Radio
Granger Forson here from and on LinkedIn, and in this episode of ScaleUp Radio I’m joined by Tom Perry and Ella Chapman, founders of Holloway Bond. In just three years, Tom and Ella have quietly built a specialist business that champions companies who are unknowingly overpaying business rates. Rather than chasing every prospect, Holloway Bond flips the model on its head by using data to proactively identify who they can truly help, before ever picking up the phone. What stands out immediately is their integrity. Operating on a no-win-no-fee basis, they only take on...
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Episode #565 - Unlocking Drug Discovery in Space - with Aqeel Shamsul of Frontier Space
ScaleUp Radio
What if the future of drug discovery isn’t on Earth? In this episode of ScaleUp Radio, Kevin Brent is joined by Aqeel Shamsul, the visionary CEO and co-founder of Frontier Space, a UK-based space biotech company developing shoebox-sized biolabs to unlock the power of microgravity for pharmaceutical R&D. Spun out of Aqeel’s PhD at Cranfield University, Frontier Space is on a mission to make in-space research and biomanufacturing accessible, affordable, and impactful, and they’ve already achieved what few startups can: bootstrapping two space missions and securing over £1.3M in...
info_outlineIn this episode of ScaleUp Radio Shorts, Kevin Brent and Granger Forson unpack the remarkable ScaleUp journey of Dr. Mark Kotter, a neurosurgeon, stem cell biologist, and founder of Bit Bio, a deep-tech biotech company that’s raised over $200 million and scaled to 200+ people.
It’s a story that starts with clinical frustration and leads to a cutting-edge company using AI to literally reprogram cells.
But beyond the science lies a business story that any entrepreneur can learn from, full of lessons on leadership, values, team alignment, and the bumpy road of scale.
💡 Episode Highlights
- From Surgeon to ScaleUp CEO: Mark didn’t set out to start a company, he was driven by necessity. After realising he couldn’t cure spinal damage with surgery alone, he went searching for answers in research, ultimately spinning out Bit Bio after university support fell short.
- A Painful Co-Founder Conflict: Mark’s first attempt at scaling ended in near disaster. Misalignment in values and vision led to a business breakup that forced him to remortgage his house to buy back control.
- Hiring with Intention: After that, Mark built a recruitment process focused on alignment and values, Purposeful, Ambitious, Trustworthy, Empirical, with a “Secret Vote” used to prevent bias and protect culture.
- Recognising the Breaking Points: Mark shares how communication changes at 20, 50, and 100 people, and how he had the humility to step aside and hire experienced operators to build structure when it was time.
- Living Drugs & AI: Bit Bio is on the frontier of medicine, moving from traditional "dead molecules" to "living drugs". They use AI and machine learning to crack complex genetic programming challenges that could change the future of healthcare.
🚀 The One Key Thing
“Don’t assume alignment, be explicit about your values from day one.”
💬 Standout Quote
“I thought curing disease would be enough to align people, but it wasn’t. You have to say the hard stuff upfront.” – Mark Kotter
💡 Smart90 Lite – Try It Free
Quick heads-up , we’re looking for a handful of founders to test our new AI-powered Smart90 Lite app. It’s built to help you stay accountable and actually deliver on your goals , in just a few minutes a day. It’s free while we’re in testing, and your feedback will directly shape the final version.
👉 Email kevin@biz-smart.co.uk to get access.
🎧 Listen & Subscribe
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And if you know a founder with an inspiring story, check the show notes to nominate them!