ImputePGTA and PGT-P Explained: The Latest in Polygenic Embryo Testing with guest Jonathan Anomaly of Herasight
Release Date: 11/12/2025
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Read the full episode notes: Today I’m thrilled to dive into the world of polygenic embryo testing (PGTP) and ImputePGTA with my guest, Jonathan Anomaly, Director of Communications at Herasight. And, I'm beyond delighted that Herasight is choosing to share their newest tech, ImputePGTA with us here, for the first time as an Egg Whisperer Show exclusive! Jonathan brings a unique perspective as both a former philosophy professor focused on the ethics of reproductive technologies and a leader at a company developing cutting-edge embryo screening tools. Together, we explore the...
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New PGT-A test Shows that Nearly All Blastocysts and Fetal Tissue are Mosaic with Meaghan Doyle
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Did you know that nearly all embryos show some level of mosaicism, even in successful pregnancies? In this conversation with Meaghan Doyle, a Licensed Certified Genetic Counselor specializing in fertility genetics and the founder of DNAide Genetic Counseling, we’re discussing the latest findings on PGT-A testing and what it means for embryo selection and fertility treatment: and this is fascinating! Meaghan joins me to discuss a fascinating new article titled “New PGT-A Test Shows that Nearly All Blastocysts and Fetal Tissue are Mosaic.” We’ll break down what this means for fertility...
info_outlineRead the full episode notes: https://www.draimee.org/imputepgta-and-pgt-p-explained-the-latest-in-polygenic-embryo-testing-with-guest-jonathan-anomaly-of-herasight
In our conversation, we unpack the science and ethics behind polygenic testing, discuss how it differs from traditional embryo screening, and address the hopes and concerns that come with these new technologies. We talk about the real-world impact for patients, the importance of informed consent, and how families can make empowered choices about their reproductive journeys. Whether you’re a patient, a provider, or just curious about the future of fertility medicine, this episode is packed with insights.
In this episode, we cover:
- The basics of PGTP and how it compares to PGTA and PGTM
- Announcement of ImputePGTA, a new technique that enables accurate polygenic embryo screening from a routine test (PGT-A)
- How polygenic risk scores are developed and validated
- The potential and limitations of predicting disease risk and traits in embryos
- Ethical considerations and common misconceptions about “designer babies”
- The role of family history and ancestry in genetic testing
- How Herasight’s technology can help patients with different backgrounds and needs
- What the future holds for embryo testing, including IVG and gene editing
Resources:
- Herasight: herasight.com
- Jonathan Anomaly’s website: jonathan-anomaly.com
- Dr. Aimee’s resources: draimee.org
- IVF calculator and white papers (available on herasight.com)
- Subscribe to the Egg Whisperer Show on YouTube and Spotify
Click here to join Dr. Aimee for The IVF Class.