TWiV 1273: Myocarditis and mimicry
This Week in Virology
TWiV explains studies which reveal that Inhibition of CXCL10 and IFN-γ mitgates myocarditis associated with SARS-CoV-2 mRNA vaccination, and identification of a bacteriophage T7 protein that antagonizes the DNA restriction system of the host by mimicking B form DNA. Hosts: and Subscribe (free): , , Become a of TWiV! Links for this episode at MicrobeTV Understanding mRNA (Sci Transl Med) T7 protein overcomes (J Mol Biol) Structure of T7 protein that (Mol Cell) on TWiV 1283 Timestamps by Ramsey. Thanks! ...
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TWiV 1282: Clinical update with Dr. Daniel Griffin
This Week in Virology
Calling out “Happy Christmas to all and to all a good-night, Dr. Griffin and Vincent Racaniello discuss high path influenza in dairy herds in Wisconsin and Marburg virus in Ethiopia before Dr. Griffin then deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, the slightly higher association of COVID-19 infection with death than following influenza infection, benefit of passive infant immunization with niresevimab, association of COVID-19 vaccine immunogenicity protection...
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TWiV 1281: Sex, herpes, and plankton
This Week in Virology
Vincent travels to Tegernsee, Germany for the Sixth Ringberg Symposium on Giant Viruses, where he talks with John Archibald, Susana Coelho, and Tom Delmont about their work on – you guessed it – giant viruses. Host: Guests: , , and Subscribe (free): , , Become a of TWiV! Links for this episode Transposable elements shaping (Genome Biol) link herpesviruses to giant viruses (Nature) Mirusviruses predicted to (Nat Micro) in the marine protist Aurantiochytrium (Nat Com) Timestamps by Ramsey....
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TWiV 1280: Clinical update with Dr. Daniel Griffin
This Week in Virology
In his weekly clinical update, Dr. Griffin and Vincent Racaniello protest Vinjay Prasad, head of CBER FDA Nov memo stating administration of the COVID-19 vaccine resulted in 10 children’s deaths, but are cautiously delighted by the December memo from those in CBER who dispute this data-less claim, how in 31 states pertussis vaccination rates have declined before Dr. Griffin then deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, of clinical outcomes of oseltamivir versus baloxavir...
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TWiV 1279: Let hepatitis b
This Week in Virology
TWiV reviews considerations and perspectives on phage therapy, and the Nobel Prize-winning discovery of hepatitis b virus. Hosts: , , , and Subscribe (free): , , Become a of TWiV! Links for this episode at MicrobeTV Immune 100 WHO global expert committee: (News-Medical) Considerations on (Nat Comm) What is ? (CDC) History of phage therapy (, ) JAMA Viruses that (can) make you well () The InVinceable TWiV () Blumberg Particles associated with (Nature) HBV vaccination...
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TWiV 1278: Clinical update with Dr. Daniel Griffin
This Week in Virology
In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss the rise in norovirus infections, contamination of infant formula and botulism outbreak, confusion and response to the CDC’s ACIP decision to reverse the recommendation for a birth dose of the hepatis B virus vaccine and how states in the Northwest and Northeast are responding as well as some insurance companies, then deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, South Carolina’s imposed quarantine of...
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TWiV 1277: Vaccine talk with Jake Scott
This Week in Virology
Infectious diseases physician Jake Scott returns to TWiV to discuss the dangerous anti-vaccine policies being established in the US and what RFK Jr. and his associates get wrong. Hosts: , , and Angela Mingarelli Guest: Subscribe (free): , , Become a of TWiV! Links for this episode at MicrobeTV Vaccine RCT (CIDRAP) What RFK Jr gets (Conversation) RFK Jr’s case (STAT) Too many kids’ vaccines? (STAT) Timestamps by Ramsey. Thanks! Weekly Picks Angela – Angela Palmer, science meets art...
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TWiV 1276: Clinical update with Dr. Daniel Griffin
This Week in Virology
In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss the positive side effect of the shingles vaccine on dementia outcomes and how one dose of the HPV vaccine is non-inferior to two doses, but are dismayed about the FDA’s secrecy around the inflammatory statement that the COVID-19 vaccine is linked to the death of 10 children. Dr. Griffin then deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, effectiveness of maternal administration of the RVS vaccine or the...
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TWiV 1275: An amazing sequence and a gutsy therapy
This Week in Virology
TWiV explains the Nobel Prize-winning discovery of pre-mRNA splicing, and engineering bacteriophage to deliver proteins to the human intestine. Hosts: , , and Subscribe (free): , , Become a of TWiV! Links for this episode at MicrobeTV Immune 100 of adenovirus mRNA (PNAS) An in adenovirus mRNA (Cell) Nobel Prize for (Nobel) A in adenovirus late mRNAs (Cell) with Phillip A. Sharp (ASM) Protein production in the gut by (Nat Biotech) phage T4 (Curr Op Virol) Timestamps by Ramsey....
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TWiV 1274: Clinical update with Dr. Daniel Griffin
This Week in Virology
In his weekly clinical update, Dr. Griffin and Vincent Racaniello wish everyone a Happy Thanksgiving and then decry appointment of the Louisiana State surgeon general as deputy chief of the CDC, the 3 children’s deaths during this fall’s pertussis outbreak, the Marburg virus outbreak in Ethiopia, results of the phase 1 safety trial for the novel poliovirus vaccines nOPV1 and nOPV3, and the first human death from H5N5 influenza virus infection in the US this fall, before Dr. Griffin deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the...
info_outlineIn his weekly clinical update, Dr. Griffin with Vincent Racaniello are dismayed by the government shutdown, the firings at the CDC including EIS agents, H5N1 isolation from backyard birds and its stability in raw milk and cheese, before Dr. Griffin deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, the quarantining of college students in the US due to measles, Japan’s declaration of a national influenza outbreak, effectiveness of the influenza and COVID vaccines, where to find PEMGARDA, how to access and pay for Paxlovid, can you be retreated with Paxlovid, long COVID treatment center, results from PLATCOV studies- still no antiviral activity attributed to ivermectin, where to go for answers to your long COVID questions, long COVID in pediatrics, patient reported outcomes from the STOP-PASC clinical trial, contacting your federal government representative to stop the assault on science and biomedical research and the listener reminder that measles vaccine in those with interferonopathy may result in severe adverse affects.
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Links for this episode
- Trump Administration Lays Off Dozens of C.D.C. Officials (NY Times)
- CDC walks back hundreds of firings as US shutdown persists (Yahoo News/ Reuters)
- CDC battered by government shutdown firings, while some are rescinded (STAT 10)
- Confirmations of Highly Pathogenic Avian Influenza in Commercial and Backyard Flocks (USDA: Animal and Plant Health Inspection Service)
- Flurry of H5N1 activity noted in commercial poultry, wild birds(CIDRAP)
- H5N1 influenza virus stability and transmission risk in raw milk and cheese(Nature Medicine)
- Hundreds of U.S. students quarantined amid measles outbreaks (NBC News)
- Wastewater for measles (WasterWater Scan)
- Measles cases and outbreaks (CDC Rubeola)
- Tracking Measles Cases in the U.S. (Johns Hopkins)
- Measles vaccine recommendations from NYP (jpg)
- Weekly measles and rubella monitoring (Government of Canada)
- Measles (WHO)
- Get the FACTS about measles (NY State Department of Health)
- Measles (CDC Measles (Rubeola))
- Measles vaccine (CDC Measles (Rubeola))
- Presumptive evidence of measles immunity (CDC)
- Contraindications and precautions to measles vaccination (CDC)
- Measles (CDC Measles (Rubeola))
- Adverse events associated with childhood vaccines: evidence bearing on causality (NLM)
- Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America)
- Deaths following vaccination: what does the evidence show (Vaccine)
- Influenza: Waste water scan for 11 pathogens (WastewaterSCan)
- US respiratory virus activity (CDC Respiratory Illnesses)
- Respiratory virus activity levels (CDC Respiratory Illnesses)
- Weekly surveillance report: clift notes (CDC FluView)
- Japan sees early flu activity, with school closures(CIDRAP)
- Japan Declares Nationwide Flu Outbreak Following Early Surge in Cases (insightscare)
- ACIP Recommendations Summary (CDC: Influenza)
- American Academy of Pediatrics
- Flu and Children (CDC: Influenza (flu))
- Effectiveness of influenza vaccination to prevent severe disease (CMI: Clinical Microbiology and Infection)
- Influenza Vaccine Composition for the 2025-2026 U.S. Influenza Season(FDA)
- RSV: Waste water scan for 11 pathogens (WastewaterSCan)
- US respiratory virus activity (CDC Respiratory Illnesses)
- RSV-Network (CDC Respiratory Syncytial virus Infection)
- Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV))
- Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP)
- Evidence to Recommendations Framework (EtR): RSV Vaccination in Adults Aged 50–59 years (CDC: National Center for Immunization and Respiratory Diseases)
- Efficacy and safety of respiratory syncytial virus vaccines (Cochrane Library)
- Waste water scan for 11 pathogens (WastewaterSCan)
- COVID-19 deaths (CDC)
- Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses)
- COVID-19 national and regional trends (CDC)
- COVID-19 variant tracker (CDC)
- SARS-CoV-2 genomes galore (Nextstrain)
- Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (bioRxiV)
- Effectiveness of NVX-CoV2373 and BNT162b2 COVID-19 Vaccination in South Korean Adolescents (The Pediatric Infectious Disease Journal)
- Trump gets Covid vaccine and flu shot during second checkup of the year (NBC News)
- Where to get pemgarda (Pemgarda)
- EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
- Infusion center (Prime Fusions)
- CDC Quarantine guidelines (CDC)
- NIH COVID-19 treatment guidelines (NIH)
- Drug interaction checker (University of Liverpool)
- Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro)
- Understanding Coverage Options (PAXCESS)
- Pharmacometrics of high-dose ivermectin in early COVID-19 from an open label, randomized, controlled adaptive platform trial (PLATCOV)(eLife)
- Antiviral efficacy of oral ensitrelvir versus oral ritonavir-boosted nirmatrelvir in COVID-19 (PLATCOV) (LANCET: Infectious Diseases)
- Infectious Disease Society guidelines for treatment and management (ID Society)
- Molnupiravir safety and efficacy (JMV)
- Convalescent plasma recommendation for immunocompromised (ID Society)
- What to do when sick with a respiratory virus (CDC)
- Managing healthcare staffing shortages (CDC)
- Anticoagulation guidelines (hematology.org)
- Daniel Griffin’s evidence based medical practices for long COVID (OFID)
- Long COVID hotline (Columbia : Columbia University Irving Medical Center)
- The answers: Long COVID
- Nirmatrelvir-Ritonavir and Symptoms in Adults With Postacute Sequelae of SARS-CoV-2 Infection (JAMA Internal Medicine)
- Longitudinal patient-reported outcome trajectories in Long COVID: Findings from the STOP-PASC Clinical Trial (OFID)
- Reaching out to US house representative
- Severe Adverse Reaction to Measles Vaccine Due to Homozygous Mutation in the IFNAR2 Gene: A Case Report and Literature Review (Journal of Clinical Immunology)
- Letters read on TWiV 1262
- Dr. Griffin’s COVID treatment summary (pdf)
- Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.