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Dr RR Baliga's Philosophical Discourses:  Mencius (China, c. 372โ€“289 BCE) โ€“ Confucian Philosopher show art Dr RR Baliga's Philosophical Discourses: Mencius (China, c. 372โ€“289 BCE) โ€“ Confucian Philosopher

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

Mencius (c. 371โ€“289 BC) was a prominent Confucian philosopher known as the โ€œSecond Sageโ€ after Confucius. He emphasized the innate goodness of human nature, advocating for humane governance, moral cultivation, and the welfare of citizens. His teachings greatly influenced Confucianism and later Neo-Confucian thought.

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Mutants, Mitochondria & Metformin ๐Ÿ”ฌ๐Ÿ”‹๐Ÿ’Š: Powering Down Clonal Haematopoiesis show art Mutants, Mitochondria & Metformin ๐Ÿ”ฌ๐Ÿ”‹๐Ÿ’Š: Powering Down Clonal Haematopoiesis

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

๐Ÿงฌ Clonal haematopoiesis (CH)โ€”especially with DNMT3A-R882 mutationsโ€”increases with age and raises leukemia risk. ๐Ÿ’Š New studies reveal that metformin targets mutant blood stem cells by suppressing mitochondrial metabolism, sparing healthy cells. ๐Ÿ“‰ UK Biobank data shows lower CH prevalence in metformin users. ๐Ÿ”‹ Targeting oxidative phosphorylation may offer a safe, preventative strategy against CH progression.

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A Shot ๐Ÿ’‰ at Memory ๐Ÿง : Can Diabetes Drugs Fight Forgetfulness โ“ show art A Shot ๐Ÿ’‰ at Memory ๐Ÿง : Can Diabetes Drugs Fight Forgetfulness โ“

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

In this large real-world study ๐Ÿงช using electronic health records ๐Ÿ“Š, GLP-1RAs and SGLT2isโ€”two diabetes drugs ๐Ÿ’‰โ€”were associated with a lower risk of Alzheimerโ€™s and related dementias ๐Ÿง  in people with type 2 diabetes ๐Ÿฌ. Both showed protective effects ๐Ÿ›ก๏ธ, with no significant difference between them, suggesting promise for drug repurposing โ™ป๏ธ in brain health strategies.

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Sweat ๐Ÿ’ฆ, Synapses ๐Ÿง , Survival ๐Ÿ›ก๏ธ: Exercise and the Ageing Brain show art Sweat ๐Ÿ’ฆ, Synapses ๐Ÿง , Survival ๐Ÿ›ก๏ธ: Exercise and the Ageing Brain

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

๐Ÿง  Regular endurance exercise boosts brain health by increasing blood flow ๐Ÿ’“, enhancing neuroplasticity ๐Ÿ”, and reducing inflammation ๐Ÿ”ฅ.   ๐Ÿƒโ€โ™‚๏ธ High cardiorespiratory fitness (CRF) lowers dementia risk ๐Ÿงฉ, supports memory ๐Ÿ“, and promotes the release of powerful brain molecules like BDNF ๐Ÿงฌ and irisin ๐Ÿ’ช.   โœจ In short: Move more, age slower, think sharper!

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๐Ÿ”ฌ Cataracts Decoded: Clarity, Surgery, and the Silver Years ๐Ÿ‘“โ€ show art ๐Ÿ”ฌ Cataracts Decoded: Clarity, Surgery, and the Silver Years ๐Ÿ‘“โ€

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

๐Ÿ‘๏ธ Cataracts are a common cause of vision loss in older adults, leading to blurry vision, glare, and difficulty with daily tasks. ๐Ÿ’‰ Surgery is safe, quick, and effective โ€” restoring clarity, reducing fall risk, and even lowering dementia risk. ๐Ÿ”ฌ Advanced lenses can reduce dependence on glasses, while intraocular antibiotics help prevent rare infections. โš ๏ธ Watch out for meds like tamsulosin that may complicate surgery โ€” always inform your eye doctor!

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Staph Aureus Bacteremia ๐Ÿฆ  Detect. ๐Ÿ’Š Treat. ๐Ÿ” Control the Source!โ€ show art Staph Aureus Bacteremia ๐Ÿฆ  Detect. ๐Ÿ’Š Treat. ๐Ÿ” Control the Source!โ€

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

๐Ÿฆ  Staphylococcus aureus bacteremia (SAB) is a deadly bloodstream infection with high rates of complications like endocarditis and abscesses. ๐Ÿ’‰ Early detection, MRSA coverage with vancomycin/daptomycin, and source control (๐Ÿช› remove catheters, drain abscesses) are critical. ๐Ÿ” Use echocardiography and VIRSTA score to guide management. โœ… Once susceptibilities return, de-escalate and tailor therapyโ€”MSSA loves cefazolin!

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๐Ÿง  Fast Wins, Flawed Logic, Real Choices show art ๐Ÿง  Fast Wins, Flawed Logic, Real Choices

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

๐Ÿง  People often say they want big wins (like lotteries), but in practice, they choose what wins more oftenโ€”even if it pays less. ๐ŸŽฎ In experiments, when outcomes are shown side-by-side, we tend to favor the โ€œfrequent winner.โ€ ๐Ÿ“‰ This bias can make us overlook rare, high rewardsโ€”shaping real-world choices in money, health, and risk. ๐Ÿ” Bottom line: Itโ€™s not just what we choose, but how the choice is shown that changes everything.

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Dr. RR Baligaโ€™s Philosophical Discourses: Zhuangzi (China, c. 369โ€“286 BCE) โ€“ Taoist Philosopher show art Dr. RR Baligaโ€™s Philosophical Discourses: Zhuangzi (China, c. 369โ€“286 BCE) โ€“ Taoist Philosopher

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

Zhuang Zhou, also known as Zhuangzi, was an influential 4th-century BCE Chinese philosopher during the Warring States period. As a foundational figure of Taoism, he authored the Zhuangzi, a text known for its profound philosophical insights, parables, and critiques of societal norms, emphasizing personal freedom and harmony with the Tao. His ideas remain central to Chinese philosophy and continue to inspire discussions on ethics, metaphysics, and human nature.

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Hands Down, Cream Wins! ๐Ÿ–๏ธ๐Ÿงด๐Ÿ’ฅ Delgocitinib vs Alitretinoin in Chronic Eczema show art Hands Down, Cream Wins! ๐Ÿ–๏ธ๐Ÿงด๐Ÿ’ฅ Delgocitinib vs Alitretinoin in Chronic Eczema

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

๐Ÿงด Delgocitinib cream outperformed oral alitretinoin in treating severe chronic hand eczema over 24 weeks. ๐Ÿ“‰ Greater reduction in HECSI, ๐Ÿ˜Š better quality of life, and โš ๏ธ fewer side effects make it a promising non-steroidal alternative. ๐Ÿ’Š Time to rethink systemic pills โ€” topical wins hands down! ๐Ÿ–๏ธโœ…

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๐Ÿง ๐Ÿฆด๐Ÿšผ โ€œBrains, Balance, and Birth: Cracking the Pelvic Code show art ๐Ÿง ๐Ÿฆด๐Ÿšผ โ€œBrains, Balance, and Birth: Cracking the Pelvic Code

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

๐Ÿงฌ Human pelvic evolution reflects a tug-of-war between ๐Ÿšถโ€โ™€๏ธ efficient walking, ๐Ÿง  growing brains, and ๐Ÿšผ safe childbirth. Using AI and genetic data from 31,115 individuals, Xu et al. found the pelvis is highly heritable, sex-dimorphic, and shaped by multiple selective pressuresโ€”not just bipedalism or birth. Larger canals ease delivery but risk ๐Ÿ’ฅ pelvic floor disorders, while narrower ones boost mobility but raise โš ๏ธ labor complications. This study reframes the โ€œobstetrical dilemmaโ€ as a ๐Ÿ”„ multifactorial evolutionary compromise.

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Alcohol is a proven carcinogen ๐Ÿšจ, increasing the risk of at least 7 cancers (mouth, throat, breast, liver, etc.) ๐Ÿฆ ๐Ÿ’€.

Even small amounts (5g ethanol/day) raise cancer risk, with no safe threshold ๐Ÿ“Š๐Ÿšซ.

Similarly, exceeding 14 drinks/week (men) or 7 (women) raises CHD risk by up to 43% ๐Ÿ’”๐Ÿ“ˆ.

Past claims of heart benefits from moderate drinking are now being challenged ๐Ÿงโ“.

Best advice? Limit or avoid alcohol for better long-term health ๐Ÿšซ๐Ÿฅƒโœ”๏ธ.