JHLT: The Podcast

The Journal of Heart and Lung Transplantation podcast features editor Daniel Goldstein, MD, in round table talks with the JHLT's digital media editors.

Episode 72: Impact of Donor-Specific Antibodies on Longitudinal Lung Function and BLAD 11/05/2025

Episode 71: Cardiogenic Shock Working Group: Patients on Impella 5.5 for more than 14 days 10/15/2025

Episode 70: Passive Leg Raise and Occult HFpEF in Pulmonary Hypertension 10/01/2025

Episode 69: Optimal Pre-Transplant Duration with HeartMate III LVADs 09/03/2025

Episode 68: DCD lung procurement in the UK 08/20/2025

Episode 67: Metabolic and transcriptomic insights into temperature-controlled donor heart transportation 08/06/2025

Episode 65: Regional differences in primary graft dysfunction 07/02/2025

Episode 65: Refining the grading of mild CAV 06/19/2025

Episode 64: A look back at ISHLT2025 05/22/2025

Episode 63: Severe PGD Using DCD Hearts 05/07/2025

Episode 62: Apixaban Plasma Levels in Patients with HeartMate 3 04/10/2025

Episode 61: Is Sotatercept safe in patients with PAH? 04/02/2025

Episode 60: Riociguat in patients with PAH and Cardiometabolic Comorbidities 03/18/2025

Episode 59: Rewarming Ischemia Time in Lung Transplantation 03/05/2025

Episode 58: Sympathetic Reinnervation 02/20/2025

Episode 57: Trends and Outcomes in EVLP 02/05/2025

Episode 56: The Best Studies of 2024 01/16/2025

Episode 55: Meet the Editors! 01/08/2025

Episode 54: Long-term follow up on the SCHEDULE trial 12/18/2024

Episode 53: Pollution exposure in the first 3 months post-lung transplant 12/04/2024

Episode 52: State of the art review on aortic Insufficiency in durable LVADs 11/20/2024

Episode 51: Can you be pragmatic about tMCS in Acute RV Failure? 11/06/2024

Episode 50: Age matching lung donors and recipients in Europe 10/16/2024

Episode 49: The Evaluation and Care of Cardiac Transplant Candidates 10/02/2024

Episode 48: A Tribute to Daniel R Goldstein 09/13/2024

Episode 47: An Interview with JHLT EIC Joe Rogers 09/04/2024

Episode 46: August 2024 08/14/2024

Episode 45: August 2024 08/07/2024

Episode 44: July 2024 07/03/2024

Episode 44: July 2024 On this episode of JHLT: The Podcast, the JHLT Digital Media Editors explore two studies from the July issue of The Journal of Heart and Lung Transplantation. Digital Media Editor Marty Tam, MD, a transplant cardiologist from the University of Michigan in Ann Arbor, hosts this episode. First, Dr. Tam and Digital Media Editor Erika Lease, MD, FCCP, interview their first guest, Daniel Calabrese, MD, first author on the study “.” The study’s authors sought to tackle challenges behind early detection of chronic lung allograft dysfunction (CLAD) by identifying biomarkers associated with acute lung allograft dysfunction (ALAD) progression to CLAD. To do this, they collected bronchoalveolar lavage (BAL) cells at the time of ALAD diagnosis and performed single cell RNA sequencing to identify significant differences in 26 unique cell populations across groups, with discordant CD8 T cells and macrophages providing the best discrimination between ALAD with decline from ALAD with recovery and controls. Dr. Calabrese discusses how his team identified the diagnostic criteria, why the biomarkers might lead ALAD to progress to CLAD, and how the findings might lead to early targeted therapies. Next, Dr. Tam joins and Digital Media Editor Khue Ton, MD and David Schibilsky, MD, to interview their next guest, David D’Alessandro, MD, the Surgical Director of Cardiac Transplantation and MCS at Massachusetts General Hospital in Boston. Dr. D’Alessandro was the first author on the study “,” which sought to assess the impact of the Paragonix SherpaPak Cardiac Transport System, a device allowing controlled hypothermic preservation, on rates of primary graft dysfunction (PGD) and post-transplant mortality. The key finding was that controlled hypothermic preservation was associated with a lower incidence of severe PGD – 6.6% compared to ice storage at 10.4%. In the conversation, Dr. D’Alessandro answers questions about the need for innovation over traditional ice cold storage, the greatest advantages of controlled hypothermic approaches, and the next steps in this research. Follow along at , or, if you’re an ISHLT member, access your Journal membership at . Don’t already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at for a free subscription, or subscribe today at . /episode/index/show/thejhlt/id/31979052

Episode 43: June 2024 06/05/2024

Episode 43: June 2024 On this episode of JHLT: The Podcast, the JHLT Digital Media Editors explore two studies from the June issue of The Journal of Heart and Lung Transplantation. Digital Media Editor Van-Khue Ton, MD, a transplant cardiologist from Massachusetts General Hospital, hosts this episode. First, Dr. Ton and Digital Media Editor Marty Tam, MD, interview their first guests, first author Matthew Carey, MD, MBA, and senior author Justin Fried, MD, both of the Columbia University Irving Medical Center in New York City, on their study “.” This retrospective study of all patients receiving a HeartMate 3 LVAD at a single center between November 2014 and August 2020. The study evaluated findings related to patients with aortic root thrombosis, classified as having at least 1 echocardiogram or contrast-enhanced CT scan with thrombus. In the population of 197 patients, 19 had aortic root thrombus, which was ultimately associated with an increased risk of developing significant aortic regurgitation during the study period. Drs. Carey and Fried discuss whether aortic valve opening is associated with increased risk of aortic root thrombus, how to balance the bleeding-thrombosis scale in patients, and how the study fits in the context of prior generations of LVAD. Next, Dr. Ton joins and Digital Media Editor Erika Lease, MD, FCCP, to interview, Jacqueline DesJardin, MD, a Fellow in the department of medicine at the University of California San Francisco. Dr. DesJardin is first author on the study “.” PHAR is a multicenter US-based registry of patients with PAH, and this study analyzed 1,891 patients from the registry, 1,425 (75%) of whom were female. At baseline, compared to men, women had worse functional status and worse hemodynamics. Women were more likely to be on triple therapy or parenteral prostacyclin therapies at baseline. Interestingly, women had better survival than men, even after adjusting for numerous variables. In the discussion, Dr. DesJardin explains what collider stratification bias is, and how it may illuminate the complex epidemiological system that creates this disparity. She shares the three potential causal models posed in the study, and considers how the study might be followed up. Follow along at , or, if you’re an ISHLT member, access your Journal membership at . Don’t already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at for a free subscription, or subscribe today at . /episode/index/show/thejhlt/id/31601037

JHLT: The Podcast

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