Astral Codex Ten Podcast
You can sign the letter . The Trump administration has been , and people and groups with business before the administration have started laundering criticism through other sources with less need for goodwill. So I have been asked to share , which needs signatures from scientists, doctors, and healthcare professionals. The authors tell me (THIS IS NOT THE CONTENTS OF THE LETTER, IT’S THEIR EXPLANATION, TO ME, OF WHAT THE LETTER IS FOR): The NIH has spent at least than Congress has appropriated to them, which is bad because medical research is good and we want more of it. In May, that he...
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AI psychosis (, ) is an apparent phenomenon where people go crazy after talking to chatbots too much. There are some high-profile anecdotes, but still many unanswered questions. For example, how common is it really? Are the chatbots really driving people crazy, or just catching the attention of people who were crazy already? Isn’t psychosis supposed to be a biological disease? Wouldn’t that make chatbot-induced psychosis the same kind of category error as chatbot-induced diabetes? I don’t have all the answers, so think of this post as an exploration of possible analogies and precedents...
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Finalist #9 in the Review Contest [This is one of the finalists in the 2025 review contest, written by an ACX reader who will remain anonymous until after voting is done. I’ll be posting about one of these a week for several months. When you’ve read them all, I’ll ask you to vote for a favorite, so remember which ones you liked] Ollantay is a three-act play written in Quechua, an indigenous language of the South American Andes. It was first performed in Peru around 1775. Since the mid-1800s it’s been performed more often, and nowadays it’s pretty easy to find some company in Peru...
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[original post ] #1: Isn’t it possible that embryos are alive, or have personhood, or are moral patients? Most IVF involves getting many embryos, then throwing out the ones that the couple doesn’t need to implant. If destroying embryos were wrong, then IVF would be unethical - and embryo selection, which might encourage more people to do IVF, or to maximize the number of embryos they get from IVF, would be extra unethical. I think a default position would be that if you believe humans are more valuable than cows, and cows more valuable than bugs - presumably because humans are more...
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Finalist #8 in the Review Contest [This is one of the finalists in the 2025 review contest, written by an ACX reader who will remain anonymous until after voting is done. I’ll be posting about one of these a week for several months. When you’ve read them all, I’ll ask you to vote for a favorite, so remember which ones you liked] I. The Men Are Not Alright Sometimes I’m convinced there’s a note taped to my back that says, “PLEASE SPILL YOUR SOUL UPON THIS WOMAN.” I am not a therapist, nor in any way certified to deal with emotional distress, yet my presence seems to cause people...
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A guest post by David Schneider-Joseph The “amyloid hypothesis” says that Alzheimer’s is caused by accumulation of the peptide amyloid-β. It’s the leading model in academia, but a favorite target for science journalists, contrarian bloggers, and neuroscience public intellectuals, who point out problems like: Some of the research establishing amyloid's role turned out to be fraudulent. The level of amyloid in the brain doesn’t correlate very well with the level of cognitive impairment across Alzheimer’s patients. Several strains of mice that were genetically programmed to have...
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[Original post: ] 1: Comments About The Theory 2: Comments About Specific Communities 3: Other Comments Comments About The Theory Darwin : I think you may (*may*, I'm not sure) be vastly underestimating how many people are in some form of nontraditional tight-knit community. Notice that many of the communities you list are things you've directly personally encountered through your online interests or social circle. Most people have never heard of libertarian homesteaders or rationalist dating sites, perhaps you have also never heard of the things most other people belong to. For my part, I...
info_outlineAstral Codex Ten Podcast
[This is one of the finalists in the 2025 review contest, written by an ACX reader who will remain anonymous until after voting is done. I’ll be posting about one of these a week for several months. When you’ve read them all, I’ll ask you to vote for a favorite, so remember which ones you liked] My dad only actually enjoys about ten foods, nine of them beige. His bread? White. His pizza? Cheese. His meat? Turkey breast. And his side dish? Mashed potatoes. As a child I hated mashed potatoes, despite his evangelization of them. I too was a picky eater growing up, but I would occasionally...
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Slightly contra Fukuyama on liberal communities Francis Fukuyama is on Substack; last month he wrote . As always, read the whole thing and don’t trust my summary, but the key point is: R. R. Reno, editor of the magazine First Things, the liberal project of the past three generations has sought to weaken the “” of populism, nationalism, and religion that were held to be the drivers of the bloody conflicts of the early 20th century. Those gods are now returning, and are present in the politics of both the progressive left and far right—particularly the right, which is characterized...
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Finalist #6 in the Review Contest [This is one of the finalists in the 2025 review contest, written by an ACX reader who will remain anonymous until after voting is done. I’ll be posting about one of these a week for several months. When you’ve read them all, I’ll ask you to vote for a favorite, so remember which ones you liked] When the prefect of Alexandria’s daughter converted to Christianity, nothing in particular happened - it wasn’t as though the laws outlawing the cult would be enforced against her. She was smart, she was pretty (beautiful, even) and she had connections. So...
info_outlineYou can sign the letter here.
The Trump administration has been retaliating against its critics, and people and groups with business before the administration have started laundering criticism through other sources with less need for goodwill. So I have been asked to share an open letter, which needs signatures from scientists, doctors, and healthcare professionals. The authors tell me (THIS IS NOT THE CONTENTS OF THE LETTER, IT’S THEIR EXPLANATION, TO ME, OF WHAT THE LETTER IS FOR):
The NIH has spent at least $5 billion less of that money than Congress has appropriated to them, which is bad because medical research is good and we want more of it.
In May, NIH Director Jay Bhattacharya told a room full of people that he would spend all the money by the end of the fiscal year. That is good news, because any money not spent by that point will disappear. The bad news is the fiscal year ends on September 30th and according to the American Association of Medical Colleges, “the true shortfall far exceeds $5 billion.”
Our open letter requests that Dr. Bhattacharya do what he said he would and spend all the money by September 30th.
We as the originators of the letter do not want to be named publicly because we are concerned about being the focal point for blame and retaliation. We would rather be members of a large crowd of signatories than be singled out as individuals to make an example of. Based on our understanding of current administration norms, we do not expect retaliation against private individuals who sign this letter.
We are looking for signatures from scientists, doctors, and healthcare professionals. So if that is you, please sign here. If you want to help support the letter more broadly, email [email protected]. Our stretch goal is to have a thousand people sign the letter within the next two weeks.
To hammer home (since many people failed to understand it) that this is not the contents of the letter, I am including the actual contents below:
We, the undersigned scientists, doctors, and public health stakeholders, commend your commitment to spend all funds allocated to the NIH, as reported in The Washington Post. At the same time, we are concerned by reports that U.S. institutions received nearly $5 billion less in NIH awards over the past year. With less than one month to the end of the fiscal year, we submit this urgent request to ensure that your commitment is upheld. If you anticipate that all appropriated funds cannot be spent in time, we request a public disclosure of the barriers preventing the achievement of this crucial responsibility.
We present this request in the spirit of the broad, bipartisan consensus in favor of spending appropriated NIH funds. In their July letter to the Office of Management and Budget, fourteen Republican senators, led by Senators Collins, Britt, and McConnell, forcefully argued that suspension of NIH funds “could threaten Americans' ability to access better treatments and limit our nation's leadership in biomedical science.” The case for investment in medical research transcends political divides as it serves our collective national interest.
The return on investment from research is compelling. Synthesizing the empirical literature, economist Matt Clancy estimates that each public and private R&D dollar yields roughly $5.50 in GDP—and about $11 when broader benefits are counted. Every dollar of NIH funding not deployed represents lost opportunities for breakthrough treatments, missed chances to train the next generation of scientists, and diminished returns on America's innovation ecosystem.
Spending these funds is also a competitiveness imperative as China attempts to transform itself from a low-end manufacturer to a high-tech research and innovation juggernaut. In 2024, the Chinese government increased its spending on science and technology by 10%, and the nation’s total expenditure on research and development increased by 50% in nominal terms between 2020 and 2024. As China’s number of clinical trials and new drug candidates begin to outpace the U.S., America cannot afford to allow biomedical research funding to go unspent.
We respectfully ask that you ensure that NIH will obligate all FY25 funds by September 30, 2025, and, if that is not possible, that you address the scientific community to explain why and what must be done to ensure all appropriated funds are spent in FY26. We stand ready to support your efforts to preserve this vital national investment.
https://readscottalexander.com/posts/acx-open-letter-to-the-nih