CAR T-cell therapy with Dr. Mazyar Shadman
From Bench to Bedside and Beyond
Release Date: 11/25/2025
How Wildfire Smoke, Light at Night, and 'Solar Jet Lag' Can Increase Cancer Risk
From Bench to Bedside and Beyond
In this episode, Trang VoPham, PhD, MPH, MS, from Fred Hutch Cancer Center discusses the impact of environmental exposures like wildfire smoke and solar jet lag on health with Diane Mapes from Fred Hutch News. Dr. VoPham also lists other potential risks, such as for liver cancer, and offers potential strategies for mitigation of these impacts. One takeaway: Where you live in a time zone impacts your circadian rhythms and your risks for disease.
info_outline
Why do we choose the ‘quick fix’ over tried-and-true cancer prevention?
From Bench to Bedside and Beyond
In this episode of From Bench to Bedside and Beyond, Fred Hutch psychologist and public health researcher Dr. Jonathan Bricker, who holds the Endowed Chair in Cancer Prevention, talks to Diane Mapes about why people embrace dietary supplements, which are unregulated by the FDA and require no safety or scientific studies, and turn away from science-based cancer prevention like the HPV vaccine. “It’s not about ignorance or misinformation,” Bricker said. “It’s about a basic human desire to avoid discomfort and to have control.” Takeaways: Many people...
info_outline
From diagnosis to biking in Croatia: a kidney cancer patient’s journey
From Bench to Bedside and Beyond
In this episode of From Bench to Bedside and Beyond, Dr. Yaw Nyame and patient Dave Lucas talk with Fred Hutch's Bonnie Rochman on exploring innovative kidney cancer treatments, robotic surgery and the importance of personalized care. Discover how advanced surgical techniques and patient-centered approaches can lead to remarkable recovery stories like Lucas's. Takeaways Robotic surgery can significantly reduce recovery time for complex cases Personalized care involves understanding patient goals and lifestyle. Advanced surgical techniques require meticulous planning and...
info_outline
Cancer patient advocate reinforces importance of normalizing conversations about symptoms
From Bench to Bedside and Beyond
In this conversation, Margie Wilson talks to Fred Hutch Cancer Center’s Bonnie Rochman about her experience being diagnosed with endometrial cancer and her evolution into a patient advocate for Black women. She discusses her initial symptoms and treatment, the challenges of navigating the medical system, and the importance of having open conversations about women's health and finding a supportive healthcare provider. Margie was diagnosed with endometrial cancer in 2016 after experiencing unexplained bleeding that she attributed to menopause. The first oncologist she saw was...
info_outline
CAR T-cell therapy with Dr. Mazyar Shadman
From Bench to Bedside and Beyond
Dr. Mazyar Shadman is a blood cancer specialist at Fred Hutch Cancer Center who focuses on lymphoid malignancies. In a conversation with Bonnie Rochman, they explore the advancements in CAR T-cell therapy, particularly for large B-cell lymphoma, highlighting its impact on patient outcomes and survival rates. Takeaways CAR T therapy is a significant advancement in cancer treatment. The future of cancer treatment may heavily rely on CAR T advancements. CAR T therapy represents a shift in cancer care paradigms. It is particularly effective for large B-cell...
info_outline
Delivering the Best Possible Cancer Care with Tom Purcell
From Bench to Bedside and Beyond
In this conversation, Dr. Tom Purcell, Chief Medical Officer at Fred Hutch Cancer Center, discusses his role in overseeing quality care delivery and patient satisfaction with Bonnie Rochman. He reflects on his previous experience in a community cancer program and emphasizes the importance of a multidisciplinary team approach in optimizing patient care. The conversation also touches on the cultural shifts necessary for improving healthcare delivery and the ongoing efforts to enhance patient access and satisfaction.
info_outline
Frogs help Fred Hutch find the shape of small things
From Bench to Bedside and Beyond
Frogs are back at Fred Hutch after a long absence to study the structure of DNA-linked molecular complexes that change during the cell cycle and malfunction in cancer and other diseases. Fred Hutch writer / editor John Higgins discusses his latest story on the current and past frog research with multimedia editor Robert Hood.
info_outline
The Message Is the Medium - David Patton and Robert Hood
From Bench to Bedside and Beyond
After more than a decade of providing high-quality cancer and research stories via the Fred Hutch website, the organization is evolving its storytelling to go beyond the browser. David Patton, Fred Hutch's content strategy lead, talks with Heart of the Hutch producer and multimedia editor Robert Hood about this dynamic storytelling evolution. The goal is to reach audiences with the same high value cancer and science information in the platforms and formats they are now relying on more often. Learn more at FredHutch.com/News
info_outline
When work becomes personal - John Scheleen
From Bench to Bedside and Beyond
Welcome to Bench to Bedside and Beyond, stories from Fred Hutch Cancer Center about how our scientists and clinicians are combining innovative research with compassionate care to address the impact of cancer and infectious disease. You'll hear from patients, researchers, doctors, caregivers, supporters and others seeking to prevent and eliminate cancer. In this conversation, John Scheleen talks about his experience being treated for cancer for much of his tenure as a Fred Hutch employee with Bonnie Rochman, a writer for Fred Hutch News. Scheleen recounts how he found a "weird mole" that...
info_outline
Gratitude inspires a job search - Tiffany Bucklin
From Bench to Bedside and Beyond
Welcome to Bench to Bedside and Beyond, stories from Fred Hutch Cancer Center about how our scientists and clinicians are combining innovative research with compassionate care to address the impact of cancer and infectious disease. You'll hear from patients, researchers, doctors, caregivers, supporters and others seeking to prevent and eliminate cancer. In this conversation, Tiffany Bucklin talks about her unwavering commitment to getting a job at Fred Hutch after her husband was treated here for leukemia. She tells Bonnie Rochman, a writer for Fred Hutch News, how her husband's care team...
info_outlineDr. Mazyar Shadman is a blood cancer specialist at Fred Hutch Cancer Center who focuses on lymphoid malignancies. In a conversation with Bonnie Rochman, they explore the advancements in CAR T-cell therapy, particularly for large B-cell lymphoma, highlighting its impact on patient outcomes and survival rates.
Takeaways
- CAR T therapy is a significant advancement in cancer treatment.
- The future of cancer treatment may heavily rely on CAR T advancements.
- CAR T therapy represents a shift in cancer care paradigms.
- It is particularly effective for large B-cell lymphoma.
- Patients with relapsed disease historically had limited survival chances.
- CAR T therapy has improved outcomes for high-risk patients.
- 30 to 40% of patients are now being cured with CAR T therapy.
- The treatment offers better quality of life compared to standard care.
- Ongoing research is crucial for further advancements in CAR T.
- Patient selection is key for the success of CAR T therapy.