95. William Cheng, Hospitalist and Singer
The 92 Report
William Cheng has been working in the Silicon Valley area since 2000. He graduated from Harvard as a bio concentrator and later attended UCLA's David Geffen School of Medicine. He completed residency training in internal medicine at Santa Clara Valley Medical Center, a county hospital affiliated with Stanford Hospital System. He then joined the Palo Alto Medical Foundation as a hospitalist, focusing on acutely ill patients. Working as a Hospitalist William's understanding of the world has changed over the two decades as a hospitalist. He now understands the importance of non-hard science...
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94. Jeanne Simpson, Actor/Dancer/Choreographer/Director/Teacher
The 92 Report
Jeanne Simpson moved to New York after graduating. She started doing day jobs in New York City to make ends meet while attending free dance classes, which allowed her to continue her training without having to pay for grad school. She eventually joined the American Isadora Dance Company, a modern company. Beginning a Career in the Performing Arts Jeanne began her acting career at HB Studios, where she was given a scholarship and studied under Austin Pendleton, a talented teacher who taught the advanced Acting Program at HB. She worked with other amazing actors and learned to choreograph scenes...
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93. Joshua Brandon Holden, Math Professor and Author of The Mathematics of Secrets
The 92 Report
Joshua Brandon Holden, the author of The Mathematics of Secrets, Cryptography from Caesar Ciphers to Digital Encryption, graduated with a degree in pure math and went on to teach at the University of Massachusetts and Duke. He discovered that he was spending most of his time on teaching, so he sought jobs where they would reward teaching. He then worked at the Rose Hulman Institute of Technology, where he did both teaching and research. Common Misconceptions about Cryptography Joshua discusses common misconceptions about cryptography and its connection to the internet. He explains that...
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92. Mark Jacobstein, Accidental Entrepreneur
The 92 Report
Mark Jacobstein resides in Stanford, California with his wife, two children, and his mother in law. Mark's career has primarily focused on entrepreneurial technology, primarily in health tech, biotech, molecular diagnostics, and digital health arenas. After Cambridge, he worked with Scott Murphy, a close friend and business partner. He moved to California in 2003 to start a technology company and has been there ever since. He lives on the Stanford campus, which allows his children to grow up on a college campus. Founding a Fantasy Sports Business Mark shares his journey from writing...
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91. Andreas Stavropoulos, Entering the Third Act
The 92 Report
Andreas Stavropoulos, a venture capitalist and entrepreneur, came to the United States from Greece at 18 and has been in the United States ever since. His big moves include marrying his high school sweetheart, arranging their lives around graduate school, medical school, business school, and moving to California. He is now 55-years-old and is excited about the third act of his life, where he can choose where to spend his time more than he used to. A Career as a Venture Capitalist Andreas started his career as a venture capitalist in 1999 and has been doing so for over two and a half years. He...
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90. Shannon Frison, Marine and Judge
The 92 Report
Show Notes: Shannon Frison joined the United States Marine Corps during her time in law school. She spent her second year at officer candidate school and became commissioned as an officer. After law school, she returned to Massachusetts, worked for a year at the TAs office, took the bar, and went on active duty with the Marine Corps. After serving at Marine Corps Air Station, New River, North Carolina, she worked for a litigation firm called Dwyer and Clora before opening a law firm. In 2009, she applied for the bench in Massachusetts and was appointed to the Boston Municipal Court. She then...
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89. Anastasia Fernands, Patent Litigator
The 92 Report
Show Notes: Anastasia Fernands has been practicing law since graduating from NYU. She started practicing in Boston at Hutchins, Wheeler and Dittmar, which was the oldest continuously running firm in Boston at the time. Anastasia has since moved to New York and now practices at Quinn Emanuel. Anastasia’s career primarily focuses on intellectual property litigation, particularly patent litigation since the mid to late 90s. At that time there were two schools of thought on patent litigation: technical people who understood technology and those who were litigators by trade. There was a...
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88. Brett Janis, Principal at Strong Bridge Advisers
The 92 Report
After Brett Janis left Harvard, he worked as a journalist in Southeast Asia and later attended Georgetown University's Masters of Science and Foreign Service program, which introduced him to the International Affairs world. After a stint in Egypt, Brett joined the Central Intelligence Agency (CIA) in 1995, where he focused on economic issues related to the Southeast Asia crisis, including issues related to banks and financial markets. He left the CIA just before 9/11, which was a critical moment in his life. He went back to Asia and started a business which dealt with finances for family...
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87. Richard Primus, Constitutional Law Professor
The 92 Report
Show Notes: Richard Primus initially had no idea what he wanted to do professionally after graduation, but eventually realized that he wanted to be a professor with interests in both law and political theory. He took HW Perry's constitutional interpretation class and decided to pursue graduate school and political theory before going to law school. Richard decided to study political theory at Oxford with the idea of becoming a law professor. He found his studies there focused on the abstract nature of political theory at the time, which required abstract questions about justice, liberty, and...
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86. Chris Ball, Research Scientist in the ElectroScience Laboratory
The 92 Report
Show Notes: After graduation, Chris Ball spent his summer working in Cambridge before returning to Columbus, Ohio, where he began graduate school in physics at The Ohio State University. He worked with Professor Frank DeLuca, a world-renowned researcher in microwave spectroscopy. Chris’ research focused on the microwave absorption of sulfur dioxide and its relationship to NASA's Microwave Limb Sounder instrument. Studying Interstellar Bands During his time at OSU, Chris collaborated with Professor Patrick Thaddeus from the Harvard Smithsonian Center for Astrophysics, who was looking to hire...
info_outlineMark Jacobstein resides in Stanford, California with his wife, two children, and his mother in law. Mark's career has primarily focused on entrepreneurial technology, primarily in health tech, biotech, molecular diagnostics, and digital health arenas. After Cambridge, he worked with Scott Murphy, a close friend and business partner. He moved to California in 2003 to start a technology company and has been there ever since. He lives on the Stanford campus, which allows his children to grow up on a college campus.
Founding a Fantasy Sports Business
Mark shares his journey from writing software for Mike Bloomberg in the early 90s to inventing the first online fantasy sports business [Small World] in 1994. He and his partner, Scott, initially struggled with starting a technology company due to their naivety and lack of experience in the tech startup ecosystem. However, they eventually built the first online fantasy sports business, which was one of the biggest consumer sites in the world at the time. In 1995, they spun out a web consultancy to solve various problems for corporate clients, building stateful and database-driven websites. They later built corporate websites for companies like Xerox and consulting for McKinsey on the internet's future. The business was sold to i-EXL in 1998. One common thread Mark has seen over the past 30 years is looking for systemic paradigm shifting changes in technology. Mark’s career highlights the importance of adapting to new technologies and finding the most effective way to grow a business.
Entrepreneurship in Machine Learning and AI
Mark’s last two companies and new venture studio focuses on machine learning and AI. He discusses his journey as an entrepreneur and the transition from a hobby to a business. He emphasizes the importance of looking for latent demand in businesses, he also emphasizes the importance of not engaging in gambling and making ethical choices in business decisions. His first experience as an entrepreneur was when he and his roommate Scott started hiring employees. They faced challenges like the.com crash and the need to lay off employees.
Startup Business Mistakes
Mark discusses the mistakes made by his company in structure and decision-making processes. He believes that they were naive and didn't put enough thought into the process of disagreements, which caused friction and strained relationships. He also mentions that the biggest mistakes they made were sins of omission. They were too early to realize the monstrous opportunities that nobody was taking advantage of. One example is hiring Matt Funk, a summer intern who later became a hedge fund manager. He suggested they buy domain names, but Mark argued that this was unethical. Another example is building the first Business to Business Exchange (B2B) website, TextTrade.com, in 1996. This was an effort to make the textiles business more efficient. However, Mark argues that they missed out on the commercial implications of the internet and how they could have used their technology to service other industries.
Silicon Valley and the Tech Landscape in the 2000s
Mark shares his experiences in the 2000s, particularly in the mobile business industry. He sold his fantasy sports business, Small World Sports, to Paul Allen, who bought Sporting News, an interactive TV channel. After a burnout at Sporting News. Mark met Trip Hawkins, founder of Electronic Arts and 3DO. Mark was offered a position as co-founder and president of a mobile phone company. He was invited to Silicon Valley to meet with Sequoia and Kleiner Perkins. He was mentored by Trip and his experience in Silicon Valley was a pivotal moment in his life. He shares his experiences in the tech industry, starting with his time at Digital Chocolate and then moving on to venture capital firm Sequoia. He was introduced to Sam Altman, a young wunderkind, and worked with him to build a company called Looped, which was later sold to Qualcomm.
Working in Health Technologies
After leaving Digital Chocolate, he decided to make a career shift into health tech. He enjoyed his work in fantasy sports but felt that nothing had changed the world in a profoundly important way. He eventually joined Guardant Health, a molecular diagnostic company that applied machine learning to big omics and developed cancer detection using blood draws. He was drawn to the intellectual challenge of working on circulating tumor DNA for early detection of cancer. Mark worked with Immunai, a company that uses single cell genomics and machine learning to improve immunomodulatory therapeutics. He appreciates the importance of the immune system's complexity and the work in the field. He recently founded Jiminy Health, a company that aims to address care gaps in mental health care through mobile and MLMs.
The Importance of Authentic Leadership
Mark has learned the importance of authenticity in running a company that is non-obvious or counterintuitive. He believes that authenticity is crucial in leadership and having a compelling vision. As a CEO, he focuses on making that vision clear and helping organizations untangle their knots to pull towards a common goal. He has learned from Sam's outrageous ambition and his ability to build companies that start with seemingly outrageous ideas. He applies these lessons to his own work, thinking about what different people would do in different situations as long as it aligns with his values and aligns with his values. He compares running a lab to running a business, which involves raising money, hiring people, meeting deadlines, and missing milestones.
Influential Harvard Professors and Courses
Mark discusses his experiences at Harvard, focusing on courses and professors that resonate with him. He mentions Harry Lewis, who was a computer scientist, and his career in tech. He emphasizes the importance of having a vision and articulating it to attract customers and recruit a team. He also highlights the importance of social reflection classes like Robert Coles, which taught him how telling a story can change the world and create an ethos that cares about the world. Mark’s mental health startup, Jiminy Health, aims to make scalable mental health services for millions of people. He believes that being raised in a liberal, progressive family still helps his businesses make the world a better place.
Timestamps:
02:59 Entrepreneurship, technology, and business success
08:46 Entrepreneurship and technology trends
10:36 Entrepreneurship, business decisions, and growth
16:58 Missed opportunities in tech and entrepreneurship
23:34 Entrepreneurship, leadership, and the video game industry
27:03 Career shift from tech to healthcare with valuable insights
32:55 Entrepreneurship, leadership, and management style
38:02 Leadership, authenticity, and lessons learned from mentors
41:29 Relying on a spouse as a counselor in healthcare
45:58 Entrepreneurship, technology, and mental health
Links:
https://twitter.com/mjacobstein
https://www.linkedin.com/in/markjacobstein/