Frogs help Fred Hutch find the shape of small things
From Bench to Bedside and Beyond
Release Date: 10/27/2025
From Bench to Bedside and Beyond
In this episode of Bench to Bedside and Beyond, we talk to a 25-year prostate cancer survivor and the director of the new sexual health clinic at Fred Hutch about why it’s important to include sexual health in the survivorship conversation. Prostate cancer survivor James DeLong and Kelly Nelson, director of Fred Hutch’s new sexual health clinic, discuss how a cancer diagnosis can wreak havoc on a person’s sex life—and how people no longer need to suffer in silence. Key takeaways: The side effects of cancer treatment can make having a healthy sex life...
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John Higgins interviews Dr. Rashmi Mishra, a postdoctoral research fellow in the Hsieh Lab at Fred Hutch Cancer Center, about how aggressive prostate cancer shapeshifts from a form that is treatable with drugs to a more lethal form that is much less treatable. In a recent study, she and her colleagues found potential ways to reverse that trick, forcing tumor cells to shapeshift back into the more treatable form. Their discovery opens a new line of attack against aggressive prostate cancer, as well as breast cancer and possibly other cancers. Key Takeaways: Prostate...
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In this episode of Bench to Bedside and Beyond, Bonnie Rochman talks to a bone marrow transplant survivor and the director of psychiatry at Fred Hutch. Leukemia survivor and bone marrow transplant recipient Nicole Sandburg and Jesse Fann, MD, MPH, Medical Director, Psychiatry and Psychology, discuss the ways a cancer diagnosis can upend emotional health and how mental health services including mindfulness can help patients cope. Key takeaways: Dealing with cancer can have profound emotional effects that outlast the treatment. Recovery requires more than physical healing....
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Dr. Lucas Sullivan, a cancer metabolism expert at Fred Hutch Cancer Center talks with John Higgins about a new study showing that cancers driven by a specific mutation crave a nutrient so much that eating too much of it can be lethal. Healthy cells aren’t prone to stuffing themselves with this nutrient. That difference presents an opportunity for precision oncology: we can supplement a patient’s diet to force-feed tumors the nutrient while sparing healthy cells. Key takeaways: A recent study by Dr. Lucas Sullivan, a cancer metabolism expert, finds that feeding NRF2-mutated...
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Cancer survivorship is about far more than finishing treatment. In this episode of Bench to Bedside and Beyond, Diane Mapes speaks with prostate cancer survivor and advocate Marty Chakoian and cancer rehabilitation specialist Dr. Hanna Hunter about the physical, emotional and practical realities of life after a cancer diagnosis. Together, they discuss treatment side effects, the value of patient advocacy and support groups, advances in less toxic therapies, and how rehabilitation, exercise and supportive care services help patients maintain quality of life throughout the cancer continuum. Key...
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In this episode of From Bench to Bedside and Beyond, host Diane Mapes talks with Dr. Vidhya Nair, medical director of adult cancer survivorship at Fred Hutch, about what truly happens after active cancer treatment ends. Together, they explore late and long-term side effects, fear of recurrence, and the emotional whiplash many patients feel when treatment stops but symptoms and worries do not. Dr. Nair also explains how Fred Hutch’s evolving survivorship program—from embedded care in disease clinics to specialized services in rehab, sexual health, and integrative medicine—helps survivors...
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As cancer survival rates rise, “survivorship” has emerged as a critical new phase of care - one that extends far beyond treatment and into long-term physical, emotional, and psychological recovery. Through firsthand stories from a breast cancer survivor and a melanoma survivor-turned-provider, this episode reveals how patients navigate side effects, fear of recurrence, and life-altering changes that can last for decades. It also highlights how survivorship programs at Fred Hutch are evolving to support patients earlier and more holistically, helping them move from treatment toward living...
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In this episode, Trang VoPham, PhD, MPH, MS, from Fred Hutch Cancer Center discusses the impact of environmental exposures like wildfire smoke and solar jet lag on health with Diane Mapes from Fred Hutch News. Dr. VoPham also lists other potential risks, such as for liver cancer, and offers potential strategies for mitigation of these impacts. One takeaway: Where you live in a time zone impacts your circadian rhythms and your risks for disease.
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In this episode of From Bench to Bedside and Beyond, Fred Hutch psychologist and public health researcher Dr. Jonathan Bricker, who holds the Endowed Chair in Cancer Prevention, talks to Diane Mapes about why people embrace dietary supplements, which are unregulated by the FDA and require no safety or scientific studies, and turn away from science-based cancer prevention like the HPV vaccine. “It’s not about ignorance or misinformation,” Bricker said. “It’s about a basic human desire to avoid discomfort and to have control.” Takeaways: Many people...
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In this episode of From Bench to Bedside and Beyond, Dr. Yaw Nyame and patient Dave Lucas talk with Fred Hutch's Bonnie Rochman on exploring innovative kidney cancer treatments, robotic surgery and the importance of personalized care. Discover how advanced surgical techniques and patient-centered approaches can lead to remarkable recovery stories like Lucas's. Takeaways Robotic surgery can significantly reduce recovery time for complex cases Personalized care involves understanding patient goals and lifestyle. Advanced surgical techniques require meticulous planning and...
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