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The Brain Fog Fix No One Is Talking About: Nicotine, Methylene Blue and the Midlife Brain with Dr. Scott Scherr

The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health

Release Date: 05/30/2026

Quick Hits: The Testosterone Replacement for Women Conundrum: Libido Highs and Hair Loss Lows with James O'Hara

The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health

Welcome to Quick Hits — where we bring you the most impactful moments from past episodes in under 15 minutes. Today’s clip comes from one of our most replayed conversations. If you want the full episode, check the link in the description below. James O'Hara is a family nurse practitioner who utilizes a utilizes an integrative approach to health which combines lifestyle interventions, appropriate supplementation, and medications when indicated to empower patients to feel better and live longer, healthier lives. Today we're speaking with James about testosterone replacement for women plus...

The Truth About Female Desire, Orgasms, and Sex That We Were Never Taught with Dr. Sally Greenwald

The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health

If you've ever wondered why you don't want your husband to walk through the door and rip your clothes off anymore, this episode is for you. If you've ever quietly believed something was wrong with you because you don't orgasm easily, or at all, this episode is for you too. I sat down with Dr. Sally Greenwald, a board-certified OB/GYN with specialized training in menopause medicine, and what she shared genuinely stopped me in my tracks. We were taught to protect ourselves from pregnancy and disease. We were never taught how our bodies actually work. No one explained the difference between the...

Quick Hits: The Hidden Influence of Sunlight and Circadian Rhythm on Blood Sugar & Metabolism

The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health

Welcome to Quick Hits — where we bring you the most impactful moments from past episodes in under 15 minutes. Today’s clip comes from one of our most replayed conversations. If you want the full episode, check the link in the description below. With Dani's guidance, we're exploring how simple changes in light exposure and grounding can revolutionize metabolic health, particularly for those grappling with conditions like PCOS, hypoglycemia, acne, or weight loss resistance. Dani shares her personal journey and expert insights on how morning sunlight can reset circadian rhythms, enhance...

Part 3 The Midlife Stress Crash: What Your Midlife Breakdown Is Actually Trying to Tell You

The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health

You've made it to part three, and this is the one that ties everything together. If parts one and two left you with a clearer picture of your stress system and your sleep, this episode takes you somewhere deeper: into your thyroid, your brain chemistry, and a layer of midlife that almost nobody talks about on a podcast about hormones. I'm breaking down why your thyroid and your adrenal system are locked in a relationship that most doctors never explain, and why a normal TSH does not mean your thyroid is actually working. Then we go into your neurotransmitters. Serotonin, dopamine, GABA, the...

Why You Struggle to Build Muscle in Midlife (Even If You're Doing Everything Right) with Liz Plosser

The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health

You're eating "pretty well." You're moving your body. So why does it feel like your muscle is disappearing and your effort isn't paying off the way it used to? In this episode, I sit down with Liz Plosser, former editor-in-chief of Women's Health and a woman who has spent her entire career reporting on health and fitness, to talk about what changes in midlife and why the old rules stop working. Then we go deep on amino acids, what they actually are, why your body becomes less efficient at using them as estrogen declines, and why an essential amino acid supplement might be one of the smartest,...

Part 2 The Midlife Stress Crash: Why Midlife Women Wake Up at 3 AM and Can’t Fall Back Asleep

The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health

If you are exhausted all day, wired at night, and waking up between 2:00 and 4:00 AM with your heart pounding and your brain suddenly wide awake, this episode is for you. Because midlife sleep issues are rarely just about needing more progesterone or taking a melatonin gummy. They are usually a sign that a whole system is asking to be recalibrated. In this episode, I go deeper into the sleep side of the midlife stress puzzle and break down what may actually be happening beneath the surface. In this episode: Why so many women in midlife feel exhausted all day but wide awake at night Why...

Part 1 The Midlife Stress Crash: Why You Feel Wired, Tired, Anxious & Done

The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health

If you are waking up between 2:00 and 4:00 AM, lying there wide awake with your heart beating a little too fast and your mind solving every problem in your life, this episode is for you. Because this is not just about bad sleep. It is about what happens when the hormonal, adrenal, and nervous system shifts of midlife collide with the stress load most women are already carrying. And for a lot of women, this is the moment they stop feeling like themselves. In this episode, I do a deep dive into what is actually happening beneath the surface when women in perimenopause and menopause start feeling...

Quick Hits: The Great Menopause Myth: The Truth on Mastering Midlife Hormonal Mayhem

The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health

Welcome to Quick Hits — where we bring you the most impactful moments from past episodes in under 15 minutes. Today’s clip comes from one of our most replayed conversations. If you want the full episode, check the link in the description below. If you have been told menopause is just hot flashes, aging, and something you have to “push through,” this episode will challenge that entire narrative. In this episode, I sit down with Maria Claps and Kristin Johnson, the founders of Wise and Well and authors of The Great Menopause Myth. Maria is an FDN practitioner, and Kristin is a...

JJ Virgin: The Untold Story of Aging, Weight Gain, HRT, Peptides, Facelifts, and Muscle

The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health

This conversation is not just about menopause symptoms. It is about what it actually feels like to live inside a changing female body in midlife. The grief, the confusion, the vanity, the softness, the strength, the reinvention. All of it. In this episode, I sit down with fitness hall of famer, JJ Virgin for a real conversation about what happens when your body starts changing in ways you did not expect, the things that stop working, and how to hold onto yourself while also becoming someone new. We talk about the reality of perimenopause and menopause when you are living it, not just teaching...

Quick Hits: GLP-1s (Ozempic & Mounjaro) Masterclass: Busting Myths, Mastering Micro Dosing, Retaining Muscle and Unlocking Benefits Beyond Weight Loss with Dr. Gus Vickery

The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health

Welcome to Quick Hits — where we bring you the most impactful moments from past episodes in under 15 minutes. Today’s clip comes from one of our most replayed conversations. If you want the full episode, check the link in the description below. How can GLP-1s like Ozempic truly transform weight management and wellness—and what makes them so controversial? Dr. Gus Vickery, who specializes in total body and mind optimization, dives deep into how these groundbreaking treatments are revolutionizing weight management, nutrition, and even menopause. Why are they causing such a stir, and are...

More Episodes

We talk a lot about hormones in midlife, hot flashes, weight gain, sleep issues, low libido. But one of the biggest complaints I hear from women is actually about their brain. The brain fog. The anxiety that comes out of nowhere. The flat motivation. The unpredictable sleep. The feeling that you just do not feel like yourself anymore. And for a lot of women, that is the part that feels the most unsettling.

In this episode, I sit down with Dr. Scott Sherr to go much deeper into what may actually be happening underneath those symptoms. We talk about mitochondria, brain energy, neurotransmitters, methylene blue, nitric oxide, GABA, glutamate, and even nicotine, and how all of these may play a role in the way the midlife brain feels and functions.

This is one of those conversations that helps connect the dots between hormones and everything else that is happening in the brain and nervous system during this transition.

If you have been feeling mentally flat, overstimulated, exhausted, or like your brain has changed in ways no one can fully explain, this conversation is going to open up a whole new lens on what may be going on.

In this episode, we cover:

Why brain fog is such a common midlife complaint
What mitochondria actually are and why they matter for brain energy
How estrogen loss may contribute to mitochondrial dysfunction
How methylene blue may support mitochondria, energy production, and mental clarity
The difference between low-dose and high-dose methylene blue use
The truth about methylene blue and nitric oxide
Why GABA, glutamate, progesterone, magnesium, and B6 matter for the midlife brain
How stress and sympathetic overload affect mood, sleep, and focus
Why nicotine is being explored for cognition, brain inflammation, and vagus nerve support
Why HRT may help, but may not be the whole story for every woman

Who this episode is for

This episode is for women in perimenopause and menopause who are dealing with brain fog, anxiety, fatigue, poor motivation, sleep disruption, feeling overstimulated, or simply not feeling like themselves anymore. It is especially for women who want to understand what may be happening beyond hormones alone and are curious about the role of mitochondrial health, brain energy, and neurotransmitters in midlife symptoms.

Dr. Sherr is a board-certified internal medicine physician and a specialist in Hyperbaric Oxygen Therapy. He’s the COO of Troscriptions, a company developing physician-formulated buccal troches designed to support things like energy, focus, sleep, and stress resilience using compounds like methylene blue and other novel ingredients.

Troscriptions: Use coupon code HORMONE for 10% off your order.

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