Quest For Longevity

Hi I'm Tim, just an average guy figuring out how to slow the effects of aging to live a long and healthy life. I'm diving deep and sharing everything I learn right here. And the future looks bright because there are many things you can do to slow the effects of aging. Small changes that will keep your bones and muscles strong, your mind sharp, lower your risk of many common diseases and help you look and feel great at any age. I explore the latest developments alongside tried and tested approaches grounded in science and ancient wisdom and importantly, I’ll give you an honest, unbiased take, cutting through marketing hype and unfounded claims. My goal is to find practical ways to stay healthier for longer and extend life. If that sounds good to you, come and join me on my quest for longevity.

The 5:2 Diet Explained - How To Lose Weight & Get Healthy In 2026: Weight Loss Diets Explained Pt.1 01/20/2026

US Dietary Guidelines VS UK Dietary Guidelines 01/16/2026

5 Very Simple Steps to Better Health in 2026 01/07/2026

5 Very Simple Steps to Better Health in 2026 Show Description The start of a new year often comes with big health goals, bold promises, and plenty of noise. In this episode of Quest for Longevity, Tim cuts through the hype and shares five simple, evidence-based ways to improve your health in 2026. You’ll learn practical strategies to support weight loss, fitness, energy, and healthy aging — including how to move more and build strength, eat more protein and fibre for better metabolic and gut health, improve sleep quality, reduce stress, and create habits that actually stick. Rather than extreme diets, supplements, or quick fixes, this episode focuses on realistic lifestyle changes backed by science that support long-term health and longevity. If you’re looking for a clear, trustworthy guide to starting the year in a healthier, more sustainable way, this episode is a great place to start. Probiotic and Prebiotic Food Cheat Sheet X: Facebook: Quality Health Supplements If you’re looking for quality health supplements I can highly recommend . They produce great value, quality products and I’ve been very pleased with the results. (I may be affiliated with brands mentioned here and receive a small commission if you buy via my link or use my checkout code. This doesn’t cost you extra and anything I earn helps me to devote more time to researching and producing this podcast.) Connect With Me X: Facebook: Instagram: Research Sources Here is a list of sources I consulted to help me produce this episode of Quest For Longevity: Breathing Practices for Stress and Anxiety Reduction (PMC) — a peer-reviewed article summarizing how controlled breathing influences autonomic nervous system activity and supports stress and anxiety reduction. Effect of breathwork on stress and mental health: A meta-analysis (Nature) — evidence that structured breathwork interventions can improve stress and mental-health outcomes, though research design matters. The Role of Protein Intake and its Timing on Body Composition and Muscle Function in Healthy Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials — a comprehensive review showing that increased protein intake improves lean body mass and muscle function, which are key to healthy ageing. Systematic review and meta-analysis of protein intake to support muscle mass and function in healthy adults — meta-analytic evidence that higher daily protein intake contributes to gains in lean body mass and muscle performance. Higher dietary fibre intake is associated with increased skeletal muscle mass and strength in adults aged 40 years and older — research linking greater fibre intake with higher lean mass, better body composition, and muscle strength, which supports functional health as we age. What Happens to Your Body When You Eat 30 Grams of Fiber Every Day — a recent overview explaining how higher fibre intakes improve digestion, satiety, cholesterol, and blood sugar control. Daily steps and health outcomes in adults: a systematic review and dose-response meta-analysis — this meta-analysis shows that around 7,000 steps per day is linked with significantly lower risk of mortality and major diseases compared with very low step counts, making daily movement both evidence-based and achievable. Sleep regularity is a stronger predictor of mortality risk than sleep duration — research demonstrating that both sleep consistency and adequate duration are linked with lower premature mortality risk and improved cardiometabolic outcomes. Sleep and healthy aging: A systematic review and path forward — a broad review showing associations between positive sleep indicators (e.g., adequate, consistent sleep) and healthy aging outcomes. Breathing Practices for Stress and Anxiety Reduction (PMC) — a peer-reviewed article summarizing how controlled breathing influences autonomic nervous system activity and supports stress and anxiety reduction. Effect of breathwork on stress and mental health: A meta-analysis (Nature) — evidence that structured breathwork interventions can improve stress and mental-health outcomes, though research design matters. /episode/index/show/5221ea2f-0c32-45ab-8b19-901d30eddcc0/id/39648515

Gut Health Explained & How to Fix Your Gut in 2026 01/03/2026

Gut Health Explained & How to Fix Your Gut in 2026 Show Description There is an increasing amount of buzz around gut health right now, so I decided to dive in and find out why. In this episode, I explore what the gut is, what gut health means and why it matters far more than you might think. And most importantly, what we can do, starting today, to improve our gut health through simple dietary and lifestyle changes. Quality Health Supplements If you’re looking for quality health supplements I can highly recommend . They produce great value, quality products and I’ve been very pleased with the results. (I may be affiliated with brands mentioned here and receive a small commission if you buy via my link or use my checkout code. This doesn’t cost you extra and anything I earn helps me to devote more time to researching and producing this podcast.) Connect With Me Facebook: Instagram: X: Research Sources - PMC A comprehensive review of the gut-brain axis and how gut microbiota influences neurotransmitter production, including serotonin, and its connection to mood disorders like anxiety and depression. - PMC Explores the bidirectional communication between the gut microbiota and the central nervous system, and the role of dysbiosis in mental illnesses. - PMC Discusses how gut microbiome dysbiosis plays a role in autoimmune diseases including rheumatoid arthritis, Crohn's disease, and multiple sclerosis, and how the microbiome regulates immune system development and function. - Frontiers in Immunology Examines how gut microbiota influences autoimmune disease onset and progression through immune cell regulation and intestinal barrier function. - Stanford Medicine Groundbreaking Stanford research showing how a diet rich in fermented foods enhances microbiome diversity and reduces inflammation markers. - PMC Reviews how dietary fiber is fermented by gut microbiota to produce beneficial short-chain fatty acids and how fiber intake modulates microbiome structure and diversity. - ScienceDaily Recent 2025 research from Harvard identifying gut-produced metabolites that influence liver function and insulin sensitivity, with implications for obesity and diabetes treatment. - The Journal of Clinical Endocrinology & Metabolism Comprehensive 2024 review examining how gut microbiota composition differs in people with obesity and diabetes, and the role of bacterial diversity in metabolic health. /episode/index/show/5221ea2f-0c32-45ab-8b19-901d30eddcc0/id/39584590

Collagen: What Does It Do & Are Supplements Worth The Money? 11/26/2025

Autophagy: Your Disease Fighting, Life-Extending Super Power 11/09/2025

Health & Longevity Insight: Metabolic Disease & Dementia, Eat 5-A-Day For Better Sleep, AI Prostate Cancer Diagnosis 11/05/2025

Rosehip Supplements: What Are They & What Are The Health Benefits? 11/01/2025

Chronic Inflammation: What it is, why it’s bad, and what you can do to avoid it 10/22/2025

Creatine & The Brain: Can It Prevent Age-Related Mental Decline and Enhance Cognitive Function? 10/07/2025

Vitamin K2: The Quiet Nutrient Protecting Hearts & Strengthening Bones 09/30/2025

Walking: The Easiest Way To Enhance Your Health, Happiness & Lifespan 09/26/2025

Are Cold Plunges & Cold Showers Good For You? 09/10/2025

Is Coffee Good For Your Health? 09/04/2025

Intermittent Fasting: What is it, how does it work and is it right for you? 08/22/2025

Magnesium: What Does It Do & Should You Take a Supplement? 08/17/2025

Eggs: Are They Good Or Bad & How Many is Too Many? 08/10/2025

Creatine: What is It, What Does It Do & Should You Take It? 08/06/2025

Creatine: What is It, What Does It Do & Should You Take It? Creatine has recently gone mainstream. So in this episode we dive into the surprising benefits of creatine—not just for athletes, but for anyone looking to boost cognitive performance, energy, and longevity. Often associated with gym-goers and muscle building, creatine is actually one of the most researched and effective supplements out there, with growing evidence that it supports brain health, mental clarity, and even protects against age-related cognitive decline. We explore how creatine works in the body and why it might be especially helpful for older adults, vegetarians, and those looking to stay mentally sharp. Plus, I look at how to supplement safely and effectively. Research Sources Creatine in Health and Disease Creatine for Exercise and Sports Performance, with Recovery Considerations for Healthy Populations Single dose creatine improves cognitive performance and induces changes in cerebral high energy phosphates during sleep deprivation Creatine: The bodybuilding supplement that boosts brainpower Creatine as a food supplement for the general population Show Transcript Creatine Overview In this episode I dive deep, researching a powerful supplement. And the results this supplement deliver are that good it might be the closest thing to a legitimate "secret weapon" you can get. It’s a supplement that's been around for over 30 years and is widely used by athletes and bodybuilders around the world. It’s been studied in more than 500 peer-reviewed scientific papers, and continues to deliver results that few other supplements can match. It's been shown to increase muscle strength by up to 15%, improve high-intensity exercise performance by 10-20%, enhance brain function under stress, speed up recovery after intense workouts, and even help preserve muscle mass as we age. So what is this wonder supplement I’m talking about? It’s creatine! And unlike many supplements that make big promises but deliver very little, creatine has decades of studies and anecdotal evidence to back it up. Now if we rewind 25 years to when I was weight training in my early 20’s I remember creatine making waves back then and I used it for a while and saw some phenomenal results in strength and it helped me pack on noticeable lean mass over just a few months. But there’s a history of kidney disease in my family so I’ve always been very cautious about taking a supplement long-term if there isn’t a boatload of evidence to demonstrate that it’s safe. And back then creatine supplementation was really in its infancy, and while it was generally thought to be safe there were concerns about potential strain on your kidneys with long-term usage. And because creatine is a substance that our bodies produce naturally, some scientists were also concerned that sustained usage over a longer period of time could impair our bodies ability to make it naturally. But that was 25 years ago and since then study after study has confirmed that it's incredibly safe for most people. And we're now talking about a supplement that everyone from elite athletes to weekend warriors have relied on for decades. So whether you're looking to push through plateaus in the gym, recover faster between workouts, retain and build lean mass as you age or even support your brain health, today's deep dive into creatine might be one of the most valuable 20 minutes you'll spend on your health and wellness journey. So, shall we dive in? Creatine Basics: What is it and How Does it Work? So let's start with the basics. What exactly is creatine? Well, contrary to what some might believe, creatine isn't some artificial chemical concocted in a lab. As I just mentioned, it's actually something your body produces naturally every single day. Your liver, kidneys, and pancreas team up to create about 1-2 grams of creatine daily by combining three amino acids: and those are glycine, methionine, and arginine. Think of these amino acids as building blocks that your body assembles to make creatine. But we also get creatine from our diet, particularly from animal products like meat and fish. A nice juicy steak? That's got about 2 grams of creatine per pound. Love salmon? You're getting about 1.5 grams per pound there. But here's where it gets fascinating. Your body can only store so much creatine - about 120-140 grams total, with the vast majority of it - around 95% - stored directly in your muscles. The remaining 5% hangs out in your brain, liver, and kidneys. The ATP Energy System Now, I want you to imagine your muscles as a kind of biological battery. These batteries need energy to function, especially during intense activity. And that energy comes in a form called ATP - adenosine triphosphate. Let me break that down a bit. ATP is essentially your body's energy currency. The "tri" in triphosphate means it has three phosphate groups attached to it. When your muscles need energy, ATP breaks off one of those phosphate groups, releasing energy in the process. This turns ATP into ADP - adenosine diphosphate. The "di" means it now has just two phosphate groups. Think of it like this: ATP is like a fully charged battery, and ADP is like a partially drained battery. To recharge that battery - to turn ADP back into ATP - your body needs to attach another phosphate group. And this is where creatine comes into play. In your muscles, creatine exists as phosphocreatine - essentially creatine with a phosphate group attached. When your muscles use up ATP and need to regenerate it quickly, phosphocreatine donates its phosphate group to ADP, turning it back into ATP. It's like having a backup generator that kicks in when your main power source runs low! This process happens incredibly fast, which is why creatine is so effective for short, intense bursts of activity like lifting weights or sprinting. Without this system, your muscles would only have enough ATP for about 8-10 seconds of all-out effort. The creatine phosphate system extends that to around 10-15 seconds. That might not sound like much, but those extra seconds can make a huge difference in performance. How Creatine Supplementation Affects ATP Now, let's talk about what happens when we supplement with creatine. Essentially, we're topping up our natural creatine stores to optimize this energy recycling system. When your muscle cells are saturated with creatine, they can recycle ATP more efficiently during high-intensity exercise. This translates to real-world benefits that you can feel and measure. Let me paint a picture for you. Imagine you're at the gym, doing your final set of squats. Without creatine supplementation, your muscles might fatigue after 8 reps. But with creatine-saturated muscles, you might be able to push out 10 or 11 reps with the same weight. Over time, those extra reps add up to greater strength gains and muscle growth. I remember when I first started taking creatine years ago. I was skeptical, to be honest. But within a couple of weeks, I noticed I could push harder in my workouts. That final set wasn't quite as brutal, and I recovered faster between sets. It wasn't a dramatic, overnight transformation - and anyone who promises that is probably trying to sell you something - but the difference was noticeable and consistent. The Research Backing Up Creatine Let's talk about the research behind creatine, because this is where things get really interesting. Creatine isn't just some fly-by-night supplement with shaky evidence. It's been studied extensively for decades, with over 500 peer-reviewed studies examining its effects. What's remarkable is how consistent the findings are. Study after study shows that creatine supplementation can increase maximal strength by about 5-15% and power output by a similar margin. That might not sound like much, but in athletic performance, those margins can be the difference between winning and losing. But it's not just about raw strength. Creatine has been shown to increase lean body mass too. Now, to be clear, this isn't just about growing bigger muscles - though that's part of it. Creatine works through multiple mechanisms. First, it draws water into your muscle cells through a process called cell volumization. Imagine your muscle cells as water balloons. When they're filled with more water, they're larger and more rigid. This increased cell volume can trigger protein synthesis - the process by which your body builds new muscle tissue. Second, creatine appears to increase satellite cell activity. Satellite cells are like the construction workers of your muscles. When activated, they help repair and build new muscle tissue. And third, creatine might reduce muscle protein breakdown. Think of your muscles as constantly being built up and broken down. If you can slow down the breakdown while maintaining or increasing the build-up, you end up with net muscle growth. But wait, there's more! The benefits of creatine extend beyond just muscles and strength. Some research suggests it might improve exercise recovery by reducing muscle damage and inflammation after intense workouts. How Creatine Affects Cognitive Function And here's something that might surprise you - creatine might also have cognitive benefits. Remember how I mentioned that about 5% of your body's creatine is stored in your brain? Well, your brain also uses ATP for energy, and creatine can help maintain brain energy levels, especially during stressful situations or when you're sleep-deprived. Some studies have shown improvements in memory, attention, and reasoning skills with creatine supplementation. The research in this area is still evolving, but it's fascinating to think that a supplement primarily known for physical performance might also help keep your mind sharp. Now, I know what some of you might be thinking. "This sounds too good to be true. What's the catch?" And that's a fair question. The supplement industry is notorious for over-promising and under-delivering. Common Myths About Taking Creatine So let's talk about some common myths and misconceptions about creatine. First up, the big one: "Creatine is like steroids." I can't tell you how many times I've heard this, and it's completely false. Creatine and anabolic steroids couldn't be more different. Steroids are synthetic versions of testosterone that directly alter your hormonal balance. Creatine, as we've discussed, is simply a compound that helps recycle energy in your cells. It has no direct hormonal effects whatsoever. Another common concern is, "Creatine will damage my kidneys." This myth likely stems from the fact that a byproduct of creatine metabolism, creatinine, is used as a marker for kidney function in blood tests. But here's the critical distinction: elevated creatinine from creatine supplementation doesn't mean your kidneys are being damaged. It's just a reflection of increased creatine turnover in your body. Multiple studies have examined kidney function in people taking creatine for extended periods - we're talking years - and found no adverse effects in healthy individuals. Now, if you have pre-existing kidney issues, it's always best to consult with your doctor before starting any supplement regimen. But for most people, creatine is completely safe for your kidneys. I've also heard people say, "Creatine will make me bloated and puffy." There is a grain of truth here, but it's often misunderstood. When you first start taking creatine, especially if you do a loading phase, your muscles will retain more water. But this water retention is intracellular - meaning it's inside your muscle cells, not under your skin. This actually contributes to the beneficial effects of creatine by increasing cell volume. Some people might experience a slight increase in total body water during the initial loading phase, but this typically subsides, and it's not the same as the kind of bloating you might get from eating too much sodium. And finally, one of my favorites: "Creatine is only for bodybuilders or serious athletes." Not true at all! While it's certainly popular among those groups, creatine can benefit anyone involved in activities that require bursts of power or strength. That includes weekend warriors, recreational sports players, and even older adults looking to maintain muscle mass as they age. In fact, some research suggests that older adults might benefit significantly from creatine supplementation, as it can help combat age-related muscle loss and improve functional strength for daily activities. How To Get Started With Creatine So, if you're considering trying creatine, how should you go about it? Let's break down the practical aspects. First, let's talk about types of creatine. Walk into any supplement store, and you'll see a dizzying array of options: creatine monohydrate, creatine HCL, buffered creatine, creatine ethyl ester, and so on. Here's the simple truth: creatine monohydrate is the most researched form, and it's also the most affordable. The fancy, expensive forms haven't consistently shown advantages over good old monohydrate. Now, for dosing, there are two common approaches: The traditional method is a loading protocol. This involves taking 20-25 grams per day (divided into 4-5 doses) for 5-7 days, then maintaining with 3-5 grams daily. This approach saturates your muscles more quickly, so you'll see benefits sooner. Alternatively, you can skip the loading phase and simply take 3-5 grams daily from the start. This approach takes longer to fully saturate your muscles - about 3-4 weeks - but it's equally effective in the long run and might cause less digestive discomfort. I personally prefer the gradual approach. I've found that the loading phase sometimes gives me a bit of stomach discomfort, and I'm not in a huge rush to see results. But if you're preparing for a competition or just want to see benefits as quickly as possible, the loading protocol is a valid option. As for timing, it's not actually as crucial as some might think. You can take creatine any time of day. Some research suggests taking it post-workout might be slightly more beneficial, but the differences are minimal. The most important thing is consistency - taking it daily allows your muscles to stay saturated. Who Can Benefit From Taking Creatine Now, let's talk about who might benefit most from creatine supplementation. First and most obviously, strength and power athletes. If you're into weightlifting, sprinting, or sports that require explosive movements like basketball or football, creatine can give you a meaningful edge. Vegetarians and vegans might also benefit significantly. Since dietary creatine comes almost exclusively from animal products, plant-based eaters typically have lower baseline creatine levels. Supplementation can help bridge that gap. Older adults, and by older I mean anyone over the age of 30. Because after this age we start losing muscle mass at a rate of about 3-8% per decade - which is pretty depressing to thing about isn’t it really? But we can significantly reduce or even reverse this muscle wastage through resistance training. And taking creatine will help you to get the maximum benefit from your training sessions to help combat age-related muscle loss. And finally, anyone looking to maximize their high-intensity exercise performance, regardless of their fitness level or goals, could potentially benefit from creatine. And because of the emerging evidence that suggests that creatine can also help with cognitive functioning — keeping our mind sharp — and could potentially help to prevent against age-related cognitive decline, there is a valid argument that absolutely everybody could benefit from taking creatine. But if we put the emerging evidence about cognitive benefits aside and just focus on the physical side of things, creatine isn't a magic pill. It works best when combined with consistent training, good nutrition, adequate sleep, and proper hydration. But if you do combine it with these, I think it is probably one of the most beneficial supplements you can take. Creatine Summary So, we’ve covered today how creatine is a naturally occurring compound that helps recycle energy in your muscles during high-intensity activities. It's backed by decades of research showing benefits for strength, power, muscle mass, and potentially even cognitive function. It's safe for most people, with myths about kidney damage and steroid-like effects being unfounded. The most studied and cost-effective form is creatine monohydrate, and you can either do a loading protocol or take a maintenance dose of 3-5 grams daily from the start. In the often-overhyped world of fitness supplements, creatine stands out as something that actually delivers on its promises. If you're looking to optimize your performance in high-intensity activities, it's definitely worth considering. Of course, as with any supplement, it's always a good idea to consult with your healthcare provider before starting, especially if you have any pre-existing health conditions. /episode/index/show/5221ea2f-0c32-45ab-8b19-901d30eddcc0/id/37699460

Sun Exposure & Sunscreen: Health Benefits & Risks and is Sunscreen Safe? 07/30/2025

Sun Exposure & Sunscreen: Health Benefits & Risks and is Sunscreen Safe? Discover why sun exposure is both good and bad for us and how to get your daily vitamin D and other health benefits while protecting against ageing and cancer. Is sunscreen toxic and what’s the difference between chemical and mineral sunscreens? Which SPF factor should you use and what other ways can you protect yourself from the sun while still getting the benefits? In this episode of Quest Biohacking I dive into sun exposure and protection. Looking at the science and the practical considerations of being out in the sun and answering many of the common questions we all have. Show Notes Social Links X: Instagram: Research Sources Best sun creams: Which? Best Buys and expert buying advice Sunlight and Vitamin D What to know about the health benefits of sunlight The Health Benefits of Sunshine (and How Much You Need Per Day) Sunscreen and Sun Safety Sunscreen: What science says about ingredient safety The ABCs of sunscreen How to Apply Sunscreen Sun protection 101: essential tips from Cancer Council for UV safety Ultraviolet Index Radiation: The ultraviolet (UV) index How does the sun and UV cause cancer? Sunlight and skin cancer UV Radiation & Your Skin American Cancer Society Vitamin D Deficiency and Cardiovascular Disease Risk Factors Among American Indian Adolescents: The Strong Heart Family Study Definition of Solar Radiation How to Have More Energy: Recharging Your Mitochondria (with infrared energy) Is a Real Thing UV Index App Full Show Transcript Sun Exposure & Sunscreen: Health Benefits, Risks and is Sunscreen Safe? 00:45 Hey everybody, Welcome back to Quest Biohacking. Now this episode is pretty relevant right now for all of us in the Northern hemisphere as we approach the middle of summer and the hottest time of year - although as always here in the UK, it’s anyone's guess as to how much sun we’ll actually get. The great British weather likes to keep us guessing! But regardless, I wanted to get a better understanding of sun exposure and the best way to protect ourselves from it – because aside from hearing that a bit of sun is good for us but more than a bit is bad for us, I was pretty ignorant to be honest. And what spurred me to dig deeper was a recent report I read in Which?, the consumer magazine, that reviewed and compared various sunscreens for their effectiveness, with many of them falling short of their claims about how protective they were. And you frequently hear how damaging the sun’s rays are and how it’s a major cause of skin cancer. But then you have others talking about the benefits and how we need it for vitamin D production, which is vital for bone health, immune function, and calcium absorption and it’s also an instant mood booster for many of us. Then I also had lot of questions about sunscreen - what is the best type? What factor should I use? How often should I re-apply it, is it bad for my skin? So I felt like I needed some clarity. So I popped my research goggles on and hit the archives. And these are the key questions I went in with: Is the sun bad for us? Is the sun good for us? Should we get a minimum amount of daily unprotected sun exposure or is it best to always wear sunscreen? Does the amount of sun we need depend on our skin type and if so how do I know what the right amount is for me? Is sunscreen bad for us? What factor should I use? How often should I reapply? What’s the best type of sunscreen? Does clothing alone protect from the sun’s rays? And this is what I found: So, I’m not gonna beat around the bush and it’ll probably come as no surprise that from the research I did I discovered that excessive sun exposure represents one of the most significant environmental health risks we face. The sun absolutely emits harmful rays that damage our bodies at a cellular level and mess with our DNA. Skin cancer rates have tripled over the past three decades, with over 5,500 people diagnosed with skin cancer every day in the US alone. But, at the same time vitamin D deficiency affects over a 3rd of the population, partly due to not getting enough sunlight. And it’s a similar story here in the UK and many other countries. So let’s take a look at these serious health risks posed by excessive sun exposure and get a better handle on why some is good for us but too much is bad for us and just how much too much actually is. I’ll explore a bit of the science behind different types of UV radiation, and try to provide some evidence-based guidance on the best ways to protect yourself from the sun. 04:08 UNDERSTANDING UV RADIATION To understand the risks and benefits it’s helpful to understand ultraviolet or UV radiation. The sun emits three types of UV radiation: UVA, UVB, and UVC. UVC radiation is the most dangerous, but it's completely absorbed by the Earth's atmosphere and doesn't reach the surface. So unless you're an astronaut or until space tourism becomes a thing we don’t need to worry about this. So UVA and UVB are what we need to understand. UVA radiation makes up about 95% of the UV radiation reaching Earth's surface. These rays have longer wavelengths and can penetrate deeper into the skin to the dermis layer. UVA is present at relatively constant levels throughout the day and it can penetrate glass and clouds. UVA radiation is the primary type responsible for skin aging, wrinkles, and age spots. It also contributes to skin cancer development, particularly melanoma, and suppresses immune function in the skin. UVB radiation accounts for around 5% of UV reaching Earth but is more intense. These shorter wavelengths primarily affect the epidermis, the skin's outer layer. UVB intensity varies wildly throughout the day, being strongest between 10 AM and 4 PM. And it is the primary cause of sunburn and is directly linked to most skin cancers. However, UVB is also responsible for vitamin D synthesis and that’s a good thing! The UV Index, developed by the World Health Organization, measures UV radiation intensity on a scale from 1 to 11+. A UV Index of 1-2 is considered low risk, 3-5 is moderate, 6-7 is high, 8-10 is very high, and 11+ is extreme. At UV Index levels above 3, it recommends you use sun protection measures for extended outdoor exposure. And by the way, if you have an iphone there’s a neat free app called UV Index that shows you what the UV index is where you are and it gives you a forecast so you can plan ahead. You can even set it to give you alerts if it gets above a certain UV level. It’s really good, so I’ll pop a link in the show notes if you want to try it out. I’m not sure if it’s available on Android. So what is the definition of extended sun exposure? Well it’s tricky because there’re a lot of variables. Things like your geographical location, altitude, time of day, season, and weather conditions all affect UV exposure. UV radiation increases by 10-12% for every 1,000 meters of altitude. Snow can reflect up to 90% of UV radiation, water reflects 10-15%, and sand reflects 15-25%, so all of these can significantly increase exposure to UV and the intensity of the UV. And your skin type also plays a big part in determining what constitutes too much. So it is difficult to give an accurate answer but there are guidelines and I’ll come onto these a little later. 07:58 THE DANGERS OF EXCESSIVE SUN EXPOSURE So what I’d like to do now is talk about the dangers of excessive sun exposure. And I’ll split this into short-term, acute effects and long-term chronic effects. Acute Effects of Sun Exposure Sunburn is the most immediate and recognizable sign of UV damage. When UV radiation damages skin cells, it triggers an inflammatory response that causes redness, pain, and swelling. Severe sunburn can cause blistering, nausea. fever, chills and other symptoms. Each sunburn episode increases skin cancer risk, with five or more sunburns in youth doubling melanoma risk later in life. UV radiation also causes acute immune suppression in the skin. This suppression can reactivate dormant viral infections, such as cold sores, and may reduce the skin's ability to detect and eliminate cancerous cells. So short-term it’s bad news! Chronic Effects of Sun Exposure And if too much short-term exposure sounded bad, it gets even worse over the long haul. Skin Cancer Skin cancer is the most serious long-term consequence of too much sunlight. There are three main types: Basal cell carcinoma is the most common form, typically appearing as a pearly or waxy bump, often with visible blood vessels. While rarely fatal, it can be locally destructive and disfiguring if untreated. Then you have squamous cell carcinoma, which often appears as a firm, red nodule or a flat lesion with a scaly surface. This cancer can spread to other parts of the body if not treated quickly. And finally you have melanoma, which is the deadliest form of skin cancer. It can develop in existing moles or appear as new, irregular pigmented lesions. Melanoma can spread rapidly through the lymphatic system and bloodstream. The five-year survival rate for melanoma caught early is over 90%, but drops to 15% once it spreads to distant organs. Photoaging and Skin Damage Chronic sun exposure also causes photoaging, which is distinct from chronological aging. UV radiation breaks down collagen and elastin fibers in the skin, leading to wrinkles, leathery texture, and loss of skin elasticity. This process is cumulative and largely irreversible. Solar lentigines, commonly called age spots or liver spots, are flat, brown spots that appear on sun-exposed areas. These represent areas of increased melanin production in response to UV damage. Actinic keratoses are rough, scaly patches that develop on sun-exposed skin. These are considered precancerous lesions, with 5-10% potentially progressing to squamous cell carcinoma. Eye Damage UV radiation can cause serious eye damage, including cataracts, macular degeneration, and pterygium (growths on the white part of the eye). Acute exposure can cause photokeratitis, essentially a sunburn of the cornea. Individual Risk Factors Skin type significantly affects how quickly the sun will damage your skin. The Fitzpatrick scale classifies skin types from 1 (very fair, always burns) to 6 (very dark, never burns). People with Types I and II face the highest risk of UV damage. Other risk factors include family history of skin cancer, numerous moles, previous skin cancer diagnosis, immunosuppression, and occupational sun exposure. 13:03 THE BENEFITS OF SUN EXPOSURE Given the serious health risks we've discussed, why does it feel so good to feel the warmth of the sun on our skin? Understanding the biology behind this can help explain why we're naturally drawn to something that can be so harmful. So let’s run through what sunlight is actually good for. I’ve identified 5 things: 1. Neurochemical Responses Sunlight triggers several neurochemical responses that create feelings of well-being. When sunlight hits the skin, it stimulates the release of endorphins - the body's natural "feel-good" chemicals. And I suppose if you think about it, being out in the sun is often associated with positive experiences like vacations, outdoor activities, and summer garden parties. These psychological associations can create conditioned responses where sunlight becomes linked with positive memories and emotions. The sun also increases production of serotonin in the brain. Serotonin is a neurotransmitter that regulates mood, sleep, and appetite. Higher serotonin levels are associated with improved mood and feelings of calm and focus. This is why many people experience mood improvements on sunny days and why light therapy is used to treat seasonal affective disorder. From an evolutionary standpoint, our attraction to sunlight likely developed because moderate exposure provided survival advantages through vitamin D synthesis, which is a key component for bone health, immune function, and reproduction. Our brains evolved reward pathways that encouraged behaviors that would help us survive - including getting adequate sunlight. And this evolutionary instinct is no doubt still hard-wired into our DNA. 2. Vitamin D The most well-documented benefit of sun exposure is vitamin D production. When UVB radiation hits the skin, our body produces vitamin D3 - this is the type of vitamin D we can produce naturally. This process is most efficient when the sun is high in the sky and shadows are shorter than body height. Vitamin D is essential for bone health, immune function, and cellular regulation. Deficiency is linked to increased risk of respiratory infections, autoimmune diseases, cardiovascular disease, and certain cancers. Now the amount of sun needed for adequate vitamin D production depends on skin type, location, season, and time of day. And from my research, generally, people with fair skin need 10-15 minutes of midday sun several times per week, while those with darker skin may need 20-30 minutes or more. 3. Warmth and Comfort The physical sensation of warmth from sunlight activates thermoreceptors in the skin, which send signals to the brain that can trigger the release of dopamine, which is a comfort-inducing chemical and is associated with motivation, reward, and pleasure. And this may explain why some people develop what appears to be an addiction to tanning. 4. Circadian Rhythm Optimization: Our circadian rhythm is the body's natural, internal process that regulates the sleep-wake cycle and repeats roughly every 24 hours. It influences various biological processes, including hormone release, body temperature, and alertness, and is primarily affected by light and darkness Getting sunlight in the morning, helps to anchor our circadian rhythms by suppressing melatonin production (melatonin is the chemical our body produces in response to darkness and helps to make us sleepy) So by reducing production this promoting alertness. When our circadian rhythms are properly aligned, we experience better sleep, improved mood, and enhanced cognitive function. And this is something I can personally vouch for. For a good couple of years now I’ve made it part of my daily routine to go for a walk first thing in the morning. And I can physically feel my body waking up and becoming more alert as I walk and I’ve definitely noticed my energy levels are more stable during the day and I typically start to get tired in the evening around the same time every day, where previously it’d vary wildly. 5. Increased Energy As we age we, have less energy and this is linked to how well our mitochondria function. And mitochondria are essentially the powerhouses of our cells and produce the energy needed for the cell to function. A new study shows that we can effectively recharge our mitochondria and boost our energy levels through exposure to infrared light of a certain frequency (around 850 nm). And light of this frequency passes straight through our bodies and as it does it essentially rejuvenates our mitochondria and sunlight naturally provides this wavelength. This is something that Professor Andrew Huberman recently talked about and I’ll drop a link to his video in the show notes. The Paradox So all of these pros and cons leave us with a bit of a biological paradox: our bodies are programmed to seek something that can be beneficial in small doses but harmful if you get too much. The sun is a great example of how you can actually get too much of a good thing! So the key is to strike a balance - getting enough sun to reap all of these wonderful benefits but being mindful of when we have had enough. So this poses a question: 19:13 DO YOU ALWAYS NEED TO PROTECT YOURSELF IF YOU ARE GOING OUT IN THE SUN? on a bright, sunny day, should we get some exposure before applying sunscreen or covering up? Well, turns out there’s no black and white answer. Because it depends on how long you are going to be in the sun, how strong the sun is on any given day, how dark your natural skin tone is, what altitude you are at and other factors. But from all of the research I did, the overwhelming advice from dermatologists is that if you are going to be out in the sun for an extended period you should cover up or apply sunscreen first.🟢 If you have light skin, you only need around 10-15 minutes of sunlight to give you all of the vitamin D benefits you need and if you have darker skin you still only need 15-30 minutes. Anything above these upper limits won’t give you any additional benefits but they will increase your risk of skin damage - aging your skin quicker and increasing your risk of cancer. And bear in mind that sun exposure is cumulative. So it’s not like you can say “well, I’m only nipping to the corner shop or I’m just doing the school run and I’m only going to be in the sun for 10 minutes” if you are going to be in the sun for 10 minutes multiple times that day without any protection you could be getting a fair amount of skin damage. For example, you might say, well, I am literally going to be in the office all day so I’ve only got a 5 minute walk in the sun either side of my working day. But in reality you’ll probably get a lot more than that by the time you’ve driven to the station and absorbed sunlight through the windows of your car for 15 minutes and also through the windows of the train for another 40 minutes. Then you’ve got your 5 minute walk from the station to the office. You pop out for 15 minutes in your lunch break to grab some food and then you might absorb some sunlight through the office windows during your working day. Then you’ve got your return journey where you’ll get a load more sun. Now I’m not suggesting we all slap sunscreen on just to go to work but I’m just trying to illustrate how, before you know it, you’ve easily been in the sun for a significant amount of time, far in excess of what we need for our daily vitamin D needs. So we need to be mindful of protecting our skin and another good way of doing this is to avoid the sun when it’s most intense, which is when it is highest in the sky. And the general advice is to avoid being out in it for roughly a 4-6 hour window around midday. In the UK, it tends to be most fierce between 11am-3pm but it will vary depending on where in the world you are. Another way of gauging intensity is by using the shadow test. Just look at your shadow on the ground, if it’s taller than you the sun’s rays will less damaging than if your shadow is shorter than you. 22:35 TYPES OF SUNSCREEN: HOW DO THEY WORK AND HOW EFFECTIVE ARE THEY? But ultimately, if the sun is bright - that UV index is 3 or higher, and you are going to be in the sun for an extended period with your skin exposed you should be using a sunscreen. So let’s do a bit of a dive into sunscreen because I had lots of unanswered questions about them. We’ll run through the different types of sunscreens that are available, how they work, how effective they are and address some of the health concerns about them. Mineral Sunscreens Mineral sunscreens contain zinc oxide and/or titanium dioxide as active ingredients. These compounds sit on the skin's surface and physically block or scatter UV radiation. They provide broad-spectrum protection against both UVA and UVB rays. Zinc oxide provides the best UVA protection of any sunscreen ingredient approved by the FDA. It's photostable, meaning it doesn't break down in sunlight, and is generally considered safe for all skin types, including sensitive skin and children. Titanium dioxide is also photostable and provides good UVB protection, though its UVA protection is less comprehensive than zinc oxide. It's often used in combination with zinc oxide for broad-spectrum coverage. Mineral sunscreens often leave a... /episode/index/show/5221ea2f-0c32-45ab-8b19-901d30eddcc0/id/37610050

Movement As Medicine: How Exercise Fights Disease And Extends Life 07/23/2025

Movement As Medicine: How Exercise Fights Disease And Extends Life Show Summary Discover how exercise can be used as a potent medicine in the fight to extend life. In this episode I explore how physical activity can transform your health and help you live longer. I dive into the science-backed benefits of movement, revealing how regular exercise can be a powerful weapon against chronic disease and why it should be a foundational pillar of any biohacking protocol. Show Transcript Movement As Medicine: How Exercise Fights Disease And Extends Life 00.00 In this episode of Quest Biohacking, we're exploring the last of what I consider the 3 core pillars of health, wellness and a long life - Exercise. And I’ll kick-off with a statistic to back-up why I feel it is one of the fundamentals of any longevity protocol: Meeting the minimum recommended exercise guidelines laid down by the World Health Organisation (WHO) can reduce your risk of dying by any cause by 20-30%. Yes, you heard me right. You could cut your chance of dying by nearly a third by simply being more active. So what is the recommended amount of exercise? For adults the WHO recommends between 150 minutes - 300 minutes of moderate exercise per week, or 75-150 minutes of vigorous exercise. To get 20-30% reduction in mortality you only need to achieve the minimum. You can potentially reduce your risk of dying even more if you exercise more. But focusing on just those minimum recommended amounts. It works out at around just over 20 minutes of moderate activity daily, or about 11 minutes of vigorous activity. This is all you need to do to massively reduce your risk of dying. Now, I’m going to come onto the definitions of moderate and vigorous exercise and suggest some types of activities that meet these definitions but before I do, I want to give you a brief explanation of why exercise is so good for us. Because most of us know that it is good for us, we hear this frequently. But most of us don’t understand how it impacts our body at a biological level — how it helps prevent disease and helps us to live longer. And not only do I think this is really interesting stuff but knowing what’s going on inside my body when I exercise and how it fights disease and aging helps to keep me motivated and exercising regularly. How Exactly Does Exercise Prevent Aging And Disease? 03:12 Cellular Repair and Maintenance Our bodies are made up of over 30 trillion cells. And our cells are constantly broken down and damaged by various stresses that we place on them (UV radiation, alcohol, extreme temperatures, the food that we eat - just life in general). But our cells can repair, grow and reproduce by a process called cell division. This process allows for the replacement of worn-out or damaged cells and the development of new tissues and organs. Within our cells are chromosomes, thread-like structures that carry the genetic instructions from our DNA. During cell division, these instructions are important because they tell our body how to rebuild the cell - essentially they are the building blueprint of our cells and they make sure that a skin cell is repaired or replaced as a skin cell and a liver cell is replaced by another liver cell. On the end of our chromosomes are protective caps called telomeres. They act like the plastic tips on shoelaces, protecting the chromosome and preventing the ends of it from fraying or sticking to each other because if this does happen it makes it harder for our body’s repair crews to read the genetic blueprint and can lead to all sorts of nasty things happening. For example the cell could turn into what’s called a senescent cell - This is a cell that has permanently stopped dividing but remains active in our bodies and can release harmful substances. These cells accumulate with age and contribute to age-related diseases and inflammation. The cell could just die - a process known as apoptosis, or it could even become a cancerous cell. And if you think about it this makes a lot of sense. Imagine those repair crews in our bodies immune system trying to read the blueprint to repair a stomach cell for example. But we’ve damaged this blueprint through all the junk food we’ve been eating over the years and they can’t quite make out the instructions as they repair it and they rebuild it slightly differently - it’s no longer a stomach cell, it’s an abnormal cell and this is thought to be one of the ways at least that cancers start. So these telomeres, these protective caps prevent our chromosomes from being damaged. But as we age, these telomeres naturally shorten, which ultimately leads to disease, aging and death. But our clever bodies have a way of helping to prevent this by releasing a substance called telomerase (tuh-lom-eraze). You can think of this as a special cellular repair crew who reinforces those protective end caps. Which finally brings me to my point. Because regular exercise has been shown to increase the production of telomerase which helps maintain telomere length, essentially slowing down cellular aging. Exercise also enhances your mitochondria - these are the tiny powerhouses inside every cell that produce energy. As we age, our mitochondria naturally become less efficient, like old batteries that don't hold a charge as well. Exercise essentially upgrades these cellular power plants, keeping your energy production systems running optimally. 06:30 Fighting Inflammation and Oxidative Stress Exercise is also a great way to reduce inflammation and oxidative stress in our bodies. Exercise is one of the most powerful anti-inflammatory interventions we have. Chronic inflammation is like a slow-burning fire in your body that accelerates aging and disease. Exercise kinda pours water on this fire reducing inflammation. It also help to combat oxidative stress - which is essentially cellular rust that builds up over time and stops our bodies from working properly. Disease Prevention On a broader level, exercise directly tackles the major killers. It reduces your risk of high blood pressure, type 2 diabetes, heart disease, stroke, and many forms of cancer. 07:17 Protein Balance and Stem Cell Function Exercise also maintains proper protein balance in your cells - ensuring that damaged proteins are cleared away and new, healthy proteins are manufactured efficiently. It also helps preserve your stem cell populations, which are responsible for repairing and regenerating tissues throughout your body. The remarkable thing is that all these mechanisms work together synergistically. Exercise isn't just addressing one aspect of aging - it's simultaneously tackling multiple pathways that drive the aging process itself. So hopefully, this snapshot into the inner-mechanics of exercise have given you a deeper insight into why it is so important to do regular exercise. It’s not just about losing weight or keeping fit — although it will absolutely help you do this too — there’s a whole lot more good stuff going on under the hood than meets the eye. 08:11 Understanding Exercise Intensity: What Moderate and Vigorous Exercise Actually Means Alright, now I’ve finished my little nerdy session let's get practical about what the recommendations actually mean. Because there's often confusion about what "moderate" and "vigorous" exercise really look like. Moderate Exercise According to the NHS, moderate activity will raise your heart rate and make you breathe faster and feel warmer. Here's a simple way to gauge if you’re doing moderate intensity exercise: if you can still talk but not sing, you're in the moderate intensity zone. So what type of exercise is moderate? Brisk walking - not a leisurely stroll, but walking with purpose like you're late for an appointment or you’ve left a few minutes late for the school run. Swimming at a comfortable but steady pace. Cycling on level ground or with slight hills. Gentle dancing, gardening that involves a bit of digging or lifting, or playing doubles tennis. The key is that you should feel like you're working, but you're not gasping for breath. You could carry on a conversation, but you probably wouldn't want to give a lengthy speech. Vigorous Exercise Vigorous exercise takes things up a notch. This makes you breathe hard and fast - if you're working at this level, you won't be able to say more than a few words without pausing for breath. Think jogging or running, swimming laps at a fast pace, cycling uphill or at speed, playing singles tennis or basketball, or doing high-intensity interval training. Something that gets your heart really pumping. And most moderate activities can be modified to become vigorous simply by increasing your effort. That brisk walk becomes vigorous when you add hills or pick up the pace. If you’re swimming, switch from breaststroke to a front crawl. And the beauty is that 75 minutes of vigorous activity seems to give you similar benefits to 150 minutes of moderate activity - so you can essentially halve your exercise time by increasing intensity. The important thing is finding what works for you and what you'll actually stick to consistently. 10:29 Beyond Traditional Exercise: The Movement Revolution Okay, in this next section I’d like to dive into some of the more recent research about exercise and how we can use it as a disease prevention and life extension tool. And some of this research is beginning to challenge conventional thinking. So first of all, we're seeing emerging evidence that moving regularly throughout the day might be more beneficial than condensing all your activity into one daily exercise session. 10:57 Exercise Snacking: Small Bursts, Big Benefits Scientists are studying something called "exercise snacking" - brief bursts of activity lasting just 2 minutes or less, scattered throughout your day. Research studies and anecdotal evidence from longed-lived people show these micro-workouts can provide significant health benefits and are surprisingly effective at improving cardiovascular fitness. I suppose if you think about it from an evolutionary perspective: our ancestors didn't hit the gym for an hour and then sit motionless for the rest of the day. They moved frequently throughout the day in varied ways — hunting, foraging, running away from wild animals, fighting rivals — and these activities probably wouldn’t have been done for an extended period but when they were done they would likely be pretty intense and really get the blood pumping. And they would have been interspersed between the more sedentary life tasks. Exercise snacking mimics this natural pattern. You might do jumping jacks while waiting for your coffee to brew, take the stairs two at a time, or pop out a set of bodyweight squats or pressups in-between episodes of the box set you're currently binging. The key is getting your heart rate up briefly but regularly throughout the day. 12:11 The Power of Non-Exercise Activity (NEAT) These exercise snacks contribute to something called NEAT - Non-Exercise Activity Thermogenesis. This includes all the energy you burn through movement that isn't formal exercise, and apparently it can contribute significantly to your daily energy expenditure and metabolic health. The beauty of this approach is that it's incredibly accessible. You don't need gym memberships, special equipment, or large blocks of time. You just need to break up periods of sitting with brief bursts of movement that get your heart pumping. And this is something that I’ve started to work into my day and I find it real easy to do. I’ve just popped an alarm on my phone that goes off hourly and when it does I step away from the desk and do some lunges, pressups, high kicks, whatever! Just as long as it keeps me moving! 13:03 Strength Training: Your Insurance Policy Against Aging The next thing I want to talk about is something that's often overlooked in exercise discussions because the focus tends to be on cardiovascular exercise that elevates your heart rate and breathing but is so, so important - Maintaining muscle mass as we age and how regular strength training can help us do this. The Muscle Loss Crisis Starting around age 30, we naturally lose muscle mass at a rate of about 3-8% per decade. And with this muscle loss comes a reduction in functional capacity, bone density, and metabolic health as we age. Here's a sobering statistic that really drives this home: one in three adults over the age of 65 who break a hip will die within 12 months of the injury. Recent studies show that just 67.7 percent of men and 78.5 percent of women survive one year after a hip fracture. The mortality in the first year after hip fracture surgery ranges between 15% and 36%. Why are these statistics so grim? Because falls and fractures in the elderly often trigger a whole bunch of other complications - from reduced mobility to infections to blood clots. But here's the thing: many of these fractures are preventable through maintaining muscle strength and bone density. Strength Training to Prevent Muscle Loss Resistance training doesn't just build muscle - it stimulates bone formation, improves balance and coordination, and maintains the functional strength you need for daily activities. Longevity researchers now emphasize that resistance training and grip strength have strong correlations with healthy aging. Grip strength, in particular, has emerged as a strong predictor of overall health and longevity because it’s a good measure for overall muscle strength and function. The great news is that you don't need to become a powerlifter. Using basic resistance training - bodyweight exercises like push-ups and squats, resistance bands, or simple weightlifting - you can get some big benefits. The key is consistency and gradually increasing the challenge over time. Even two strength training sessions per week can make a real difference in maintaining muscle mass, bone density, and functional capacity as you age. 15:21 How To Build Your Exercise Longevity Blueprint So how do you put all this together into a practical approach that works for your life? Start with the Foundation First, aim for those minimum guidelines we discussed - 150 minutes of moderate aerobic exercise or 75 minutes of vigorous aerobic exercise per week. And by aerobic, I mean exercise that gets you breathing more quickly, gets your heart beating faster and gets you sweating. Remember, this could be as simple as a 20-minute brisk walk daily. Add Movement Snacking Next, incorporate exercise snacking throughout your day. Set reminders to move every couple of hours. Even 30 seconds of jumping jacks or a minute of bodyweight squats can make a difference when done consistently. Include Strength Training Add basic strength training twice a week. This doesn't need to be complicated and you absolutely don’t need to join a gym, just use what you have at home. Push-ups, squats, resistance bands and some light dumbbells can provide big wins and are an excellent starting point for most people. 16:36 Movement as Medicine As we wrap up, I want you to try to think about exercise as medicine that happens to come in the form of movement. The research is clear: regular exercise and movement throughout the day can add years to your life and greatly improve the quality of that life. Because you're not just burning calories when you exercise - you're activating cellular repair mechanisms, fighting inflammation, maintaining muscle mass, strengthening bones, and directly preventing the diseases most likely to cut your life short. Start where you are. Use what you have. Do what you can. Choose movement over stillness. It will seem like an inconvenient effort to begin with but stick with it and it will start to become a habit and become easier. And I promise you, your future self will thank you for it. Alright that wraps up this episode of Quest Biohacking,Thanks for joining me. I hope you’ll join me next time when I’ll be exploring another biohack. But until then, keep moving, keep optimizing and keep biohacking your way to better health and a longer life. By the way, I want help as many people as possible extend their lives, so if you feel this podcast has benefited you and you could spare 2 minutes to leave me a positive review, I’d really appreciate it, as it will help other health-conscious people like you find it. Quick medical disclaimer: It’s important to understand that anything discussed on this podcast are my own opinions based on my research. I’m not a nutritionist or a medical professional and nothing here is medical advice. You’ll find my research links in the show-notes and I always recommend you do your own research before starting any biohacking routine. Research Sources WHO guidelines on physical activity and sedentary behaviour Physical activity guidelines for adults aged 19 to 64 Exercise Linked With Lower Risk of 13 Types of Cancer Exercise for stroke prevention No limit to the benefits of exercise in reducing the risk of cardiovascular disease Exercise may lower type 2 diabetes risk even in those genetically predisposed Exercise: A drug-free approach to lowering high blood pressure Mortality and cause of death in hip fracture patients aged 65 or older - a population-based study Telomere extension turns back aging clock in cultured human cells, study finds Telomere Apoptosis Does cellular senescence hold secrets for healthier aging? Dissecting the mechanisms of cell division Understanding the effects of nutrition and post-exercise nutrition on skeletal muscle protein turnover: Insights from stable isotope studies . /episode/index/show/5221ea2f-0c32-45ab-8b19-901d30eddcc0/id/37516890

How to Live Longer by Changing When and What You Eat 07/16/2025

How to Live Longer by Changing When and What You Eat Are you interested in learning about an easy, inexpensive way to add many healthy years to your life? Something that is grounded in ancient wisdom and growing scientific research and is accessible to almost everyone. In this episode, I’m talking about diet, one of the foundational pillars of health and longevity. And I’m exploring not just what we should eat but also when we should eat and how getting these two things right can have such a positive impact on our health and how long we live. Full Episode Transcript 00:00:45 So here’s a question for you. Are you interested in learning about an easy, inexpensive way to add many healthy, active years to your life? Potentially decades! I'm not talking about some expensive new supplement or the latest fad diet. I'm talking about something that is grounded in ancient wisdom and growing scientific research. In this episode, I’m talking about food, the second foundational pillar of health and longevity — the first pillar being sleep, which I covered in the last episode and the third being movement and exercise, and I find it helpful to remember these three pillars as SLEEP, EAT AND FEET. But today is about food and I’m exploring not just what we eat but also when we eat and how getting these two things right can have such a massively beneficial effect on our health and can slow down and possibly even reverse the ageing process. 00:01:47 1. CAN EATING LESS OFTEN HELP YOU LIVE LONGER? So, I want to kick this episode off by focusing first on not what we should eat but when we should eat. And let's start with a fundamental principle of longevity that might surprise you: eating less often might help you live longer. Yes, you heard me right. One of the most consistent findings in longevity research in recent years, is that giving your body regular breaks from food can trigger powerful rejuvenation processes. Throughout human evolution, our bodies didn't evolve with the expectation of constant food availability. Three meals a day plus snacks is actually a very recent development in human history. Our ancestors experienced regular periods without food—sometimes by necessity, sometimes by design. Research now shows that these fasting periods are far from harmful—they actually trigger a cascade of repair and rejuvenation processes in the body. When we're constantly fed, our bodies are stuck in growth and reproduction mode. Our cells are like, yeah, life is good we’ve got plenty of readily available nutrients, let’s just kick back and relax guys. But in this euphoric state our cells can fail to spot things that are going wrong in the background – like the build up of toxins and the formation of cancerous cells. Things that, left unchecked are going to start damaging our bodies and cut our lives short. Basically, constant eating causes our cells to get a bit complacent. But when we starve our bodies of nutrients for a while we shift into repair mode. And our cells are like, hang on a minute guys, we aren’t being fed! We need to batton down the hatches and go into survival mode. And in this state, they effectively go on guard and actively hunt down any bad stuff that’s hanging around and dispose of it. Now clearly, it is a far more scientific process than this and I’ll go into some of the more nerdy stuff in a minute but this is my laymans explanation and it helps me to easily get my head around it. And this isn't just a theory. Studies across multiple species, from yeast to primates, show that controlling food intake patterns can extend lifespan. And the evidence in humans is increasingly compelling. 00:04:13 2. EATING LESS CALORIES AND EATING LESS OFTEN CAN HELP YOU LIVE LONGER Let's talk about why reducing calories or simply extending the length of time we go without food works at a biological level. Caloric restriction means reducing overall food intake without malnutrition and it is one of the most consistently effective anti-aging interventions across species. In the 1930s, researchers discovered that rats fed fewer calories lived significantly longer than their well-fed counterparts. Since then, similar findings have been shown in yeast, worms, flies, mice, and even preliminary studies in primates. What's remarkable is how conserved this mechanism is evolutionarily and by conserved, I mean how it has been passed down through the generations in our genes. The same pathways that respond to reduced calorie intake in a simple yeast cell appear to work in very similar ways in human cells. This suggests we're looking at a fundamental biological process that evolved very early and has been maintained across species. So why would this be? The leading theory is that when food is scarce, organisms shift resources from reproduction and growth to maintenance and repair. So as I mentioned a moment ago, It's as if the body says, "Times are tough, let's focus on surviving longer until conditions improve." Now I can guess what you might be thinking. Your thinking, great Tim, so your just telling me I need to eat less, tell me something I don’t know. Because we all know that reducing calories is much easier said than done. The good news is that you don't necessarily need to reduce your overall calories to get many of these benefits. Emerging research suggests that when you eat might be just as important as what you eat or how much you eat. 00:06:17 3. FASTING IS ACCESSIBLE (AND SAVES MONEY!) Here's something I love about fasting-based approaches to longevity: they are accessible to almost everyone. Unlike expensive supplements or other lifestyle interventions, eating less costs nothing. In fact, you'll likely save money because eating within a smaller time-window often means we can’t cram as much food in! But of course, what you put into your body is also very important and the fundamental strategy is: eat less frequently, focus on nutrient-dense, natural foods and give your body regular breaks from digestion. Don’t think of this as deprivation. It's about optimization. Many people who adopt time-restricted eating or intermittent fasting report not only better health markers, for the ones that are actively measuring and monitoring, but also increased energy, mental clarity, and a healthier relationship with food overall. And I want to emphasize that caloric restriction or fasting, isn’t about starving yourself. It’s about finding a sustainable pattern that works for your body and lifestyle. For some, that might mean a 16-hour daily fast. For others, it could be a more moderate 12-hour overnight fast. And for others still, it might mean occasional longer fasting periods. The key is consistency and listening to your body and probably mixing things up every once in a while to stop our cells getting complacent. 00:07:48 4. A LOW ENERGY STATE TRIGGERS GENETIC ANTI-AGING PATHWAYS So, let's get a bit more technical now and explore what happens in your cells when you fast. When you restrict your eating window or reduce calories, your body experiences a mild energy stress, also known as hormesis or hormetic stress. This triggers several genetic pathways that are associated with longevity and cellular protection. One of the key players in this process is a family of proteins called sirtuins. These are sometimes called "longevity genes" because they appear to play a central role in regulating lifespan across different species. Sirtuins act as cellular sensors, detecting energy levels and stress, and coordinating appropriate responses. When activated by fasting or caloric restriction, they help repair damaged DNA, regulate inflammation, improve mitochondrial function, and facilitate cellular cleanup processes. In particular, SIRT1—the most studied sirtuin in mammals—helps cells adapt to stress and may delay age-related decline. Studies show that mice with higher SIRT1 activity live longer and stay healthier. The fascinating thing about sirtuins is that they seem to be the link between our lifestyle choices and our genetic destiny. They respond to environmental cues like food availability and translate them into cellular actions that can either accelerate or slow aging. 00:09:25 5. NAD+ IS ELEVATED BY A LOW ENERGY STATE For sirtuins to work properly, they need a critical cofactor called NAD+, or nicotinamide adenine dinucleotide. And you can think of NAD+ as a helper molecule in our bodies that binds to other molecules to help with molecular reactions. NAD+ is essential for hundreds of biological processes, especially those related to energy metabolism. Here's where it gets really interesting: Because our bodies don’t have an endless supply of NAD+ and our levels naturally decline as we age, which may contribute to age-related dysfunction. But fasting elevates NAD+ levels, giving sirtuins the fuel they need to do their job effectively. When you fast, your cells shift from using glucose as their primary fuel to using fatty acids and ketones. This metabolic switch increases the ratio of NAD+ to NADH, effectively boosting sirtuin activity. This helps explain why fasting seems to have such broad benefits. By increasing NAD+ and activating sirtuins, fasting doesn't just affect one tissue or system—it triggers a coordinated response throughout the body that promotes resilience and repair. So you’re probably thinking that it sounds like it would be a smart move to try and increase the amount of NAD+ in your body, and you’d be right. So how do we do this? Well, you can buy NAD+ boosters to increase the amount of NAD+ in your system but these aren’t terribly effective due to poor absorption of supplemental NAD+. Now, with further research and development these may become more effective but currently, the most reliable way to boost NAD+ currently, seems to be through lifestyle approaches like fasting, exercise, and getting adequate amounts of what we call NAD+ precursors from food. The next question is: What are NAD+ precursors? Well, they're simply the raw materials or building blocks that our bodies use to manufacture NAD+. These include compounds like nicotinamide riboside (found in milk), niacin and nicotinamide (forms of vitamin B3 found in mushrooms, fish, and many other foods), and tryptophan (an amino acid present in protein-rich foods). When we consume these precursors, our bodies convert them through various metabolic pathways into NAD+. And this becomes increasingly important as we age, since our natural ability to produce NAD+ declines over time and it’s just one very good reason why we should be eating a diverse range of foods. 00:12:37 6. FASTING, mTOR, AND AMPK Sirtuins aren't the only important players in the fasting-longevity connection. Two other crucial pathways are mTOR and AMPK. mTOR, or mechanistic target of rapamycin, is a protein complex that acts as a master regulator of cell growth and metabolism. When nutrients are abundant, mTOR ramps up protein synthesis and cell growth while suppressing autophagy—the process by which cells break down and recycle damaged components. While growth is necessary at certain life stages, constant mTOR activation is associated with accelerated aging and increased cancer risk. Fasting inhibits mTOR, allowing cellular cleanup processes to occur and potentially slowing aging. On the flip side, fasting activates AMPK (which stands for (and it’s another mouthful) adenosine monophosphate-activated protein kinase), which acts as a cellular energy sensor. When energy is low, AMPK kicks in to increase energy production and reduce energy-consuming processes. And it’s interesting to note that AMPK activation has been shown to extend lifespan in various model organisms and is associated with many of the benefits of exercise and fasting in humans. It improves insulin sensitivity, promotes fat burning, reduces inflammation, and enhances mitochondrial function. And mitochondria are the special cells that generate most of the energy needed to power our other cells to ensure they work efficiently. The interplay between these pathways—sirtuins, mTOR, and AMPK—creates a complex regulatory network that responds to nutrition and determines how our cells age. Fasting helps shift this network toward a state that favors longevity. 00:14:43 7. FASTING & LONGEVITY DATA: HUMANS VS. MODEL ORGANISMS Now, I should acknowledge that much of what we know about fasting and longevity comes from studies in model organisms like yeast, worms, flies, and mice. Human studies are more challenging for obvious reasons—we live a long time, and it's difficult to control all variables over decades and of course, there are also many regulatory and ethical considerations. However, the evidence in humans is growing and promising. Multiple studies have shown that various fasting regimens can improve biomarkers associated with longevity and reduce risk factors for age-related diseases. For example, a study published in the New England Journal of Medicine found that alternate-day fasting reduced biomarkers of aging and disease risk in healthy, non-obese humans. Other research has shown improvements in insulin sensitivity, blood pressure, inflammation markers, and even cognitive function with different fasting protocols. We also have evidence from population studies. Regions with the highest concentrations of centenarians—people who live to 100 years of age and beyond—often practice some form of caloric moderation or time-restricted eating, whether intentionally or due to cultural patterns. The Okinawans of Japan, for instance, traditionally practice "hara hachi bu"—an ancient teaching that tells us to eat until we are about 80% full. They also tend to eat their last meal earlier in the day. These practices may contribute to their extraordinary longevity. Now, while we don't have definitive proof that fasting extends human lifespan, the consistency of findings across species and the improvements in health markers suggest that it's a reasonable approach for those seeking to optimize their aging process. And I firmly believe that we’ll see a growing evidence base to support this over the coming years. Which leads us nicely into part… 00:16:53 8. EVIDENCE SHOWS FASTING IS A PRO-LONGEVITY INTERVENTION IN HUMANS With my last statement in mind, let's look more closely at some of the human evidence for fasting as a pro-longevity intervention. One of the most compelling lines of evidence comes from research on biomarkers of aging. These are measurable indicators that predict biological age—how old your body actually is, versus your chronological age. Studies have found that various fasting protocols can improve several key biomarkers of aging, including: Reduced insulin and glucose levels, which are associated with metabolic health and longevity Lower levels of inflammation markers like C-reactive protein Improved lipid profiles, with higher HDL "good" cholesterol and lower triglycerides Reduced oxidative stress markers, indicating less cellular damage Favorable changes in hormones related to longevity, like growth hormone and IGF-1 Beyond these biomarkers, we also see functional improvements—better physical performance, cognitive function, and resilience to stress—all hallmarks of successful aging. Another interesting line of evidence comes from religious groups that practice regular fasting. Observational studies of Seventh-day Adventists, who often practice time-restricted eating and vegetarianism, show significantly longer lifespans than the general population. While these studies can't prove causation, they add to the growing body of evidence suggesting that giving our bodies regular breaks from food may promote longevity. 00:18:35 9. EVIDENCE THAT FASTING CAN REDUCE HUMAN DISEASE Fasting also shows promise for preventing and even treating various diseases, which of course is linked to increased lifespan. Multiple studies have found that fasting can improve markers of metabolic health, potentially reducing risk for or helping to manage conditions like type 2 diabetes, cardiovascular disease, and metabolic syndrome. There's also emerging evidence that fasting may help with neurodegenerative conditions. Animal studies show that fasting triggers processes that protect brain cells and even promote the growth of new neurons. Early human studies suggest potential benefits for conditions like Alzheimer's and Parkinson's disease. Perhaps most intriguing is the research on fasting and cancer. Studies have found that fasting may make cancer cells more vulnerable to treatments like chemotherapy while protecting healthy cells from damage. This "differential stress resistance" as it is known, could potentially improve treatment outcomes for cancer patients. Fasting also appears to have anti-inflammatory effects, which is significant because chronic inflammation is implicated in almost every age-related disease, from arthritis to heart disease to dementia. So the broad range of conditions that seem to respond to fasting supports the idea that it's addressing fundamental processes of aging and disease, rather than just targeting specific symptoms. 00:20:06 10. DIFFERENT FASTING REGIMENS Now that we've covered the "why" of fasting, let's talk about the "how." There are several approaches to fasting, each with its own potential benefits and considerations. Time-restricted eating involves limiting your daily eating window to a specific number of hours, typically 8-12 hours. For example, you might eat between 8 AM and 6 PM, then fast until 8 AM the next day. This approach is relatively easy to implement and allows for daily eating, making it sustainable for many people. Intermittent fasting usually refers to patterns that include longer fasting periods. Common approaches include: 5:2 fasting: Eating normally for five days of the week and restricting calories (typically to about 500-600) on two non-consecutive days Alternate-day fasting: Alternating between days of normal eating and days of very low calorie intake 24-hour fasts: Fasting completely for 24 hours once or twice a week Periodic longer fasts, lasting 2-5 days, are less common but may offer unique benefits. These extended fasts trigger more profound autophagy and cellular reset processes. However, they should generally be done under medical supervision, especially for people with health conditions. There's no one-size-fits-all approach to fasting. The best regimen is one that you can maintain consistently and that fits your lifestyle, preferences, and health needs. Some people find that starting with a modest 12-hour overnight fast and gradually extending it works well. Also, it's important to note that what you eat during your eating window still matters a lot. Fasting paired with a junk food diet won't yield optimal results. Focus on nutrient-dense minimally processed foods that support your overall health. And I’ll talk about what to eat a bit later. 00:22:23 11. FOCUS ON TIME-RESTRICTED FEEDING Of all the fasting approaches, time-restricted feeding with at least 16 hours of fasting per day seems to offer a particularly good balance of benefits and practicality for many people and this is what I personally find works best. This typically means confining your eating to an 8-hour window—for example, eating between 10 AM and 6 PM, and fasting from 6 PM to 10 AM the next day. Research suggests that this 16:8 pattern may offer many of the benefits of longer fasts while being sustainable for most people. It's long enough to trigger significant metabolic shifts and cellular cleanup processes, but not so demanding that it's difficult to maintain. One study found that even without changing what they ate, overweight adults who restricted their eating to an 8-hour window lost weight and improved markers of metabolic health. Other research has shown improvements in insulin sensitivity, blood pressure, and inflammatory markers with... /episode/index/show/5221ea2f-0c32-45ab-8b19-901d30eddcc0/id/37400170

Sleep Optimization: Enhance Your Body & Mind Plus Live Longer 07/03/2025

Sleep Optimization: Enhance Your Body & Mind Plus Live Longer If I told you there was a treatment that could reduce your risk of heart disease, diabetes, cancer, and dementia while also improving your mood, cognitive function, and physical performance —and it was completely free — would you be interested in learning more? In this episode, I explore one of the 3 pillars of longevity — Sleep. I investigate the relationship between quality, restful sleep and living a longer life, free of disease. You'll discover why recent research, tracking over 172,000 people, found that those who followed just five simple sleep habits lived significantly longer. Why sleep regularity might be even more important than sleep duration and how your brain washes itself clean of Alzheimer's-causing proteins while you sleep. I break down the different stages of sleep and gain a deeper understanding of why each one is so important for cellular repair, immune function, and brain health. I also walk you through how to design the perfect bedtime routine and the things you should and shouldn’t do to upgrade your sleep for better health and a longer life. Research Sources Recommended Amount of Sleep for a Healthy Adult: A Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society Seven hours of sleep is optimal in middle and old age, say researchers Sleeping hours: what is the ideal number and how does age impact this Sleep regularity is a stronger predictor of mortality risk than sleep duration: A prospective cohort study Getting Good Sleep Could Add Years to Your Life Human longevity is associated with regular sleep patterns, maintenance of slow wave sleep, and favorable lipid profile Shine light on sleep: Morning bright light improves nocturnal sleep and next morning alertness among college students Systematic review of light exposure impact on human circadian rhythm Sleep tips: 6 steps to better sleep How to fall asleep faster and sleep better The Connection Between Diet, Exercise, and Sleep Effectiveness of Magnesium Supplementation on Sleep Quality and Mood for Adults with Poor Sleep Quality: A Randomized Double-Blind Placebo-Controlled Crossover Pilot Trial Study: Magnesium-L-Threonate Improves Objective, Subjective Sleep Quality Magnesium Supplementation Increases Sleep Quality and Sleep Duration and Reduces Stress in a Healthy Adult Population: A Double-Blind, Randomised, Placebo-Controlled Study The effectiveness of melatonin for promoting healthy sleep: a rapid evidence assessment of the literature /episode/index/show/5221ea2f-0c32-45ab-8b19-901d30eddcc0/id/37273650

What is Biohacking and Can it Help You Live Longer? 07/02/2025

Quest For Longevity

TOPICS