TWiN 59: AI co-scientistTim explains AI co-scientist, a tool released by Google, which it hopes to help scientists generate hypotheses and research proposals, and to accelerate the speed of scientific and biomedical discoveries. Hosts: , Tim Cheung, and Vivianne Morrison Subscribe (free): , , Links for this episode AI cracks (BBC) scientific breakthroughs (Google Research) Towards an (arXiv) Timestamps by . Thanks! Music is by Send your neuroscience questions and comments to [email protected]/episode/index/show/twin1/id/35964625
TWiN 58: Tongue-dragging rescue behaviorTWiN explains a study showing that when a mouse is confronted with an unconscious conspecific, it engages in behavior including tongue-dragging to resuscitate the animal via a tongue-brain connection. Hosts: , Tim Cheung, and Vivianne Morrison Subscribe (free): , , Links for this episode in mice (Sci Adv) Timestamps by . Thanks! Music is by Send your neuroscience questions and comments to [email protected]/episode/index/show/twin1/id/35595105
TWiN 57: Repetitive injury, herpes, and Alzheimer'sTWiN discusses a study showing that repetitive injury reactivates HSV-1 in a human brain tissue model and induces phenotypes associated with Alzheimer’s disease. Hosts: and Tim Cheung Subscribe (free): , , Links for this episode Repetitive injury, herpes, and (Sci Signal) The tau of herpesvirus () Fishing for viruses in senile () Timestamps by . Thanks! Music is by Send your neuroscience questions and comments to [email protected]/episode/index/show/twin1/id/35148410
TWiN 56: Astrocytes help neurons rememberTWiN explains a study showing that while groups of neurons, form the basis for memory, astrocytes are key components of the adaptive reponse to learning experiences, and regulate the flow of information during circuit plasticity and memory recall. Hosts: , , and Tim Cheung Subscribe (free): , , Links for this episode , oppose RFK Jr nomination Astrocytes and (Nature) Timestamps by . Thanks! Music is by Send your neuroscience questions and comments to [email protected]/episode/index/show/twin1/id/34165630
TWiN 55: A brain circuit for day/night balanceTWiN explains the identification of a brain circuit and periodic branch-specific neurotransmitter deployment that regulates organismal adaptation to photoperiod change. Hosts: , , and Tim Cheung Subscribe (free): , , Links for this episode Brain circuit for (Nature) Timestamps by . Thanks! Music is by Send your neuroscience questions and comments to [email protected]/episode/index/show/twin1/id/33630382
TWiN 54: How pregnancy transforms the brainTWiN explores how pregnancy leads to modifications in brain structure and function that may prepare the mother for parenting. Hosts: , , and Vivianne Morrison Subscribe (free): , , Links for this episode transforms the brain (Nature) during pregnancy (Science) on brain activity (Nature Comm) Timestamps by . Thanks! Music is by Send your neuroscience questions and comments to [email protected]/episode/index/show/twin1/id/33282192
TWiN 53: Slowing time by cooling the brainJoseph Paton and Felipe Rodrigues join TWiN to explain how they used temperature manipulation to alter the speed of neuronal dynamics in the dorsal striatum of rats, a manipulation that selectively slowed down or sped up time perception, illuminating the mechanisms of time-based decisions. Hosts: , , , and Vivianne Morrison Guest: and Subscribe (free): , , Links for this episode Using temperature to analyze the (Nat Neurosci) for the dorsal striatum (Nat Neurosci) Timestamps by . Thanks! Music is by Send your neuroscience questions and comments to [email protected]/episode/index/show/twin1/id/32324262
TWiN 52: Probiotic improves social behavior in children with ASDMauro Costa-Mattioli returns to TWiN to discuss the results of a placebo controlled, double blind clinical trial of a probiotic which improved social behavior but not autism severity in children with ASD. Hosts: , , and Vivianne Morrison Guest: Subscribe (free): , , Links for this episode Probiotics for (Cell Host Microbe) Timestamps by . Thanks! Music is by Send your neuroscience questions and comments to [email protected]/episode/index/show/twin1/id/31858027
TWiN 51: Sensory processing dysfunction in autism spectrum disordersTWiN reviews altered somatosensory reactivity, which is frequently observed among individuals with autism spectrum disorders (ASD), and in mouse models the developmental timing of aberrant touch processing can predict the manifestation of ASD-associated behaviors in mouse models. Hosts: , , , and Vivianne Morrison Subscribe (free): , , Links for this episode Mouse models of (Nature Neuroscience) Timestamps by . Thanks! Music is by Send your neuroscience questions and comments to [email protected]/episode/index/show/twin1/id/31500017
TWiN 50: Neurological sequelae after COVID-19TWiN reviews experiments which show that SARS-CoV-2 triggers the up-regulation of synaptic components and perturbs local electrical field potential in cerebral organoids, organotypic culture of human brain explants and post-mortem brain samples from individuals with COVID-19. Hosts: , , , and Vivianne Morrison Subscribe (free): , , Links for this episode SARS-CoV-2 perturbs (Nature Micro) Timestamps by . Thanks! Music is by Send your neuroscience questions and comments to [email protected]/episode/index/show/twin1/id/31020833
TWiN 49: Mirror, mirror on the wall, who's the fairest mouse of all?TWiN welcomes mice to the elite club of ‘self-aware’ animals, with a study demonstrating a mirror-induced self-directed behavior in mice resembling visual self-recognition. Hosts: , , and Vivianne Morrison Subscribe (free): , , Links for this episode Mice are (Neuron) Mirror in mice (Neuron) Timestamps by . Thanks! Music is by Send your neuroscience questions and comments to [email protected]/episode/index/show/twin1/id/30534378
TWiN 48: Traumatic brain injury and retrovirusesTWiN describes a study that reveals activation of endogenous retroviruses in oligodenroglia from patients with traumatic brain injury. Hosts: , , and Subscribe (free): , , Links for this episode Activation of e in TBI oligodendroglia (Cell Rep) Timestamps by . Thanks! Music is by Send your neuroscience questions and comments to [email protected]/episode/index/show/twin1/id/30009298
TWiN 47: Walking after spinal cord injuryTWiN explains an amazing study of a man who was paralyzed after a spinal cord injury and regained the ability to walk after implantation of a brain-spinal cord interface. Hosts: , , and Subscribe (free): , , Links for this episode Walking naturally after spinal cord injury (Nature) The that walked (YouTube) Mike the (Wikipedia) Timestamps by . Thanks! Music is by Send your neuroscience questions and comments to [email protected]/episode/index/show/twin1/id/29682778
TWiN 46: Neuronal activity promotes glioma progressionTWiN explains research showing that interaction between glioma cells and neurons in the brain shares mechanistic features with synaptic plasticity that contributes to memory and learning in the healthy brain. Hosts: , , and Subscribe (free): , , Links for this episode recruit mechanisms of adaptive plasticity (Nature) Timestamps by . Thanks! Music is by Send your neuroscience questions and comments to [email protected]/episode/index/show/twin1/id/29299123
TWiN 45: Acupuncture modulates the immune systemTWiN discusses research showing that sciatic nerve activation with electroacupuncture at the sciatic nerve controls systemic inflammation and rescues mice from polymicrobial peritonitis, by inducing vagal activation of aromatic L-amino acid decarboxylase, leading to the production of dopamine in the adrenal medulla. Hosts: , , and Subscribe (free): , , Links for this episode modulates the immune system (Nat Med) Electroacupuncture drives the (Nature) Timestamps by . Thanks! Music is by Send your neuroscience questions and comments to [email protected]/episode/index/show/twin1/id/29060903
TWiN 44: ADHD and persistent painTWiN reviews a mouse model of ADHD to characterize hypersensitivity to pain, and that sensitization is further amplified in a pathological inflammatory state. Hosts: , , and Subscribe (free): , , Links for this episode in ADHD model (PNAS) Timestamps by . Thanks! Music is by Send your neuroscience questions and comments to [email protected]/episode/index/show/twin1/id/28502099
TWiN 43: Pavlovian opioid toleranceTWiN discusses a study of on the pathways that control opioid analgesic tolerance, a root cause of opioid overdose and misuse, which can develop through an associative learning. Hosts: , , and Subscribe (free): , , Links for this episode opioid analgesic tolerance (Sci Adv) opioid tolerance (Sci Adv) Timestamps by . Thanks! Music is by Send your neuroscience questions and comments to [email protected]/episode/index/show/twin1/id/28223432
TWiN 42: Therapeutic effects of psychedelic drugsTWiN explains how psychedelic drugs such as LSD, psilocybin, and MDMA, which are being explored for treating a wide range of neuropsychiatric diseases, reopen the social reward period for critical learning. Hosts: , , and Click arrow to play Download (34 MB .mp3, 57 min) Subscribe (free): , , Links for this episode open critical period (Nature) Psychedelics reopen (News-Med) doesn’t work (U Chicago Med) Timestamps by . Thanks! Music is by Send your neuroscience questions and comments to [email protected]/episode/index/show/twin1/id/27494460
TWiN 41: Alzheimer's and melanin-concentrating hormoneVivianne explains how early in Alzheimer’s disease, the brain attempts to counteract the increased excitatory drive caused by amyloid deposition, and that melanin-concentrating hormone, produced during sleep, is involved in this protective response. Hosts: , , , and Vivianne Morrison Subscribe (free): , , Links for this episode Melanin-concentrating hormone and (Nat Neurosci) Timestamps by . Thanks! Music is by Send your neuroscience questions and comments to [email protected]/episode/index/show/twin1/id/27200088
TWiN 40: Dopamine organizes behavior's syllablesTim takes TWiN through two studies on the role of dopamine: that syllables are natural units of spontaneous behavior used by the brain to structure action, and that mesolimbic dopamine release conveys causal associations but not reward prediction errors, thereby challenging the dominant theory of reward learning. Hosts: , , , and Vivianne Morrison Subscribe (free): , , Links for this episode without explicit reward (Nature) Dopamine release conveys (Science) Timestamps by . Thanks! Music is by Send your neuroscience questions and comments to [email protected]/episode/index/show/twin1/id/26813601
TWiN 39: Virus-like capsids trigger paraneoplastic diseaseJunjie from Jason’s lab joins TWiN to discuss the observation that the cell gene PNMA2 encodes non-enveloped virus-like capsids that induce autoantibodies which underlie paraneoplastic syndrome. Hosts: , , , and Subscribe (free): , , Links for this episode Virus-like capsids in (bioRxiv) Timestamps by . Thanks! Music is by Send your neuroscience questions and comments to [email protected]/episode/index/show/twin1/id/26656722
TWiN 38: Bacterial immunity heals sensory neuronsTWiN explains the finding that immunity to commensal bacteria promotes sensory neuron regeneration via the cytokine interleukin-17A. Hosts: , , , and Vivianne Morrison Subscribe (free): , , Links for this episode Immunity to the microbiota promotes (Cell) Timestamps by . Thanks! Music is by Send your neuroscience questions and comments to [email protected]/episode/index/show/twin1/id/26345208
TWiN 37: Microglia at the crossroadsTWiN reviews the field of microgial research, which has advanced in recent decades but is constrained by nomenclature that is necessary but often implies specific functions. Hosts: , , , and Vivianne Morrison Subscribe (free): , , Links for this episode and nomenclature (Nature) Timestamps by . Thanks! Music is by Send your neuroscience questions and comments to [email protected]/episode/index/show/twin1/id/25692954
TWiN 36: Unbearable neurologistsTWiN answers listener questions about Alzheimer’s disease, glaucoma and the microbiota, Dravet’s Syndrome, schizophrenia, brain development, and chips implanted in the human brain. Hosts: , , , and Vivianne Morrison Subscribe (free): , , Links for this episode on TWiN 36 Timestamps by . Thanks! Music is by Send your neuroscience questions and comments to [email protected]/episode/index/show/twin1/id/25497192
TWiN 35: Neuromodulation in treatment-resistant depressionJason and Tim review the use of an implanted chronic deep brain sensing and stimulation device to carry out biomarker-driven closed-loop therapy that resulted in a rapid and sustained improvement in depression. Hosts: and Subscribe (free): , , , email Links for this episode Closed-loop neuromodulation for (Nat Med) Timestamps by . Thanks! Music is by Send your neuroscience questions and comments to [email protected]/episode/index/show/twin1/id/25243413
TWiN 34: Microglia vital after spinal cord injuryTWiN explains how central nervous system resident macrophages known as microglia coordinate cellular interactions during spinal cord repair in mice. Hosts: , , , and Subscribe (free): , , , email Links for this episode Microglia coordinate (Nat Commun) Timestamps by . Thanks! Music is by Send your neuroscience questions and comments to [email protected]/episode/index/show/twin1/id/24518076
TWiN 33: Viruses leaving the brainTWiN describes how neurotropic viruses leave the brain via meningeal lymphatic vessels located dorsally and basally beneath the skull. Hosts: , , , and Subscribe (free): , , , email Links for this episode Meningeal lymph vessels and (Nature Neuroscience) video (YouTube) Timestamps by . Thanks! Music is by Send your neuroscience questions and comments to [email protected]/episode/index/show/twin1/id/24226101
TWiN 32: Relearning how to move after strokeTWiN reviews how, in a mouse stroke model, recovery of movement is associated with the remaining cortex and the striatum coordinating their activity together. Hosts: Ori Lieberman, , and Vivianne Morrison Subscribe (free): , , , email Links for this episode Recovery after (Cell Rep) Timestamps by . Thanks! Music is by Send your neuroscience questions and comments to [email protected]/episode/index/show/twin1/id/23941542
TWiN 31: HIV-1 co-receptor shapes window for memory linkingTWiN explains the observation that in mice, the HIV-1 co-receptor CCR5 closes the temporal window for linking different memories. Hosts: , , , and Vivianne Morrison Subscribe (free): , , , email Links for this episode CCR5 and (Nature) Timestamps by . Thanks! Music is by Send your neuroscience questions and comments to [email protected]/episode/index/show/twin1/id/23579108
TWiN 30: Gut to brain spread of alpha-synuclein in Parkinson's diseaseTWiN describes experiments demonstrating that gut injection of alpha-synuclein fibrils in mice converts endogenous alpha-synuclein to a pathologic form that spreads to the brain and leads to features of Parkinson’s disease. Hosts: , , , , and Vivianne Morrison Subscribe (free): , , , email Links for this episode Gut-brain in PD (Neuron) Gut has a (Colbert Report) Timestamps by . Thanks! Music is by Send your neuroscience questions and comments to [email protected]/episode/index/show/twin1/id/23216282
