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Brain Energetics & 2 New Potential Therapies in Alzheimer's

Evolving Past Alzheimer's

Release Date: 11/10/2020

Lisa's Story - Chap. 2 - Living Well with Alzheimer's  show art Lisa's Story - Chap. 2 - Living Well with Alzheimer's

Evolving Past Alzheimer's

Earlier this year, podcast episode #65 - we spoke to Lisa and her daughters Stacy and Natalie. They told us about how they were Living Well with Alzheimer's and improving using lifestyle and personalized approach. Her cognitive decline had stabilized and seen small, but significant improvements in brain function.  This episode we review some of the elements  that have led to their success

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Usable Technology for Brain Aging & Dementia with Ben Hampstead PhD show art Usable Technology for Brain Aging & Dementia with Ben Hampstead PhD

Evolving Past Alzheimer's

“We’re actually able to change the brain, even in the face of things like Alzheimer’s disease.” This was the statement made by our guest for this show, Dr. Ben Hampstead. Dr. Hampstead is a professor at the Univ of Michigan and leads a lab that is doing several studies using transcranial direct current stimulation for mild cognitive impairment, Alzheimer's, and other forms of cognitive impairment. 

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Your Brain On Sugar  show art Your Brain On Sugar

Evolving Past Alzheimer's

Nikki Gould, a registered dietician at Kemper Cognitive Wellness is also joining us today to talk about what sugar can do to your brain and your overall health and how we can navigate the holidays with this information in mind.

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Working with Trauma in Alzheimer's & Dementia show art Working with Trauma in Alzheimer's & Dementia

Evolving Past Alzheimer's

Trauma can be defined as any event that alters how we process, react to, and recall memories, by overwhelming the individual’s central nervous system. Additionally, trauma is defined as any event in which a person feels helpless and unsafe. It is not only an occurrence that happened in the past; instead, trauma is an event that leaves an imprint upon the body and the brain which persists to the present day.

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Why I'm excited about Aducanumab (Aduhelm)! show art Why I'm excited about Aducanumab (Aduhelm)!

Evolving Past Alzheimer's

Dr. Nate Bergman quickly summarizes the story up the FDA's recent "accelerated approval" of Biogen's - Aducanumab (brand named, Aduhelm). He ends off with surprise about why he is excited about the approval...and it's probably not what you think! A quick, but useful listen.

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Living well with Alzheimer's - Lisa's story of getting back to herself. show art Living well with Alzheimer's - Lisa's story of getting back to herself.

Evolving Past Alzheimer's

This episode is an important listen for anyone with doubts, reservations, or skepticism around a precision, functional medicine approach to the treatment of Alzheimer's disease.

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Does the new Alzheimer's drug Aducanumab mean the end of Alzheimer's? with Marwan Sabbagh, MD. show art Does the new Alzheimer's drug Aducanumab mean the end of Alzheimer's? with Marwan Sabbagh, MD.

Evolving Past Alzheimer's

In this episode, we hear the argument in favor of the new Alzheimer's drug, Aducanumab (Aduhelm).  Dr. Marwan Sabbagh is a clinical and research leader at the Cleveland Clinic's Lou Ruvo Center for Brain Health. He was a doctor that saw patients in one of the trials that led to the FDA's Accelerated (provisional) Approval. 

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People Getting Better- More Trial Results with Drs Ann Hathaway & Deborah Gordon show art People Getting Better- More Trial Results with Drs Ann Hathaway & Deborah Gordon

Evolving Past Alzheimer's

This week we will do almost a Part 2 from the last episode with Drs Dale Bredesen and Kat Toups.  In that episode, we featured recently released results data on MedArchive from a clinical trial in which 84% of 25 patients with early Alzheimer's Disease and Mild Cognitive Impairment improved with a Precision Medicine approach.  

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New Study Results with Drs Kat Toups & Dale Bredesen show art New Study Results with Drs Kat Toups & Dale Bredesen

Evolving Past Alzheimer's

Our guests today are Drs Kat Toups & Dale Bredesen.

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Being Patient - The Evolution of Data in Alzheimer's & Dementia with Deborah Kan show art Being Patient - The Evolution of Data in Alzheimer's & Dementia with Deborah Kan

Evolving Past Alzheimer's

Deborah Kan is a former executive producer with the Wall Street Journal. In 2017 she founded the website BeingPatient.com, a comprehensive website dedicated to Alzheimer's news, stories, and support.

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More Episodes

This is a super technical episode. The guest is a world leader in brain energy and its impact on cognition and cognitive change that leads to Alzheimer’s. We had to break this episode into two parts.

The difference between early-onset Alzheimer’s (which is usually genetic) and late-onset Alzheimer’s that usually happens after age 65.

Dr. Gonzalez-Lima argues that there is a common pathway, a problem with the way the brain produces energy, which leads to late-onset Alzheimer’s. The causes of this can be multiple, and the major one is simply getting older.

So as individuals, we have to lead healthy lifestyles to push back on these changes.

The earliest changes in the brain are different than are commonly understood. They are changes in the way the brain metabolizes energy. These changes show up long before the common atrophies we see in Alzheimer’s patients.

Many of the factors that lead to the development of Alzheimer’s are vascular. Test that may help catch Alzheimer’s before cognitive symptoms…

Carotid Intima-Media Thickness Test (CIMT)

EEG or QEG - brain maps

Genetics, head injuries, and brain trauma are other factors that can lead to Alzheimer’s. There are also some infections and viruses that can be associated with the development of the disease. Environmental toxins are a new cause that is being accepted worldwide by even the most conservative organizations.

We finish by talking about mitochondria therapy, a low-level laser therapy, where photons are shot into the brain’s photon acceptors. It essentially makes more space, making the cells more likely to bind and use oxygen. The main risk with this laser is the need to protect the eyes.

Ultimately, the hope is that this treatment can be done with LED lights, and people can do it themselves.

The ketogenic diet can help repair even a damaged brain. We have seen a number of people improve through adopting this diet, even though it can be difficult to sustain, and I don’t recommend sustaining it for long. That conversation will lead us into part 2 which will be released in two weeks.

 

12:17 - Fundamental problems in the brain and nervous system that are leading to diseases like Alzheimer’s

21:05 - Why are some brains more vulnerable than others to Alzheimer’s?

38:48 - A practical way to assess cerebral brain flow

40:02 - Laser light treatment to help with brain flow

1:09:39 - The ketogenic diet and its potential to help with improving cognition