Revolutionizing Humanity And Tech With Pablos Holman - TWMJ #1033
Release Date: 04/26/2026
Winning With AI With Charlene Li - TWMJ #1041
Thinking With Mitch Joel
Welcome to episode #1041 of Thinking With Mitch Joel (formerly Six Pixels of Separation). At a time when every leadership team is being told that artificial intelligence will change everything, has spent her career helping organizations separate signal from noise. A New York Times bestselling author and trusted advisor to CEOs and boards, Charlene first became widely known for helping leaders understand transformative shifts through books like , and . Her latest book, , co-authored with , tackles one of the most pressing questions facing business leaders today: not what AI is, but what to do...
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AI And The Knowledge Economy With Sangeet Paul Choudary
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Developing A Vital Voice With Carmine Gallo - TWMJ #1039
Thinking With Mitch Joel
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Thinking With Mitch Joel
Welcome to episode #1038 of Thinking With Mitch Joel (formerly Six Pixels of Separation). At a time when technology feels simultaneously more powerful and more opaque than ever, is making a case for something many people feel they’ve lost: agency. A Technical Fellow and Corporate Vice President at , Marcus has spent decades helping build the infrastructure that powers the modern internet, including leadership roles at , and . His new book, , is both a guide to understanding the technologies shaping our lives and a reminder that we are not merely passengers along for the ride. Drawing on...
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The Value Of Uncertainty With Simone Stolzoff - TWMJ #1037
Thinking With Mitch Joel
Welcome to episode #1037 of Thinking With Mitch Joel (formerly Six Pixels of Separation). At a moment when certainty has become both a cultural obsession and a commercial product, is asking a far more uncomfortable question: what if the real skill is learning how to live without it? A journalist whose work has appeared in publications like and author of the bestselling book , Simo has built his work around examining the hidden psychological contracts shaping modern life… especially our increasingly tangled relationship with work, ambition and identity. His new book, , pushes that...
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Unlocking The Best In People With Ashley Herd - TWMJ #1036
Thinking With Mitch Joel
Welcome to episode #1036 of Thinking With Mitch Joel (formerly Six Pixels of Separation). did not set out to become a management expert. Trained as an employment lawyer and later serving in senior HR and leadership roles supporting organizations including , Ashley built her career at the intersection of people, performance and workplace culture. What began as practical leadership advice shared through short-form social media videos evolved into a , with hundreds of thousands of managers turning to her for direct, actionable guidance on how to lead teams without burning people out. Her new...
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Modern Marketing With MichaelAaron Flicker - TWMJ #1035
Thinking With Mitch Joel
Welcome to episode #1035 of Thinking With Mitch Joel (formerly Six Pixels of Separation). At a time when marketers have more data, more technology and more precision than ever before… consumer trust, attention and loyalty somehow feel more fragile than ever. Few people are exploring that paradox more deeply than . An entrepreneur who started his company at just fourteen years old, Michael has spent years studying the intersection of marketing, behavioral science and human decision-making (he runs an agency, vventure capital firm and leads several other businesses). His book, (along with...
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The Business Of Culture And Art With Douglas Woodham - TWMJ #1034
Thinking With Mitch Joel
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Revolutionizing Humanity And Tech With Pablos Holman - TWMJ #1033
Thinking With Mitch Joel
Welcome to episode #1033 of Thinking With Mitch Joel (formerly Six Pixels of Separation). We spent the last twenty-five years calling software “technology,” which was convenient, profitable and just a little bit delusional. Apps got smarter. Feeds got stickier. Ads got creepier. Dashboards got dashboards. Meanwhile, the real world kept asking harder questions. How do we produce enough clean energy for eight billion people? How do we build things again? How do we manufacture without waste? How do we use AI for science, not just better chatbots and faster slop? has spent his career living...
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Unlocking Creativity And Productivity With Natalie Nixon - TWMJ #1032
Thinking With Mitch Joel
Welcome to episode #1032 of Thinking With Mitch Joel (formerly Six Pixels of Separation). At a time when productivity is still measured in speed, output and constant motion, few voices are pushing for a more human… and ultimately more effective… way of working than . A creativity strategist, keynote speaker and founder of , Natalie has built her career helping leaders unlock the business value of imagination… not as a soft skill, but as a strategic capability. Her work sits at the intersection of design thinking, anthropology and business innovation, and her previous book, , positioned...
info_outlineWelcome to episode #1033 of Thinking With Mitch Joel (formerly Six Pixels of Separation).
We spent the last twenty-five years calling software “technology,” which was convenient, profitable and just a little bit delusional. Apps got smarter. Feeds got stickier. Ads got creepier. Dashboards got dashboards. Meanwhile, the real world kept asking harder questions. How do we produce enough clean energy for eight billion people? How do we build things again? How do we manufacture without waste? How do we use AI for science, not just better chatbots and faster slop? Pablos Holman has spent his career living inside those questions. He is a hacker, inventor, venture capitalist, and founder of Deep Future, an invention capital firm backing the mad scientists, rogue engineers and maverick entrepreneurs trying to build technologies that actually matter. His career has touched everything from cryptocurrency in the 1990s and AI for financial markets to the early days of Blue Origin and the launch of Intellectual Ventures Lab, where the work included mosquito-killing lasers, malaria-diagnosing microscopes, vaccine coolers, advanced antennas and nuclear reactors powered by waste. His book, Deep Future - Creating Technology That Matters, argues that the next wave of innovation will not come from making software marginally more addictive. It will come from solving the physical, messy, expensive, essential problems that humanity depends on: energy, water, food, waste, construction, manufacturing, medicine and infrastructure. In this conversation, Pablos makes the case for optimism with teeth. Not optimism as a mood. Optimism as a discipline. A willingness to stare at massive problems without flinching… and then go build something. We talk about why software can’t save the world by itself, why energy may be the root problem behind almost everything, why AI’s most meaningful work may happen in science, and why the future belongs to people willing to work on problems big enough to scare everyone else. Enjoy the conversation…
- Running time: 1:04:47.
- Hello from beautiful Montreal.
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- Here is my conversation with Pablos Holman.
- Deep Future - Creating Technology That Matters.
- Check out Pablos on the Tim Ferriss Podcast: One of The Scariest Hackers I’ve Ever Met — Pablos Holman.
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Chapters:
(00:00) - Introduction to Deep Future and Venture Capital.
(02:47) - The Shift from Software to Deep Tech.
(06:08) - Revolutionizing Manufacturing with Robotics.
(08:49) - The Environmental Impact of Energy Production.
(12:13) - Innovative Solutions for Energy Challenges.
(15:08) - The Role of AI in Scientific Advancements.
(17:53) - Cultural Shifts in Manufacturing and Education.
(20:55) - The Future of Energy and Nuclear Solutions.
(23:56) - The Importance of Long-Term Thinking.
(26:45) - Connecting Work to Meaning and Purpose.
(30:13) - The Role of Corporations in Infrastructure Investment.
(33:03) - The Future of Jobs in an Automated World.
(36:13) - AI’s Role in Solving Global Problems.
(39:01) - The Need for Optimism in Technology.
(41:59) - Final Thoughts and the Future of Humanity.