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Dr. Helen Messier on AI, Epigenetics & the Future of Aging | SNH Podcast #165

Release Date: 03/04/2026

Microglia, Metabolism & the Future of Brain Health | HOMe Podcast #005

Health Optimization Medicine Podcast

In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr is joined by renowned neurologist and bestselling author Dr. David Perlmutter to explore one of the most important breakthroughs in brain health — the role of microglia. Often overlooked, microglial cells are the brain’s immune system and play a central role in determining whether the brain thrives or degenerates over time. Dr. Perlmutter explains how these cells can shift between protective (M2) and destructive (M1) states — and how this shift underlies neurodegenerative diseases like Alzheimer’s,...

The Science of Chronobiology & Health Optimization | HOMe Podcast #004

Health Optimization Medicine Podcast

In this episode of the Health Optimization Medicine Podcast, join Boomer Anderson, Dr. Ted Achacoso, Dr. Allen Bookatz, and Jodi Duval as they explore chronobiology — and how modern life is disrupting the body’s natural rhythms. From jet lag and shift work to late-night scrolling and irregular meals, the conversation dives into what Dr. Ted calls “circadian pollution” — the mismatch between our biology and the environments we’ve created. More importantly, the team breaks down simple, powerful tools to re-entrain your body clock using light, food timing, and movement — all...

Health vs Disease Markers: What Doctors Miss | HOMe Podcast #003

Health Optimization Medicine Podcast

In this episode of the Health Optimization Medicine Podcast, join Boomer Anderson, Jodi Duval, Dr. Allen Bookatz, and Dr. Ted Achacoso as they explore the future of clinical intelligence — and why medicine must move beyond single biomarkers to understanding networks within the body. Rather than chasing isolated lab values like glucose, cholesterol, or testosterone, the conversation shifts toward a systems-based approach — where every biomarker is part of a dynamic network of relationships. From metabolomics to hormone balance, this episode explains why optimizing health requires...

The Biology of Comfort and Why We Need Stress | HOMe Podcast #002

Health Optimization Medicine Podcast

In this episode of the Health Optimization Medicine Podcast, join Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Allen Bookatz, and Jodi Duval as they explore the hidden cost of convenience and comfort in modern life. From ultra-processed foods and low-fiber diets to sedentary lifestyles and technology-driven comfort, the conversation dives into how convenience is quietly reshaping our biology. The HOMeHOPe Faculty explains why small daily habits — like eating whole foods, moving regularly, and embracing mild discomfort — are essential for maintaining cellular health and...

What Is Health Optimization Medicine? | HOMe Podcast #001

Health Optimization Medicine Podcast

In this episode of the Health Optimization Medicine Podcast, the HOMeHOPe Faculty comes together for a roundtable conversation exploring the core philosophical framework behind Health Optimization Medicine. Dr. Scott Sherr, Boomer Anderson, and Dr. Allen Bookatz break down the three fundamental perspective shifts that redefine how we think about health, disease, aging, and the human body itself. Rather than focusing on disease management, this episode introduces the foundational principles behind building health from the cellular level up. Join us as we delve into: • The shift from...

Dr. Helen Messier on AI, Epigenetics & the Future of Aging | SNH Podcast #165

Health Optimization Medicine Podcast

In this episode of the Smarter Not Harder Podcast, Dr. Helen Messier joins Dr. Scott Sherr for a wide-ranging and thought-provoking conversation about longevity, epigenetics, AI-powered medicine, and the real meaning of healthspan. From whole genome sequencing to digital twins and emotional resilience, this episode bridges cutting-edge science with deeply human healing in a way that challenges how we think about aging. Join us as we delve into: The difference between lifespan and healthspan — and why resilience matters more than years Whole genome sequencing, polygenic risk scores, and...

52 Years in Nutritional Medicine with Dr. Alan Gaby | SNH Podcast #164

Health Optimization Medicine Podcast

In this episode of the Smarter Not Harder Podcast, Dr. Alan Gaby joins Jodi Duval to explore over five decades of clinical experience in nutritional medicine. From vitamin C and magnesium to hidden food allergies and the Myers’ Cocktail, this conversation unpacks what actually works — and why much of it is still ignored by conventional medicine. Join us as we delve into: • Why magnesium may be the most overlooked nutrient deficiency • Folic acid vs. methylfolate — what the research really says • The truth about vitamin C, IV therapy, and immune resilience • Hidden food allergies...

Dr. Linda Kiley: Bladder Health, Peptides & Pelvic Repair | SNH Podcast #163

Health Optimization Medicine Podcast

In this episode of the Smarter Not Harder Podcast, Dr. Linda Kiley joins Dr. Scott Sherr for a groundbreaking conversation on functional urogynecology — exploring the real causes of pelvic and bladder pain that most conventional models miss. Dr. Kiley shares how she uses muscle exams, peptide protocols, and root-cause diagnostics to treat conditions like interstitial cystitis, chronic UTIs, pelvic floor dysfunction, and endometriosis — often without surgery or long-term antibiotics. If you or someone you love has been told “there’s nothing wrong” but still struggles with pelvic...

Grace Hawkins on Personalized Health & Hidden Root Causes | SNH Podcast #162

Health Optimization Medicine Podcast

In this episode of the Smarter Not Harder Podcast, Grace Hawkins joins Jodi Duval to share her inspiring journey from medical misdiagnosis to becoming a personalized health mentor. With a background in naturopathy and clinical diagnostics, Grace blends DNA, blood chemistry, and HTMA testing to help her clients uncover the root causes of dysfunction and reclaim agency in their health journey. From endometriosis and burnout to lab interpretation and emotional patterns, this episode is a roadmap for how to think critically, test wisely, and personalize healing in a system that often fails to see...

The New Rules for Aging Better, Smarter, and Sharper | SNH Podcast #161

Health Optimization Medicine Podcast

In this episode of the Smarter Not Harder Podcast, Dr. Amanda Wiggins joins Jodi Duval to explore one of the most promising frontiers in longevity and neuroscience: brain vascular health. From her discovery of CGP (cyclic glycine-proline) to the science behind neurovascular aging, Dr. Wiggins explains why capillaries, inflammation, and even insulin play a much bigger role in dementia than most people realize. From biotech insights to personal stories, this conversation reveals what we can all do — starting now — to protect our brains as we age. Join us as we explore: • What CGP is and...

More Episodes

Join us as we delve into:

The difference between lifespan and healthspan — and why resilience matters more than years
Whole genome sequencing, polygenic risk scores, and the limits of genetic hype
Multi-omics medicine: genomics, metabolomics, proteomics, and systems biology
AI in healthcare, digital twins, and the return of the “country doctor” model

This episode is for you if:

You’re curious about biological age vs. chronological age
You want to understand what genetic testing can (and can’t) tell you
You’re fascinated by AI’s role in the future of personalized medicine
You want smarter, not harder ways to build resilience and optimize longevity

You can also find this episode on…
Youtube: https://youtu.be/QQ-kIH3XbF0

Learn more about Dr. Helen Messier:
Fountain Life: https://www.fountainlife.com/
Instagram: https://www.instagram.com/fountainlife/
Website: https://www.ifm.org/educator/helen-messier
LinkedIn: https://www.linkedin.com/in/helen-messier-phd-md/

Find more from Smarter Not Harder:
Website: Smarter Not Harder Podcast
Instagram: https://instagram.com/troscriptions/
HOMeHOPe Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026

Get 10% off your purchase of the Metabolomics module with code PODCAST10 at https://www.homehope.org/
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