Reversing Alzheimers 2.0 Summit Preview
Evolution of Medicine Podcast
What if cognitive decline and Alzheimer’s could be reversed? In this episode of The Evolution of Medicine , James Maskell and Dr. Kristine Burke discuss the 2026 summit’s advances in precision medicine and team-based approaches to brain health. You’ll learn about a first-of-its-kind randomized trial showing measurable cognitive improvement, the importance of addressing multiple root causes, and strategies for making these interventions accessible to clinicians and patients alike. This is a conversation about science, hope, and creating a new standard of care for cognitive decline. - - -...
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My Bevan Commission Presentation
Evolution of Medicine Podcast
In this solo episode, I’m diving into a concept that’s been coming up again and again—in my work, in the data, and in conversations with practitioners around the world: network insufficiency. Put simply, when connections break down—whether in the body, in our communities, or in our healthcare systems—things stop working. I share highlights from my recent talk at the Bevan Commission, where I explored why chronic disease is rising, why healthcare systems are under pressure, and what we can actually do about it. This is also the foundation of my upcoming book, The Great Reconnection. -...
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The Thyroid to IBS Journey
Evolution of Medicine Podcast
Host James Maskell interviews Dr. Izabella Wentz, a leader in thyroid health and functional medicine, about her new work on IBS (irritable bowel syndrome). The conversation explores how IBS is often misunderstood as a standalone diagnosis when it is actually an umbrella term with multiple root causes. Dr. Wentz shares her personal journey from IBS to Hashimoto’s, explains the connection between gut health and autoimmunity, and outlines the many drivers of IBS—from medications and food sensitivities to infections and stress. The episode highlights how functional medicine practitioners can...
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The Pracititoner Burnout Trap
Evolution of Medicine Podcast
In this episode of The Evolution of Medicine, host James Maskell interviews Seth Conger, COO of Freedom Practice Coaching and long-time functional medicine practitioner and mentor. The conversation explores the structural burnout many practitioners experience when running their own clinics, wearing multiple hats as clinician, CEO, marketer, and manager. Seth shares practical strategies for avoiding burnout, including proactive business management, deliberate reconnection with patient outcomes, effective hiring and delegation, and schedule design. The episode also dives into how coaching,...
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Why Brain Health Is the Future of Longevity Medicine
Evolution of Medicine Podcast
In this episode of The Evolution of Medicine, host James Maskell interviews Dr. Ryan Arnold, founder of Clava Health and a former emergency and critical care physician who transitioned into functional medicine. The conversation explores Dr. Arnold’s journey from hospital-based medicine to building a scalable functional medicine clinic focused on root-cause care, longevity, and brain health. He shares how frustration with traditional disease-focused medicine pushed him to pursue functional medicine training and eventually launch a cash-based practice. Dr. Arnold explains why brain health is...
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Betrayal and the Brain
Evolution of Medicine Podcast
In this episode of The Evolution of Medicine, host James Maskell interviews Debbie Silber, PhD, founder of the Post Betrayal Transformation Institute and author of Unstuck. The conversation explores why betrayal is a distinct and often overlooked root cause of chronic physical and mental health conditions. Dr. Silber shares her groundbreaking research on Post-Betrayal Syndrome (PBS), the predictable 5 stages of healing, and why so many patients remain “stuck” despite functional or conventional care. This episode reframes betrayal not as an emotional inconvenience—but as a physiological...
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Your Best Shot: Holistic Approach to GLP-1
Evolution of Medicine Podcast
In this episode of The Evolution of Medicine, host James Maskell interviews registered dietitian Ashley Koff about her new book Your Best Shot. The conversation explores the seismic impact of GLP-1 agonists like Ozempic and Wegovy—and how functional medicine can pivot from a “weight loss” mindset to a “weight health” approach. Koff reframes these medications not as magic bullets, but as biosimilar hormone replacement tools that “switch on” receptor sites—without repairing the underlying ecosystem. She outlines a five-part Weight Health Hormone assessment and introduces a...
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From Artisan to Infrastructure
Evolution of Medicine Podcast
In this episode of The Evolution of Medicine, host James Maskell outlines a pivotal shift for functional medicine practitioners. He argues that the era of the “artisan” solo practitioner is ending—and that survival in 2026 and beyond requires building scalable clinical infrastructure. Maskell explains how AI-powered platforms, venture-backed telehealth companies, and direct-to-consumer lab brands are redefining patient expectations around speed, convenience, and affordability. To compete, functional medicine clinics must evolve into “full stack” models—combining objective data,...
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An Evolutionary Perspective on Brain Diseases
Evolution of Medicine Podcast
In this episode of The Evolution of Medicine podcast, host James Maskell speaks with health educator and researcher Ari Whitten about why modern medicine has failed to meaningfully prevent or reverse Alzheimer’s disease—and how an evolutionary and lifestyle-based framework offers a far more effective path forward. The conversation reframes Alzheimer’s not as an inevitable consequence of aging, but as a disease of evolutionary mismatch—the result of modern lifestyles that conflict with our ancient biological design. Drawing on anthropological data, long-term population studies, and...
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Metabolic Psychiatry: Healing the Brain
Evolution of Medicine Podcast
In this episode of The Evolution of Medicine podcast, host James Maskell speaks with Dr. Matthew Bernstein about the emerging field of metabolic psychiatry. They explore how addressing metabolic health—particularly through ketogenic diets—can treat and, in some cases, reverse serious mental health conditions that conventional psychiatric medications often fail to resolve. Through personal stories, clinical insights, and a forward-looking discussion on research and policy, the episode challenges the long-standing “chemical imbalance” narrative and reframes mental illness as a...
info_outlineIn this episode of The Evolution of Medicine podcast, host James Maskell speaks with Dr. Matthew Bernstein about the emerging field of metabolic psychiatry. They explore how addressing metabolic health—particularly through ketogenic diets—can treat and, in some cases, reverse serious mental health conditions that conventional psychiatric medications often fail to resolve.
Through personal stories, clinical insights, and a forward-looking discussion on research and policy, the episode challenges the long-standing “chemical imbalance” narrative and reframes mental illness as a systemic, energy-based disorder rooted in metabolic dysfunction.
James Maskell interviews Dr. Matthew Bernstein on metabolic psychiatry, ketogenic diets, and the future of mental health care, exploring how metabolic health can reverse depression, bipolar disorder, and psychosis on The Evolution of Medicine Podcast.
Dr. Matthew Bernstein is a psychiatrist and pioneer in metabolic psychiatry. After a family health crisis involving his sons’ diagnosis of PANS (Pediatric Acute Neuropsychiatric Syndrome), he shifted away from medication-centric psychiatry toward addressing root causes such as metabolic dysfunction, inflammation, and immune dysregulation. He is the founder of Accord, an immersive metabolic health program near Boston.
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