Episode 210: Hashimoto’s Revisited - A Conversation with Dr. Izabella Wentz
Release Date: 11/11/2025
Thyroid Answers Podcast
Most people are told: “If you have thyroid antibodies, you have Hashimoto’s. If you don’t, you don’t.” In this episode, Dr. Eric Balcavage, creator of the Adaptive Thyroid Model™, revisits that idea and shows why antibodies are only one piece of a much bigger picture. Discover how: ✅ Th1 and Th17 T-cells, CD8 T-cells, and low T-regs drive thyroid inflammation and tissue damage ✅ PAMPs (pathogen signals) and DAMPs (cell-danger signals) can bind to pattern-recognition receptors [PRRs] on thyroid cells, triggering cytokines and interferon activity ✅ Antibodies may confirm...
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In this episode of Thyroid Answers, Dr. Eric Balcavage sits down with pharmacist and bestselling author Dr. Izabella Wentz to revisit one of the most misunderstood conditions in modern medicine — Hashimoto’s thyroiditis. They explore how new research and clinical experience are reshaping what we know about autoimmune thyroid disease, why so many women still struggle with fatigue, weight gain, and brain fog despite “normal” thyroid labs, and what it really takes to recover thyroid function from the inside out. Dr. Wentz and Dr. Balcavage break down the differences between managing...
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Are you struggling with hypothyroid symptoms like fatigue, weight gain, hair loss, or brain fog? Have you been told the reason is that you have “low T3”? Many patients are told the solution is simple: add T3 thyroid hormone replacement. But is that the truth? Is that the correct strategy? In this Thyroid Answers Shorts episode, Dr. Eric Balcavage, functional medicine thyroid expert and host of the Thyroid Answers Podcast, explains: ✅ Why low T3 doesn’t always mean you need medication ✅ How stress, inflammation, and the Cell Danger Response affect T4-to-T3 conversion ✅ Why...
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Are you ready to challenge the myths of aging and discover how to stay strong, vital, and resilient for decades to come? In this episode of the Thyroid Answers Podcast, Dr. Eric Balcavage sits down with Dr. Mani Kukreja to explore the cutting-edge science of healthy aging. We dive into: Why aging is not just about years—but about cellular health and resilience The hidden role of thyroid physiology in longevity and vitality Nutrition, movement, and lifestyle strategies that slow the aging clock The difference between simply “managing” disease and truly recovering health Practical steps...
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Your thyroid doesn’t work in isolation. It relies on your liver, your bile, and even your gut bacteria to keep hormone conversion running smoothly. In this episode of Thyroid Shorts, Dr. Eric Balcavage explains how thyroid hormone T3 regulates bile acid production, shapes your microbiome, and keeps your gut lining strong in a state of homeostasis. But what happens when stress, inflammation, or the Cell Danger Response lower circulating T3? The liver shifts bile chemistry, gut bugs change, and your barrier can loosen. This isn’t necessarily dysfunction — it’s your body’s intelligent...
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Episode 208: Nitric Oxide - The Missing Link in Thyroid & Chronic Disease with Dr. Nathan Bryan In this episode, Dr. Eric Balcavage is joined by nitric oxide researcher and author Dr. Nathan Bryan, whose new book The Secret of Nitric Oxide explores why this tiny signaling molecule may be the key to preventing and reversing chronic illness. Together, they dive deep into: What nitric oxide is and why it’s foundational for human health. How nitric oxide is made in the body—through both enzymatic and dietary pathways. The connection between nitric oxide, inflammation, oxidative...
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Episode 15 – Myth: Low fT3 Means You Just Need More T3 Many people struggling with chronic hypothyroid symptoms are told the answer is simple: “Your free T3 is low, so you just need more T3 medication.” But is that really the solution? In this episode of Thyroid Shorts, Dr. Eric Balcavage explains why low T3 is often an adaptive response to stress, not a sign that your body is broken. He explores how gut health, diet, inflammation, and immune activity drive thyroid conversion, and why simply adding T3 may provide temporary relief but can worsen long-term issues. Key insights include: ...
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In this Thyroid Answers Shorts episode, Dr. Eric Balcavage explores the critical role your mitochondria—the true powerhouses of your cells—play in thyroid health and recovery. Too often, thyroid care focuses solely on optimizing lab values like TSH, Free T4, or Free T3. But true recovery isn’t about chasing numbers. It’s about understanding what happens inside your cells. Dr. Balcavage explains how cellular stress impacts mitochondrial function, how this stress disrupts thyroid hormone conversion, and why patients can still feel hypothyroid even when their labs look “normal.” In...
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Are you stuck in "thyroid purgatory" - optimized labs but persistent symptoms? The missing piece might be emotional. In this powerful conversation, Dr. Eric sits down with Licensed Professional Counselor and Board-Certified Art Therapist Kate King to explore the hidden emotional roots of thyroid dysfunction that conventional medicine completely ignores. What You'll Discover: How ancestral trauma and intergenerational patterns literally encode themselves in your cellular metabolism Why your thyroid might be your body's intelligent way of protecting you from feeling too much...
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Tired of being told "your labs are normal" while you still feel terrible? This episode will transform you from a passive patient into an informed advocate who understands what comprehensive thyroid testing should include and how to interpret the results. Dr. Eric Balcavage reveals why most doctors run incomplete thyroid panels and miss critical patterns that explain persistent symptoms. Discover the complete 9-marker thyroid panel you need, including the often-overlooked T3 Uptake that can reveal binding protein issues masquerading as hormone deficiencies. Learn why "normal"...
info_outlineIn this episode of Thyroid Answers, Dr. Eric Balcavage sits down with pharmacist and bestselling author Dr. Izabella Wentz to revisit one of the most misunderstood conditions in modern medicine — Hashimoto’s thyroiditis.
They explore how new research and clinical experience are reshaping what we know about autoimmune thyroid disease, why so many women still struggle with fatigue, weight gain, and brain fog despite “normal” thyroid labs, and what it really takes to recover thyroid function from the inside out.
Dr. Wentz and Dr. Balcavage break down the differences between managing Hashimoto’s with medication and restoring thyroid health through the Adaptive Thyroid Model™, focusing on root causes suc as gut health, inflammation, hormone balance, and stress physiology.
Key Topics:
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What most doctors miss about Hashimoto’s and autoimmune thyroiditis
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The connection between stress, sleep, gut health, and thyroid autoimmunity
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Why “normal labs” can hide ongoing thyroid dysfunction
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How estrogen, cortisol, and inflammation alter thyroid hormone conversion
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The role of diet, supplements, and lifestyle in reversing Hashimoto’s patterns
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How to know if your low T3 is adaptive — not failure
- And more ...
Dr. Izabella Wentz is a compassionate, innovative, solution-focused integrative pharmacist dedicated to finding the root causes of chronic health conditions. Her passion stems from her own diagnosis with Hashimoto’s thyroiditis in 2009, following a decade of debilitating symptoms.
As an accomplished author, Dr. Wentz has written several best-selling books, including the New York Times best seller Hashimoto’s Thyroiditis: Lifestyle Interventions for Finding and Treating the Root Cause, the protocol-based #1 New York Times best seller Hashimoto’s Protocol: A 90-Day Plan for Reversing Thyroid Symptoms and Getting Your Life Back, and the Wall Street Journal best seller Hashimoto’s Food Pharmacology: Nutrition Protocols and Healing Recipes to Take Charge of Your Thyroid Health.
Her latest book, Adrenal Transformation Protocol, was released on April 18th, 2023. The book focuses on resetting the body’s stress response through targeted safety signals and features a 4-week program that has already helped over 3,500 individuals. The program has an impressive success rate, with over 80% of participants improving their brain fog, fatigue, anxiety, irritability, sleep issues, and libido.
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