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๐จ New hope for high Lp(a)! ๐ Lepodisiran, a long-acting siRNA, slashed Lp(a) by 94% with just 2 shots/year. ๐ฌ RNA precision meets cardiac prevention. ๐ Silent killer, silenced. #CardioTwitter #RNAtherapy #LipoproteinA
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๐ฌ๏ธ๐ถโโ๏ธ COPD comes in many forms! From chronic bronchitis ๐ชซ to emphysema ๐จ, frequent exacerbators ๐จ, asthma-COPD overlap ๐ช๏ธ, and eosinophilic type ๐งซ. Tailoring treatment to phenotype is key! #COPD #PrecisionMedicine #RespiratoryCare
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๐ TANDEM Trial: Combining Obicetrapib & Ezetimibe for a powerful LDL reduction! ๐ โ -48.6% vs placebo, -27.9% vs Ezetimibe, -16.8% vs Obicetrapib ๐ช Safe, effective, and oral! #Cardiology #LipidManagement #ASCVD
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A gut fungus ๐ (Fusarium foetens) secretes FF-C1 ๐งช, a metabolite that inhibits CerS6 and lowers ceramides ๐ฉธโshielding mice from MASH ๐ก๏ธ. Fungi arenโt just freeloadersโthey may be our next therapeutic allies! ๐๐ง #Microbiome #LiverHealth #FungalTherapy #Science
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๐ Obicetrapib: A Breakthrough in LDL Lowering! ๐ Reduced LDL by 29.9% in high-risk patients (p<0.001) ๐ก Promising adjunct to lipid-lowering therapy! #Cardiology #LipidManagement #HeartHealth ๐
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Hereโs a tweet with emojis based on the article: ๐งฌ Middle-age spread decoded! ๐ฐ๏ธ Visceral fat grows in midlife not from bigger cellsโbut new ones! ๐ฏ CP-A cells fire up fat formation via LIFRโSTAT3 ๐ฅ ๐ Targeting them may halt metabolic disease before it starts. #Aging #Obesity #CellBiology #Metabolism ๐งซ Would you like a version with a more humorous tone or one tailored for clinicians?
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๐จ New era in heart disease prediction! ๐งฌ + ๐งช + ๐ค = Meta-prediction model that beats PCE & QRISK3 ๐ Detects hidden CAD risk in young, women & โlow-riskโ groups ๐ฏ Precision prevention just got personal. ๐ซ Published in Nature Medicine #CardioTwitter #AI #Genomics #CAD
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Epicurus (341โ270 BC) was an ancient Greek philosopher who founded Epicureanism, emphasizing the pursuit of a tranquil, happy life through ataraxia (freedom from fear) and aponia (absence of pain). His teachings combined atomism, ethics, and naturalistic theology, advocating simple living, friendship, and the rejection of superstition.
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๐จECLIPSE Trial Results๐จ Orbital atherectomy ๐ vs. balloon angioplasty ๐ before stenting in severe coronary calcification ๐ ๐ฏ No added benefit with atherectomy ๐ง Balloon-first + imaging = smart strategy ๐ Lancet 2025 | #CardioTwitter #InterventionalCardiology #ECLIPSETrial
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โYour DNA ๐งฌ is just half the story โ your exposome ๐ writes the rest! From air ๐ซ๏ธ to food ๐ to stress ๐ฐ, exposomics unlocks the hidden drivers of health ๐๐ฅ. Predict. Prevent. Prosper. ๐ #Exposomics #PrecisionMedicineโ
info_outlineThe blood-brain barrier (BBB) ๐ก๏ธ protects the brain from harmful molecules but weakens with aging ๐ง, leading to neuroinflammation ๐ฅ and cognitive decline ๐.
Mucins ๐งฌ, slippery proteins in the glycocalyx ๐๏ธ, help maintain BBB integrity ๐ง . This study found that mucin loss ๐จ increases BBB permeability, allowing toxins to enter.
Using gene therapy ๐งช, researchers restored mucins, improving memory and learning ๐ in aged mice.
This breakthrough suggests that mucin-based treatments ๐ฅ could prevent neurodegenerative diseases like Alzheimerโs and Parkinsonโs ๐ฏ while also enhancing brain drug delivery ๐.