loader from loading.io

Plasma Exchange, Albumin & IVIg for Alzheimer's - AMBAR Trial Results with Merce Boada MD PhD

Evolving Past Alzheimer's

Release Date: 02/18/2022

Alzheimer’s Disease - Going Beyond the Hypothesis show art Alzheimer’s Disease - Going Beyond the Hypothesis

Evolving Past Alzheimer's

What if what we thought to be the primary cause ofAlzheimer'swas not true? Dr. NateBergman delves into a research article published by Dr. Weaver to assess if the primary cause of Alzheimer's can be limited to only the amyloid area. For years it has been believed that the main causes of Alzheimer’s disease are the abnormal build-up of proteins in and around the brain cells. The main toxic protein involved in this is called the amyloid beta which accumulates and builds up like plaque around the brain cells. However, in recent times, the hypothesis that originated in 2006 and was believed by...

info_outline
Brain Stimulation for Early Alzheimer's Disease show art Brain Stimulation for Early Alzheimer's Disease

Evolving Past Alzheimer's

In This Episode You Will Learn: Where are you in your career right now?  Neuroscience research is fascinating. Dr. Ted is most interested in attention, perception, and memory. These three things work together harmoniously because you can’t remember something you ignore, and it’s difficult to notice something if you don’t perceive it in the beginning.  Dr. Ted studied how the brain encodes beats. He uses music perception to enable people to pay attention, listen, and remember information. He worked with Adam Gaza and researched aging's attention, memory, and perception. Their...

info_outline
Strong Heart, Sharp Mind with Marwan Sabbagh MD show art Strong Heart, Sharp Mind with Marwan Sabbagh MD

Evolving Past Alzheimer's

6 Effective Ways of Heart Disease Prevention Anyone who wishes to optimize health by protecting the heart and brain must listen to this! Dr. Marwan Sabbagh and Joe Piscatella combine the six most effective principles for heart disease prevention. They unfold valuable heart and brain facts in their new book Strong Heart, Sharp Mind, which are equally beneficial for the prevention of Alzheimer's disease. In a way, they open hope for effective heart disease treatments, dealing with Alzheimer's, and other brain ailments with a multidisciplinary approach. What is good for your heart is good for...

info_outline
Strong Heart, Sharp Mind with Marwan Sabbagh MD show art Strong Heart, Sharp Mind with Marwan Sabbagh MD

Evolving Past Alzheimer's

A familiar guest rejoins us for the show! Marwan Sabbagh MD is currently a professor of Neurology at Barrow Neurological Institute and a leader in Alzheimer's disease diagnosis and treatment. Dr. Sabbagh and his bestselling co-author and heart disease survivor, Joe Piscatella reveals new hope for treating and preventing these heart, blood vessel, and brain diseases like Alzheimer's with their new book, Strong Heart, Sharp Mind. We discuss how, for the first time in his career, Dr Sabbagh is starting to see people with very early Alzheimer's hold the symptoms at bay. He attributes, in part, to...

info_outline
Plasma Exchange, Albumin & IVIg for Alzheimer's - AMBAR Trial Results with Merce Boada MD PhD show art Plasma Exchange, Albumin & IVIg for Alzheimer's - AMBAR Trial Results with Merce Boada MD PhD

Evolving Past Alzheimer's

The conversation had on this episode is a little complex but is an excellent review in how science is done and "how the sausage is made" in terms of medical evidence in peer review for Alzheimer's treatments.   We discuss the results of the - The Alzheimer Management by Albumin Replacement - where people with mild to moderate Alzheimer's showed significant improvements after having their blood plasma exchanged in addition to receiving either IV Albumin as well as IVIg (in some of the experimental groups).   The study doesn't offer an explanation of the mechanisms around why Albumin...

info_outline
Towards Understanding Towards Understanding "Lyme" & Alzheimer's Relationships with Alan MacDonald MD

Evolving Past Alzheimer's

In July 2021, the journal Frontiers in Neurology reported on "groundbreaking research" out of Tulane pointing to the relationship between Lyme disease and Alzheimer’s dementia.  But since the 1980s our guest on this episode, Dr. Alan MacDonald, was stirring up the scientific debate by publishing and presenting data from his pathology laboratory that the bacteria - Borrelia Burgdorferi  often synonymous with what's called Lyme disease, because of its association with its US origins in the town of Lyme, Connecticut. Dr. MacDonald graduated with an MD from Columbia University. ...

info_outline
Our Sense of Smell - Brainwaves of COVID and Alzheimer's with Thom Cleland PhD show art Our Sense of Smell - Brainwaves of COVID and Alzheimer's with Thom Cleland PhD

Evolving Past Alzheimer's

This is a more theoretical episode that gives us some idea about what might be happening with the rhythms of an Alzheimer's or POST-COVID brain.

info_outline
Our Brains Need Meditation - Here's Why  with Hemal Patel PhD  show art Our Brains Need Meditation - Here's Why with Hemal Patel PhD

Evolving Past Alzheimer's

In this episode, we go deep into the potential benefits of specialized meditation for our immune systems, brain-related proteins, Alzheimer's, cellular energy, and much more. Our guest, Dr Hemal Patel - is a full professor and serves as the Vice-Chair for Research in the Department of Anesthesiology at the University of California, San Diego.

info_outline
Lisa's Story - Chap. 2 - Living Well with Alzheimer's  show art Lisa's Story - Chap. 2 - Living Well with Alzheimer's

Evolving Past Alzheimer's

Earlier this year, podcast episode #65 - we spoke to Lisa and her daughters Stacy and Natalie. They told us about how they were Living Well with Alzheimer's and improving using lifestyle and personalized approach. Her cognitive decline had stabilized and seen small, but significant improvements in brain function.  This episode we review some of the elements  that have led to their success

info_outline
Usable Technology for Brain Aging & Dementia with Ben Hampstead PhD show art Usable Technology for Brain Aging & Dementia with Ben Hampstead PhD

Evolving Past Alzheimer's

“We’re actually able to change the brain, even in the face of things like Alzheimer’s disease.” This was the statement made by our guest for this show, Dr. Ben Hampstead. Dr. Hampstead is a professor at the Univ of Michigan and leads a lab that is doing several studies using transcranial direct current stimulation for mild cognitive impairment, Alzheimer's, and other forms of cognitive impairment. 

info_outline
 
More Episodes

The conversation had on this episode is a little complex but is an excellent review in how science is done and "how the sausage is made" in terms of medical evidence in peer review for Alzheimer's treatments.

 

We discuss the results of the AMBAR trial - The Alzheimer Management by Albumin Replacement - where people with mild to moderate Alzheimer's showed significant improvements after having their blood plasma exchanged in addition to receiving either IV Albumin as well as IVIg (in some of the experimental groups).

 

The study doesn't offer an explanation of the mechanisms around why Albumin and IVIg might have been effective, but a robust conversation about the research and the durability of the positive results ensues.

 

Our guest is an international leader in Alzheimer's, Mercé Boada Rovira MD, PhD founder and director of the ACE Alzheimer's Center in Barcelona, Spain. Dr Boada has led and published results of over 100 Alzheimer's prevention and treatment trials over the many decades of her career.

 

This episode was co-produced and co-hosted by, Brett Graham, MD. Brett is a 2nd year neurology resident at Vanderbilt University Medical Center.

 

What is plasma exchange?

 

Also called plasmapheresis or PLEX. A procedure in which a machine is used to separate the liquid part of blood from the blood cells and then filtered similar to dialysis except that in plasma exchange big things like protein and antibodies are removed whereas in dialysis smaller molecules and electrolytes are the target. Because proteins are removed from blood in the process they are usually replaced with something like albumin afterwards. This treatment is mostly commonly used in treating certain autoimmune diseases like myasthenia gravis, Guillan Barre Syndrome, and thrombotic thrombocytopenic purpura (TTP) but it is also used in diseases where too much of a particular substance builds up in the blood such as in multiple myeloma or familial hypercholesterolemia.

 

What is albumin?

 

Albumin is the main protein component of blood that serves to balance concentration gradients between the blood and tissues as well as shuttle many other molecules through the bloodstream. This is removed during plasma exchange and so must be at least partially replaced after a session.

What is IVIG?

 

IVIG stands for intravenous immunoglobulin and is basically pooled antibodies from blood donors, which when administered to a patient have a variety of effects, many of which are still not fully understood, but you can basically think about these antibodies non-specifically binding to and neutralizing autoantibodies and other bad stuff in the blood. Again, this is most commonly used to treat autoimmune diseases.

 

For consultation or evaluation by Dr Nate Bergman call, 216-337-1400 or visit our website www.Kemperwellness.com