Sahil Chopra, MD: How to Sleep Well for Better Health Tonight
Release Date: 09/23/2025
Brad Younggren, MD: The Blood-Cleaning Therapy Tackling Microplastics and Aging
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Imagine flushing your engine oil and coolant to make an old car run like new; now imagine doing that for your bloodstream. That's the idea behind therapeutic plasma exchange (TPE), a treatment for autoimmune and blood disorders that's now being explored as a tool to slow biological aging and clear the body of inflammatory buildup. In this episode of Healthy Longevity, Brad Younggren, MD, CEO and co-founder of Circulate Health, joins the show to unpack groundbreaking new research co-conducted with the Comite Center showing that TPE can measurably reduce microplastic levels in human blood....
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How to Keep Your Brain Young, Part 2
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How to Keep Your Brain Young, Part 1
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Sahil Chopra, MD: How to Sleep Well for Better Health Tonight
Healthy Longevity
Want to perform better tomorrow at anything you do? Then get a good night’s sleep tonight. “Sleep plays a critical role in restoration for humans; it is the housekeeping process for our physiology that allows us to restore and start the next day,” says sleep expert Sahil Chopra, MD, today’s guest on Healthy Longevity with Florence Comite MD. Dr. Chopra is co-founder and chief medical officer for Empower Sleep, a virtual sleep care program that makes personalized multi-night sleep analysis and treatment accessible from...
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Delphine Le Grand: Know Your Body to Lengthen Your Healthspan
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Longevity isn’t just a roll of the genetic dice; it’s something you can actively shape. By building a plan to expand your healthspan, you’re investing in your future self, ensuring that as you age, you continue to feel strong, keep your brain sharp, and live life to the fullest. Being proactive is the point of longevity medicine, which takes the best parts of conventional healthcare and wellness and helps you play an active role in your health like never before, says Delphine Le Grand, an entrepreneur in the booming longevity space. Delphine is a bridge builder, fostering partnerships...
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Carolyn DeLucia, MD: How to Build a Better Orgasm
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Trouble with arousal or orgasm? Low (or no) libido? Dryness and painful intercourse? Nearly half of all women will experience sexual dysfunction or intimacy issues like these at some point in their lives. Men suffer from some of these problems, too. But it doesn’t have to be that way. Advances in sexual health medicine offer exciting new solutions for these common obstacles to a healthy (and hot) sex life. Today’s Healthy Longevity guest is Carolyn DeLucia, MD, a former OBGYN, who’s now helping thousands of women and men rekindle their sexuality at her practice, The Secret Orchid, in...
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Rudy Eberwein, MD: The One-Two Punch Against Obesity
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A decade ago, the idea of a drug that could tackle obesity, insulin resistance, and cardiovascular disease sounded like pure science fiction. Today, thanks to peptides like Ozempic and Zepbound, it’s a reality and a lifeline to the more than 90 percent of Americans who have metabolic disease. In this episode, Dr. Comite discusses GLP-1s and other “booster shots to preventive medicine” with Rudy Eberwein, MD, founder of A New You Wellness in Miami, who specializes in weight loss, hormone optimization, and longevity. This episode answers many of the questions you may have...
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Alexander Volchonok, DMD: What Your Mouth Says About Your Health
Healthy Longevity
Not unlike your skin, your gums, the periodontal support tissues for your teeth, act as a frontline defense against bacteria and pathogens trying to enter your body. “If your gums are not healthy, you are not healthy,” says biologic dentist and periodontal surgeon Alexander Volchonok, DMD, co-founder of TetraHealth Dentistry in New York City. In this episode of Healthy Longevity with Florence Comite, MD, you’ll learn that the mouth is the window into the health of your entire body. Bleeding gums, a hallmark of periodontal disease, warn of dysbiosis of the mouth's microbiome ...
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Eric Klein, MD: The Promise of Multi-Cancer Early Detection Screening
Healthy Longevity
Would you want to know if cancer is in your health future? In many cases, detecting cancers early before they metastasize and when they are more easily treated is the key to survival and return to good health. Unfortunately, many aggressive cancers are identified in the later stages of progression, making treatment difficult and sometimes ineffective. Today, however, biomedical companies are racing to develop cancer screening technologies that may ultimately change the trajectory of cancer mortality. Leading that effort is GRAIL with its first-to-market Galleri multi-cancer early detection...
info_outlineWant to perform better tomorrow at anything you do? Then get a good night’s sleep tonight. “Sleep plays a critical role in restoration for humans; it is the housekeeping process for our physiology that allows us to restore and start the next day,” says sleep expert Sahil Chopra, MD, today’s guest on Healthy Longevity with Florence Comite MD.
Dr. Chopra is co-founder and chief medical officer for Empower Sleep, a virtual sleep care program that makes personalized multi-night sleep analysis and treatment accessible from home.
Nearly 40% of adults report falling asleep during the day without meaning to at least once a month. Also, an estimated 50 to 70 million Americans have chronic, or ongoing, sleep disorders, according to the Centers for Disease Control and Prevention.
“If people don’t sleep well, the likelihood of having cardiovascular disease … is higher, the possibility of cancer is six-fold higher,” says Chopra. “Growth hormone levels are lower; cortisol dysregulation is higher. Circadian rhythms, if they are misaligned, result in a compromised metabolic state. REM sleep plays a critical role in emotional stability.”
If you’re suffering from brain fog or nodding off at your desk after lunch, you’ll want to tune in to discover how to dramatically improve your health and health trajectory by improving your sleep habits.
You’ll learn:
* Sleep debt builds slowly, so you may not recognize what it’s doing to you.
* Why a one-night sleep study is not an effective way to diagnose a sleep disorder.
* Sleep trackers like Empower Sleep’s medical-grade ring and consumer models like the Oura Ring provide patients with real-time analysis of their sleep quality in their own bed without spending a restless night in a sleep lab wired to a machine.
* Poor sleep is a gut punch, affecting the gut microbiome by disrupting the GI tract’s normal nightly slow-down, which allows its epithelial lining to repair and recover.
* Lack of sleep compromises the immune system. Studies show that sleep-deprived people (getting four to six hours of sleep) don’t respond to vaccines as well as people who get adequate sleep (seven to eight hours).
* During deep sleep stages, blood flow to the brain peaks through the glymphatic system, which clears the beta amyloid and tau proteins that are believed to play a role in Alzheimer’s dementia.
* What to do an hour before bedtime and within 15 minutes of waking to reset a healthy circadian rhythm.
* Remedies for restless leg syndrome, including new technology that stimulates nerves in the legs to make the brain think that your lower limbs are moving.
* And much more!
About Florence Comite, MD
Dr. Comite began her medical journey at Yale University School of Medicine and continued at Yale with a residency in medicine. She completed a fellowship in Reproductive Endocrinology (multidisciplinary training incorporating pediatrics, gynecology, and andrology) at the National Institute of Child Health and Human Development. She remained at the National Institutes of Health as a senior clinical research associate before joining the Yale faculty as an associate professor in endocrinology. During her 25-year faculty tenure, Dr. Comite founded and directed Women’s Health at Yale.
In 2005, she launched her bespoke medical practice, Comite Center for Precision Medicine & Healthy Longevity, in New York City and subsequently expanded offices to Palo Alto and Miami Beach.
Through her medical practice and decades of clinical research, Dr. Comite recognized that all humans have inherited a disorder of carbohydrate metabolism (a glucose disorder leading toward diabetes), which is accelerated by aging and the natural decline of the hormones testosterone and estrogen, which begins around age 30.
Dr. Comite’s podcast delivers the truth about your health—that age-related disease begins early in life at the cellular level. By slowing and even reversing the biological aging process, we can stay active and in great health for life. She interviews renowned physicians, researchers, and thought leaders offering surprising insights and practical tips that listeners can use to improve their own health trajectory.