Ep. 10: Dalton Graham: How to Induce Fatty Liver—with Dr. Brian Kerley
Tucker Goodrich: Debugging Life
Release Date: 10/26/2023
Ep. 20: Are Seed Oils a Problem?—with Jacob Hands (Ep. 19 Excerpt)
Tucker Goodrich: Debugging Life
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Ep. 19: Jacob M. Hands—What's Wrong With Fish Oil (Chocolate too!?!)?
Tucker Goodrich: Debugging Life
Introduction What about fish oil? Is it a problem due to oxidation and contamination? Is it beneficial to health as many claim or is it a PUFA that’s bad for your health? Jacob recently published an analysis of various fish oils with the team at Consumer Labs, looking at oxidative toxicity and purity of a wide variety of commercially available fish oils. We discuss omega-3 and health, fish oils and oxidation, the science of seed oils and health, and, as a bonus, the problem with chocolates. This is definitely a bit of a geek fest, so let me know if you have any questions. Guest info Jacob...
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Ep. 18: What Causes Insulin Resistance?—with Matt Quinn and Dr. Brian Kerley
Tucker Goodrich: Debugging Life
Diabetes, broadly defined, afflicts greater than 50% of the U.S. population. The hallmark of type 2 diabetes is insulin resistance. While many are unable to answer the question of why a formerly rare disease now afflicts the majority of the population, we go over research dating back to 1964 that makes it clear that we have a pretty good idea of what causes insulin resistance. Scientists can easily induce insulin resistance in humans. How do they do it, and what might it tell us about what has caused our epidemic of diabetes? Guest info Matt Quinn Biography: TL;DR Here's what I...
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Ep. 17: Making Better Meat—Autumn Smith and John Etchart
Tucker Goodrich: Debugging Life
Introduction We’re honored to be joined today by Autumn Smith of Paleovalley and John Etchart of Wild Pastures. These related companies (John is Autumn’s brother-in-law) work to deliver healthy, regeneratively-farmed foods to their customers. “At Paleovalley, our mission is to help people reclaim vibrant health. We provide products that prioritize nutrient density in an industry that prioritizes everything else. We believe that every dietary choice and every added ingredient is a powerful opportunity to love and care for oneself.” Wild Pastures: “Turning The Page To A Healthier You...
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Ep. 16: Understanding HNE, Biomarkers, and LPO—with Matt Quinn and Dr. Brian Kerley
Tucker Goodrich: Debugging Life
Introduction We look at a paper about the process of how the fats in seed oils become toxic, and what effects those toxins can have. This paper is a broad overview of the related disease processes, which we will discuss to further understand how one thing can be driving many different disease processes. “The study of lipid peroxidation (LPO) processes has become a rapidly growing field in medicine and biology, based on increasing evidence that LPO is involved in the development of many chronic diseases, e.g. [references removed] (1) Asthma (2) ...
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Ep. 15: A.J. Hulbert on the Omega Balance—with Dr. Brian Kerley
Tucker Goodrich: Debugging Life
Introduction We are honorored to be joined by Prof. A. J. Hulbert, noted zoologist and author of Omega Balance: Nutritional Power for a Happier, Healthier Life. “In Omega Balance, noted scientist Anthony J. Hulbert explains how the balance between [Omega-3 and omega-6 fatty acids] in the human food chain has changed over the last half-century and the very serious negative health impacts this imbalance has created. An imbalance of these omega fats contributes to increased rates of obesity, diabetes, cardiovascular diseases, allergies, asthma, as well as cancer and a variety of other...
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Ep. 14: How a Common Asian Genetic Mutation Leads to Chronic Disease, and What to Do—with Matt Quinn and Dr. Brian Kerley
Tucker Goodrich: Debugging Life
Introduction We look at a paper enlightening what causes chronic disease, in the context of a huge population of people who suffer from the most common human mutation, to the aldehyde dehydrogenase enzyme that detoxifies both alcohol and seed oil metabolites, the ALDH2*2 mutation. We discuss how this mutation is thought to affect the people who have it through the lens of the paper at hand. This was a difficult video for me to edit, as both Matt and Brian share their experiences with the topic we are discussing in their own families. I thought this was excellent, and hope many others can learn...
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Ep. 13: Chef Andrew Gruel: Learning to Cook Again—with Dr. Brian Kerley
Tucker Goodrich: Debugging Life
Introduction Brian and I are honored to be joined by the illustrious Chef Andrew Gruel. He tells us the story of how he got into cooking, how he had to learn to cook again after discovering that his academic chef training left out natural fats, and the impact using proper fats has had on his health, the health of his staff, and his customers in his latest restaurant venture. We also have an extensive and very interesting discussion on fish, fish farming, and the health benefits of eating fish. Guest info Web: (It throws a security error…) X: Substack: “The Food Porn Master”! ...
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Ep. 12: Study: What's Worse—Carbs or Seed Oils? Understanding a High-PUFA Diet—with Dr. Brian Kerley and Matt Quinn
Tucker Goodrich: Debugging Life
Introduction We’re trying something a bit different today. Dr. Brian Kerley and I have found a victim, Matt Quinn. Matt’s a smart guy but he’s not as immersed in these topics as we are, and so he’s going to play our straight man, the every-day guy who can hopefully come to easily-digested conclusions about the papers we discuss. In our inaugural episode we discuss “Brief Episode of STZ-Induced Hyperglycemia Produces Cardiac Abnormalities in Rats Fed a Diet Rich in N-6 PUFA”. Ghosh, S., Qi, D., An, D., Pulinilkunnil, T., Abrahani, A., Kuo, K.-H., Wambolt, R. B., Allard, M., Innis,...
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Ep. 11: Paul Saladino, MD: The Intellectual Journey of a Physician—with Dr. Joshua Durham
Tucker Goodrich: Debugging Life
We interview Paul Saladino MD about his intellectual journey from being a raw vegan with rotting teeth as a physician’s assistant, through becoming the “Carnivore MD”, to where he is today. We discuss the training a physician receives in medical school about nutrition, and how he filled that gap with his own experience and research. And how it impacted his health and his ideas about being a physician. Josh Durham, my personal physician, joins me as co-host today to recount his personal health journey as well and how it changed his practice. (He recently quit his job at a large hospital...
info_outlineDr. Kerley and I are joined by Dalton Graham, a student who found himself in a liver pathology lab at Tulane. He had the interesting idea to test if a high-linoleic acid diet could be shown to produce fatty liver disease at the same time it was causing obesity.
The scientists in the lab required a little convincing that this was a worthy experiment, but one day he arrived to find all the materials he need waiting for him.
Be careful what you wish for! Find out how it turned out.
Graham, D. S., Liu, G., Arasteh, A., Yin, X.-M., & Yan, S. (2023). Ability of High Fat Diet to Induce Liver Pathology Correlates with the Level of Linoleic Acid and Vitamin E in the Diet. PLOS ONE, 18(6), e0286726. https://doi.org/10.1371/journal.pone.0286726
Biography:
• Dalton is currently a PhD student at University of Florida, studying Biochemistry with a focus on metabolism. When he wrote the paper we are discussing, he was an undergrad, and then grad student at Tulane University, studying Biochemical Engineering and Pathology.
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Co-host Dr. Brian Kerley
https://www.seedoilrebellion.com/
https://twitter.com/SeedOilDsrspctr
Looking to fix your diet by getting rid of seed oils?
Check out the Seedy app!
https://www.seedyapp.com/
Tucker Goodrich
Substack: https://tuckergoodrich.substack.com/
Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com/
Youtube: https://www.youtube.com/channel/UCDpWmYeRapRkrZ9zw8M7iFg
Apple podcast: https://podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825
Podcast: https://sites.libsyn.com/408758
Twitter: https://twitter.com/TuckerGoodrich
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Show Notes
“Alvheim papers out of the NIH”
Alvheim, A. R., Malde, M. K., Osei‐Hyiaman, D., Hong, Y. H., Pawlosky, R. J., Madsen, L., Kristiansen, K., Frøyland, L., & Hibbeln, J. R. (2012). Dietary Linoleic Acid Elevates Endogenous 2-AG and Anandamide and Induces Obesity. Obesity, 20(10), 1984–1994. https://doi.org/10.1038/oby.2012.38
Alvheim, A. R. (2012). Dietary linoleic acid induces obesity through excessive endocannabinoid activity [Doctor of Philosophy, The University of Bergen]. https://bora.uib.no/bora-xmlui/handle/1956/5962
NAFLD discovered in 1980:
Ludwig, J., Viggiano, T. R., McGill, D. B., & Oh, B. J. (1980). Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clinic Proceedings, 55(7), 434–438.
Liver transplants and NAFLD:
Lindenmeyer, C. C., & McCullough, A. J. (2018). The Natural History of Nonalcoholic Fatty Liver Disease—An Evolving View. Clinics in Liver Disease, 22(1), 11. https://doi.org/10.1016/j.cld.2017.08.003
Linoleic acid and breast milk:
Goodrich, T. D. (2022, September 1). Podcast Ep. 5: Prof. Tom Brenna on Omega-3 and Omega-6 in Human Health—with Dr Brian Kerley [Blog]. Yelling Stop. http://yelling-stop.blogspot.com/2022/09/podcast-ep-5-prof-tom-brenna-on-omega-3.html
Gornoski, D. (2021, June 15). Bruce German on How Human Milk Does the Body Good (Jun 15 2021) [Mp3]. https://podcastaddict.com/episode/124448388
Speakman paper on lethargy:
Speakman, J. R., De Jong, J. M. A., Sinha, S., Westerterp, K. R., Yamada, Y., Sagayama, H., Ainslie, P. N., Anderson, L. J., Arab, L., Bedu-Addo, K., Blanc, S., Bonomi, A. G., Bovet, P., Brage, S., Buchowski, M. S., Butte, N. F., Camps, S. G. J. A., Cooper, J. A., Cooper, R., … Wong, W. W. (2023). Total Daily Energy Expenditure Has Declined Over the Past Three Decades Due to Declining Basal Expenditure, Not Reduced Activity Expenditure. Nature Metabolism, 5(4), 579–588. https://doi.org/10.1038/s42255-023-00782-2
Vitamin E:
Masterjohn, C. (2017, June 24). 032: Is Coconut Oil Killing Us? [Substack newsletter]. Harnessing the Power of Nutrients. https://chrismasterjohnphd.substack.com/p/041-is-coconut-oil-killing-us
Raghavamenon, A., Garelnabi, M., Babu, S., Aldrich, A., Litvinov, D., & Parthasarathy, S. (2009). α-Tocopherol Is Ineffective in Preventing the Decomposition of Preformed Lipid Peroxides and May Promote the Accumulation of Toxic Aldehydes: A Potential Explanation for the Failure of Antioxidants to Affect Human Atherosclerosis. Antioxidants & Redox Signaling, 11(6), 1237–1248. https://doi.org/10.1089/ars.2008.2248
NAFLD and Fructose:
Vos, M. B., Weber, M. B., Welsh, J., Khatoon, F., Jones, D. P., Whitington, P. F., & McClain, C. J. (2009). Fructose and Oxidized LDL in Pediatric Nonalcoholic Fatty Liver Disease: A Pilot Study. Archives of Pediatrics & Adolescent Medicine, 163(7), 674–675. https://doi.org/10.1001/archpediatrics.2009.93
Cardiolipin:
Goodrich, T. (2016, February 5). The Cause of Metabolic Syndrome: Excess Omega-6 Fats (Linoleic Acid) in Your Mitochondria. Yelling Stop. http://yelling-stop.blogspot.com/2016/02/the-cause-of-metabolic-syndrome-excess.html
Quotable:
“I made a presentation about the role of excess linoleic acid in liver diseases. …I sat down and I pitched it… to the individuals in that lab. At first they didn’t really get it… I remember when I first finished laying out the mechanisms and why this is needed. Typically at the end of a presentation there are a bunch of questions, and there was just… silence.
“They’d never been presented with this idea that lipid peroxidation (or oxidative stress) manifests itself mainly due to this dietary factor—that no one seems to realize because it’s so ubiquitous.”
“These animals that are eating the higher linoleic acid they appear physical slower.”
“The females that were fed the high linoleic acid, they actually lost a lot of their fur [while under stress]. We couldn’t continue the experiment with them.”
“I don’t think they understood the importance of [linoleic acid] in the real world.”