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Episode 21: Can AI catch cardiomegaly on chest CTs ordered for other reasons?
05/06/2026
Episode 21: Can AI catch cardiomegaly on chest CTs ordered for other reasons?
This episode explores a study from the University of Texas Southwestern Medical Center and MD Anderson Cancer Center in the United States that clinically validates an FDA-cleared AI tool for measuring total cardiac volume on non-contrast, non-gated chest CT. Across 307 patients with paired echocardiography, the AI discriminated normal from abnormal cardiac volume with an AUC of 0.81 in men and 0.77 in women, and far outperformed routine radiologist sensitivity for cardiomegaly. The tool offers a tunable, reproducible opportunistic screening layer on chest CT's already being performed.
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