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How Circadian Rhythms Shape Strength, Recovery, and Health with Dr. Karen Esser #829

Barbell Shrugged

Release Date: 12/31/2025

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Barbell Shrugged

In this episode of Barbell Shrugged, Doug Larson and Travis Mash officially welcome Dr. Mike Lane as the show’s new co-host. Mike shares his full origin story, from growing up a sports-loving kid in St. Louis, to discovering strength and conditioning in college, to earning his PhD and becoming a professor of exercise physiology. Along the way, he reflects on the mentors who shaped his thinking, including time spent around Westside Barbell, Olympic lifting culture, and elite academic labs that blended hard training with hard science. The conversation dives deep into the intersection of...

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In this episode, Dr. Karen Esser Professor and Chair of the Department of Physiology and Aging at the University of Florida joins the crew to break down one of the most overlooked performance variables in human physiology: circadian timing. After a career spent studying muscle adaptation, Dr. Esser shifted her research toward the molecular clocks inside our tissues, uncovering how every cell in the body keeps its own time. She explains how these clocks govern fuel storage, protein repair, metabolic readiness, and ultimately the way muscle responds to training. The team digs into what these...

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In this week’s episode of Barbell Shrugged, Anders Varner, Doug Larson, Coach Travis Mash, and Dr. Chris Perry dive deep into the real science of muscle mass, why it’s the single most important tissue in the human body and what happens when you don’t have enough of it. They cover everything from how muscle mass impacts disease risk, hormone balance, metabolism, and injury prevention to why being “under-muscled” may be just as dangerous as being overweight. Dr. Perry explains how strength training and nutrition can reverse age-related muscle loss and why the decade between your...

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In this episode, neuroscientist and U.S. Army sleep expert Dr. Allison Brager joins Anders Varner, Doug Larson, and Travis Mash to explore the real science behind sleep, recovery, and wearable technology. They discuss which devices actually deliver useful data, such as the Oura Ring for sleep tracking and Garmin for cardiovascular measurements, and why being consistent with one tool is more important than chasing perfect accuracy. Dr. Brager explains how wearables are now being used in place of sleep labs in both clinical and military settings to help athletes and operators make better...

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More Episodes

In this episode, Dr. Karen Esser Professor and Chair of the Department of Physiology and Aging at the University of Florida joins the crew to break down one of the most overlooked performance variables in human physiology: circadian timing. After a career spent studying muscle adaptation, Dr. Esser shifted her research toward the molecular clocks inside our tissues, uncovering how every cell in the body keeps its own time. She explains how these clocks govern fuel storage, protein repair, metabolic readiness, and ultimately the way muscle responds to training. The team digs into what these clocks do, how they synchronize, and why misalignment affects everything from daily performance to long-term health.

The conversation dives deep into time-of-day effects on strength, endurance, and adaptation. Dr. Esser highlights that humans are consistently stronger and more explosive in the afternoon, a pattern reflected in Olympic records and decades of performance data. But her lab’s animal research reveals something game changing: consistent morning training can shift the internal clock system, allowing morning athletes to achieve equal or even better adaptations after several weeks, despite using lower absolute training loads. She also explains how travel, jet lag, and mistimed eating disrupt organ specific clocks, reducing performance and creating metabolic consequences similar to pre-diabetes. The crew tests these ideas against real world training habits, coaching experience, and what happens when athletes switch from evening to early morning training.

Finally, Dr. Esser unpacks the broader health implications of circadian disruption from increased risk of metabolic disease and cardiovascular dysfunction to higher rates of depression and cancer in chronically misaligned shift workers. She outlines simple, actionable strategies: anchor your sleep and training times, keep eating within a roughly 10 hour window, avoid late night calories, and arrive early when competing across time zones. The conversation closes with practical takeaways for athletes, coaches, and everyday lifters who want to maximize adaptation, improve metabolic health, and align their biology with the rhythms built into every cell.

Links:

Anders Varner on Instagram

Doug Larson on Instagram

Coach Travis Mash on Instagram