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Redefining Parkinson’s Treatment: Dr. Jonathan Sackner-Bernstein on a Novel Approach to Treatment and Disease Reversal

Release Date: 02/28/2025

CNS Neurons That Actually Regenerate Throughout Life

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In this eye-opening episode of The Neuron Regeneration Podcast, we explore the remarkable regenerative power of olfactory neurons—and what that could mean for healing damage in the central nervous system. Host Jarod Carter is joined by Claudia Garrigós (PhD student) and Jaume Lillo (postdoctoral researcher), two scientists from the University of Barcelona who are authors on a fascinating review paper titled: . While neurons in the brain and spinal cord typically don’t regenerate after injury, olfactory neurons do—and they do so throughout adulthood. This unique biological process may...

Redefining Parkinson’s Treatment: Dr. Jonathan Sackner-Bernstein on a Novel Approach to Treatment and Disease Reversal

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In this insightful episode of the Neuron Regeneration Podcast, we explore a groundbreaking new perspective on Parkinson’s disease treatment. Dr. Jonathan Sackner-Bernstein, a physician, engineer, and former FDA and DARPA leader, challenges the long-held belief that Parkinson’s is solely a disease of dopamine deficiency. Instead, his research suggests that excess dopamine inside neurons may be a key driver of the disease—an insight soon-to-be-tested in human clinical trials with a repurposed drug that could potentially stop Parkinson’s progression. Dr. Sackner-Bernstein shares his...

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Bench to Bedside Translation Masterclass: Dr. Jeff Karp on the Art of Innovation and Radical Simplicity

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How to Fund Breakthroughs in Neuron Regeneration with Tom Kalil

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In this episode of the Neuron Regeneration podcast, we step outside the lab and into a topic that's just as critical as the science itself—funding. While most episodes focus on the cutting-edge discoveries behind neuron regeneration, today, we’re talking about how those discoveries can make it into the clinic to help people. We’re joined by Tom Kalil, a leader in innovation and science policy who has spent decades helping researchers turn high-risk, high-reward ideas into reality. With an incredible background that includes working in the White House for Presidents Clinton and Obama, and...

Advances in Neuroregeneration: Biomimetic Scaffolds, Hydrogels, and Biomaterials for Optic, Facial, Spinal, and Peripheral Nerve Repair

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Dr. Reggie Edgerton - Neuromodulation for Spinal Cord Injury, Cerebral Palsy, Parkinsons, and more

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The Latest in Neural Regeneration Research and News

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This third episode of The Neuron Regeneration Podcast is the News and Abstract reading episode of the show. We will frequently produce these episodes aimed at providing listeners with a convenient way to stay up to date on the latest in neural regeneration research, innovations, and advancements. Papers and Topics Discussed: P75 ECD 10 FC and Neonatal Hypoxic Ischemic Encephalopathy (NHIE) Published in the Journal of Biomedicine and Pharmacotherapy, this study examines how a recombinant fusion protein, P75 ECD-FC, reverses neurological deficits and promotes neuronal regeneration in...

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The Neuron Regeneration Podcast Introduction

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In this heartfelt and inspiring inaugural episode, host Jarod Carter shares the deeply personal story behind the creation of The Neuron Regeneration Podcast and the Neuron Regeneration community. As the father of twins diagnosed with Spinal Muscular Atrophy (SMA), Jarod opens up about the challenges his family has faced and the ongoing fight to reverse the devastating effects of neurodegenerative diseases. He explains his mission to accelerate breakthroughs in neuron regeneration and the hope of finding treatments that can fully heal and repair damaged neurons—work that could impact millions...

More Episodes

Instead, his research suggests that excess dopamine inside neurons may be a key driver of the disease—an insight soon-to-be-tested in human clinical trials with a repurposed drug that could potentially stop Parkinson’s progression.

Dr. Sackner-Bernstein shares his journey from cardiology to neuroscience, how personal experience led him to question conventional wisdom, and why breaking out of silos in research is key to advancing new treatments.

Key Topics Discussed:

Rethinking Parkinson’s Disease:
Why the prevailing dopamine deficiency model may be incomplete—and how shifting our understanding could transform treatment.
From Discovery to Clinical Trials:
How a repurposed drug, already FDA-approved for other uses, will soon being tested for its potential to stop or even reverse Parkinson’s disease.
The Challenge of Scientific Dogma:
What it takes to challenge long-standing medical assumptions and gain acceptance for new ideas in the scientific community.
Cross-Disciplinary Innovation:
How expertise in cardiology, drug development, and regulatory science informed Dr. Sackner-Bernstein’s unique approach to Parkinson’s research.
Funding and the Future of Repurposed Drugs:
Why securing investment for repurposed drugs is difficult, and how strategic patenting can help ensure their viability as new treatments for new indications.
The Power of “First Principles” Thinking:
How revisiting the fundamental assumptions of a disease can unlock new therapeutic possibilities.

Articles being discussed:

Stay connected:

Connect with Dr. Jonathan Sackner-Bernstein:

Website: https://www.parkinsonsdisease.blog
LinkedIn: https://www.linkedin.com/in/jonathansb/

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