Tucker Goodrich: Debugging Life
An exploration of healthy diet and lifestyle.
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Ep. 23: "Ep 23 Doctors Should Tell Patients that High Linoleic Acid Seed Oils are Unhealthy"—with Raphael Sirtoli and Dave Feldman
05/17/2024
Ep. 23: "Ep 23 Doctors Should Tell Patients that High Linoleic Acid Seed Oils are Unhealthy"—with Raphael Sirtoli and Dave Feldman
Introduction So apparently there is some demand for discussion/debate on the topic of seed oils and health. Dave Feldman (Ep. 9) had considered doing this at his recent conference, but couldn’t fit in the time. He’s since regained interest in the idea, and reached out to Andreas Eenfeldt and Ted Naiman, who have expressed skepticism. They replied: “We decline as we feel this debate is a distraction. The reason is that we see no good scientific evidence for replacing any source of added pure fat with another. It's not the right question.” Since there’s so much interest, and clearly that opinion is not defensible—probably why they avoided the debate!—Raphael Sirtoli volunteered to take the con side of a debate, topic: “Doctors Should Tell Patients that High Linoleic Acid Seed Oils are Unhealthy” This was a debate proposition that Raphi had suggested recently, and it had also been declined. (More about that in a future episode.) So, here we are. Please enjoy, and as always, post questions or comments in the comments below. The debate on Dave’s YouTube channel is here: https://www.youtube.com/live/JDsbpAJ28U4?si=4n7mSt56JiQDXTGN _______________________________________ Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! https://www.seedyapp.com/ Tucker Goodrich Substack: https://tuckergoodrich.substack.com/ Twitter: https://twitter.com/TuckerGoodrich Youtube: https://www.youtube.com/tuckergoodrich0 Apple podcast: https://podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825 Spotify podcast: https://open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y Podcast: https://sites.libsyn.com/408758 Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com/ _______________________________________ Show Notes Pro Ramsden, C. E., Zamora, D., Majchrzak-Hong, S., Faurot, K. R., Broste, S. K., Frantz, R. P., Davis, J. M., Ringel, A., Suchindran, C. M., & Hibbeln, J. R. (2016). Re-Evaluation of the Traditional Diet-Heart Hypothesis: Analysis of Recovered Data from Minnesota Coronary Experiment (1968-73). BMJ, 353. https://doi.org/10.1136/bmj.i1246 Steinberg, D., Parthasarathy, S., Carew, T. E., Khoo, J. C., & Witztum, J. L. (1989). Beyond Cholesterol. Modifications of Low-Density Lipoprotein That Increase Its Atherogenicity. The New England Journal of Medicine, 320(14), 915–924. https://doi.org/10.1056/NEJM198904063201407 de Lorgeril, M., Renaud, S., Mamelle, N., Salen, P., Martin, J. L., Monjaud, I., Guidollet, J., Touboul, P., & Delaye, J. (1994). Mediterranean Alpha-Linolenic Acid-Rich Diet in Secondary Prevention of Coronary Heart Disease. Lancet (London, England), 343(8911), 1454–1459. https://doi.org/10.1016/s0140-6736(94)92580-1 Wien, M., Rajaram, S., Oda, K., & Sabaté, J. (2010). Decreasing the Linoleic Acid to α-Linolenic Acid Diet Ratio Increases Eicosapentaenoic Acid in Erythrocytes in Adults. Lipids, 45(8), 683–692. https://doi.org/10.1007/s11745-010-3430-3 Borén, J., Chapman, M. J., Krauss, R. M., Packard, C. J., Bentzon, J. F., Binder, C. J., Daemen, M. J., Demer, L. L., Hegele, R. A., Nicholls, S. J., Nordestgaard, B. G., Watts, G. F., Bruckert, E., Fazio, S., Ference, B. A., Graham, I., Horton, J. D., Landmesser, U., Laufs, U., … Ginsberg, H. N. (2020). Low-Density Lipoproteins Cause Atherosclerotic Cardiovascular Disease: Pathophysiological, Genetic, and Therapeutic Insights: A Consensus Statement from the European Atherosclerosis Society Consensus Panel. European Heart Journal, 41(24), 2313–2330. https://doi.org/10.1093/eurheartj/ehz962 Con Arris, F. A., Thai, V. T. S., Manan, W. N., & Sajab, M. S. (2020). A Revisit to the Formation and Mitigation of 3-Chloropropane-1,2-Diol in Palm Oil Production. Foods, 9(12), 1769. https://doi.org/10.3390/foods9121769 de Lorgeril, M., Renaud, S., Mamelle, N., Salen, P., Martin, J. L., Monjaud, I., Guidollet, J., Touboul, P., & Delaye, J. (1994). Mediterranean Alpha-Linolenic Acid-Rich Diet in Secondary Prevention of Coronary Heart Disease. Lancet (London, England), 343(8911), 1454–1459. https://doi.org/10.1016/s0140-6736(94)92580-1 Ramsden, C. E., Faurot, K. R., Zamora, D., Palsson, O. S., MacIntosh, B. A., Gaylord, S., Taha, A. Y., Rapoport, S. I., Hibbeln, J. R., Davis, J. M., & Mann, J. D. (2015). Targeted alterations in dietary n-3 and n-6 fatty acids improve life functioning and reduce psychological distress among patients with chronic headache: A secondary analysis of a randomized trial. Pain, 156(4), 587–596. https://doi.org/10.1097/01.j.pain.0000460348.84965.47 Ramsden, C. E., Zamora, D., Faurot, K. R., MacIntosh, B., Horowitz, M., Keyes, G. S., Yuan, Z.-X., Miller, V., Lynch, C., Honvoh, G., Park, J., Levy, R., Domenichiello, A. F., Johnston, A., Majchrzak-Hong, S., Hibbeln, J. R., Barrow, D. A., Loewke, J., Davis, J. M., … Mann, J. D. (2021). Dietary Alteration of N-3 and N-6 Fatty Acids for Headache Reduction in Adults with Migraine: Randomized Controlled Trial. BMJ, 374, n1448. https://doi.org/10.1136/bmj.n1448 Rastogi, T., Reddy, K. S., Vaz, M., Spiegelman, D., Prabhakaran, D., Willett, W. C., Stampfer, M. J., & Ascherio, A. (2004). Diet and risk of ischemic heart disease in India. The American Journal of Clinical Nutrition, 79(4), 582–592. https://doi.org/10.1093/ajcn/79.4.582 If you have any questions about sources for things discussed please ask in the comments.
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Ep. 22: John Speakman—What Causes Obesity?
05/09/2024
Ep. 22: John Speakman—What Causes Obesity?
Introduction I am honored to be joined by John Speakman, a leading authority on energy balance in animals, and in the use of the doubly-labeled water method of determining energy balance. This has led him into the study of obesity, among other topics, where he has become a recognized expert. Our discussion was prompted by his recent paper, “Total Daily Energy Expenditure Has Declined Over the Past Three Decades Due to Declining Basal Expenditure, Not Reduced Activity Expenditure”, which casts a new light onto the world pandemic of obesity. In addition to discussing a few of the papers that give some background to that one, and his future research plans in light of that paper, we have an enlightening discussion on the potential role of deuterium in obesity and chronic disease. Biography: “John Roger Speakman (born 1958) FRS FRSE FRSB FRSA FMedSci FRSS is a British biologist working at the University of Aberdeen, Institute of Biological and Environmental Sciences, for which he was Director from 2007 to 2011. He leads the University's Energetics Research Group, which is one of the world's leading groups using doubly labeled water (DLW) to investigate energy expenditure and balance in animals. Between 2011-2020, he was a '1000 talents' Professor at the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, in Beijing, China, where he ran the molecular energetics group. In 2020 he moved to the Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences in Shenzhen, China where he works at the Center for Energy Metabolism and Reproduction and Head of the Shenzhen Key laboratory of Metabolic Health.” _______________________________________ Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! Tucker Goodrich Substack: Twitter: Youtube: Apple podcast: Spotify podcast: Podcast: Blog (deprecated, but still a lot there!): _______________________________________ Show Notes Hu, S., Wang, L., Yang, D., Li, L., Togo, J., Wu, Y., Liu, Q., Li, B., Li, M., Wang, G., Zhang, X., Niu, C., Li, J., Xu, Y., Couper, E., Whittington-Davies, A., Mazidi, M., Luo, L., Wang, S., … Speakman, J. R. (2018). Dietary Fat, but Not Protein or Carbohydrate, Regulates Energy Intake and Causes Adiposity in Mice. Cell Metabolism, 28(3), 415-431.e4. Wu, Y., Li, B., Li, L., Mitchell, S. E., Green, C. L., D’Agostino, G., Wang, G., Wang, L., Li, M., Li, J., Niu, C., Jin, Z., Wang, A., Zheng, Y., Douglas, A., & Speakman, J. R. (2021). Very-Low-Protein Diets Lead to Reduced Food Intake and Weight Loss, Linked to Inhibition of Hypothalamic Mtor Signaling, in Mice. Cell Metabolism, 33(6), 1264–1266. McNay, D. E. G., & Speakman, J. R. (2013). High Fat Diet Causes Rebound Weight Gain. Molecular Metabolism, 2(2), 103–108. Speakman, J. R., De Jong, J. M. A., Sinha, S., Westerterp, K. R., Yamada, Y., Sagayama, H., Ainslie, P. N., Anderson, L. J., Arab, L., Bedu-Addo, K., Blanc, S., Bonomi, A. G., Bovet, P., Brage, S., Buchowski, M. S., Butte, N. F., Camps, S. G. J. A., Cooper, J. A., Cooper, R., … Wong, W. W. (2023). Total Daily Energy Expenditure Has Declined Over the Past Three Decades Due to Declining Basal Expenditure, Not Reduced Activity Expenditure. Nature Metabolism, 5(4), 579–588. Gurven, M., Kraft, T. S., Alami, S., Adrian, J. C., Linares, E. C., Cummings, D., Rodriguez, D. E., Hooper, P. L., Jaeggi, A. V., Gutierrez, R. Q., Suarez, I. M., Seabright, E., Kaplan, H., Stieglitz, J., & Trumble, B. (n.d.). Rapidly Declining Body Temperature in a Tropical Human Population. Science Advances, 6(44), eabc6599. Protsiv, M., Ley, C., Lankester, J., Hastie, T., & Parsonnet, J. (2020). Decreasing Human Body Temperature in the United States Since the Industrial Revolution. eLife, 9, e49555. Linares, C., & Su, D. (2005). Body Mass Index and Health Among Union Army Veterans: 1891–1905. Economics & Human Biology, 3(3), 367–387. Sørensen, T. I. A., Martinez, A. R., & Jørgensen, T. S. H. (2022). Epidemiology of Obesity. In J. Eckel & K. Clément (Eds.), From Obesity to Diabetes (pp. 3–27). Springer International Publishing. Schramm, S., Sørensen, T. I. A., Davidsen, M., & Tolstrup, J. S. (2023). Changes in Adult Obesity Prevalence in Denmark, 1987–2021: Age–Period–Cohort Analysis of Nationally Representative Data. European Journal of Public Health, 33(3), 463–467. Haggerty, C., Hoggard, N., Brown, D. S., Clapham, J. C., & Speakman, J. R. (2008). Intra-Specific Variation in Resting Metabolic Rate in Mf1 Mice Is Not Associated with Membrane Lipid Desaturation in the Liver. Mechanisms of Ageing and Development, 129(3), 129–137. Zhang, L.-N., Gamo, Y., Sinclair, R., Mitchell, S. E., Morgan, D. G., Clapham, J. C., & Speakman, J. R. (2012). Effects of Chronic Oral Rimonabant Administration on Energy Budgets of Diet-Induced Obese C57BL/6 Mice. Obesity, 20(5), 954–962. “There were four suicides in the rimonabant group (0·07%) and one in the placebo group (0·02%). The number of deaths for bariatric surgery, a widely used alternative treatment for severe obesity, would have been expected to be far greater, and in centres of excellence has been reported to be 0·3% at 90 days.2” Topol, E. J., Bousser, M.-G., Fox, K. A., & Montelescot, G. (2010). Termination of the CRESCENDO trial – Authors’ reply. The Lancet, 376(9757), 1984–1985. Else, P. L., & Hulbert, A. J. (1987). Evolution of Mammalian Endothermic Metabolism: “Leaky” Membranes as a Source of Heat. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 253(1), R1–R7. Speakman, J. R., Sørensen, T. I. A., Hall, K. D., & Allison, D. B. (2023). Unanswered Questions About the Causes of Obesity. Science, 381(6661), 944–946. Deuterium Boros, L., Collins, Q., & Somlyai, G. (2018, September 24). Deuterium and Metabolic Water Matter – What This Means Biochemically and Clinically. If you have any questions about sources for things discussed please ask in the comments.
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Ep. 21: How Seed Oils Promote Cancer—with Matt Quinn and Dr. Brian Kerley
05/02/2024
Ep. 21: How Seed Oils Promote Cancer—with Matt Quinn and Dr. Brian Kerley
Introduction Cancer is the second-leading killer of Americans, and is increasing both around the world and increasingly affecting younger and younger people. It’s obviously important to understand what environmental factors might affect our susceptibility to the various cancers. Here we discuss what I think is a key paper showing a link between our environment, genetic mutation, and metabolic dysfunction in cancer cells. “The Major Lipid Peroxidation Product, Trans- 4-Hydroxy-2-Nonenal, Preferentially Forms DNA Adducts at Codon 249 of Human P53 Gene, a Unique Mutational Hotspot in Hepatocellular Carcinoma” (Hu et al., 2002) Guest info Matt Quinn Biography: TL;DR Here's what I am working on: I run Rebel - a fund that buys distressed SAAS and turns it around - if you want to support share our apps here I'm in the very early stages of building/buying a regenerative farm. Our food system is beyond broken. Our healthcare system doesn't heal people. If you're interested in the thoughts behind this read this I've built companies, bought companies and burned companies - if you're looking for pro bono advice or mentoring - tweet/DM me here In my day job I run a product consulting team at Tanzu Labs - if you have deep pockets and need a team to teach you how to build great software that users love - connect with me here I have failed at so so so many things - read about them here _______________________________________ Co-host Dr. Brian Kerley Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! Tucker Goodrich Substack: Twitter: Youtube: Apple podcast: Spotify podcast: Podcast: Blog (deprecated, but still a lot there!): _______________________________________ Show Notes Hu, W., Feng, Z., Eveleigh, J., Iyer, G., Pan, J., Amin, S., Chung, F.-L., & Tang, M. (2002). The Major Lipid Peroxidation Product, Trans- 4-Hydroxy-2-Nonenal, Preferentially Forms DNA Adducts at Codon 249 of Human P53 Gene, a Unique Mutational Hotspot in Hepatocellular Carcinoma. Carcinogenesis, 23(11), 1781–1789. Ravenous: Otto Warburg, the Nazis, and the Search for the Cancer-Diet Connection Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer Goodrich, T. D. (2021, July 8). Interview: Thomas Seyfried on Glioblastoma, Metabolic Cancer Breakthroughs, with David Gornoski on A Neighbor’s Choice [Blog]. Yelling Stop. Soussi, T. (2000). The P53 Tumor Suppressor Gene: From Molecular Biology to Clinical Investigation. Annals of the New York Academy of Sciences, 910, 121–137; discussion 137-139. Matoba, S., Kang, J.-G., Patino, W. D., Wragg, A., Boehm, M., Gavrilova, O., Hurley, P. J., Bunz, F., & Hwang, P. M. (2006). P53 Regulates Mitochondrial Respiration. Science, 312(5780), 1650–1653. The American Oil Chemists’ Society. (2004, June). Wilhelm Normann (1870-1939). INFORM Magazine. Goodrich, T. D. (2016, January 14). Thyroid and Low-Carb: What Do Thyroid Hormones Do? [Blog]. Yelling Stop. If you have any questions about sources for things discussed please ask in the comments.
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Ep. 20: Are Seed Oils a Problem?—with Jacob Hands (Ep. 19 Excerpt)
04/19/2024
Ep. 20: Are Seed Oils a Problem?—with Jacob Hands (Ep. 19 Excerpt)
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Ep. 19: Jacob M. Hands—What's Wrong With Fish Oil (Chocolate too!?!)?
04/11/2024
Ep. 19: Jacob M. Hands—What's Wrong With Fish Oil (Chocolate too!?!)?
Introduction What about fish oil? Is it a problem due to oxidation and contamination? Is it beneficial to health as many claim or is it a PUFA that’s bad for your health? Jacob recently published an analysis of various fish oils with the team at Consumer Labs, looking at oxidative toxicity and purity of a wide variety of commercially available fish oils. We discuss omega-3 and health, fish oils and oxidation, the science of seed oils and health, and, as a bonus, the problem with chocolates. This is definitely a bit of a geek fest, so let me know if you have any questions. Guest info Jacob Hands, MD candidate and consultant for Consumer Lab on quality control and testing of supplements, and consultant to Rhonda Patrick, MD, of Found my Fitness. Consumer Lab Found my Fitness Biography: “Medical student passionate about patient care, research, and emerging therapeutics. “M.D. Candidate at The George Washington University School of Medicine and Health Sciences.” _______________________________________ Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! Tucker Goodrich Substack: Twitter: Youtube: Apple podcast: Spotify podcast: Podcast: Blog (deprecated, but still a lot there!): _______________________________________ Show Notes Hands, J. M., Anderson, M. L., Cooperman, T., & Frame, L. A. (2023). A Multi-Year Rancidity Analysis of 72 Marine and Microalgal Oil Omega-3 Supplements. Journal of Dietary Supplements, 0(0), 1–12. This is the only human study I’m aware of showing harm from eating marine foods. The Japanese and the Eskimos do not suffer from infertility, so I think this gentleman must have been doing something wrong. “I lived for 100 days on nothing but marine animal food (seal, fish, crustaceans and molluscs) and water; weights of all food were recorded….” “In seminal fluid, the total amount of prostaglandins decreased significantly and small amounts of the [Ω-]3-series appeared; spermatozoa became immobile and then disappeared.” Sinclair, H. M. (1981). The Relative Importance of Essential Fatty Acids of the Linoleic and Linolenic Families: Studies with an Eskimo Diet. Progress in Lipid Research, 20, 897–899. Goodrich, T. D. (2022, April 13). The Folate Experiment [Blog]. Yelling Stop. Goodrich, T. (2021, October 19). What Is The Most Fattening Food? [Blog]. Yelling Stop. Mozaffarian, D., Hao, T., Rimm, E. B., Willett, W. C., & Hu, F. B. (2011). Changes in Diet and Lifestyle and Long-Term Weight Gain in Women and Men. New England Journal of Medicine, 364(25), 2392–2404. Zong, G., Liu, G., Willett, W. C., Wanders, A. J., Alssema, M., Zock, P. L., Hu, F. B., & Sun, Q. (2019). Associations Between Linoleic Acid Intake and Incident Type 2 Diabetes Among U.S. Men and Women. Diabetes Care, 42(8), 1406–1413. Johns, D. M. (2023, April 13). Nutrition Science’s Most Preposterous Result: Could Ice Cream Possibly Be Good for You? The Atlantic, 5/2023. Pearce, N. (2011). Epidemiology in a Changing World: Variation, Causation and Ubiquitous Risk Factors. International Journal of Epidemiology, 40(2), 503–512. Huang, Z., Sun, S., Lee, M., Maslov, A. Y., Shi, M., Waldman, S., Marsh, A., Siddiqui, T., Dong, X., Peter, Y., Sadoughi, A., Shah, C., Ye, K., Spivack, S. D., & Vijg, J. (2022). Single-Cell Analysis of Somatic Mutations in Human Bronchial Epithelial Cells in Relation to Aging and Smoking. Nature Genetics, 54(4), Article 4. Jacob’s Discussion Notes Topics to cover Omega-3 paper – Overall, our results revealed that 68% (23/34) of flavored and 13% (5/38) unflavored consumer Ω3 supplements exceeded the TOTOX upper limit set by the Global Organization for EPA and DHA (GOED) voluntary monograph standard of ≤ 26, with 65% (22/34) flavored supplements and 32% (12/38) unflavored supplements failing the PV upper limit of ≤ 5 and 62% (21/34) flavored supplements exceeding the p-AV upper limit of ≤ 20. What’s important is that peroxide was still significantly different in those with added versus non added extracts (0.04) almost double the PV How does fish oil metabolize? Peroxides, then aldehydes (Ω-3HHE & Ω-6 HNE, etc.) Why do I think it probably doesn't matter? 2 big studies – in the first study, after seven weeks of supplementation with 8 grams of oil per day, the authors found no signs of oxidative stress in any of the groups after looking at nine different measures (4-HHE, 4-HNE, 8-iso-prostaglandin F2α, alpha-tocopherol, total glutathione, glutathione reductase, glutathione peroxidase, catalase, and C-Reactive Protein) of oxidative stress in the blood and urine 4. This study demonstrated that high dosages of highly oxidized fish oil do not induce oxidative stress in our bodies.” “The second study was conducted by the same group and used the same study design, but looked at four additional markers of oxidative stress related to vascular inflammation (intercellular adhesion molecule 2 (sICAM-2), soluble vascular adhesion molecule 1 (sVCAM-1), interleukin 6 (IL-6) and oxidized LDL cholesterol) 5. Again, no impact on these markers was found with consumption of abnormally oxidized fish oil.” BUT point to consider is that may have adverse effects on lipids Would want to point out that ICAM and VCAM does How should I think more generally about oxidized oils? First of all, let’s go over fats and how that works – note that we don't have 15 desaturase which would convert 06 to 03 – what’s going to be the broad point? Each 06 and 03 come with anti-inflammatory elements, one is just less inflamm Notice that AA derived eicosanoids products such as lipoxins actually follow Something sympathetic for you – Nicolantino et al. argue 06 is a driver because oxidation products of LA are high in atheromas https://openheart.bmj.com/content/5/2/e000898 – why is this not replicated in most of the systematic analysis? )%20risk%20%5B9%5D. (granted this FBG and other markers of coronary disease increase etc) (more linolenic = less diabetes) (linear LA = less CHD) More LA less CVD https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334131/ LA inverse AA positively associated with diabetes https://www.sciencedirect.com/science/article/abs/pii/S026156142030008X Cochrane style review unclear https://pubmed.ncbi.nlm.nih.gov/24723079/ Cancer risk? Minimal except maybe prostate cancer More to the point, there is no evidence that even giving straight ARA still unclear up to 1 gram https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/systematic-review-of-the-effects-of-increasing-arachidonic-acid-intake-on-pufa-status-metabolism-and-healthrelated-outcomes-in-humans/6A0167CBF8EC148B4855C25D002E4AC4 Even if metabolized, the oxidative derivatives can do cool things would other oils increase oxidative stress? Maybe (source) Is the body made to deal with oxidative stress? What is the evidence that the mouse model is valid? Note Scandinavian SNPs associated with rancid consumption Changes in MDA are unpredictable and highly oxidized meals can generate low MDA etc not easy to say that Omega 3 attenuates effects of oxidation and increases parameters of oxidative stability Chocolate Cadmium is toxic lol but here it data on recruiting pro-inflammatory macrophages in artery Lead also bad for various reasons Lets go over levels, why prop 65 exists versus what an IRL is and 2.2 8.8 mcg/day means in any context If you have any questions about sources for things discussed please ask in the comments.
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Ep. 18: What Causes Insulin Resistance?—with Matt Quinn and Dr. Brian Kerley
04/04/2024
Ep. 18: What Causes Insulin Resistance?—with Matt Quinn and Dr. Brian Kerley
Diabetes, broadly defined, afflicts greater than 50% of the U.S. population. The hallmark of type 2 diabetes is insulin resistance. While many are unable to answer the question of why a formerly rare disease now afflicts the majority of the population, we go over research dating back to 1964 that makes it clear that we have a pretty good idea of what causes insulin resistance. Scientists can easily induce insulin resistance in humans. How do they do it, and what might it tell us about what has caused our epidemic of diabetes? Guest info Matt Quinn Biography: TL;DR Here's what I am working on: I run Rebel - a fund that buys distressed SAAS and turns it around - if you want to support share our apps here I'm in the very early stages of building/buying a regenerative farm. Our food system is beyond broken. Our healthcare system doesn't heal people. If you're interested in the thoughts behind this read this I've built companies, bought companies and burned companies - if you're looking for pro bono advice or mentoring - tweet/DM me here In my day job I run a product consulting team at Tanzu Labs - if you have deep pockets and need a team to teach you how to build great software that users love - connect with me here I have failed at so so so many things - read about them here _______________________________________ Co-host Dr. Brian Kerley Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! Tucker Goodrich Substack: Twitter: Youtube: Apple podcast: Spotify podcast: Podcast: Blog (deprecated, but still a lot there!): _______________________________________ Show Notes Felber, J. P., & Vannotti, A. (1964). Effects of Fat Infusion on Glucose Tolerance and Insulin Plasma Levels. Medicina Experimentalis: International Journal of Experimental Medicine, 10, 153–156. Nowotny, B., Zahiragic, L., Krog, D., Nowotny, P. J., Herder, C., Carstensen, M., Yoshimura, T., Szendroedi, J., Phielix, E., Schadewaldt, P., Schloot, N. C., Shulman, G. I., & Roden, M. (2013). Mechanisms Underlying the Onset of Oral Lipid–Induced Skeletal Muscle Insulin Resistance in Humans. Diabetes, 62(7), 2240–2248. https://doi.org/10.2337/db12-1179 Attia, P. (2020, December 7). #140 - Gerald Shulman, M.D., Ph.D.: A masterclass on insulin resistance—molecular mechanisms and clinical implications (140) [Mp3]. Koch, S., Cohen, D., & Carroll, L.. (2013, June 7). Drug treatment Omegaven that could save infants’ lives not yet approved by FDA [Mp4]. In NBC News. NBC. If you have any questions about sources for things discussed please ask in the comments.
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Ep. 17: Making Better Meat—Autumn Smith and John Etchart
03/28/2024
Ep. 17: Making Better Meat—Autumn Smith and John Etchart
Introduction We’re honored to be joined today by Autumn Smith of Paleovalley and John Etchart of Wild Pastures. These related companies (John is Autumn’s brother-in-law) work to deliver healthy, regeneratively-farmed foods to their customers. “At Paleovalley, our mission is to help people reclaim vibrant health. We provide products that prioritize nutrient density in an industry that prioritizes everything else. We believe that every dietary choice and every added ingredient is a powerful opportunity to love and care for oneself.” Wild Pastures: “Turning The Page To A Healthier You & A Healthier Planet “We provide healthy, rotationally grazed, pasture-raised meats without hormones or antibiotics. Rotational grazing helps restore soil and sequester carbon from the atmosphere. We use no chemicals on our pastures... ever. “We only work with small family farmers located in the USA using regenerative farming practices. As I mention in the episode, Autumn sent me a sample box of the various products they offer, include meat from Wild Pastures and beef sticks and other products from Paleovalley. Guest info Wild Pastures Paleovalley Wild Pastures Burger Company Biography: “Autumn Smith suffered from debilitating digestive issues and crippling anxiety for most of her life. Specialist after specialist told her nothing could be done, and she was ready to give up. But as one final attempt at a life free of health issues, Autumn decided to harness the power of whole foods. She cleaned up her diet and in just 30 days, her IBS was cured. But that was just the beginning. She also had less anxiety, was mentally sharper, and a bubbly side of her that she forgot existed came back. Since then, Autumn has dedicated her life to helping others harness the power of whole foods to live vibrant lives. “In 2013, she and her husband Chas launched Paleovalley, a company dedicated to helping people get the essential nutrients they need, without added sugars, grains, and other harmful ingredients. But they didn’t stop there. After learning about the healing powers of grass fed, pasture raised meat - both for our bodies and the planet - Autumn and Chas started their next venture. In 2018, they launched Wild Pastures, a regenerative meat delivery service that sends 100% grass fed pasture raised meat directly to your doorstep.” _______________________________________ Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! Tucker Goodrich Substack: Twitter: Youtube: Apple podcast: Spotify podcast: Podcast: Blog (deprecated, but still a lot there!): _______________________________________ Show Notes Autumn’s podcast interview of Tucker Goodrich EP286: Seed Oils: History, Science and Negative Health Impacts with Tucker Goodrich Our Robb Wolf interview: Podcast Ep. 3: Robb Wolf on 'Sacred Cow', His Health Issues, Beyond Paleo, and More... with Co-host Dr. Brian Kerley van Vliet paper on fake meat: “Despite apparent similarities based on Nutrition Facts panels, our metabolomics analysis found that metabolite abundances between the plant‑based meat alternative and grass‑fed ground beef differed by 90% (171 out of 190 profiled metabolites; false discovery rate adjusted p < 0.05). Several metabolites were found either exclusively (22 metabolites) or in greater quantities in beef (51 metabolites) (all, p < 0.05).” van Vliet, S., Bain, J. R., Muehlbauer, M. J., Provenza, F. D., Kronberg, S. L., Pieper, C. F., & Huffman, K. M. (2021). A Metabolomics Comparison of Plant-Based Meat and Grass-Fed Meat Indicates Large Nutritional Differences Despite Comparable Nutrition Facts Panels. Scientific Reports, 11(1), 13828. Bareburger If you have any questions about sources for things discussed please ask in the comments.
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Ep. 16: Understanding HNE, Biomarkers, and LPO—with Matt Quinn and Dr. Brian Kerley
03/11/2024
Ep. 16: Understanding HNE, Biomarkers, and LPO—with Matt Quinn and Dr. Brian Kerley
Introduction We look at a paper about the process of how the fats in seed oils become toxic, and what effects those toxins can have. This paper is a broad overview of the related disease processes, which we will discuss to further understand how one thing can be driving many different disease processes. “The study of lipid peroxidation (LPO) processes has become a rapidly growing field in medicine and biology, based on increasing evidence that LPO is involved in the development of many chronic diseases, e.g. [references removed] (1) Asthma (2) Atherosclerosis (3) Alzheimer’s disease (4) Rheumatoid arthritis (5) Burn injury (6) Cataractogenesis (7) Diabetes (8) Endotoxin liver injury (9) Multiple sclerosis (10)Myocardial infarction (11)Organ transplantation (12)Parkinson disease (13)Psoriasis (14)Reperfusion injury (15)Stroke (16)Aging “The obvious involvement of LPO processes in the majority of severe diseases stimulated worldwide efforts to elucidate the mechanisms of their generation. “These efforts are expressed in the exploding flood of papers, conference reports, review articles (see above) and books dealing with LPO. This paper is, therefore, not intended to add to these reviews but rather to address aspects previously overlooked: the dominant role of linoleic acid (LA) in LPO and the application of a combination of modern separation and identification techniques to isolate LPO products. Knowledge of these products provides insight into the mechanisms of their generation and offers a better understanding of the diseases in which LPO is involved.” (Spiteller 1998) Guest info Matt Quinn Biography: TL;DR Here's what I am working on: I run Rebel - a fund that buys distressed SAAS and turns it around - if you want to support share our apps here I'm in the very early stages of building/buying a regenerative farm. Our food system is beyond broken. Our healthcare system doesn't heal people. If you're interested in the thoughts behind this read this I've built companies, bought companies and burned companies - if you're looking for pro bono advice or mentoring - tweet/DM me here In my day job I run a product consulting team at Tanzu Labs - if you have deep pockets and need a team to teach you how to build great software that users love - connect with me here I have failed at so so so many things - read about them here _______________________________________ Co-host Dr. Brian Kerley Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! Tucker Goodrich Substack: Twitter: Youtube: Apple podcast: Spotify podcast: Podcast: Blog (deprecated, but still a lot there!): _______________________________________ Show Notes Episode 14 Post Script: Matt Has a Surprising Easter Egg Spiteller, G. (1998). Linoleic Acid Peroxidation—The Dominant Lipid Peroxidation Process in Low Density Lipoprotein—And Its Relationship to Chronic Diseases. Chemistry and Physics of Lipids, 95(2), 105–162. If you have any questions about sources for things discussed please ask in the comments.
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Ep. 15: A.J. Hulbert on the Omega Balance—with Dr. Brian Kerley
02/22/2024
Ep. 15: A.J. Hulbert on the Omega Balance—with Dr. Brian Kerley
Introduction We are honorored to be joined by Prof. A. J. Hulbert, noted zoologist and author of Omega Balance: Nutritional Power for a Happier, Healthier Life. “In Omega Balance, noted scientist Anthony J. Hulbert explains how the balance between [Omega-3 and omega-6 fatty acids] in the human food chain has changed over the last half-century and the very serious negative health impacts this imbalance has created. An imbalance of these omega fats contributes to increased rates of obesity, diabetes, cardiovascular diseases, allergies, asthma, as well as cancer and a variety of other inflammatory diseases. Omega balance is also important for normal brain function, and an imbalance in these fatty acids is associated with depression, mood disorders, and neurodegenerative diseases. Hulbert provides extensive information on the omega balance of different foods and discusses fascinating details about human evolution, dietary changes throughout history, the effect of diet on human development and physiological processes, and more. He investigates the paleo diet of our ancestors and describes the dramatic changes that have accompanied the increased ultra-processing of modern foods. Omega Balance is an essential guide to understanding a significant problem in our modern food chain and will make us rethink the food we eat. Amazon link to benefit this podcast: This book won a “Best Book” award from the American Book Fest in the category “Health: Diet and Exercise”. Guest info I was introduced to Prof. Hulbert by Prof. Tom Brenna, our guest in Ep. 5: Prof. Tom Brenna, Omega-3 and Omega-6 in Human Health. Biography: “Anthony John Hulbert (UNSW, AUS), PhD, DSc, is an internationally renowned researcher on metabolism, longevity, and nutrition. He is emeritus professor in Science, Medicine, and Health at the University of Wollongong, Australia.” _______________________________________ Co-host Co-host Dr. Brian Kerley Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! Tucker Goodrich Substack: Twitter: Youtube: Apple podcast: Spotify podcast: Podcast: Blog (deprecated, but still a lot there!): _______________________________________ Show Notes In order of discussion. Borchman, D., Stimmelmayr, R., & George, J. C. (2017). Whales, Lifespan, Phospholipids, and Cataracts. Journal of Lipid Research, 58(12), 2289–2298. Hulbert, A. J., & Else, P. L. (1999). Membranes as Possible Pacemakers of Metabolism. Journal of Theoretical Biology, 199(3), 257–274. Abbott, S. K., Else, P. L., Atkins, T. A., & Hulbert, A. J. (2012). Fatty Acid Composition of Membrane Bilayers: Importance of Diet Polyunsaturated Fat Balance. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1818(5), 1309–1317. McCollum, E. V. (1919). The Newer Knowledge of Nutrition. Macmillan Company. Speakman, J. R., De Jong, J. M. A., Sinha, S., Westerterp, K. R., Yamada, Y., Sagayama, H., Ainslie, P. N., Anderson, L. J., Arab, L., Bedu-Addo, K., Blanc, S., Bonomi, A. G., Bovet, P., Brage, S., Buchowski, M. S., Butte, N. F., Camps, S. G. J. A., Cooper, J. A., Cooper, R., … Wong, W. W. (2023). Total Daily Energy Expenditure Has Declined Over the Past Three Decades Due to Declining Basal Expenditure, Not Reduced Activity Expenditure. Nature Metabolism, 5(4), 579–588. Allport, S. (2010, November). One Person’s Response to a High Omega-6 Diet [Magazine]. American Oil Chemists’ Society. If you have any questions about sources for things discussed please ask in the comments.
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Ep. 14: How a Common Asian Genetic Mutation Leads to Chronic Disease, and What to Do—with Matt Quinn and Dr. Brian Kerley
02/12/2024
Ep. 14: How a Common Asian Genetic Mutation Leads to Chronic Disease, and What to Do—with Matt Quinn and Dr. Brian Kerley
Introduction We look at a paper enlightening what causes chronic disease, in the context of a huge population of people who suffer from the most common human mutation, to the aldehyde dehydrogenase enzyme that detoxifies both alcohol and seed oil metabolites, the ALDH2*2 mutation. We discuss how this mutation is thought to affect the people who have it through the lens of the paper at hand. This was a difficult video for me to edit, as both Matt and Brian share their experiences with the topic we are discussing in their own families. I thought this was excellent, and hope many others can learn from it. Here’s this paper: “A Common East Asian-Specific ALDH2 Mutation Causes Obesity and Insulin Resistance: Therapeutic Effect of Reducing Toxic Aldehydes by ALDH2 Activation” Preprint: Chang, Y.-C., Lee, H.-L., Yang, W., Hsieh, M.-L., Liu, C.-C., Lee, T.-Y., Huang, J.-Y., Nong, J.-Y., Li, F.-A., Chuang, H.-L., Ding, Z.-Z., Su, W.-L., Chueh, L.-Y., Tsai, Y.-T., Chen, C.-H., Mochly-Rosen, D., & Chuang, L.-M. (2020). A Common East Asian-Specific ALDH2 Mutation Causes Obesity and Insulin Resistance: Therapeutic Effect of Reducing Toxic Aldehydes by ALDH2 Activation. Published: Chang, Y.-C., Lee, H.-L., Yang, W., Hsieh, M.-L., Liu, C.-C., Lee, T.-Y., Huang, J.-Y., Nong, J.-Y., Li, F.-A., Chuang, H.-L., Ding, Z.-Z., Su, W.-L., Chueh, L.-Y., Tsai, Y.-T., Chen, C.-H., Mochly-Rosen, D., & Chuang, L.-M. (2023). A Common East-Asian ALDH2 Mutation Causes Metabolic Disorders and the Therapeutic Effect of ALDH2 Activators. Nature Communications, 14(1), Article 1. Guest info Matt Quinn Biography: TL;DR Here's what I am working on: I run Rebel - a fund that buys distressed SAAS and turns it around - if you want to support share our apps here I'm in the very early stages of building/buying a regenerative farm. Our food system is beyond broken. Our healthcare system doesn't heal people. If you're interested in the thoughts behind this read this I've built companies, bought companies and burned companies - if you're looking for pro bono advice or mentoring - tweet/DM me here In my day job I run a product consulting team at Tanzu Labs - if you have deep pockets and need a team to teach you how to build great software that users love - connect with me here I have failed at so so so many things - read about them here https://www.mquinn.online/ _______________________________________ Co-host Dr. Brian Kerley https://www.seedoilrebellion.com/ https://twitter.com/SeedOilDsrspctr Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! Tucker Goodrich Substack: Twitter: Youtube: Apple podcast: Spotify podcast: Podcast: Blog (deprecated, but still a lot there!): _______________________________________ Show Notes Previous paper: Ghosh, S., Qi, D., An, D., Pulinilkunnil, T., Abrahani, A., Kuo, K.-H., Wambolt, R. B., Allard, M., Innis, S. M., & Rodrigues, B. (2004). Brief Episode of STZ-Induced Hyperglycemia Produces Cardiac Abnormalities in Rats Fed a Diet Rich in N-6 Pufa. American Journal of Physiology. Heart and Circulatory Physiology, 287(6), H2518-2527. Discussed in this episode: Ep. 12 Study: What's Worse—Carbs or Seed Oils? Understanding a High-PUFA Diet—with Dr. Brian Kerley and Matt Quinn HNE/4-HNE in Wikipedia Gomes, K. M. S., Campos, J. C., Bechara, L. R. G., Queliconi, B., Lima, V. M., Disatnik, M.-H., Magno, P., Chen, C.-H., Brum, P. C., Kowaltowski, A. J., Mochly-Rosen, D., & Ferreira, J. C. B. (2014). Aldehyde Dehydrogenase 2 Activation in Heart Failure Restores Mitochondrial Function and Improves Ventricular Function and Remodelling. Cardiovascular Research, 103(4), 498–508. If you have any questions about sources for things discussed please ask in the comments.
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Ep. 13: Chef Andrew Gruel: Learning to Cook Again—with Dr. Brian Kerley
02/01/2024
Ep. 13: Chef Andrew Gruel: Learning to Cook Again—with Dr. Brian Kerley
Introduction Brian and I are honored to be joined by the illustrious Chef Andrew Gruel. He tells us the story of how he got into cooking, how he had to learn to cook again after discovering that his academic chef training left out natural fats, and the impact using proper fats has had on his health, the health of his staff, and his customers in his latest restaurant venture. We also have an extensive and very interesting discussion on fish, fish farming, and the health benefits of eating fish. Guest info Web: (It throws a security error…) X: Substack: “The Food Porn Master”! Instagram: Calico Fish House: Biography: “Andrew Gruel, a graduate of Johnson & Wales University, is a food entrepreneur and television personality – he is the Founder of Slapfish Restaurant Group (27 locations), the award-winning food truck turned international brick and mortar, based out of Huntington Beach, CA and currently CEO and founder of American Gravy Restaurant Group which comprises Calico Fishhouse, Big Parm Pizza, Two Birds Chicken, Butterleaf, Lolo’s Tacos and 101 Burger. “Andrew has appeared on multiple television series including his most recent role as a judge on Food Network’s “Chopped Junior” with Megan Markle. He was the Host of FYI Series “Say It To My Face”, as well as a judge on Food Network’s “Food Truck Face Off.” He has made appearances on the TODAY show, Fox News, CNN, NBC Nightly News, PBS, Cooking Channel, and has been featured in numerous publications including The Wall Street Journal, Forbes, Men’s Health, Food & Wine magazine, USA Today, Entrepreneur and Nation’s Restaurant News. He was named Top 25 Business Executives for Fast Casual magazine as well as featured in Nation’s Restaurant News’ 2017 Power List. In 2013 he was named top 40 under 40 entrepreneurs in Orange County. He and his wife Lauren Gruel were named Pandemic Heroes by Restaurant Business Magazine alongside Guy Fieri and Jose Andres. He is currently the Co-Host of The SoCal Restaurant Show on AM 830 and a regular contributor on various national news channels.” _______________________________________ Co-host Dr. Brian Kerley https://www.seedoilrebellion.com/ https://twitter.com/SeedOilDsrspctr Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! Tucker Goodrich Substack: Twitter: Youtube: Apple podcast: Spotify podcast: Podcast: Blog (deprecated, but still a lot there!): _______________________________________ Show Notes Slapfish: Nina Planck, “Real Food” Callico Fish House Restaurant: Tom Brenna ep. 5: Cargill & McDonalds: “Removing Trans Fats from McDonald’s® Famous Fries” “Podcast Ep. 0: What VICE Left Out: Bitcoin and Seed Oils—Starting a Podcast” If you have any questions about sources for things discussed please ask in the comments.
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Ep. 12: Study: What's Worse—Carbs or Seed Oils? Understanding a High-PUFA Diet—with Dr. Brian Kerley and Matt Quinn
01/25/2024
Ep. 12: Study: What's Worse—Carbs or Seed Oils? Understanding a High-PUFA Diet—with Dr. Brian Kerley and Matt Quinn
Introduction We’re trying something a bit different today. Dr. Brian Kerley and I have found a victim, Matt Quinn. Matt’s a smart guy but he’s not as immersed in these topics as we are, and so he’s going to play our straight man, the every-day guy who can hopefully come to easily-digested conclusions about the papers we discuss. In our inaugural episode we discuss “Brief Episode of STZ-Induced Hyperglycemia Produces Cardiac Abnormalities in Rats Fed a Diet Rich in N-6 PUFA”. Ghosh, S., Qi, D., An, D., Pulinilkunnil, T., Abrahani, A., Kuo, K.-H., Wambolt, R. B., Allard, M., Innis, S. M., & Rodrigues, B. (2004). Brief Episode of STZ-Induced Hyperglycemia Produces Cardiac Abnormalities in Rats Fed a Diet Rich in N-6 Pufa. American Journal of Physiology. Heart and Circulatory Physiology, 287(6), H2518-2527. https://doi.org/10.1152/ajpheart.00480.2004 Guest info Matt Quinn Biography: TL;DR Here's what I am working on: I run Rebel - a fund that buys distressed SAAS and turns it around - if you want to support share our apps here I'm in the very early stages of building/buying a regenerative farm. Our food system is beyond broken. Our healthcare system doesn't heal people. If you're interested in the thoughts behind this read this I've built companies, bought companies and burned companies - if you're looking for pro bono advice or mentoring - tweet/DM me here In my day job I run a product consulting team at Tanzu Labs - if you have deep pockets and need a team to teach you how to build great software that users love - connect with me here I have failed at so so so many things - read about them here https://www.mquinn.online/ _______________________________________ Co-host Dr. Brian Kerley https://www.seedoilrebellion.com/ https://twitter.com/SeedOilDsrspctr Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! Tucker Goodrich Substack: Twitter: Youtube: Apple podcast: Spotify podcast: Podcast: Blog (deprecated, but still a lot there!): _______________________________________ Show Notes Ghosh, S., Qi, D., An, D., Pulinilkunnil, T., Abrahani, A., Kuo, K.-H., Wambolt, R. B., Allard, M., Innis, S. M., & Rodrigues, B. (2004). Brief Episode of STZ-Induced Hyperglycemia Produces Cardiac Abnormalities in Rats Fed a Diet Rich in N-6 Pufa. American Journal of Physiology. Heart and Circulatory Physiology, 287(6), H2518-2527. https://doi.org/10.1152/ajpheart.00480.2004 I discussed this in a blog post. I won’t be doing this for most of the studies we discuss, but I figured it was handy to start with one where I had already done some work! What's Worse—Carbs or Seed Oils? Understanding a High-PUFA Diet. tl;dr: The one study I'm aware of that shows conclusively that excess glucose acts as an accelerant for excess omega-6 fat, but it not nearly so harmful without the omega-6, in vivo. https://tuckergoodrich.substack.com/p/whats-worsecarbs-or-seed-oils-understanding If you have any questions about sources for things discussed please ask in the comments.
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Ep. 11: Paul Saladino, MD: The Intellectual Journey of a Physician—with Dr. Joshua Durham
01/22/2024
Ep. 11: Paul Saladino, MD: The Intellectual Journey of a Physician—with Dr. Joshua Durham
We interview Paul Saladino MD about his intellectual journey from being a raw vegan with rotting teeth as a physician’s assistant, through becoming the “Carnivore MD”, to where he is today. We discuss the training a physician receives in medical school about nutrition, and how he filled that gap with his own experience and research. And how it impacted his health and his ideas about being a physician. Josh Durham, my personal physician, joins me as co-host today to recount his personal health journey as well and how it changed his practice. (He recently quit his job at a large hospital to go independent!) Paul Saladino, MD: Dr. Saladino’s "The Carnivore Code" book: Biography of Paul Saladino: I’m a double board certified MD, host of the Fundamental Health podcast, and author of The Carnivore Code and The Carnivore Code Cookbook. I believe in questioning our assumptions about health and nutrition, which makes me controversial in modern medicine. I'm much more interested in optimal health than in dogmatic adherence to a mainstream narrative. I graduated from medical school at the University of Arizona in Tucson, and completed my residency at the University of Washington in Seattle. After residency, I attained a board certification as a Physician Nutrition Specialist. Throughout my medical training, I came to one very saddening conclusion: our Western medical system isn’t helping people lead richer lives. Western medicine fails to treat the root cause of chronic illness, and doctors are only taught to treat symptoms with medications, rather than trying to understand the roots of illness. I firmly believe that nutritional choices lie at the ROOT of so many chronic illnesses that western medicine deems irreversible. And I also believe that most chronic illnesses are preventable AND reversible. _______________________________________ Co-host Joshua Durham, DO: Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! Tucker Goodrich Substack: Twitter: Youtube: Apple podcast: Spotify podcast: Podcast: Blog (deprecated, but still a lot there!): _______________________________________ Show Notes Jordan Petersen on Joe Rogan discussing carnivore diet: https://www.youtube.com/watch?v=HLF29w6YqXs Farley Mowat "People of the Deer" book: https://amzn.to/3Uc42bh Amgen: "8 Things to Know About Lipoprotein(a)" https://www.amgen.com/stories/2023/02/8-things-to-know-about-lipoproteina "AMGEN ANNOUNCES POSITIVE TOPLINE PHASE 2 DATA FOR INVESTIGATIONAL OLPASIRAN IN ADULTS WITH ELEVATED LIPOPROTEIN(a)": https://www.amgen.com/newsroom/press-releases/2022/05/amgen-announces-positive-topline-phase-2-data-for-investigational-olpasiran-in-adults-with-elevated-lipoproteina "Seed oils are BS" t-shirt: If you have any questions about sources for things discussed please ask in the comments.
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Ep. 10: Dalton Graham: How to Induce Fatty Liver—with Dr. Brian Kerley
10/26/2023
Ep. 10: Dalton Graham: How to Induce Fatty Liver—with Dr. Brian Kerley
Dr. Kerley and I are joined by Dalton Graham, a student who found himself in a liver pathology lab at Tulane. He had the interesting idea to test if a high-linoleic acid diet could be shown to produce fatty liver disease at the same time it was causing obesity. The scientists in the lab required a little convincing that this was a worthy experiment, but one day he arrived to find all the materials he need waiting for him. Be careful what you wish for! Find out how it turned out. Graham, D. S., Liu, G., Arasteh, A., Yin, X.-M., & Yan, S. (2023). Ability of High Fat Diet to Induce Liver Pathology Correlates with the Level of Linoleic Acid and Vitamin E in the Diet. PLOS ONE, 18(6), e0286726. https://doi.org/10.1371/journal.pone.0286726 Biography: • Dalton is currently a PhD student at University of Florida, studying Biochemistry with a focus on metabolism. When he wrote the paper we are discussing, he was an undergrad, and then grad student at Tulane University, studying Biochemical Engineering and Pathology. _______________________________________ Co-host Dr. Brian Kerley https://www.seedoilrebellion.com/ https://twitter.com/SeedOilDsrspctr Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! https://www.seedyapp.com/ Tucker Goodrich Substack: https://tuckergoodrich.substack.com/ Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com/ Youtube: https://www.youtube.com/channel/UCDpWmYeRapRkrZ9zw8M7iFg Apple podcast: https://podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825 Podcast: https://sites.libsyn.com/408758 Twitter: https://twitter.com/TuckerGoodrich _______________________________________ Show Notes “Alvheim papers out of the NIH” Alvheim, A. R., Malde, M. K., Osei‐Hyiaman, D., Hong, Y. H., Pawlosky, R. J., Madsen, L., Kristiansen, K., Frøyland, L., & Hibbeln, J. R. (2012). Dietary Linoleic Acid Elevates Endogenous 2-AG and Anandamide and Induces Obesity. Obesity, 20(10), 1984–1994. https://doi.org/10.1038/oby.2012.38 Alvheim, A. R. (2012). Dietary linoleic acid induces obesity through excessive endocannabinoid activity [Doctor of Philosophy, The University of Bergen]. https://bora.uib.no/bora-xmlui/handle/1956/5962 NAFLD discovered in 1980: Ludwig, J., Viggiano, T. R., McGill, D. B., & Oh, B. J. (1980). Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clinic Proceedings, 55(7), 434–438. Liver transplants and NAFLD: Lindenmeyer, C. C., & McCullough, A. J. (2018). The Natural History of Nonalcoholic Fatty Liver Disease—An Evolving View. Clinics in Liver Disease, 22(1), 11. https://doi.org/10.1016/j.cld.2017.08.003 Linoleic acid and breast milk: Goodrich, T. D. (2022, September 1). Podcast Ep. 5: Prof. Tom Brenna on Omega-3 and Omega-6 in Human Health—with Dr Brian Kerley [Blog]. Yelling Stop. http://yelling-stop.blogspot.com/2022/09/podcast-ep-5-prof-tom-brenna-on-omega-3.html Gornoski, D. (2021, June 15). Bruce German on How Human Milk Does the Body Good (Jun 15 2021) [Mp3]. https://podcastaddict.com/episode/124448388 Speakman paper on lethargy: Speakman, J. R., De Jong, J. M. A., Sinha, S., Westerterp, K. R., Yamada, Y., Sagayama, H., Ainslie, P. N., Anderson, L. J., Arab, L., Bedu-Addo, K., Blanc, S., Bonomi, A. G., Bovet, P., Brage, S., Buchowski, M. S., Butte, N. F., Camps, S. G. J. A., Cooper, J. A., Cooper, R., … Wong, W. W. (2023). Total Daily Energy Expenditure Has Declined Over the Past Three Decades Due to Declining Basal Expenditure, Not Reduced Activity Expenditure. Nature Metabolism, 5(4), 579–588. https://doi.org/10.1038/s42255-023-00782-2 Vitamin E: Masterjohn, C. (2017, June 24). 032: Is Coconut Oil Killing Us? [Substack newsletter]. Harnessing the Power of Nutrients. https://chrismasterjohnphd.substack.com/p/041-is-coconut-oil-killing-us Raghavamenon, A., Garelnabi, M., Babu, S., Aldrich, A., Litvinov, D., & Parthasarathy, S. (2009). α-Tocopherol Is Ineffective in Preventing the Decomposition of Preformed Lipid Peroxides and May Promote the Accumulation of Toxic Aldehydes: A Potential Explanation for the Failure of Antioxidants to Affect Human Atherosclerosis. Antioxidants & Redox Signaling, 11(6), 1237–1248. https://doi.org/10.1089/ars.2008.2248 NAFLD and Fructose: Vos, M. B., Weber, M. B., Welsh, J., Khatoon, F., Jones, D. P., Whitington, P. F., & McClain, C. J. (2009). Fructose and Oxidized LDL in Pediatric Nonalcoholic Fatty Liver Disease: A Pilot Study. Archives of Pediatrics & Adolescent Medicine, 163(7), 674–675. https://doi.org/10.1001/archpediatrics.2009.93 Cardiolipin: Goodrich, T. (2016, February 5). The Cause of Metabolic Syndrome: Excess Omega-6 Fats (Linoleic Acid) in Your Mitochondria. Yelling Stop. http://yelling-stop.blogspot.com/2016/02/the-cause-of-metabolic-syndrome-excess.html Quotable: “I made a presentation about the role of excess linoleic acid in liver diseases. …I sat down and I pitched it… to the individuals in that lab. At first they didn’t really get it… I remember when I first finished laying out the mechanisms and why this is needed. Typically at the end of a presentation there are a bunch of questions, and there was just… silence. “They’d never been presented with this idea that lipid peroxidation (or oxidative stress) manifests itself mainly due to this dietary factor—that no one seems to realize because it’s so ubiquitous.” “These animals that are eating the higher linoleic acid they appear physical slower.” “The females that were fed the high linoleic acid, they actually lost a lot of their fur [while under stress]. We couldn’t continue the experiment with them.” “I don’t think they understood the importance of [linoleic acid] in the real world.”
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Ep 9: Dave Feldman, Citizen Scientist—What Causes Heart Disease
10/16/2023
Ep 9: Dave Feldman, Citizen Scientist—What Causes Heart Disease
Dave Feldman and I discuss the what causes heart disease, specifically focusing on the consensus view and how it differs from what the science actually shows. Youtube: Rumble: X: Podcast: Topics: Basic theory of CVD causation: · High ApoB/LDL/Cholesterol · Gradient causes penetration of arterial wall · Cholesterol/lipid oxidation in wall · Progression through stages of atherosclerosis · Blockage/rupture of plaque · Ischemia of blood to heart · Death/morbidity via MI Electro-negative LDL Aggregated LDL TG-rich Lipoproteins Risk and factor models FH mortality—implications for causality ApoB48 Albumin Vasa vasorum 'Atherosclerosis' in veins _______________________________________ Dave Feldman Biography: “I’m a senior software engineer and entrepreneur. “I began a Low Carb, High Fat diet in April 2015 and have since learned everything I could about it with special emphasis on cholesterol given my lipid numbers spiked substantially after going on the diet. As an engineer, I spotted a pattern in the lipid system that’s very similar to distributed objects in networks. “I’ve since learned quite a bit on the subject both through research and experimentation which has revealed some very powerful data. With this new general theory, I’ve shifted around my cholesterol substantially without any drugs or special supplements of any kind. From: https://cholesterolcode.com/about/ Blog: https://cholesterolcode.com/ Twitter: https://twitter.com/realDaveFeldman Citizen Science Foundation: Site: Twitter: DONATE: https://citizensciencefoundation.org/donate/ Own Your Labs: Tucker Goodrich Blog: http://yelling-stop.blogspot.com/ Youtube: https://www.youtube.com/channel/UCDpWmYeRapRkrZ9zw8M7iFg Podcast: https://sites.libsyn.com/408758 Twitter: Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! https://www.seedyapp.com/ _______________________________________ Show Notes Notes See the canine LMHR study: Kronfeld, D. S., Hammel, E. P., Ramberg, C. F., & Dunlap, H. L. (1977). Hematological and metabolic responses to training in racing sled dogs fed diets containing medium, low, or zero carbohydrate. The American Journal of Clinical Nutrition, 30(3), 419–430. https://doi.org/10.1093/ajcn/30.3.419 Lipid-Energy Model Norwitz, N. G., Feldman, D., Soto-Mota, A., Kalayjian, T., & Ludwig, D. S. (2022). Elevated LDL Cholesterol with a Carbohydrate-Restricted Diet: Evidence for a “Lean Mass Hyper-Responder” Phenotype. Current Developments in Nutrition, 6(1), nzab144. https://doi.org/10.1093/cdn/nzab144 Norwitz, N. G., Soto-Mota, A., Kaplan, B., Ludwig, D. S., Budoff, M., Kontush, A., & Feldman, D. (2022). The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets. Metabolites, 12(5), Article 5. https://doi.org/10.3390/metabo12050460 PubMed for Dave's other papers: https://pubmed.ncbi.nlm.nih.gov/?term=norwitz+feldman&sort=pubdate Thoracic duct image: Rosenblum, H., Kapur, N. K., Abraham, W. T., Udelson, J., Itkin, M., Uriel, N., Voors, A. A., & Burkhoff, D. (2020). Conceptual Considerations for Device-Based Therapy in Acute Decompensated Heart Failure: DRI 2 P 2 S. Circulation: Heart Failure, 13(4), e006731. https://doi.org/10.1161/CIRCHEARTFAILURE.119.006731 Lipoprotein lipase effect on heart: Khan, R. S., Lin, Y., Hu, Y., Son, N.-H., Bharadwaj, K. G., Palacios, C., Chokshi, A., Ji, R., Yu, S., Homma, S., Schulze, P. C., Tian, R., & Goldberg, I. J. (2013). Rescue of Heart Lipoprotein Lipase-Knockout Mice Confirms a Role for Triglyceride in Optimal Heart Metabolism and Function. American Journal of Physiology-Endocrinology and Metabolism, 305(11), E1339–E1347. https://doi.org/10.1152/ajpendo.00349.2013 EAS Consensus: Ference, B. A. et. al. (2017). Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel. European Heart Journal, 38(32), 2459–2472. https://doi.org/10.1093/eurheartj/ehx144 Borén, J. et. al. (2020). Low-density lipoproteins cause atherosclerotic cardiovascular disease: Pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel. European Heart Journal, 41(24), 2313–2330. https://doi.org/10.1093/eurheartj/ehz962 FH epidemiology: Sijbrands, E. J. G. et. al. (2001). Mortality over two centuries in large pedigree with familial hypercholesterolaemia: Family tree mortality study. BMJ, 322(7293), 1019–1023. https://doi.org/10.1136/bmj.322.7293.1019 Is CVD Genetic? Lee, K. T., Nail, R., Sherman, L. A., Milano, M., Lee, K. T., Deden, C., Imai, H., Goodale, F., Nam, S. C., Lee, K. T., Goodale, F., Scott, R. F., Snell, E. S., Lee, K. T., Daoud, A. S., Jarmolych, J., Jakovic, L., & Florentin, R. (1964). Geographic Pathology of Myocardial Infarction: Part I. Myocardial infarction in orientals and whites in the United States; Part II. Myocardial infarction in orientals in Korea and Japan; Part III. Myocardial infarction in Africans in Africa and negroes and whites in the United States; Part IV. Measurement of amount of coronary arteriosclerosis in Africans, Koreans, Japanese and New Yorkers. The American Journal of Cardiology, 13(1), 30–40. https://doi.org/10.1016/0002-9149(64)90219-X Presentation on Rancidity in Seed Oils AOCS American Oil Chemists’ Society (Director). (2021, April 1). Why Does Lipid Oxidation in Foods Continue to be Such a Challenge? [Mp4]. https://www.youtube.com/watch?v=B_U_9vvpDWo Mercodia OxLDL Assay Feldman, D. (2019, May 11). The Oxidized LDL Experiment [Informational]. Cholesterol Code. https://cholesterolcode.com/the-oxidized-ldl-experiment/ OxPL/ApoB test: "Oxidized Phospholipids on apoB (OxPL-apoB)" https://bostonheartdiagnostics.com/test/oxpl-apob-c-2/ Q's from X ( ): 1. Eric Rodgers @LowCarbEyeDoc ApoB48 2. Shashi Iyengar | Accredited Metabolic Health Coach @shashiiyengar Touch up on palm oil Unprocessed and Refined deodorized one.. 3. The Real Dr. Steven Horvitz @IMWHorvitz The difference between natural omega6 fats vs industrial processed omega6 fats. 4. MEATrition.com 🥩 @MEATritionCom How does adipose %LA track with blood lipids? 5. MEATrition.com 🥩 @MEATritionCom Specific ownyourlabs values to check for before and after removing seed oils from diet. What’s hypothesis? 6. TheFa(c)tHunter @DimitriRadoux This might be an interesting one, the relationship of RDW and polyunsaturated fats 😉 7. joe @vintage_worlds A few words on the ideal level of Linoleic acid as measured in rbc? Anyone set out to avoid seed oil while measuring their linoleic acid levels who have shown dramatic reductions by avoiding? 8. Michael J @astro_toaster Fish oil and effects of supplementation on cholesterol? Supplements vs eating actual fish? 🤔 9. Luigi @Bac2us Insulin resistance / consequences
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Ep 8: Paul Hart—In the Belly of the Beast: Life in a Processed Food Company
06/29/2023
Ep 8: Paul Hart—In the Belly of the Beast: Life in a Processed Food Company
Discussion with Paul Hart, formerly of Unilever and currently a consultant to the processed food industry, on the pros and cons are of processed foods, and what the food industry is hoping to accomplish.
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Ep. 7: Drs. Tro Kalayjian, Brian Lenzkes, Joshua Durham—How to Save Medicine, One Practice at a Time
06/15/2023
Ep. 7: Drs. Tro Kalayjian, Brian Lenzkes, Joshua Durham—How to Save Medicine, One Practice at a Time
Medicine needs to be fixed: “The New Crisis of Increasing All-Cause Mortality in US Children and Adolescents” · Dr. Tro Kalayjian Dr. Tro’s Medical Weight Loss · Research: · Twitter: · Dr. Brian Lenzkes Metabolic Health: · San Diego: · Arizona: Twitter: · Dr. Joshua Durham Twitter: · Dr. Eric Westman · New Atkins for a New You: The Ultimate Diet for Shedding Weight and Feeling Great by Eric C. Westman, Stephen D. Phinney, Jeff S. Volek · (this link benefits the podcast!) Philip Ovadia · Alessio Fassano · Research: · Whole30 · Virta · Dr. Tro app · Lenzkes & Kalayjian’s podcast: Low-Carb MD Podcast · _______________________________________ Co-host Dr. Brian Kerley Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! Tucker Goodrich Blog: Youtube: Podcast: Twitter: _______________________________________
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Ep. 6: Dr. Joshua Durham; Family Doc Gets Red-pilled by Seed Oils—with Dr. Brian Kerley
09/08/2022
Ep. 6: Dr. Joshua Durham; Family Doc Gets Red-pilled by Seed Oils—with Dr. Brian Kerley
Dr. Durham is a Family Physician in Boise, Idaho; and is Tucker's doctor. We discuss how his practice has changed since he figured out how to solve his own chronic health problems, how this has changed his practice, some successes, and more. Joshua Durham, DO • https://www.saintalphonsus.org/provider/joshua-durham Blog comment: Dr. Durham: “If you need a family Dr. here in Boise hit me up. I went from 235lbs to keto to carnivore and then finally came across your info. Now at 195 I feel comfortable knowing what I can and can't have and why I was so sick. Felt great on carnivore but can't live that way forever. Thank you for your work.” • http://yelling-stop.blogspot.com/2021/04/experts-do-as-we-say-not-as-we-do.html?showComment=1620609617154#c416429453974276542 “Doctor of Osteopathy vs. Medical Doctor- What are the Differences?” • https://hecec.human.cornell.edu/2016/02/12/doctor-of-osteopathy-vs-medical-doctor-what-are-the-differences/ Dr. Eric Westman • https://ericwestmanmd.com/ New Atkins for a New You: The Ultimate Diet for Shedding Weight and Feeling Great by Eric C. Westman, Stephen D. Phinney, Jeff S. Volek • https://amzn.to/3qd9fzy (this link benefits the podcast!) Dr. Durham: “Good fat/bad fat” I wrote a post about this: “Good Keto vs. Bad Keto” • http://yelling-stop.blogspot.com/2021/09/good-keto-vs-bad-keto.html Dr. Durham: “Then I saw your interview with Paul Saladino…” • “How Seed Oils Destroy Your Mitochondria and Lead To Chronic Disease, with Tucker Goodrich” https://carnivoremd.com/how-seed-oils-destroy-your-mitochondria-and-lead-to-chronic-disease-with-tucker-goodrich/ “…and then I watched Brad Marshall…” • Brad’s blog is here: https://fireinabottle.net/ Drs. Kerley and Durham compare “elevator pitches” to patients. Dr. Durham: “I needed 4 pills based on the guidelines, and I was 38 years old.” Tucker: “Lean-Mass Hyper Responder”: Norwitz, N. G., Soto-Mota, A., Kaplan, B., Ludwig, D. S., Budoff, M., Kontush, A., & Feldman, D. (2022). The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets. Metabolites, 12(5), 460. https://doi.org/10.3390/metabo12050460 Dr. Durham: 40:02 “American College of Cardiology article…” Astrup, A., Magkos, F., Bier, D. M., Brenna, J. T., de Oliveira Otto, M. C., Hill, J. O., King, J. C., Mente, A., Ordovas, J. M., Volek, J. S., Yusuf, S., & Krauss, R. M. (2020). Saturated Fats and Health: A Reassessment and Proposal for Food-based Recommendations: JACC State-of -the-Art Review. Journal of the American College of Cardiology, 76(7), 844–857. https://doi.org/10.1016/j.jacc.2020.05.077 See Episode 5, in which we interview Tom Brenna, one of the co-authors of that article: https://www.youtube.com/watch?v=rrQ8q_ctGUQ Tucker: “The AGEs, same thing—Chris Masterjohn did a great post years ago looking into it: Masterjohn, C. (2011, October 7). Where Do Most AGEs Come From? O Glycation, How Thy Name Hast Deceived Me! | [Blog]. Chris Masterjohn, PhD. https://chrismasterjohnphd.com/blog/2011/10/07/where-do-most-ages-come-from-o Tucker: “Polyunsaturated fats are about 10x as effective in producing advanced glycation end products [than glucose]…” Fu, M.-X., Requena, J. R., Jenkins, A. J., Lyons, T. J., Baynes, J. W., & Thorpe, S. R. (1996). The Advanced Glycation End Product, N-(Carboxymethyl)lysine, Is a Product of both Lipid Peroxidation and Glycoxidation Reactions. Journal of Biological Chemistry, 271(17), 9982–9986. https://doi.org/10.1074/jbc.271.17.9982 Tucker: Lp(a): • Hazard ratio 16.8: Tsimikas, S., Brilakis, E. S., Miller, E. R., McConnell, J. P., Lennon, R. J., Kornman, K. S., Witztum, J. L., & Berger, P. B. (2005). Oxidized Phospholipids, Lp(a) Lipoprotein, and Coronary Artery Disease. New England Journal of Medicine, 353(1), 46–57. https://doi.org/10.1056/NEJMoa043175 • Hazard ratio 1 in Africa: Paré, G., Çaku, A., McQueen, M., Anand, S. S., Enas, E., Clarke, R., Boffa, M. B., Koschinsky, M., Wang, X., Yusuf, S., & null, null. (2019). Lipoprotein(a) Levels and the Risk of Myocardial Infarction Among 7 Ethnic Groups. Circulation, 139(12), 1472–1482. https://doi.org/10.1161/CIRCULATIONAHA.118.034311 • 2 sure-fire ways to raise Lp(a): 1. Statins: Yeang, C., Hung, M.-Y., Byun, Y.-S., Clopton, P., Yang, X., Witztum, J. L., & Tsimikas, S. (2016). Effect of therapeutic interventions on oxidized phospholipids on apolipoprotein B100 and lipoprotein(a). Journal of Clinical Lipidology, 10(3), 594–603. https://doi.org/10.1016/j.jacl.2016.01.005 2. Healthy diet: Navab Mohamad, Reddy Srinivasa T., Van Lenten Brian J., & Fogelman Alan M. (2004). Apparent Paradox of Low-Fat “Healthy” Diets Increasing Plasma Levels of Oxidized Low-Density Lipoprotein and Lipoprotein(a). Arteriosclerosis, Thrombosis, and Vascular Biology, 24(3), 392–393. https://doi.org/10.1161/01.ATV.0000118014.49565.fc • Pork and LDL: Stewart, J. W., Kaplan, M. L., & Beitz, D. C. (2001). Pork with a high content of polyunsaturated fatty acids lowers LDL cholesterol in women. The American Journal of Clinical Nutrition, 74(2), 179–187. https://doi.org/10.1093/ajcn/74.2.179 Treating Lp(a)/OxLDL with antibodies: https://www.oxitopepharma.com/approach Dr. Kerley: Robb Wolf interview: https://www.youtube.com/watch?v=Lku8kJdHOqY Wooden breast in chickens: Soglia, F., Mudalal, S., Babini, E., Di Nunzio, M., Mazzoni, M., Sirri, F., Cavani, C., & Petracci, M. (2016). Histology, composition, and quality traits of chicken Pectoralis major muscle affected by wooden breast abnormality. Poultry Science, 95(3), 651–659. https://doi.org/10.3382/ps/pev353 “Dr. Mark Cucuzzella – A Doctor’s Perspective On Treating Diabetes” https://robbwolf.com/2016/07/26/episode-329-dr-mark-cucuzzella-a-doctors-perspective-on-treating-diabetes/
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Ep. 5: Prof. Tom Brenna, Omega 3 and Omega 6 in Human Health—with Dr Brian Kerley
09/01/2022
Ep. 5: Prof. Tom Brenna, Omega 3 and Omega 6 in Human Health—with Dr Brian Kerley
Human results of a low-linoleic diet with adequate omega-3 on neurodevelopment. The WHO change their guidelines. How to protect against blindness. Why the Dietary Guidelines can’t get it right, and where they do. Fish vs fish oil for omega-3 DHA benefits. Fish consumption and mercury, is it a problem? Farmed vs. wild-caught fish. On the essentiality of linoleic acid. Linoleic acid impairs fertility Biography: ; “Tom Brenna is a professor of pediatrics at Dell Medical School. He moved to Austin after 28 years as a professor of human nutrition, chemistry, chemical biology and food science at Cornell University in Ithaca, New York. His group’s basic research into the chemical, biochemical, metabolic, genetic and ecological aspects of fatty acids have had a decisive influence on modern knowledge of these key nutrients. “Brenna’s research couples nutrition and chemistry in a broadly interdisciplinary program. His research group has been funded by institutes and centers at the National Institutes of Health (National Institute of General Medical Sciences, National Eye Institute, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Center for Complementary and Integrative Health) since 1992. Most of the work of the Brenna Lab is translational, tying basic research to biomedicine and human nutrition….” . _______________________________________ Co-host Dr. Brian Kerley Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! Tucker Goodrich Blog: Youtube: Podcast: Twitter: _______________________________________ Show Notes Nina Teicholz’ organization is . Q: “What are you working on right now? What the most recent and interesting thing that you have published?” RCT of low-linoleic therapeutic foods: Stephenson, K., Callaghan-Gillespie, M., Maleta, K., Nkhoma, M., George, M., Park, H. G., Lee, R., Humpheries-Cuff, I., Lacombe, R. J. S., Wegner, D. R., Canfield, R. L., Brenna, J. T., & Manary, M. J. (2021). Low linoleic acid foods with added DHA given to Malawian children with severe acute malnutrition improve cognition: A randomized, triple blinded, controlled clinical trial. The American Journal of Clinical Nutrition. Hsieh, J.-C., Liu, L., Zeilani, M., Ickes, S., Trehan, I., Maleta, K., Craig, C., Thakwalakwa, C., Singh, L., Brenna, J. T., & Manary, M. J. (2015). High-Oleic Ready-to-Use Therapeutic Food Maintains Docosahexaenoic Acid Status in Severe Malnutrition. Journal of Pediatric Gastroenterology and Nutrition, 61(1), 138–143. Codex Alimentarius: . “WHO summary on the available evidence for the essential fatty acid profiles in ready-to-use therapeutic foods for treating children with severe wasting” Saturated fat and cardiovascular disease: “”: * “Though no human randomized controlled trials on minimal omega-3 requirements in pregnancy and lactation have been conducted, the weight of animal evidence compellingly shows that randomizing pregnant or lactating humans to diets that include high linoleate oils as the sole source of fat would be frankly unethical because they would result in suboptimal child development.” Brenna, J. T. (2011). Animal studies of the functional consequences of suboptimal polyunsaturated fatty acid status during pregnancy, lactation and early post-natal life. Maternal & Child Nutrition, 7 Suppl 2, 59–79. “Put another way, only 2 ways are known to increase circulating DHA status in humans: 1) consume (preformed) DHA, or 2) lower dietary LA.” Kothapalli, K. S. D., Park, H. G., & Brenna, J. T. (2020). Polyunsaturated fatty acid biosynthesis pathway and genetics. Implications for interindividual variability in prothrombotic, inflammatory conditions such as COVID-19. Prostaglandins, Leukotrienes and Essential Fatty Acids, 162, 102183. “We generated a paper showing that that is the case, back in 2007 or 2009. I think it’s this, since the last sentence is “Present evidence indicates that n-3 LCPUFA status can be improved by increasing their intake or by decreasing LA intake, and a combination of the two is likely to be most effective.”: Brenna, J. T., Salem, N., Sinclair, A. J., & Cunnane, S. C. (2009). α-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans. Prostaglandins, Leukotrienes and Essential Fatty Acids, 80(2), 85–91. “That’s why the story of just having a ratio between omega-6 and omega-3 is just not a way to think about this as a general concept. If you increase [non-DHA] omega-3 you don’t get more DHA, but if you decrease omega-6 linoleic, you do get more. “Would you like an update on that? We found a third way…” Klatt, K. C., McDougall, M. Q., Malysheva, O. V., Taesuwan, S., Loinard-González, A. (Alex) P., Nevins, J. E. H., Beckman, K., Bhawal, R., Anderson, E., Zhang, S., Bender, E., Jackson, K. H., King, D. J., Dyer, R. A., Devapatla, S., Vidavalur, R., Brenna, J. T., & Caudill, M. A. (2022). Prenatal choline supplementation improves biomarkers of maternal docosahexaenoic acid status among pregnant participants consuming supplemental DHA: A randomized controlled trial. The American Journal of Clinical Nutrition. “we had done studies in the 1990s, and followed up after the turn of the millennium, that showed that just with oils you get a better targeting of DHA and another n-3 that’s important, arachidonic acid [AA, I think he is mis-speaking here, as AA is n-6, not n-3] to the brain if they come in as a phospholipid and not a tryglyceride. Cunnane, S. C. (2002). Arachidonate metabolism in neonates. Pediatric Research, 51(3), 263–264. Wijendran, V., Huang, M.-C., Diau, G.-Y., Boehm, G., Nathanielsz, P. W., & Brenna, J. T. (2002). Efficacy of dietary arachidonic acid provided as triglyceride or phospholipid as substrates for brain arachidonic acid accretion in baboon neonates. Pediatric Research, 51(3), 265–272. Zhang, Q., Wu, W. X., Nathanielsz, P. W., & Brenna, J. T. (1995). Distribution of arachidonic, eicosapentaenoic, docosahexaenoic and related fatty acids in ovine endometrial phospholipids in late gestation and labor. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 53(3), 201–209. 5 “This one is a much more technological. I will explain it, and I will also say that I have a bit of a business interest… in the company that’s doing this….” “DHA and all PUFAs are well known to be susceptible to oxidation…” Liu, Y., Bell, B. A., Song, Y., Zhang, K., Anderson, B., Axelsen, P. H., Bohannan, W., Agbaga, M.-P., Park, H. G., James, G., Brenna, J. T., Schmidt, K., Dunaief, J. L., & Shchepinov, M. S. (2022). Deuterated docosahexaenoic acid protects against oxidative stress and geographic atrophy-like retinal degeneration in a mouse model with iron overload. Aging Cell, 21(4), e13579. Q: “Why is consuming more linoleic acid reducing DHA in the body?” A: Mohrhauer, H., & Holman, R. T. (1963). The effect of dose level of essential fatty acids upon fatty acid composition of the rat liver *. Journal of Lipid Research, 4(2), 151–159. Paper that introduced omega nomenclature for fats: Holman, R. T. (1964). Nutritional And Metabolic Interrelationships Between Fatty Acids. Federation Proceedings, 23, 1062–1067. Zhang, J. Y., Kothapalli, K. S. D., & Brenna, J. T. (2016). Desaturase and elongase limiting endogenous long chain polyunsaturated fatty acid biosynthesis. Current Opinion in Clinical Nutrition and Metabolic Care, 19(2), 103–110. Q: “Interesting. But you would think based on that… Let’s touch on your experience with the dietary guidelines a little bit, you would think that that would be reflected in some of the recommendations on how we eat.” A: Astrup, A., Teicholz, N., Magkos, F., Bier, D. M., Brenna, J. T., King, J. C., Mente, A., Ordovas, J. M., Volek, J. S., Yusuf, S., & Krauss, R. M. (2021). Dietary Saturated Fats and Health: Are the U.S. Guidelines Evidence-Based? Nutrients, 13(10), 3305. McGovern Report 1977: Needs, U. S. C. S. S. C. on N. and H., & Mottern, N. (1977). Dietary Goals for the United States. U.S. Government Printing Office. Sandy, D. B. (1989). The Production and Use of Vegetable Oils in Ptolemaic Egypt. Scholars Press. NEED TO SEND TO BRENNA Menayang, A. (2017, April 30). Mars pledges to use 100% high-oleic peanuts in M&Ms, Munch Bar, by end of 2017. Foodnavigator-Usa.Com. O’Keefe, S. F., Wiley, V. A., & Knauft, D. A. (1993). Comparison of oxidative stability of high- and normal-oleic peanut oils. Journal of the American Oil Chemists’ Society, 70(5), 489–492. Q: “What’s a plausible dream study you would like to perform?” Gornoski, D. (2021, October 3). Professor Ameer Taha on Lipid Oxidation, Linoleic Acid, OXLAMS (No. 2021-10–03) [Mp3]. Ramsden’s headache studies: Mann, J. D., Faurot, K. R., MacIntosh, B., Palsson, O. S., Suchindran, C. M., Gaylord, S. A., Lynch, C., Johnston, A., Maiden, K., Barrow, D. A., Hibbeln, J. R., & Ramsden, C. E. (2018). A sixteen-week three-armed, randomized, controlled trial investigating clinical and biochemical effects of targeted alterations in dietary linoleic acid and n-3 EPA+DHA in adults with episodic migraine: Study protocol. Prostaglandins, Leukotrienes and Essential Fatty Acids, 128, 41–52. Ramsden, C. E., Domenichiello, A. F., Yuan, Z.-X., Sapio, M. R., Keyes, G. S., Mishra, S. K., Gross, J. R., Majchrzak-Hong, S., Zamora, D., Horowitz, M. S., Davis, J. M., Sorokin, A. V., Dey, A., LaPaglia, D. M., Wheeler, J. J., Vasko, M. R., Mehta, N. N., Mannes, A. J., & Iadarola, M. J. (2017). A systems approach for discovering linoleic acid derivatives that potentially mediate pain and itch. Science Signaling, 10(493). Ramsden, C. E., Faurot, K. R., Zamora, D., Suchindran, C. M., MacIntosh, B. A., Gaylord, S., Ringel, A., Hibbeln, J. R., Feldstein, A. E., Mori, T. A., Barden, A., Lynch, C., Coble, R., Mas, E., Palsson, O., Barrow, D. A., & Mann, D. J. (2013). Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: A randomized trial. Pain, 154(11), 2441–2451. Ramsden, C. E., Ringel, A., Feldstein, A. E., Taha, A. Y., MacIntosh, B. A., Hibbeln, J. R., Majchrzak-Hong, S. F., Faurot, K. R., Rapoport, S. I., Cheon, Y., Chung, Y.-M., Berk, M., & Douglas Mann, J. (2012). Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans. Prostaglandins, Leukotrienes and Essential Fatty Acids, 87(4), 135–141. Ramsden, C. E., Zamora, D., Faurot, K. R., MacIntosh, B., Horowitz, M., Keyes, G. S., Yuan, Z.-X., Miller, V., Lynch, C., Honvoh, G., Park, J., Levy, R., Domenichiello, A. F., Johnston, A., Majchrzak-Hong, S., Hibbeln, J. R., Barrow, D. A., Loewke, J., Davis, J. M., … Mann, J. D. (2021). Dietary alteration of n-3 and n-6 fatty acids for headache reduction in adults with migraine: Randomized controlled trial. BMJ, 374, n1448. Q: COVID-19 paper: Kothapalli, K. S. D., Park, H. G., & Brenna, J. T. (2020). Polyunsaturated fatty acid biosynthesis pathway and genetics. Implications for interindividual variability in prothrombotic, inflammatory conditions such as COVID-19. Prostaglandins, Leukotrienes and Essential Fatty Acids, 162, 102183. Goodrich, T. (2020, June 2). Does Consumption of Omega-6 Seed Oils Worsen ARDS and COVID-19? [Blog]. Yelling Stop. Dyerberg, J., & Jørgensen, K. A. (1982). Marine oils and thrombogenesis. Progress in Lipid Research, 21(4), 255–269. McReynolds, C. B., Cortes-Puch, I., Ravindran, R., Khan, I. H., Hammock, B. G., Shih, P. B., Hammock, B. D., & Yang, J. (2021). Plasma Linoleate Diols Are Potential Biomarkers for Severe COVID-19 Infections. Frontiers in Physiology, 12. Quote from Ralph Holman: “It seems reasonable to suggest that 18:3w3 intake be increased during pregnancy, lactation, and infancy, when the requirements for w3 PUFA are highest, during the development of the nervous system, which is rich in lipids containing high proportions of c3 PUFA. The mental apparatus of the coming generation is developed in utero, and the time to begin supplementation is before conception. A normal brain cannot be made without an adequate supply of w3 PUFA, and there may be no later opportunity to repair the effects of an w3 fatty acid deficiency once the nervous system is formed.” Holman, R. T., Johnson, S. B., & Ogburn, P. L. (1991). Deficiency of essential fatty acids and membrane fluidity during pregnancy and lactation. Proceedings of the National Academy of Sciences of the United States of America, 88(11), 4835–4839. Q: Seafood Nutrition Partnership: Tom’s bio there: Hibbeln, J. R., Spiller, P., Brenna, J. T., Golding, J., Holub, B. J., Harris, W. S., Kris-Etherton, P., Lands, B., Connor, S. L., Myers, G., Strain, J. J., Crawford, M. A., & Carlson, S. E. (2019). Relationships between seafood consumption during pregnancy and childhood and neurocognitive development: Two systematic reviews. Prostaglandins, Leukotrienes and Essential Fatty Acids, 151, 14–36. Seychelles study (not Mauritius): Davidson, P. W., Leste, A., Benstrong, E., Burns, C. M., Valentin, J., Sloane-Reeves, J., Huang, L.-S., Miller, W. A., Gunzler, D., van Wijngaarden, E., Watson, G. E., Zareba, G., Shamlaye, C. F., & Myers, G. J. (2010). Fish consumption, mercury exposure, and their associations with scholastic achievement in the Seychelles Child Development Study. NeuroToxicology, 31(5), 439–447. Q: “Talk to us a little bit about farmed vs. wild-caught fish. That’s a big thing in the ancestral health community.”: Nichols, P. D., Glencross, B., Petrie, J. R., & Singh, S. P. (2014). Readily Available Sources of Long-Chain Omega-3 Oils: Is Farmed Australian Seafood a Better Source of the Good Oil than Wild-Caught Seafood? Nutrients, 6(3), 1063–1079. P.S. Discussion of Mark’s Puder’s research: Anez-Bustillos, L., Dao, D. T., Fell, G. L., Baker, M. A., Gura, K. M., Bistrian, B. R., & Puder, M. (2018). Redefining essential fatty acids in the era of novel intravenous lipid emulsions. Clinical Nutrition, 37(3), 784–789. Carlson, S. J., O’Loughlin, A. A., Anez-Bustillos, L., Baker, M. A., Andrews, N. A., Gunner, G., Dao, D. T., Pan, A., Nandivada, P., Chang, M., Cowan, E., Mitchell, P. D., Gura, K. M., Fagiolini, M., & Puder, M. (2019). A Diet With Docosahexaenoic and Arachidonic Acids as the Sole Source of Polyunsaturated Fatty Acids Is Sufficient to Support Visual, Cognitive, Motor, and Social Development in Mice. Frontiers in Neuroscience, 13, 72. “Mouse-o-pause”, mouse menopause: Nehra, D., Le, H. D., Fallon, E. M., Carlson, S. J., Woods, D., White, Y. A., Pan, A. H., Guo, L., Rodig, S. J., Tilly, J. L., Rueda, B. R., & Puder, M. (2012). Prolonging the female reproductive lifespan and improving egg quality with dietary omega-3 fatty acids. Aging Cell, 11(6), 1046–1054. Cunnane, S. C. (2003). Problems with essential fatty acids: Time for a new paradigm? Progress in Lipid Research, 42(6), 544–568. Quotable: “The general idea that we call Evidence-Based Medicine, which, I’m afraid eliminates 95% of all the evidence that informs nutrition, and focuses 100% on human studies. Human studies are the worst studies. They are by far the worst. I don’t think it’s possible that a serious argument can be made otherwise.” “The food industry is not a bunch of evil guys who are just out to take everybody’s money… So I’m not here to beat up food companies.” “Coconut’s a seed, but it’s a weird seed.” “Some species [of fish] will eat grain, and if they eat grain, then their fatty-acid profile will look like the grain you feed them.” “Salmon have the good sense to die if you don’t feed them DHA.” “Farmed fish actually had a higher amount of DHA than the wild caught.” Brenna’s Industrial Food Principle: “When we produce animal foods, their nutrient profile should match that of the wild-caught.” “It sounds like you’re saying you’re better off eating a farm-raised salmon than an industrially-raised chicken?” “Yeah, I’m probably going to get in trouble for saying that, but I think that’s probably right.” “Otherwise, you’ve got the cheapest food in the world and the most expensive medicines in the world. Family physicians don’t like stuff like that; pediatricians don’t like stuff like that. We want to feed people well, and worry about medicine in well-fed people, rather than having to correct nutrient deficiencies by giving them drugs.” “Low linoleic acid maintains fertility.” “You’ll often read in the medical literature that linoleic and alpha-linolenic are essential, and DHA and arachidonic are conditionally essential, and it sounds like they got it backwards.” “They do. And it’s a meme has never died, from the 1950s.”
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Ep. 4: Jayne Rees Buxton on "The Great Plant Based Con"—With Dr Brian Kerley
07/16/2022
Ep. 4: Jayne Rees Buxton on "The Great Plant Based Con"—With Dr Brian Kerley
Jayne Rees Buxton, author Amazon: "The Great Plant-Based Con" Using these Amazon link suppports this podcast, so thank you! Amazon hardcover link (UK site): Twitter _______________________________________ Youtube version: Co-host Dr. Brian Kerley Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! Tucker Goodrich Blog: Youtube: Podcast: Twitter: _______________________________________ Show Notes **these are points we mention that I think people might want to read more about, or to explain or correct a point made. I don't inlude material from the book that we discuss, you'll have to get a copy to follow up on that information! Colourful conman Obituary—Jay Dinshah, 66, American Vegan Society Leader "The Game Changers" movie Clark, M. A., Springmann, M., Hill, J., & Tilman, D. (2019). Multiple health and environmental impacts of foods. Proceedings of the National Academy of Sciences, 116(46), 23357–23362. Banta, J. E., Lee, J. W., Hodgkin, G., Yi, Z., Fanica, A., & Sabate, J. (2018). The Global Influence of the Seventh-Day Adventist Church on Diet. Religions, 9(9), 251. O, ’Hearn Meghan, Lauren, B. N., Wong, J. B., Kim, D. D., & Mozaffarian, D. (2022). Trends and Disparities in Cardiometabolic Health Among U.S. Adults, 1999-2018. Journal of the American College of Cardiology, 80(2), 138–151. "Oatly ads banned by UK watchdog over ‘misleading’ green claims" "Tesco plc" "Protein content claims and methylcellulose in the spotlight as Beyond Meat hit with new lawsuits" Physician's Committee for Responsible Medicine is run by Neal Barnard, not David Katz. There are ~1 million physicians in the U.S. (), according to PCRM, they have 17,000 physician members (see link above), so that's 1.7% of practicing physicians as members. Of course the vast majority of the rest are *also* in favor of responsible medicine, so the name is a bit of a slander. BBC Radio 4 interview () "Eating Meat, Inclusive Rents and Business Going Bust" (Thanks to David Wyant for the link! ) "Honest Burgers is to convert its all-vegan V Honest site close to London's Leicester Square back to its core concept in July, just six months after launching the spin-off brand."
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Ep. 3: Robb Wolf on 'Sacred Cow', His Health Issues, Beyond Paleo, and More... co-host Brian Kerley
06/06/2022
Ep. 3: Robb Wolf on 'Sacred Cow', His Health Issues, Beyond Paleo, and More... co-host Brian Kerley
Brian and I have an engaging chat with famed Paleo Diet advocate Robb Wolf on his recent book 'Sacred Cow', how his own health issues have kept him engaged in continuing to explore the relationship between diet and health, how he's going beyond Paleo with his new enterprise LMNT, and more. I hope you all enjoy! Video for this episode: https://youtu.be/rrQ8q_ctGUQ Robb Wolf https://robbwolf.com/ "Sacred Cow" https://amzn.to/39bzKAe Diana Rodgers, RD (co-author of "Sacred Cow") "The Paleo Solution" T. Colin Campbell's "The China Study" Zero Acre Farms *Fermentation, not "fertilization"! Carbon cycle EAT-Lancet Commission Summary Report https://eatforum.org/eat-lancet-commission/eat-lancet-commission-summary-report/ Omega Initiative TK Mat Lalonde https://fatburningman.com/mat-lalonde-why-nutrient-density-matters-paleo-fails-what-to-eat-for-dinner/ Amber O'Hearn https://www.mostly-fat.com/ Ketogains https://www.ketogains.com/ LMNT https://drinklmnt.com/ Products: https://amzn.to/3Q211pk Tim Noakes' "Waterlogged: The Serious Problem of Overhydration in Endurance Sports" https://amzn.to/38MxY8L Stan Efferding https://stanefferding.com/ LMNT make your own sodium supplement: "11 Homemad Electrolyte Drink Recipes" -> Includes the Norcal Margarita I mentioned! https://drinklmnt.com/blogs/health/the-best-homemade-electrolyte-drink-for-dehydration Roam Free Bison Ranch https://goroamfree.com/ "Restoring the land with the Savory Institute" https://www.youtube.com/watch?v=yVxLQtSqvbQ _____________________________________________________ Co-host Dr. Brian Kerley https://www.seedoilrebellion.com/ https://twitter.com/SeedOilDsrspctr Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! https://www.seedyapp.com/ Tucker Goodrich Blog: http://yelling-stop.blogspot.com/ Youtube: https://www.youtube.com/channel/UCDpWmYeRapRkrZ9zw8M7iFg Podcast: https://sites.libsyn.com/408758 Twitter: https://twitter.com/TuckerGoodrich
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Ep. 2: Professor Ameer Taha on Lipid Oxidation, Linoleic Acid, OXLAMS
05/05/2022
Ep. 2: Professor Ameer Taha on Lipid Oxidation, Linoleic Acid, OXLAMS
I interview Prof. Ameer Taha of U.C. Davis on linoleic acid, lipid peroxidation, oxLAMs, and neurodegeneration. A great discussion going over some of the seminal research he has done during his career. We also discuss his surprising dream research project, one I think would yield major benefits if he were able to pursue it... This was originally released on David Gornoski's A Neighbor's Choice podcast: My thanks to David for permission to re-release it here. Please subscribe to this podcast if you find this topic interesting! My Youtube channel link is here: https://youtu.be/rk9NnC7bS3U Here is Prof. Taha's page at U.C. Davis: Here's his PubMed research: And his most recent (one I will be reading as soon as I finish posting this!): "Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions " Blog: Twitter:
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Ep. 1: Seed Oil Disrespecter Revealed
04/21/2022
Ep. 1: Seed Oil Disrespecter Revealed
Meet the Seed Oil Disrespecter and his wife, Ashley. We talk about how and why they started doing what they are doing, and what they hope to accomplish, with a focus on how avoiding seed oils affected their family health even after eating a mostly healthy diet for many years. Some news at the end, so stick around! Seed Oil Disrespecter on Twitter: On Instagram: Healthy Oil Respecter (Ashley) on Twitter: On Instagram: Seed Oil Rebellion: My blog: Twitter: Podcast: Youtube:
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Ep. 0: What VICE Left Out: Bitcoin and Seed Oils
04/01/2022
Ep. 0: What VICE Left Out: Bitcoin and Seed Oils
Back in February, Dr. K, the , was contacted by , a reporter for the news website VICE. She had some questions about why the seed oil topic had become a 'big thing' in the bitcoin world. He mentioned me as being knowledgeable about the seed oil and health topic, and suggested I reach out to her. I did, and we had a nice chat, although it probably went on longer than she was expecting. I've often heard it's wise to record conversations with journalists, and we did so via Zoom, to which she agreed. We had a pleasant enough conversation, and she listened to me at length (~48 minutes). I followed up with (see that link for the file I sent her, references below), and offered to send more. She didn't get back to me for any follow-up discussion, and then finally the article came out: "" I'll not editorialize about the many problems with that article, but the major one is they never addressed the research from institutions like the NIH and the AHA showing that there are credible reasons to think that the benefits of seed oils are oversold, and that there are real reasons to fear harmful effects. "Misinformation is a two-edged sword in the seed oil debate, however. Figureheads like Shanahan, after all, believe that most mainstream dietary guidance around fat consumption is built on lies, the kind that have quietly fueled America’s major health epidemics for decades. Like Bitcoin itself, the anti-seed oil stance reflects a skepticism of authority, one that is often not unfounded in the least but which can quickly snowball, echoed and amplified online." It's rather routine at this time for journalists to spread misinformation while pretending to be preventing it, and this is a perfect example of that. So I am presenting here the full discussion I had with VICE, so you can be the judge yourself of the value of what they elected to leave out while claiming that being concerned about seed oils is "misinformation". Journalists have editors, and many publications have clear—often unadmitted—editorial biases. I have no particular reason to think that Audrey wrote the bias into this story, so I won't blame her for it. I appreciate the time that she took to speak to me. I do blame VICE, however, which I think is fair. They printed a biased, misleading article, while ignoring that there are valid scientific reasons to think seed oils are problematic. I'm glad they left my name out of it.
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