Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

🧬 Silencing Risk: Lepodisiran vs Lp(a)

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

🚨 New hope for high Lp(a)! 💉 Lepodisiran, a long-acting siRNA, slashed Lp(a) by 94% with just 2 shots/year. 🔬 RNA precision meets cardiac prevention. 📉 Silent killer, silenced. #CardioTwitter #RNAtherapy #LipoproteinA

💨 Breathing Battles: Navigating COPD Phenotypes

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

🌬️🚶‍♂️ COPD comes in many forms! From chronic bronchitis 🪫 to emphysema 💨, frequent exacerbators 🚨, asthma-COPD overlap 🌪️, and eosinophilic type 🧫. Tailoring treatment to phenotype is key! #COPD #PrecisionMedicine #RespiratoryCare

💊 TANDEM Triumph: Dual Power for LDL Cholesterol Reduction!

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

🚀 TANDEM Trial: Combining Obicetrapib & Ezetimibe for a powerful LDL reduction! 💊 ✅ -48.6% vs placebo, -27.9% vs Ezetimibe, -16.8% vs Obicetrapib 💪 Safe, effective, and oral! #Cardiology #LipidManagement #ASCVD

Fungal Pharmacists, Fatty Liver, Future Frontiers 🧬🩸🍄

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

A gut fungus 🍄 (Fusarium foetens) secretes FF-C1 🧪, a metabolite that inhibits CerS6 and lowers ceramides 🩸—shielding mice from MASH 🛡️. Fungi aren’t just freeloaders—they may be our next therapeutic allies! 💊🧠 #Microbiome #LiverHealth #FungalTherapy #Science

💪 Powerful Cholesterol Control: Obicetrapib in the Spotlight 🌟

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

🚀 Obicetrapib: A Breakthrough in LDL Lowering! 📉 Reduced LDL by 29.9% in high-risk patients (p<0.001) 💡 Promising adjunct to lipid-lowering therapy! #Cardiology #LipidManagement #HeartHealth 💓

Fat Chance! 🔬🧬 Middle-Age Spread Starts at the Cellular Level

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

Here’s a tweet with emojis based on the article: 🧬 Middle-age spread decoded! 🕰️ Visceral fat grows in midlife not from bigger cells—but new ones! 🎯 CP-A cells fire up fat formation via LIFR–STAT3 🔥 💊 Targeting them may halt metabolic disease before it starts. #Aging #Obesity #CellBiology #Metabolism 🧫 Would you like a version with a more humorous tone or one tailored for clinicians?

🔍📊🛡️ Detect, Decode, Defend: A New Era in Coronary Risk Prediction

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

🚨 New era in heart disease prediction! 🧬 + 🧪 + 🤖 = Meta-prediction model that beats PCE & QRISK3 📈 Detects hidden CAD risk in young, women & “low-risk” groups 🎯 Precision prevention just got personal. 🫀 Published in Nature Medicine #CardioTwitter #AI #Genomics #CAD

Dr RR Baliga's Philosophical Discourses: Epicurus (Greece, 341–270 BCE) – Founder of Epicureanism

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

Epicurus (341–270 BC) was an ancient Greek philosopher who founded Epicureanism, emphasizing the pursuit of a tranquil, happy life through ataraxia (freedom from fear) and aponia (absence of pain). His teachings combined atomism, ethics, and naturalistic theology, advocating simple living, friendship, and the rejection of superstition.

Calcium Wars: Orbital Atherectomy vs. Balloon Angioplasty — The ECLIPSE Verdict ⚔️🧠💔

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

🚨ECLIPSE Trial Results🚨 Orbital atherectomy 🌀 vs. balloon angioplasty 🎈 before stenting in severe coronary calcification 💔 🎯 No added benefit with atherectomy 🧠 Balloon-first + imaging = smart strategy 📊 Lancet 2025 | #CardioTwitter #InterventionalCardiology #ECLIPSETrial

Genes 🧬, Journeys 🌍, and Hidden Hazards ⚡: Unlocking Health with Exposomics

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

“Your DNA 🧬 is just half the story — your exposome 🌍 writes the rest! From air 🌫️ to food 🍎 to stress 😰, exposomics unlocks the hidden drivers of health 🔍💥. Predict. Prevent. Prosper. 🚀 #Exposomics #PrecisionMedicine”

Summary on Kaṇāda

Kaṇāda, also known as Ulūka or Kashyapa, was an ancient Indian natural philosopher and the founder of the Vaisheshika school of Indian philosophy. He is often regarded as the earliest proponent of atomism in the world, proposing that the universe is composed of indivisible, eternal atoms (paramanu), which combine in various ways to form different substances. His ideas were recorded in the seminal text Vaiśeṣika Sūtra, which outlined a realistic and pluralistic ontology.

Estimated to have lived between the 6th century BCE and 2nd century BCE, Kaṇāda’s philosophy explains the creation and functioning of the universe through six fundamental categories (padarthas): dravya (substance), guna (quality), karma (motion), samanya (generality), visesha (particularity), and samavaya (inherence). These categories encompass everything that can be experienced and known.

Kaṇāda’s atomistic theory influenced later Hindu, Jain, and Buddhist philosophies and may have inspired thinkers in fields like medicine and physics, including scholars like Charaka. Though primarily focused on physical phenomena, Kaṇāda also integrated metaphysical ideas, such as the concept of Atman (soul) and the pursuit of moksha (liberation) through knowledge.

Key Contributions:

1. Atomism: Proposed that all matter is made of indestructible atoms.

2. Nine Substances: Identified nine dravyas (substances) including earth, water, fire, air, ether (akasha), time, direction, mind, and soul.

3. Non-Theistic Approach: Suggested that natural laws, rather than a deity, govern the universe.

4. Empirical Observations: Explained natural phenomena such as fire rising upwards, magnetism, and rainfall using logical reasoning.

5. Ethical Framework: Defined dharma as that which leads to material progress and spiritual liberation.

Kaṇāda’s logical and analytical approach laid the groundwork for scientific inquiry in India and significantly influenced the Nyaya school of philosophy, which emphasized logic and epistemology. His ideas on atoms and matter predated similar concepts proposed by Greek philosophers like Democritus.