The Curious Clinicians

The Curious Clinicians is a medical podcast that asks "why?". Why do diseases present in certain ways? What are the mechanisms of treatments we use? Why does the human body function as it does? Join us to explore these questions and many more.

[Archive] The Fast and the Furosemide 09/04/2024

[Archive] The Fast and the Furosemide Before our 100th episode, we are rebooting some favorite early episodes! In episode 25, we asked the question: Why can furosemide improve pulmonary edema from heart failure almost immediately? Watch this episode on our new YouTube channel , and read the show notes to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). /episode/index/show/curiousclinicians/id/32890927

96 - Dr. Mike Todorovic and the Wonders of the Na+/K+ATPase Pump 08/21/2024

96 - Dr. Mike Todorovic and the Wonders of the Na+/K+ATPase Pump Dr. Mike Todorovic, medical educator and science communicator extraordinaire, joins The Curious Clinicians to discuss the Na+/K+ ATPase pump ("the most important enzyme in the human body") and his approach to digital medical education. Watch this episode on our new YouTube channel , and read the show notes ! to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Dr. Matt & Dr. Mike's podcast: Dr. Matt & Dr. Mike's YouTube channel: https://www.youtube.com/@DrMattDrMike/featured /episode/index/show/curiousclinicians/id/32665562

95 - Beethoven Redux 08/07/2024

95 - Beethoven Redux This week, the Curious Clinicians return to the topic of episode 72, "Bringing up Beethoven" with a surprising news update and new perspectives on a 200 year old tale! Watch this episode on our new YouTube channel , and read the show notes to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). /episode/index/show/curiousclinicians/id/32471702

94 - Flash in the PA 07/24/2024

94 - Flash in the PA This week, the Curious Clinicians give a 'hot take' on a common symptoms: why do hot flashes occur? Watch this episode on our new YouTube channel , and read the show notes to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). /episode/index/show/curiousclinicians/id/32270152

93 - Pumping Protons, Pumping Blood 07/10/2024

93 - Pumping Protons, Pumping Blood Producer Giancarlo Buonomo joins the Curious Clinicians this week to answer a morning report musing: why do we use IV PPIs to treat upper GI bleeding? Watch this episode on our new YouTube channel , and read the show notes to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Medical student Giancarlo Buonomo is our producer. /episode/index/show/curiousclinicians/id/32084662

92 - When the Cause is the Remedy 06/26/2024

92 - When the Cause is the Remedy Instead of "Why do we...?" this week the Curious Clinicians answer a "Why don't we?" question: why don't we use steroids in acute pancreatitis? Watch this episode on our new YouTube channel , and read the show notes to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Medical student Giancarlo Buonomo is our producer. /episode/index/show/curiousclinicians/id/31893412

91 - Ancient Antibiotics 06/12/2024

91 - Ancient Antibiotics The Curious Clinicians answer a fascinating historical perspective: what was the role of antibiotics in ancient society? Watch this episode on our new YouTube channel , and read the show notes to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Medical student Giancarlo Buonomo is our producer. /episode/index/show/curiousclinicians/id/31714132

90 - Less Sugar, More Blood 05/29/2024

90 - Less Sugar, More Blood The Curious Clinicians answer a sweet question about a new medication: Why do SGLT2 inhibitors cause erythrocytosis? Watch this episode on our new YouTube channel , and read the show notes to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Medical student Giancarlo Buonomo is our producer. /episode/index/show/curiousclinicians/id/31508537

89 - Tusks & Tumor Suppressors 05/15/2024

89 - Tusks & Tumor Suppressors The Curious Clinicians answer a gigantic oncologic and evolutionary question: Why don't elephants get (as much) cancer? Watch this episode on our new YouTube channel , and read the show notes to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Medical student Giancarlo Buonomo is our producer. /episode/index/show/curiousclinicians/id/31300832

88 - Shunting a Mismatch 05/01/2024

88 - Shunting a Mismatch Hold your breath for this one! The Curious Clinicians answer a puzzling pulmonary physiology question: Why can systemic pulmonary vasodilators worsen hypoxemia in COPD-associated pulmonary hypertension? Watch this episode on our new YouTube channel , and read the show notes to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Medical student Giancarlo Buonomo is our producer. /episode/index/show/curiousclinicians/id/31065158

87 - Aquagenic Wrinkling 04/17/2024

87 - Aquagenic Wrinkling The Curious Clinicians answer an early curiosity question: Why do my fingers wrinkle when I take a bath? Watch this episode on our new YouTube channel , and read the show notes to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Medical student Giancarlo Buonomo is our producer. /episode/index/show/curiousclinicians/id/30857423

[Archive] UMAMI 04/04/2024

[Archive] UMAMI In this episode from our archives, originally posted on September 16, 2020, The Curious Clinicians examined why the savory flavor umami is SO DELICIOUS. Dig in! Show notes: CME: Audio edited by Clair Morgan of Nodderly /episode/index/show/curiousclinicians/id/30681103

86 - Enlarging Alcohol 03/21/2024

86 - Enlarging Alcohol The Curious Clinicians are on tap to ask, why does chronic alcohol use cause macrocytosis? Read the show notes . to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Medical student Giancarlo Buonomo is our producer. /episode/index/show/curiousclinicians/id/30475793

85 - NephMadness 2024 03/05/2024

85 - NephMadness 2024 Welcome to NephMadness 2024! In collaboration with (TWDFNR), we are excited to promote the start of this amazing medical education opportunity. Inspired by the "March Madness" college basketball tournament, is a "a free online, CME-granting, evidenced-based, noncommercial learning initiative that leverages the tools of social media to teach about the latest and greatest breakthroughs in the field of nephrology!". Fill out your bracket today! Dr. Jeff Kott, NephMadness Executive Committee member, Critical Care Medicine Fellow At Stony Brook Medicine on Long Island, NY and former nephrology fellow at Mount Sinai Hospital in Manhattan, joins Avi, Hannah, and Tony to discuss two hot button TWDFNR topics in nephrology: Whether we should use phosphate binders in acute kidney injury If the urine anion gap in non-gap metabolic acidosis is helpful or not Read the show notes . Audio edited by Clair Morgan of Nodderly.com. /episode/index/show/curiousclinicians/id/30233293

84 - History & Hemochromatosis: The Ins and Outs of Iron 02/21/2024

84 - History & Hemochromatosis: The Ins and Outs of Iron The Curious Clinicians examine why the genetic mutations leading to hereditary hemochromatosis might have offered an evolutionarily advantage to our Neolithic ancestors. The answer relates to an old breakfast stalwart- cereal and milk! Read the show notes . Audio edited by Clair Morgan of Nodderly.com. This episode is sponsored by Audible! New members can try Audible free for 30 days using our own Curious Clinicians podcast code - visit Audible.com/TCCPOD or text TCCPOD to 500-500. /episode/index/show/curiousclinicians/id/30053588

[Archive] - (Trans)locating the Bacteria 02/07/2024

[Archive] - (Trans)locating the Bacteria On this episode from our archive, originally posted on March 15, 2022, The Curious Clinicians examine why cirrhosis predisposes to SBP, and why bacterial translocation across the bowel wall into ascites doesn’t actually occur! Read the show notes . to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of . This episode is sponsored by Audible! New members can try Audible free for 30 days using our own Curious Clinicians podcast code - visit or text TCCPOD to 500-500. /episode/index/show/curiousclinicians/id/29843513

83 - Thalidomide Embryopathy 01/31/2024

83 - Thalidomide Embryopathy The Curious Clinicians investigate the history and mechanisms of how thalidomide caused embryopathy in the late 1950s and early 1960s in over 10,000 babies across the world. Read the show notes . to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Medical student Giancarlo Buonomo is our producer. This episode is sponsored by Audible! New members can try Audible free for 30 days using our own Curious Clinicians podcast code - visit Audible.com/TCCPOD or text TCCPOD to 500-500. /episode/index/show/curiousclinicians/id/29737018

[Archive] In Vivo Veritas 01/26/2024

[Archive] In Vivo Veritas On this episode from our archive, originally posted on February 16, 2022, The Curious Clinicians investigate why antiphospholipid antibodies can be falsely positive during acute illness or thrombosis. Read the show notes . to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. This episode is sponsored by Audible! New members can try Audible free for 30 days using our own Curious Clinicians podcast code - visit Audible.com/TCCPOD or text TCCPOD to 500-500. /episode/index/show/curiousclinicians/id/29656633

When Normal Labs Aren't Necessary 01/17/2024

When Normal Labs Aren't Necessary In this episode, we investigate the reasons why we don't (and don't need to) transfuse to normal hemoglobin levels. Read the show notes on our website . And subscribe to our new ! Click to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of . Our producer is medical student Giancarlo Buonomo. /episode/index/show/curiousclinicians/id/29522553

[Archive] Of Ticks, Alpha-gal, and Red Meat Allergies 12/20/2023

[Archive] Of Ticks, Alpha-gal, and Red Meat Allergies The Curious Clinicians are currently on a holiday break, but we'll be back with new content in 2024! In the meantime, we hope you enjoy this episode from our archive, originally posted December 10, 2022. We told the story of a tiny carbohydrate called alpha-gal, delving into unsettling meat allergies after tick bites, ancient viruses, allergic reactions to an anti-cancer antibody, and xenotransplantation. Read the show notes . to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of . /episode/index/show/curiousclinicians/id/29174443

81 - Avoiding Malaria 12/06/2023

81 - Avoiding Malaria In this episode, we examine how sickle cell trait protects against malaria, in multiple ways. Read the show notes on our website . And subscribe to our new ! Click to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of . Our producer is medical student Giancarlo Buonomo. /episode/index/show/curiousclinicians/id/28951123

[Archive] Thanksgiving & The Food Coma 11/22/2023

[Archive] Thanksgiving & The Food Coma Today we reach back into The Curious Clinicians archives, just in time for Thanksgiving. In this episode, originally posted in November 2021, Hannah, Avi, and Tony examine whether tryptophan from turkey actually causes the infamous Thanksgiving food coma. The answer might surprise you... Check out the episode's show notes . Click to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of . /episode/index/show/curiousclinicians/id/28760408

80 - A Scleroderma Crisis 11/08/2023

80 - A Scleroderma Crisis In this episode, we explore why ACE inhibitors treat scleroderma renal crisis so effectively (and why bilateral nephrectomy used to be the treatment of choice…). Read the show notes on our website . And subscribe to our new ! Click to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of . We’d like to welcome the newest member of our team, Giancarlo Buonomo, a medical student who is joining on as a producer! /episode/index/show/curiousclinicians/id/28551515

79 - Kurious Keto 10/19/2023

79 - Kurious Keto In this episode, The Curious Clinicians ask why a ketogenic diet can help control seizures in refractory epilepsy? Read the show notes on our website . And subscribe to our new ! Click to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of . /episode/index/show/curiousclinicians/id/28367726

78 - Valve Privilege 10/04/2023

78 - Valve Privilege For this episode, The Curious Clinicians ask why patients with bioprosthetic heart valves don't require immunosuppression? Read the show notes on our website . And subscribe to our new ! Click to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of . /episode/index/show/curiousclinicians/id/28221089

77 - Irregularly Irregular 09/21/2023

77 - Irregularly Irregular On this episode, The Curious Clinicians learn about why hyperthyroidism is associated with atrial fibrillation. Read the show notes on our website . And subscribe to our new ! Click to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of . /episode/index/show/curiousclinicians/id/28099856

76 - Radical Regeneration 09/06/2023

76 - Radical Regeneration On this episode, The Curious Clinicians explore the liver's incredible ability to regenerate after injury or resection. Read the show notes on our website . And subscribe to our new ! Click to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of . This episode was sponsored by ! Use promo code "CURIOUS" for $20 off your first order + free shipping. /episode/index/show/curiousclinicians/id/27955620

[Archive] The Last Breath 08/24/2023

[Archive] The Last Breath This week, The Curious Clinicians are bringing back an episode from the archive that was originally posted in December, 2021. Tony joined Dr. Adam Rodman as a guest on the Bedside Rounds podcast. We were thrilled to share that episode here. How can we medically tell whether or not someone is alive or dead? The answer is more complicated than you’d think. This episode was a live podcast Adam and Tony gave at the Massachusetts Chapter of the American College of Physicians annual meeting on October 16, 2021. They track the evolution and controversies of the death exam, from a trans-Atlantic scandal surrounding a possible vivisection, a 19th century “X-prize” to determine a technology that could diagnose death, the important distinction between “permanent” and irreversible, and the mysterious Lazarus phenomenon. Link to episode page: /episode/index/show/curiousclinicians/id/27836817

75 - Feeling the Burn 08/09/2023

75 - Feeling the Burn On this episode, The Curious Clinicians investigate why alcohol both causes a burning sensation when you first swallow it (hint: the mechanism has something to do with chili peppers) and why you get a general sense of total body warmth within the next few minutes. Read the show notes . Click to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of . This episode was sponsored by ! Use promo code "CURIOUS" for $20 off your first order + free shipping. /episode/index/show/curiousclinicians/id/27699270

74 - DIFFerent Babies 07/26/2023

74 - DIFFerent Babies On this episode, The Curious Clinicians examine an intriguing question - why are babies protected from infection and colitis by C. Diff? We'll touch on factors relating to immunology, microbiology and human development. Read the show notes . Click to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of . /episode/index/show/curiousclinicians/id/27570645

The Curious Clinicians

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