#618 The Glycocalyx Connection: Healing Leaky Gut, Leaky Brain & Cognitive Decline with Martha Carlin
Release Date: 11/11/2025
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info_outlineThe Glycocalyx Connection: Healing Leaky Gut, Leaky Brain & Cognitive Decline with Martha Carlin
What if the secret to your gut, brain, and vascular health lies in a microscopic sugar-protein layer called the glycocalyx?
In this episode of The Coach Debbie Potts Show, I sit down with Martha Carlin, founder of BiotiQuest and The BioCollective, to explore how the glycocalyx, the gut microbiome, and the blood–brain barrier work together to protect our energy, metabolism, and cognitive health — and what happens when they break down.
Martha shares her inspiring story of turning her husband’s Parkinson’s diagnosis into a scientific mission, leading to the creation of Sugar Shift — a probiotic culture designed to rebalance sugar metabolism in the gut. We unpack the science of how this unique formulation helps convert glucose into beneficial metabolites like mannitol, supporting both metabolic and neurological resilience.
Together, we discuss:
🧠 What the glycocalyx is — and why it’s essential for vascular, gut, and brain health
💥 How inflammation, oxidative stress, and high blood sugar erode your cellular barriers
🦠 The role of gut dysbiosis and endotoxins (LPS) in triggering leaky gut and leaky brain
❤️ How endothelial damage drives fatigue, brain fog, and cognitive decline
🥦 Root Cause solutions to rebuild and protect your glycocalyx, gut lining, and blood–brain barrier
🌿 Nutritional therapy and lifestyle strategies to lower inflammation and boost nitric oxide
🧫 How BiotiQuest Sugar Shift helps redirect sugar metabolism and improve mitochondrial health
If you’ve ever wondered how your gut health connects to your brain clarity, focus, and longevity — this episode will connect the dots between your microbiome, metabolism, and mind.
🎧 Listen & Learn:
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The science of the glycocalyx and why it’s your body’s “Teflon coating”
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How “leaky gut” and “leaky brain” are two sides of the same barrier problem
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Why protecting your endothelial and gut barriers is key to preventing neurodegeneration
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The power of targeted probiotics like BiotiQuest Sugar Shift for metabolic repair
🧬 Connect with Martha Carlin & BiotiQuest:
👉 https://www.biotiquest.com
Use code COACHDEBBIEPOTTS for savings on Sugar Shift and other microbiome solutions.
🌿 Connect with Coach Debbie Potts:
Website: www.debbiepotts.net
YouTube: @coachdebbiepotts
Instagram: @coachdebbiepotts
Podcast: The Coach Debbie Potts Show – available on Apple, Spotify & all major platforms