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#582: GLP-1 Agonists: Side Effects, Management and Diet – Dr. Spencer Nadolsky

Sigma Nutrition Radio

Release Date: 10/28/2025

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GLP-1 receptor agonists have emerged as a groundbreaking tool in obesity treatment. In this episode, Dr. Spencer Nadolsky (an obesity specialist) explains how these medications are now yielding unprecedented weight loss outcomes in people with obesity. 

The discussion centers on GLP-1 agonist drugs like semaglutide and tirzepatide: how they work, how much weight loss they can produce, and why they represent a paradigm shift in obesity management. 

Importantly, the conversation addresses practical aspects of using these drugs, including managing their side effects and optimizing patients’ diet and lifestyle while on therapy.

This topic is of great significance to nutrition science, clinical practice, and public health. Obesity is a chronic, relapsing condition that has proven difficult to treat with lifestyle changes alone. The advent of GLP-1 agonists offers new hope by inducing weight loss levels previously seen only with surgical interventions. 

Understanding these medications is crucial for healthcare professionals: it enables evidence-based prescribing, proper patient counseling on diet and side effects, and integration of medication with lifestyle interventions. 

Discussing safety and long-term use is vital, as millions more patients might use these drugs in coming years. From a public health perspective, GLP-1 agonists prompt debates about access and cost, given their high price and life-changing potential.

Timestamps

  • [03:25] Conversation with Dr. Spencer Nadolsky begins
  • [05:24] Mechanism and types of GLP-1 medications
  • [07:55] Efficacy and weight loss results
  • [16:53] Common side effects and management
  • [22:57] Muscle loss concerns and clinical insights
  • [28:09] Addressing nutritional concerns with GLP-1 medications
  • [29:38] Exploring potential benefits beyond weight loss
  • [33:48] Marketing and misconceptions around GLP-1
  • [36:59] Public health and accessibility issues
  • [43:25] Future research
  • [46:16] Key ideas segment (Premium-only)

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