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Secrets of Melatonin and Methylene Blue with Dr. John Lieurance
11/21/2025
Secrets of Melatonin and Methylene Blue with Dr. John Lieurance
In this episode with Dr. John Lieurance, he drops a bombshell in the first few minutes: "I take hundreds of milligrams [of melatonin] every night, and I've gone through months and months of taking it religiously." While most melatonin supplements contain a dose of 0.3 to 3 milligrams, Dr. Lieurance has 30 years of clinical experience and, during our conversation, shares his unorthodox but largely research-backed views on melatonin, methylene blue, and mitochondrial health. As one of the world's leading clinical experts on melatonin and methylene blue, Dr. Lieurance reveals findings that most people have never heard, including why melatonin is an amazing adaptogen and how it even prevents the Warburg effect that powers cancer cells. The second half of our conversation explores methylene blue, the original compound that inspired the term "magic bullet." Dr. Lieurance explains how this brilliant blue salt was discovered while searching for a malaria cure, how it increases mitochondrial function by an average of 30%, and why it acts as both a prooxidant and antioxidant. Most fascinating is the synergy with red light therapy…methylene blue absorbs 660-nanometer photons, supports cytochrome C oxidase, and creates powerful antimicrobial effects. He shares clinical dosing protocols, debunks FDA warnings, and explains why higher doses are more effective than the micro-doses commonly recommended. In this podcast, Dr. Lieurance and I discuss: His personal health journey and why he takes hundreds of milligrams of melatonin every night, while maintaining high testosterone levels, directly contradicting Andrew Huberman's warnings based on flawed rodent studies Melatonin studies that used up to 150,000 milligrams with zero toxicity found, yet recent claims suggest melatonin is toxic to kids, with little research to support it The fact that your gut produces 400 times more melatonin than the pineal gland! Every single cell produces its own melatonin within the mitochondria, a discovery that only emerged in the last couple years, completely reframing melatonin's importance The biological reason why you can take large amounts of melatonin for extended periods and stop the next day without suppression of natural production The connection between melatonin, hormesis, and your mitochondria How high-dose melatonin protects you from sun damage The interesting story of methylene blue, the original "magic bullet" discovered while curing malaria How methylene blue increases mitochondrial function by 30% on average
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