Delphine Le Grand: Know Your Body to Lengthen Your Healthspan
Release Date: 08/05/2025
Delphine Le Grand: Know Your Body to Lengthen Your Healthspan
Healthy Longevity
Longevity isn’t just a roll of the genetic dice; it’s something you can actively shape. By building a plan to expand your healthspan, you’re investing in your future self, ensuring that as you age, you continue to feel strong, keep your brain sharp, and live life to the fullest. Being proactive is the point of longevity medicine, which takes the best parts of conventional healthcare and wellness and helps you play an active role in your health like never before, says Delphine Le Grand, an entrepreneur in the booming longevity space. Delphine is a bridge builder, fostering partnerships...
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Eric Klein, MD: The Promise of Multi-Cancer Early Detection Screening
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Would you want to know if cancer is in your health future? In many cases, detecting cancers early before they metastasize and when they are more easily treated is the key to survival and return to good health. Unfortunately, many aggressive cancers are identified in the later stages of progression, making treatment difficult and sometimes ineffective. Today, however, biomedical companies are racing to develop cancer screening technologies that may ultimately change the trajectory of cancer mortality. Leading that effort is GRAIL with its first-to-market Galleri multi-cancer early detection...
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Joelle Kaufman: Breast Cancer Champion and author of Crushing the Cancer Curveball: A Playbook for the Newly Diagnosed and their Family and Friends.
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If you or someone you know has been diagnosed with cancer, the hour you spend listening to this podcast will be life-changing and, possibly, lifesaving. In this episode, Dr. Comite talks with breast cancer survivor Joelle Kaufman, author of the book Crushing the Cancer Curveball. Kaufman was a cancer caregiver (to her mother and sister) before she was a breast cancer patient herself. “The BRACA1 gene was woven into our DNA fabric like an unwanted heirloom,” she says. Kaufman and Lauren Esserman, MD, director of the Breast Care Center at University of California, San Franciso School of...
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Many women who can benefit from hormones are still sitting on the sidelines because of long-held misconceptions about health risks of hormone therapy. “We need to move on from that crazy debate that hormones are bad,” says gynecologist and integrative medicine physician Felice Gersh MD, author of PCOS SOS and Menopause: 50 Things You Need to Know. “Estradiol is the elixir of life!” In this episode, Dr. Comite interviews Dr. Gersh about how insufficient hormones dramatically impact a woman’s current and future health. You’ll learn… ...
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Robin Rose, MD, Part II: Gastroenterologist and author of The 28-Day Gut Fix discusses hormone optimization and patient case studies with Dr. Comite.
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Hormone optimization, often referred to as HRT or hormone replacement therapy, has the power to transform women's lives—but despite its benefits, many women remain hesitant to pursue it due to unfounded fears. In Part II of her guest appearance on Healthy Longevity, gastroenterologist and long-COVID expert Robin Rose, MD, shares real-life case studies that reveal the tangible impact of hormone optimization. Combined with insights from Dr. Comite’s decades of endocrinology experience, these patient stories demonstrate how personalized treatment, regular monitoring, and education can make...
info_outline Longevity isn’t just a roll of the genetic dice; it’s something you can actively shape. By building a plan to expand your healthspan, you’re investing in your future self, ensuring that as you age, you continue to feel strong, keep your brain sharp, and live life to the fullest. Being proactive is the point of longevity medicine, which takes the best parts of conventional healthcare and wellness and helps you play an active role in your health like never before, says Delphine Le Grand, an entrepreneur in the booming longevity space. Delphine is a bridge builder, fostering partnerships with early-stage companies and longevity physicians to bring personalized, preventative care models to market. Join my conversation with Delphine as we explore this “cultural moment” that longevity medicine is currently enjoying and how it will impact you.
You’ll learn:
· The longevity medicine ecosystem is still in its infancy, but hang on for an explosion of technology, bioscience breakthrough, and more that will make living well beyond 100 years common.
· The first step in building a plan to lengthen your healthspan to match your lifespan is to know your body and understand what it’s telling you at the cellular level.
· Bio data is important but knowing what to do with that information to improve your health is essential. And that’s the piece of the puzzle that’s missing—unless you know where to look.
· The biggest breakthrough in reducing chronic cardiometabolic disease will come from reversing the carbohydrate metabolism disorder that affects 99 percent of human beings.
· To improve your health tomorrow, discover what’s holding you back from living in optimal health today. Is it poor sleep, unhealthy eating, insufficient exercise, or stress? Identify your nemesis and overcome it.
About Florence Comite, MD
Dr. Comite began her medical journey at Yale University School of Medicine and continued her training there with a residency in medicine. She completed a fellowship in Reproductive Endocrinology (multidisciplinary training incorporating pediatrics, gynecology, and andrology) at the National Institute of Child Health and Human Development. She remained at the National Institutes of Health as a senior clinical research associate before joining the Yale faculty as an associate professor in endocrinology. During her 25-year faculty tenure, Dr. Comite founded and directed Women’s Health at Yale.
In 2005, she launched her bespoke medical practice, Comite Center for Precision Medicine & Healthy Longevity, in New York City and, subsequently expanded offices to Palo Alto and Miami Beach.
Through her medical practice and decades of clinical research, Dr. Comite recognized that all humans have inherited a disorder of carbohydrate metabolism (a glucose disorder leading toward diabetes), which is accelerated by aging and the natural decline of the hormones testosterone and estrogen, which begins around age 30.
Dr. Comite’s podcast delivers the truth about your health—that age-related disease begins early in life at the cellular level. By slowing and even reversing the biological aging process, we can stay active and in great health for life. She interviews renowned physicians, researchers, and thought leaders, offering surprising insights and practical tips that listeners can use to improve their own health trajectory.
Next on Healthy Longevity with Florence Comite
Aug. 19: Dean Ornish, MD, world-renowned pioneer of lifestyle medicine, on practical steps to reverse chronic disease.