Astral Codex Ten Podcast
…the bad news is that they can’t agree which one. I explained the debate more , but the short version is: twin studies find that most traits are at least 50% genetic, sometimes much more. But molecular studies - that is, attempts to find the precise genes responsible - usually only found enough genes for the traits to be ~10-20% genetic. The remaining 35% was dubbed “missing heritability”. Nurturists argued that the twin studies must be wrong; hereditarians argued that missing effect must be in hard-to-find genes. The latter seemed plausible because typical genetic studies only...
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If we worry too much about AI safety, will this make us “lose the race with China”? (here “AI safety” means long-term concerns about alignment and hostile superintelligence, as opposed to “AI ethics” concerns like bias or intellectual property.) Everything has tradeoffs, regulation vs. progress is a common dichotomy, and the more important you think AI will be, the more important it is that the free world get it first. If you believe in superintelligence, the technological singularity, etc, then you think AI is maximally important, and this issue ought to be high on your mind. But...
info_outlineAstral Codex Ten Podcast
Most discourse on AI is low-quality. Most discourse on consciousness is super-abysmal-double-low quality. Multiply these - or maybe raise one to the exponent of the other, or something - and you get the quality of discourse on AI consciousness. It’s not great. Out-of-the-box AIs mimic human text, and humans always describe themselves as conscious. So if you ask an AI whether it is conscious, it will often say yes. But because companies know this will happen, and don’t want to give their customers existential crises, they hard-code in a command for the AIs to answer that they aren’t...
info_outlineAstral Codex Ten Podcast
ACX has been co-running a forecasting contest with Metaculus for the past few years. Lately the “co-running” has drifted towards them doing all the work and giving me credit, but that’s how I like it! included more than 4500 forecasters predicting on 33 questions covering US politics, international events, AI, and more. They’re preparing for this year’s contest, and currently looking for interesting questions. These could be any objective outcome that might or might not happen in 2026, whose answer will be known by the end of the year. Not “Will Congress do a good job?”, but...
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Last year, I wrote that it would be . Commenters argued that no, it would be easy, just build more jails and mental hospitals. A year later, San Francisco feels safer. Visible homelessness is way down. But there wasn’t enough time to build many more jails or mental hospitals. So what happened? Were we all wrong? Probably not. I only did a cursory investigation, and this is all low-confidence, but it looks like: There was a big decrease in tent encampments, because a series of court cases made it easier for cities to clear them. Most of the former campers are still homeless. They just...
info_outlineAstral Codex Ten Podcast
“Life is suffering” may be a Noble Truth, but it feels like a . Yes, obviously life includes suffering. But it also includes happiness. Many people live good and happy lives, and even people with hard lives experience some pleasant moments. This is the starting point of many people’s objection to Buddhism. They continue: if nirvana is just a peaceful state beyond joy or suffering, it sounds like a letdown. An endless gray mist of bare okayness, like death or Britain. If your life was previously good, it’s a step down. Even if your life sucked, maybe you would still prefer the heroism...
info_outlineAstral Codex Ten Podcast
In Jason Pargin’s , a manic pixie dream girl cajoles a shut-in incel loser to drive her and her mysterious box cross-country. The further they drive, the more evidence starts to build that she is a terrorist and her box is a nuke. As our protagonist becomes increasingly desperate to turn around and return to his comfortable world of social media feeds and psych meds, she pleads with him to come out of his shell, learn to trust people offline, and have a sense of adventure. The book’s dramatic tension comes from our simultaneously rooting for his character development and worrying that it...
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American Scholar has , including and . It’s good that this is getting more attention, because in theory it seems like one of the most influential things a writer could do. In practice, it leaves me feeling mostly muddled and occasionally creeped out. “Writing for AI” means different things to different people, but seems to center around: Helping AIs learn what you know. Presenting arguments for your beliefs, in the hopes that AIs come to believe them. Helping the AIs model you in enough detail to recreate / simulate you later. Going through these in order:
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[I haven’t independently verified each link. On average, commenters will end up spotting evidence that around two or three of the links in each links post are wrong or misleading. I correct these as I see them, and will highlight important corrections later, but I can’t guarantee I will have caught them all by the time you read this.]
info_outlineAstral Codex Ten Podcast
Would You Like To Buy A Bahama? The Bahamas is an archipelago-nation of 400,000 people scattered across 3,000 small islands. The Bahamas’ most populous island is the one with its capital, Nassau. The second-most-populous - and fifth-largest, and most-pretentiously-named - is Grand Bahama, home of Freeport, the archipelago’s second city. Grand Bahama has a unique history. In 1955, it was barely inhabited, with only 500 people scattered across a few villages. The British colonial government turned it into a charter city, awarding the charter to , an American whose Wikipedia article describes...
info_outlineYou can sign the letter here.
The Trump administration has been retaliating against its critics, and people and groups with business before the administration have started laundering criticism through other sources with less need for goodwill. So I have been asked to share an open letter, which needs signatures from scientists, doctors, and healthcare professionals. The authors tell me (THIS IS NOT THE CONTENTS OF THE LETTER, IT’S THEIR EXPLANATION, TO ME, OF WHAT THE LETTER IS FOR):
The NIH has spent at least $5 billion less of that money than Congress has appropriated to them, which is bad because medical research is good and we want more of it.
In May, NIH Director Jay Bhattacharya told a room full of people that he would spend all the money by the end of the fiscal year. That is good news, because any money not spent by that point will disappear. The bad news is the fiscal year ends on September 30th and according to the American Association of Medical Colleges, “the true shortfall far exceeds $5 billion.”
Our open letter requests that Dr. Bhattacharya do what he said he would and spend all the money by September 30th.
We as the originators of the letter do not want to be named publicly because we are concerned about being the focal point for blame and retaliation. We would rather be members of a large crowd of signatories than be singled out as individuals to make an example of. Based on our understanding of current administration norms, we do not expect retaliation against private individuals who sign this letter.
We are looking for signatures from scientists, doctors, and healthcare professionals. So if that is you, please sign here. If you want to help support the letter more broadly, email nihfundingletter@gmail.com. Our stretch goal is to have a thousand people sign the letter within the next two weeks.
To hammer home (since many people failed to understand it) that this is not the contents of the letter, I am including the actual contents below:
We, the undersigned scientists, doctors, and public health stakeholders, commend your commitment to spend all funds allocated to the NIH, as reported in The Washington Post. At the same time, we are concerned by reports that U.S. institutions received nearly $5 billion less in NIH awards over the past year. With less than one month to the end of the fiscal year, we submit this urgent request to ensure that your commitment is upheld. If you anticipate that all appropriated funds cannot be spent in time, we request a public disclosure of the barriers preventing the achievement of this crucial responsibility.
We present this request in the spirit of the broad, bipartisan consensus in favor of spending appropriated NIH funds. In their July letter to the Office of Management and Budget, fourteen Republican senators, led by Senators Collins, Britt, and McConnell, forcefully argued that suspension of NIH funds “could threaten Americans' ability to access better treatments and limit our nation's leadership in biomedical science.” The case for investment in medical research transcends political divides as it serves our collective national interest.
The return on investment from research is compelling. Synthesizing the empirical literature, economist Matt Clancy estimates that each public and private R&D dollar yields roughly $5.50 in GDP—and about $11 when broader benefits are counted. Every dollar of NIH funding not deployed represents lost opportunities for breakthrough treatments, missed chances to train the next generation of scientists, and diminished returns on America's innovation ecosystem.
Spending these funds is also a competitiveness imperative as China attempts to transform itself from a low-end manufacturer to a high-tech research and innovation juggernaut. In 2024, the Chinese government increased its spending on science and technology by 10%, and the nation’s total expenditure on research and development increased by 50% in nominal terms between 2020 and 2024. As China’s number of clinical trials and new drug candidates begin to outpace the U.S., America cannot afford to allow biomedical research funding to go unspent.
We respectfully ask that you ensure that NIH will obligate all FY25 funds by September 30, 2025, and, if that is not possible, that you address the scientific community to explain why and what must be done to ensure all appropriated funds are spent in FY26. We stand ready to support your efforts to preserve this vital national investment.
https://readscottalexander.com/posts/acx-open-letter-to-the-nih