#529: Addressing Popular Claims About Cholesterol, Dietary Fat and Heart Disease
Release Date: 07/16/2024
#544: Genetic Variants and Response to Nutrients – Martin Kohlmeier, MD PhD
Sigma Nutrition Radio
In the realm of nutrition science, individual differences are more profound and impactful than many realize. For decades, we’ve developed dietary recommendations with a “one-size-fits-all” approach, assuming that most people respond similarly to specific nutrients. But Dr. Martin Kohlmeier, a pioneer in precision nutrition, challenges this very notion. How might an individual’s genetic makeup alter their need for certain nutrients? With advances in nutrigenetics, we’re beginning to see how personalized nutrition could bridge long-standing gaps in dietary efficacy. Dr. Kohlmeier’s...
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#543: Eye Health & Nutrition – Prof. John Nolan
Sigma Nutrition Radio
In this episode, we dive deep into the world of ocular nutrition with Professor John Nolan, exploring how specific nutrients can play crucial roles in preserving eye health, improving vision and supporting cognitive function. With age-related macular degeneration (AMD) affecting millions globally, Professor Nolan sheds light on groundbreaking research showing how certain carotenoids—natural pigments found in plant foods—could impact eye health and perhaps even neurodegenerative conditions like Alzheimer’s disease. But what are these compounds exactly, and why are they so impactful?...
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#542: Nutrients for Cognitive Performance in Sports – Prof. Shawn Arent, PhD
Sigma Nutrition Radio
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#541: Lean Mass Hyper Responders & the Lipid Energy Model: Do the Claims Stand Up to Scrutiny?
Sigma Nutrition Radio
When discussing cardiovascular health, few topics stir as much debate as cholesterol, particularly in relation to low-carb and ketogenic diets. Recently, there’s been significant attention given to a proposed model that suggests high LDL cholesterol may not pose the same cardiovascular risk in certain individuals, specifically those labeled as “lean mass hyper-responders.” This raises important questions: Is it possible that high cholesterol might not be dangerous for everyone? Or are we witnessing a dangerous misinterpretation of the science? In this episode, we break down the ideas...
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Fasting for Health: What Do We Know? (SNP34)
Sigma Nutrition Radio
Fasting has gained immense popularity as a dietary approach, but what does the scientific evidence say about its health benefits? Studies have explored how fasting might influence metabolic markers, energy expenditure, and even aging. However, while fasting shows promise in some animal models, translating these effects to humans is less clear. A key part of the debate centers on whether fasting offers unique health advantages or whether its benefits stem primarily from reduced calorie intake. Time-restricted eating and intermittent fasting protocols show promise in regulating appetite and...
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#540: How Can We Improve Body Image and Self-Esteem Without Physique Change? – Gabrielle Fundaro, PhD & Eric Trexler, PhD
Sigma Nutrition Radio
Body image and self-worth are deeply intertwined concepts that influence how we see ourselves and interact with the world. Many people believe that changing their physique is the key to improving their body image, but is it really that simple? This connection between appearance and self-esteem raises important questions about how we define confidence and whether our sense of worth should be tied to how we look. Our relationship with food plays a crucial role in how we view ourselves. While some see food as fuel, others attach much more significance to their eating habits, often linking dietary...
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#539: How Does Carbohydrate Availability Impact Resistance Training? – Cliff Harvey, PhD & Eric Helms, PhD
Sigma Nutrition Radio
Some suggest that, since individual lifts or short-duration efforts don’t rely heavily on glycogen, carb intake might not be critical for strength athletes. If glycogen depletion isn’t a pressing issue, could athletes thrive on lower-carb diets without sacrificing performance? Or could there be overlooked benefits to having greater carbohydrate availablily in those sessions? In strength sports and resistance training, do carbohydrates play an important role or not? Are carbohydrates really necessary for resistance training? How does training volume, intensity and goals impact the...
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#538: Can Fish Oil Supplementation Increase Risk of Irregular Heart Rhythms?
Sigma Nutrition Radio
Omega-3 fatty acids are often viewed as beneficial or, at worst, neutral supplements when it comes to supporting cardiovascular health, lowering triglycerides, and offering anti-inflammatory effects. Much of the focus in recent years has centered on understanding how significant these benefits are, particularly for heart health, with many studies highlighting the potential for omega-3s to play a positive role in reducing cardiovascular risk. However, an emerging concern has complicated the conversation around omega-3 supplementation. Several large trials, including the REDUCE-IT and STRENGTH...
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#537: Appetite Regulation, Metabolic Compensation and More – Stephan Guyenet, PhD
Sigma Nutrition Radio
This is an “ask me anything” (AMA) episode with Dr. Stephan Guyenet, an expert in obesity neuroscience and eating behavior. This episode was originally published on . If you’re interested in subscribing to Sigma Nutrition Premium, then check all the details . Questions Answered: [04.27] If we surgically remove adipose tissue, do leptin levels suddenly drop? How would this impact hunger over time? [06.56] How does chronic energy restriction (or following a crash diet) affect long-term appetite regulation? [13.21] How do anorexia and pronounced obesity...
info_outlineIn episode 529 of Sigma Nutrition Radio, we discuss all things related to cholesterol, atherosclerosis, heart disease, and dietary fat. The discussion extensively covers the impact of LDL cholesterol and ApoB on atherosclerotic plaque progression, cardiovascular events, and the benefits of early LDL lowering interventions, particularly through the use of PCSK9 inhibitors alongside statins.
We address misconceptions prevalent in the low-carb and carnivore communities, dissect claims regarding saturated fats, and elucidate why atherosclerosis predominantly affects arteries and not veins. The episode sheds light on the nuanced mechanisms of cholesterol metabolism, the significance of different lipid particles, and the limited dietary impact on LP(a) levels.
Comprehensive evidence-based insights and practical recommendations for dietary patterns and cardiovascular health interventions are provided, offering clarity on these complex topics.
Note: This discussion is hosted by Simon Hill, and originally appeared as an episode of The Proof podcast.
Links:
- Subscribe to Sigma Nutrition Premium
- Receive our free weekly email: the Sigma Synopsis
- Episode with Professor Chris Packard
Timestamps:
- 07:19 Understanding Cholesterol and Lipoproteins
- 14:35 The Role of ApoB in Cardiovascular Risk
- 25:10 Atherogenic Lipoproteins and Their Impact
- 37:42 Causal Pathways and Biomarkers in Heart Disease
- 47:02 Understanding Residual Risk and Triglycerides
- 49:46 Paul Saladino’s Claims on LDL and Metabolic Health
- 01:03:01 Addressing Concerns About Lowering Cholesterol
- 01:16:16 The Importance of Early Intervention in Cholesterol Management
- 01:23:36 The Future of Cholesterol Management and Gene Editing
- 01:28:24 Atherosclerosis in Arteries vs. Veins
- 01:36:08 Dietary Interventions to Lower ApoB Levels
- 01:47:55 Modifying Keto Diet for Better Health Outcomes
- 01:56:33 Plant-Based Diets and Fat Consumption
- 02:05:10 Understanding Lp(a) and Its Impact on Health