Delphine Le Grand: Know Your Body to Lengthen Your Healthspan
Release Date: 08/05/2025
Brad Younggren, MD: The Blood-Cleaning Therapy Tackling Microplastics and Aging
Healthy Longevity
Imagine flushing your engine oil and coolant to make an old car run like new; now imagine doing that for your bloodstream. That's the idea behind therapeutic plasma exchange (TPE), a treatment for autoimmune and blood disorders that's now being explored as a tool to slow biological aging and clear the body of inflammatory buildup. In this episode of Healthy Longevity, Brad Younggren, MD, CEO and co-founder of Circulate Health, joins the show to unpack groundbreaking new research co-conducted with the Comite Center showing that TPE can measurably reduce microplastic levels in human blood....
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How to Keep Your Brain Young, Part 2
Healthy Longevity
We return to Healthy Longevity for Part 2 of our discussion about brain health with special guest neurologist Shelly Jordan, MD. In this segment, Drs. Comite and Jordan talk about inflammation in the brain, natural killer cells, the APOE4 gene variant, and advanced imaging techniques for predicting cognitive decline. Dr. Jordan also summarizes the practical steps you can take to optimize your brain power, including building muscle through resistance training, improving your sleep, managing your environment, even controlling the air you breathe, and avoiding ingesting microplastics that...
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How to Keep Your Brain Young, Part 1
Healthy Longevity
If you’ve ever misplaced your keys or cell phone or forgotten the name of a friend you’ve known for decades, you’ve probably wondered, “is it early dementia?” Fear of cognitive decline is at an all-time high. A few years back, an AARP survey found that nearly half of adults over age 40 believe they will likely develop dementia. And Alzheimer’s Disease International reports nearly 80% of the public is worried about the disease. Are you? Brain fog, memory loss, and dementia are among the seven common patterns of aging I write about in my new book, Invincible: Defy Your...
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Dr. Drew Taylor: Regrow Hair with Your Own Stem Cells
Healthy Longevity
Imagine taking your own stem cells from your hair follicles, preserving and banking them to rejuvenate your hair and skin when you start to notice those annoying signs of aging in the mirror. This is not science fiction; it’s happening right now, and you will learn all about it in today’s episode of Healthy Longevity from my guest biomedical engineer Drew Taylor, PhD, CEO of the regenerative medicine company Acorn Biolabs.
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Sahil Chopra, MD: How to Sleep Well for Better Health Tonight
Healthy Longevity
Want to perform better tomorrow at anything you do? Then get a good night’s sleep tonight. “Sleep plays a critical role in restoration for humans; it is the housekeeping process for our physiology that allows us to restore and start the next day,” says sleep expert Sahil Chopra, MD, today’s guest on Healthy Longevity with Florence Comite MD. Dr. Chopra is co-founder and chief medical officer for Empower Sleep, a virtual sleep care program that makes personalized multi-night sleep analysis and treatment accessible from...
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Delphine Le Grand: Know Your Body to Lengthen Your Healthspan
Healthy Longevity
Longevity isn’t just a roll of the genetic dice; it’s something you can actively shape. By building a plan to expand your healthspan, you’re investing in your future self, ensuring that as you age, you continue to feel strong, keep your brain sharp, and live life to the fullest. Being proactive is the point of longevity medicine, which takes the best parts of conventional healthcare and wellness and helps you play an active role in your health like never before, says Delphine Le Grand, an entrepreneur in the booming longevity space. Delphine is a bridge builder, fostering partnerships...
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Carolyn DeLucia, MD: How to Build a Better Orgasm
Healthy Longevity
Trouble with arousal or orgasm? Low (or no) libido? Dryness and painful intercourse? Nearly half of all women will experience sexual dysfunction or intimacy issues like these at some point in their lives. Men suffer from some of these problems, too. But it doesn’t have to be that way. Advances in sexual health medicine offer exciting new solutions for these common obstacles to a healthy (and hot) sex life. Today’s Healthy Longevity guest is Carolyn DeLucia, MD, a former OBGYN, who’s now helping thousands of women and men rekindle their sexuality at her practice, The Secret Orchid, in...
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Rudy Eberwein, MD: The One-Two Punch Against Obesity
Healthy Longevity
A decade ago, the idea of a drug that could tackle obesity, insulin resistance, and cardiovascular disease sounded like pure science fiction. Today, thanks to peptides like Ozempic and Zepbound, it’s a reality and a lifeline to the more than 90 percent of Americans who have metabolic disease. In this episode, Dr. Comite discusses GLP-1s and other “booster shots to preventive medicine” with Rudy Eberwein, MD, founder of A New You Wellness in Miami, who specializes in weight loss, hormone optimization, and longevity. This episode answers many of the questions you may have...
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Alexander Volchonok, DMD: What Your Mouth Says About Your Health
Healthy Longevity
Not unlike your skin, your gums, the periodontal support tissues for your teeth, act as a frontline defense against bacteria and pathogens trying to enter your body. “If your gums are not healthy, you are not healthy,” says biologic dentist and periodontal surgeon Alexander Volchonok, DMD, co-founder of TetraHealth Dentistry in New York City. In this episode of Healthy Longevity with Florence Comite, MD, you’ll learn that the mouth is the window into the health of your entire body. Bleeding gums, a hallmark of periodontal disease, warn of dysbiosis of the mouth's microbiome ...
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Eric Klein, MD: The Promise of Multi-Cancer Early Detection Screening
Healthy Longevity
Would you want to know if cancer is in your health future? In many cases, detecting cancers early before they metastasize and when they are more easily treated is the key to survival and return to good health. Unfortunately, many aggressive cancers are identified in the later stages of progression, making treatment difficult and sometimes ineffective. Today, however, biomedical companies are racing to develop cancer screening technologies that may ultimately change the trajectory of cancer mortality. Leading that effort is GRAIL with its first-to-market Galleri multi-cancer early detection...
info_outline Longevity isn’t just a roll of the genetic dice; it’s something you can actively shape. By building a plan to expand your healthspan, you’re investing in your future self, ensuring that as you age, you continue to feel strong, keep your brain sharp, and live life to the fullest. Being proactive is the point of longevity medicine, which takes the best parts of conventional healthcare and wellness and helps you play an active role in your health like never before, says Delphine Le Grand, an entrepreneur in the booming longevity space. Delphine is a bridge builder, fostering partnerships with early-stage companies and longevity physicians to bring personalized, preventative care models to market. Join my conversation with Delphine as we explore this “cultural moment” that longevity medicine is currently enjoying and how it will impact you.
You’ll learn:
· The longevity medicine ecosystem is still in its infancy, but hang on for an explosion of technology, bioscience breakthrough, and more that will make living well beyond 100 years common.
· The first step in building a plan to lengthen your healthspan to match your lifespan is to know your body and understand what it’s telling you at the cellular level.
· Bio data is important but knowing what to do with that information to improve your health is essential. And that’s the piece of the puzzle that’s missing—unless you know where to look.
· The biggest breakthrough in reducing chronic cardiometabolic disease will come from reversing the carbohydrate metabolism disorder that affects 99 percent of human beings.
· To improve your health tomorrow, discover what’s holding you back from living in optimal health today. Is it poor sleep, unhealthy eating, insufficient exercise, or stress? Identify your nemesis and overcome it.
About Florence Comite, MD
Dr. Comite began her medical journey at Yale University School of Medicine and continued her training there with a residency in medicine. She completed a fellowship in Reproductive Endocrinology (multidisciplinary training incorporating pediatrics, gynecology, and andrology) at the National Institute of Child Health and Human Development. She remained at the National Institutes of Health as a senior clinical research associate before joining the Yale faculty as an associate professor in endocrinology. During her 25-year faculty tenure, Dr. Comite founded and directed Women’s Health at Yale.
In 2005, she launched her bespoke medical practice, Comite Center for Precision Medicine & Healthy Longevity, in New York City and, subsequently expanded offices to Palo Alto and Miami Beach.
Through her medical practice and decades of clinical research, Dr. Comite recognized that all humans have inherited a disorder of carbohydrate metabolism (a glucose disorder leading toward diabetes), which is accelerated by aging and the natural decline of the hormones testosterone and estrogen, which begins around age 30.
Dr. Comite’s podcast delivers the truth about your health—that age-related disease begins early in life at the cellular level. By slowing and even reversing the biological aging process, we can stay active and in great health for life. She interviews renowned physicians, researchers, and thought leaders, offering surprising insights and practical tips that listeners can use to improve their own health trajectory.
Next on Healthy Longevity with Florence Comite
Aug. 19: Dean Ornish, MD, world-renowned pioneer of lifestyle medicine, on practical steps to reverse chronic disease.