New Landscape for Controlling Obesity and Lowering Incidence of Related Diseases with Dr. Steffen-Sebastian Bolz Aphaia Pharma TRANSCRIPT
Release Date: 06/24/2024
Innovations in Cell Therapy for Relapsed and Refractory Multiple Myeloma with Dr. Chris Heery Arcellx TRANSCRIPT
Empowered Patient Podcast
Dr. Chris Heery is Chief Medical Officer at Arcellx, a company focusing on developing anito-cel, a significant advancement in CAR-T cell therapy, to treat relapsed and refractory multiple myeloma (rrMM). Multiple myeloma is a rare type of blood cancer that affects plasma cells in the bone marrow and has few treatment options. Arcellx is showing promising data from clinical trials with patients with rrMM who have failed prior therapies and have received Fast Track, Orphan Drug, and Regenerative Medicine Advanced Therapy Designations from the FDA for anito-cel. Chris explains, "The company was...
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Innovations in Cell Therapy for Relapsed and Refractory Multiple Myeloma with Dr. Chris Heery Arcellx
Empowered Patient Podcast
Dr. Chris Heery is Chief Medical Officer at Arcellx, a company focusing on developing anito-cel, a significant advancement in CAR-T cell therapy, to treat relapsed and refractory multiple myeloma (rrMM). Multiple myeloma is a rare type of blood cancer that affects plasma cells in the bone marrow and has few treatment options. Arcellx is showing promising data from clinical trials with patients with rrMM who have failed prior therapies and have received Fast Track, Orphan Drug, and Regenerative Medicine Advanced Therapy Designations from the FDA for anito-cel. Chris explains, "The company was...
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Hyperbaric Oxygen Therapy for Treating PTSD and Cognitive Decline with Dr. Mohammed Elamir Aviv Clinics TRANSCRIPT
Empowered Patient Podcast
Dr. Mohammed Elamir, lead physician at Aviv Clinics, offers diagnostics and treatments for brain injuries such as PTSD, stroke, and traumatic brain injury and to address cognitive decline. After comprehensive physical and mental assessment, including brain scans, patients receive hyperbaric oxygen therapy and other therapies like psychotherapy and neurocognitive training. Individualized plans are designed to get to the root causes of neurological and cognitive issues and stimulate the growth of new cells and blood flow, even for patients with long-standing conditions. Dr. Mo explains,...
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Hyperbaric Oxygen Therapy for Treating PTSD and Cognitive Decline with Dr. Mohammed Elamir Aviv Clinics
Empowered Patient Podcast
Dr. Mohammed Elamir, lead physician at Aviv Clinics, offers diagnostics and treatments for brain injuries such as PTSD, stroke, and traumatic brain injury and to address cognitive decline. After comprehensive physical and mental assessment, including brain scans, patients receive hyperbaric oxygen therapy and other therapies like psychotherapy and neurocognitive training. Individualized plans are designed to get to the root causes of neurological and cognitive issues and stimulate the growth of new cells and blood flow, even for patients with long-standing conditions. Dr. Mo explains,...
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Power of Gait Analysis to Predict and Monitor Health Conditions with Tomer Shussman OneStep TRANSCRIPT
Empowered Patient Podcast
Tomer Shussman, the Co-Founder and CEO of OneStep, is at the forefront of motion intelligence and gait analysis. OneStep provides a smartphone app that monitors movement and provides real-time data about gait patterns and changes over time. The system can predict and prevent conditions like falls, provide information about overall health, and reveal early warning signs for Parkinson's, Alzheimer's, and other aging-related diseases. Integrating OneStep's gait analysis data with Epic electronic health records allows healthcare providers to streamline documentation and leverage gait data to...
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Power of Gait Analysis to Predict and Monitor Health Conditions with Tomer Shussman OneStep
Empowered Patient Podcast
Tomer Shussman, the Co-Founder and CEO of OneStep, is at the forefront of motion intelligence and gait analysis. OneStep provides a smartphone app that monitors movement and provides real-time data about gait patterns and changes over time. The system can predict and prevent conditions like falls, provide information about overall health, and reveal early warning signs for Parkinson's, Alzheimer's, and other aging-related diseases. Integrating OneStep's gait analysis data with Epic electronic health records allows healthcare providers to streamline documentation and leverage gait data to...
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Addressing Extracellular Matrix Breakdown That Leads to Age-Related Diseases with Dr. Sherif Idriss Elastin Biosciences TRANSCRIPT
Empowered Patient Podcast
Dr. Sherif Idriss is the CEO of Elastin Biosciences, a company focused on targeting aging-related diseases by restoring elastin, a key protein in the extracellular matrix that provides elasticity and resilience to organs and tissues. They are developing small molecule therapies for diseases linked to elastin deficiency, including Williams syndrome and abdominal aortic aneurysm. As elastin degrades over time due to aging, it leads to loss of tissue structural integrity and function, contributing to numerous age-related diseases. Sherif explains, "One of the hallmarks of aging is...
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Addressing Extracellular Matrix Breakdown That Leads to Age-Related Diseases with Dr. Sherif Idriss Elastin Biosciences
Empowered Patient Podcast
Dr. Sherif Idriss is the CEO of Elastin Biosciences, a company focused on targeting aging-related diseases by restoring elastin, a key protein in the extracellular matrix that provides elasticity and resilience to organs and tissues. They are developing small molecule therapies for diseases linked to elastin deficiency, including Williams syndrome and abdominal aortic aneurysm. As elastin degrades over time due to aging, it leads to loss of tissue structural integrity and function, contributing to numerous age-related diseases. Sherif explains, "One of the hallmarks of aging is...
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Treating Septic Shock with Nanoparticle Formulation that Redistributes Nitric Oxide with Dr. Harven DeShield Vivacelle Bio TRANSCRIPT
Empowered Patient Podcast
Dr. Harven DeShield is the CEO and Co-Founder of Vivacelle Bio, which is developing a nanoparticle-based treatment called VBI-S to address the underlying causes of septic shock. The treatment works by efficiently redistributing nitric oxide to help regulate blood pressure and improve organ function, reducing the need for traditional vasopressor treatments. Vivacelle is also developing a product to help address hemorrhagic shock and minimize reperfusion injury. Harven explains, "There are seven aspects to septic shock - actually eight. So, first, you have an infection. You have to have an...
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Treating Septic Shock with Nanoparticle Formulation that Redistributes Nitric Oxide with Dr. Harven DeShield Vivacelle Bio
Empowered Patient Podcast
Dr. Harven DeShield is the CEO and Co-Founder of Vivacelle Bio, which is developing a nanoparticle-based treatment called VBI-S to address the underlying causes of septic shock. The treatment works by efficiently redistributing nitric oxide to help regulate blood pressure and improve organ function, reducing the need for traditional vasopressor treatments. Vivacelle is also developing a product to help address hemorrhagic shock and minimize reperfusion injury. Harven explains, "There are seven aspects to septic shock - actually eight. So, first, you have an infection. You have to have an...
info_outlineDr. Steffen-Sebastian Bolz, Chief Scientific Officer of Swiss-based Aphaia Pharma, shines a light on the excitement around weight loss drugs due to the discovery that GLP-1 agonists and points out the shift in the perception of obesity as a root cause of various health issues. Aphaia Pharma's approach involves stimulating hormone production in the small intestine by reinvigorating the mechanism that has become dormant due to the ingestion of highly refined foods. The company is also exploring the effects of the circadian rhythm on weight loss and maintaining a healthy weight.
Steffen elaborates, "What is understood now is obesity is the root cause of many sequel pathologies like type 2 diabetes, diabetes, fatty liver disease, and a whole lot of cardiovascular disease. So, the idea is that if we get obesity under control and the obesity pandemic under control, we might also lower the incidence of all the other diseases. There’s a massive rush into this field because there are already blockbuster drugs in the market, as you just said, and there are already 1 billion people worldwide who are obese and our projections predict that rapid growth of these numbers. So this is kind of the gold rush."
"Let me start with briefly outlining the mode of action of GLP-1 agonists. A common denominator of all metabolic diseases, either obesity or a related disease, is a lack of hormone output from the small intestine. What’s behind this is that the small intestine is capable of producing hormones in response to food intake."
"All these hormones act in an orchestrated fashion to allow digestion, proper immune control, and all these things. It was found that all these hormones are reduced in patients with obesity, and GLP-1 agonists replace one of those hormones, GLP-1. They do this by injecting very high doses to yield the effects we’re seeing, such as type 2 diabetes control and weight loss. But that’s just the hormone replacement therapy. That’s just one hormone out of a large portfolio, out of hundreds of hormones produced by the small intestine. And that is exactly where our thought process started."
#AphaiaPharma #Obesity #GLP1Agonists #SmallIntestine #WeightLoss
